Abstract:
The present invention relates to methods and compounds for treating specific early stage aspects and late stage aspects of diabetic nephropathy. Methods and compounds for treating various physiological features associated with early stage and with late stage diabetic nephropathy are also provided.
Abstract:
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecules based on nucleic acid templates. The sequence of a nucleic acid template is used to direct the synthesis of non-natural molecules such as unnatural polymers and small molecules. Using this method combinatorial libraries of these molecules can be prepared and screened. Upon selection of a molecule, its encoding nucleic acid template may be amplified and/or evolved to yield the same molecule or related molecules for re-screening. The inventive methods and compositions of the present invention allow for the amplification and evolution of non-natural molecules in a manner analogous to the amplification of natural biopolymer such as polynucleotides and protein.
Abstract:
A stereo target corneal topography apparatus and method that uses two differently angled views of a target pattern reflected from a cornea to measure the shape of a cornea using a stereo reconstruction module to reconstruct the shape of a surface of a cornea. The surface elevation, surface slope and/or surface power may be determined without the need to make an initial assumption about the shape of the cornea.
Abstract:
A method for forming a set of p-channel devices with enhanced n-doping and penetration of boron into the channel region between the source and drain regions, thereby creating channel length independent p-channel threshold voltage behavior. Long channel and short channel transistors have approximately equal threshold voltages as (a) short channel effect is reduced with increased n-doping in short channel transistors (where boron penetration has little effect), and (b) the effects of boron penetration and increased n-doping are offset in longer channel transistors.
Abstract:
A flash EPROM circuit for providing a tight erase threshold voltage distribution. The circuit includes an array of memory cells having gates, sources and drains. Bit lines are coupled to the drains of a column of cells in the memory array. A plurality of word lines are each coupled to the gates of a row of cells in the memory array. A first voltage source is coupled to the bit lines to converge threshold voltages of erased memory cells. A second voltage source is coupled to the word lines to control the threshold voltages of the erased memory cells.
Abstract:
In one embodiment, a non-volatile memory cell structure 10 comprises heavily doped source 11 and drain 12 regions formed in the surface of a semiconductor substrate 8 and separated by a channel region 21. A floating gate 13 is formed over and insulated from the channel region 21 and a control gate 14 is formed over and insulated from the floating gate 13. A lightly doped region 20 is formed in the channel 21 beneath the floating gate 13 and adjoining the source region 11. The lightly doped region 20 is spaced from the surface of said substrate 8. Other embodiments and processes are also disclosed.
Abstract:
A clipboard structure includes a board having a seat formed on one end of an upper surface. A recess is formed in an outer end of the seat. A clamping element has two legs disposed in the recess. A spring element has two free ends fixed to the legs of the clamping element. The spring element can be easily assembled in the recess of the seat. The spring element biases the legs of the clamping element so that a front end of the clamping element is forced to abut against the board.
Abstract:
Improvements to electrical devices comprising conductive polymer compositions are described. The device, preferably a heater, comprises two electrodes, preferably planar electrodes and a conductive polymer composition, which preferably exhibits PTC behavior, and which is preferably sandwiched between the electrodes. At least one of the electrodes comprises a metal with a thin layer of high resistivity material attached thereto, e.g. anodized aluminum, so that the layer separates the electrode and the conductive polymer composition. This raises the room temperature resistance of the device and thus reduces the in-rush current.
Abstract:
A composite magnetic material composition includes: soft magnetic material powders; permanent magnet material powders; and a binder. The material made from this composition magnetic material composition has a relative magnetic permeability of said from 2 to 100. A magnetic core fabricated using this composite magnetic material composition is magnetized, after its fabrication, and a permanent magnetic field is retained in it, regardless of the operation status of the magnetic core. The magnetic flux density of the permanent magnetic field in this magnetic core is in the range of 10 to 2000 gauss. Magnetic components comprising this magnetic core have a higher saturation current.