公开(公告)号：US20130164794A1

公开(公告)日：2013-06-27

申请号：US13817295

申请日：2011-08-08

申请人： John Limanto ,  Gregory Beutner ,  Brendan Grau ,  Jacob Janey ,  Artis Klapars ,  Eric Ashley ,  Hallena R. Strotman ,  Matthew D. Truppo ,  Gregory Hughes ,  Fabien L. Cabirol ,  Anupam Gohel ,  Steven J. Collier ,  Jack Liang ,  Marissa Mock ,  Emily Mundorff ,  Scott Novick ,  Derek Smith

发明人： John Limanto ,  Gregory Beutner ,  Brendan Grau ,  Jacob Janey ,  Artis Klapars ,  Eric Ashley ,  Hallena R. Strotman ,  Matthew D. Truppo ,  Gregory Hughes ,  Fabien L. Cabirol ,  Anupam Gohel ,  Steven J. Collier ,  Jack Liang ,  Marissa Mock ,  Emily Mundorff ,  Scott Novick ,  Derek Smith

IPC分类号： C12N9/10

CPC分类号： C12P13/001 ,  C12N9/1096

摘要： The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.

摘要翻译： 本公开提供能够将底物2-（3,4-二甲氧基苯乙氧基）环己酮转化成至少2:1非对映异构体的反式非对映异构体产物（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的转氨酶多肽 比例相对于顺式非对映体（1R，2S）-2-（3,4-二甲氧基苯乙氧基）环己胺。 本公开还提供了多核苷酸，载体，宿主细胞，以及在制备（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺及其类似物的方法中制备和使用转氨酶多肽的方法，产物化合物可以是 进一步用于制备作为离子通道阻断剂的氨基环己基醚化合物（3R）-1 - [（1R，2R）-2- [2-（3,4-二甲氧基苯基）乙氧基]环己基]吡咯烷-3-醇。

公开(公告)号：US20130017580A1

公开(公告)日：2013-01-17

申请号：US13514750

申请日：2010-12-08

申请人： Yong Koy Bong ,  Michael D. Clay ,  Steven J. Collier ,  Benjamin Mijts ,  Michael Vogel ,  Xiyun Zhang ,  Jun Zhu ,  Jovana Nazor ,  Derek Smith ,  Shiwei Song

发明人： Yong Koy Bong ,  Michael D. Clay ,  Steven J. Collier ,  Benjamin Mijts ,  Michael Vogel ,  Xiyun Zhang ,  Jun Zhu ,  Jovana Nazor ,  Derek Smith ,  Shiwei Song

IPC分类号： C12N9/02 ,  C12N15/53 ,  C12P17/18 ,  C12P17/16

CPC分类号： C12N9/0073 ,  C12N9/0083 ,  C12P17/165 ,  C12P17/182 ,  C12Y114/13022 ,  C12Y114/99 ,  Y02P20/52

摘要： The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

摘要翻译： 本公开涉及可用于制备吡唑化合物的非天然存在的单加氧酶多肽，编码多肽的多核苷酸，以及使用该多肽的方法。

公开(公告)号：US20120139718A1

公开(公告)日：2012-06-07

申请号：US12957720

申请日：2010-12-01

申请人： Stephane Foisy ,  Oscar Noyola ,  Derek Smith ,  Reyzaldi Sacuevo

发明人： Stephane Foisy ,  Oscar Noyola ,  Derek Smith ,  Reyzaldi Sacuevo

IPC分类号： G08B1/00

CPC分类号： G08B25/014 ,  G08B25/012 ,  G08B25/14

摘要： An alarm monitoring station is capable of establishing a two way communications channel over a network to connect the monitoring station and alarm panels at monitored premises, for real time voice communication between the panels and the monitoring station. The monitoring station is further operable to provide pre-programmed voice messages to the alarm panels based on the sensed alarm condition over the two way communications channel. In this way, occupants at the premises may be notified of the sensed condition before speaking with an operator at the monitoring station.

摘要翻译： 警报监控站能够通过网络建立双向通信信道，以将监控站和监控场所的报警面板连接起来，从而实现面板与监控站之间的实时语音通信。 监测站还可操作以基于通过双向通信信道的感测到的报警状况向报警面板提供预编程语音消息。 以这种方式，在与监控站的操作员通话之前，可以向处所的乘客通知感测到的状况。

公开(公告)号：US08079953B2

公开(公告)日：2011-12-20

申请号：US11099031

申请日：2005-04-05

申请人： Jeffrey C. Braun ,  Charles J. Jacobus ,  Scott Booth ,  Michael Suarez ,  Derek Smith ,  Jeff Hartnagle ,  Glenn Leprell

发明人： Jeffrey C. Braun ,  Charles J. Jacobus ,  Scott Booth ,  Michael Suarez ,  Derek Smith ,  Jeff Hartnagle ,  Glenn Leprell

IPC分类号： A61B5/00

CPC分类号： A61B5/0006 ,  A61B5/0022 ,  A61B5/1112 ,  A61B2560/04 ,  G06F19/00 ,  G06F19/3418 ,  G16H40/40 ,  G16H40/63 ,  Y10S128/92

摘要： A general-purpose, low-cost system provides comprehensive physiological data collection, with extensive data object oriented programmability and configurability for a variety of medical as well as other analog data collection applications. In a preferred embodiment, programmable input signal acquisition and processing circuits are used so that virtually any analog and/or medical signal can be digitized from a common point of contact to a plurality of sensors. A general-purpose data routing and encapsulation architecture supports input tagging and standardized routing through modern packet switch networks, including the Internet; from one of multiple points of origin or patients, to one or multiple points of data analysis for physician review. The preferred architecture further supports multiple-site data buffering for redundancy and reliability, and real-time data collection, routing, and viewing (or slower than real-time processes when communications infrastructure is slower than the data collection rate). Routing and viewing stations allow for the insertion of automated analysis routines to aid in data encoding, analysis, viewing, and diagnosis.

摘要翻译： 一个通用的低成本系统提供了全面的生理数据采集，具有广泛的面向数据对象的可编程性和可配置性，适用于各种医疗以及其他模拟数据采集应用。 在优选实施例中，使用可编程输入信号采集和处理电路，使得实际上可以将任何模拟和/或医疗信号从公共接触点数字化到多个传感器。 通用数据路由和封装架构支持通过现代分组交换网络（包括因特网）进行输入标记和标准化路由; 从多个起点或患者之一，到医师审查的一个或多个数据分析点。 优选架构还支持冗余和可靠性的多站点数据缓冲，以及实时数据收集，路由和查看（或者当通信基础架构比数据收集速率慢时，比实时流程慢）。 路由和查看站允许插入自动化分析程序来辅助数据编码，分析，查看和诊断。

公开(公告)号：US20100035692A1

公开(公告)日：2010-02-11

申请号：US12189067

申请日：2008-08-08

申请人： Brendan K. Reville ,  Stacey Law ,  Derek Smith ,  Dan B. Kroymann

发明人： Brendan K. Reville ,  Stacey Law ,  Derek Smith ,  Dan B. Kroymann

IPC分类号： A63F9/24

CPC分类号： A63F13/69 ,  A63F13/12 ,  A63F13/79 ,  A63F13/85 ,  A63F2300/5553 ,  A63F2300/575 ,  G06Q30/06

摘要： Systems, methods and computer readable media are disclosed for updating the appearance of an avatar that exists across an online multi-player gaming system, including an executing video game. In addition to the general system, systems, methods and computer readable media for updating the avatar, techniques are disclosed for prompting networked video games to update an avatar that has been modified while the video game has been executing.

摘要翻译： 公开了系统，方法和计算机可读介质，用于更新存在于包括执行视频游戏在内的在线多人游戏系统的化身的外观。 公开了一般系统，用于更新化身的系统，方法和计算机可读介质，技术被用于促使联网的视频游戏更新在视频游戏已经执行时被修改的化身。

公开(公告)号：US07545326B2

公开(公告)日：2009-06-09

申请号：US11672047

申请日：2007-02-07

申请人： Dyami Caliri ,  Derek Smith

发明人： Dyami Caliri ,  Derek Smith

IPC分类号： G01S3/02 ,  G08B23/00

CPC分类号： G01S5/021 ,  G01S5/0252 ,  H04W64/00 ,  Y02D70/10

摘要： A system (50) and method (300) for providing multipath error mitigation for real-time wireless tracking of an object (100) is disclosed herein. A plurality of sensor readings are obtained from a tag (60) attached to an object (100) within an indoor facility (70). A plurality of reading sets are generated and sorted by zones. A zone with the highest average reading is preferably selected and the location of the object (100) is calculated based on the selected zone readings. In this manner, faulty position readings are eliminated from the location calculation thereby allowing for more accurate tracking of the object (100) within the indoor facility (70).

摘要翻译： 本文公开了一种用于为对象（100）的实时无线跟踪提供多径误差减轻的系统（50）和方法（300）。 从附接到室内设备（70）内的物体（100）的标签（60）获得多个传感器读数。 生成多个读取集合并按区域排序。 优选地选择具有最高平均读数的区域，并且基于所选择的区域读数计算对象（100）的位置。 以这种方式，从位置计算中消除故障位置读数，从而允许对室内设备（70）内的物体（100）进行更准确的跟踪。

公开(公告)号：US07443297B1

公开(公告)日：2008-10-28

申请号：US11967046

申请日：2007-12-29

申请人： Robert Baranowski ,  Dyami Caliri ,  Derek Smith

发明人： Robert Baranowski ,  Dyami Caliri ,  Derek Smith

IPC分类号： G08B13/14

CPC分类号： G08B13/1481 ,  G08B13/1436 ,  G08B13/2448

摘要： A wireless tracking system and method with a tag removal detection feature is disclosed herein. The system and method utilize a tag attached to an asset which includes a processor, a motion sensor (such as an accelerometer), a transceiver, a tag removal sensor and a power source having a limited supply of power. The tag removal sensor is an optical sensor which is activated only when the motion sensor detects motion. In this manner, the tag conserves power since the tag is typically only in motion ten percent of the day. If the tag is removed from the asset, the optical sensor confirms the removal and an alert is activated by the system.

摘要翻译： 本文公开了具有标签去除检测特征的无线跟踪系统和方法。 该系统和方法利用附加到资产的标签，该标签包括处理器，运动传感器（例如加速度计），收发器，标签去除传感器和具有有限供电功率的电源。 标签去除传感器是仅当运动传感器检测到运动时激活的光学传感器。 以这种方式，标签节省功率，因为​​标签通常仅在一天的10％的运动中运动。 如果标签从资产中移除，则光学传感器确认删除，并且系统激活警报。

公开(公告)号：US20080048914A1

公开(公告)日：2008-02-28

申请号：US11925826

申请日：2007-10-27

申请人： Derek Smith ,  James Adams ,  Nicolas Nierenberg ,  Joseph Baker

发明人： Derek Smith ,  James Adams ,  Nicolas Nierenberg ,  Joseph Baker

IPC分类号： G01S3/04

CPC分类号： G01S5/0252 ,  G01S5/021 ,  G06F19/00 ,  H04W4/029 ,  H04W4/043 ,  H04W64/00 ,  Y02D70/10

摘要： Techniques for accurate position location and tracking suitable for a wide range of facilities in variable environments are disclosed. In one aspect, a system for position location comprises a plurality of sensors (e.g. a network monitor, an environment sensor) for generating measurements of a plurality of sources, a plurality of objects or tags, each object generating measurements of the plurality of sources, and a processor for receiving the measurements and generating a position location for one or more objects in accordance with the received measurements. In another aspect, a position engine comprises a mapped space of a physical environment, and a processor for updating the mapped space in response to received measurements. The position engine may receive second measurements from an object within the physical environment, and generate a position location estimate for the object from the received second measurements and the mapped space.

公开(公告)号：US07336182B1

公开(公告)日：2008-02-26

申请号：US11875796

申请日：2007-10-19

申请人： Robert Baranowski ,  Dyami Caliri ,  Derek Smith

发明人： Robert Baranowski ,  Dyami Caliri ,  Derek Smith

IPC分类号： G08B13/14

CPC分类号： G08B13/1481 ,  G08B13/1436 ,  G08B13/2448

摘要： A wireless tracking system and method with a tag removal detection feature is disclosed herein. The system and method utilize a tag attached to an asset which includes a processor, a motion sensor (such as an accelerometer), a transceiver, a tag removal sensor and a power source having a limited supply of power. The tag removal sensor is an optical sensor which is activated only when the motion sensor detects motion. In this manner, the tag conserves power since the tag is typically only in motion ten percent of the day. If the tag is removed from the asset, the optical sensor confirms the removal and an alert is activated by the system.

公开(公告)号：US20080011063A1

公开(公告)日：2008-01-17

申请号：US11571458

申请日：2005-06-30

申请人： Derek Smith ,  Eduardo Boada ,  Gary Brayson

发明人： Derek Smith ,  Eduardo Boada ,  Gary Brayson

IPC分类号： G01N19/08

CPC分类号： G01N27/902

摘要： An inspection sensor module for an in-line pipe inspection tool has a support for mounting the module on the tool, a finger pivotally attached at one end to the support and pivotally attached at the other end to a sensor block carrying one or more inspection sensors. A first leaf spring extends from the support to the finger to bias the finger outwardly, and a second leaf spring extends from the support to the carrier to bias the sensor block. Biasing sensors are mounted on the leading and trailing edges of the first leaf spring to detect movement of the first leaf spring corresponding to movement of the inspection sensors towards or away from the support.

摘要翻译： 用于在线管道检查工具的检查传感器模块具有用于将模块安装在工具上的支撑件，手指在一端枢转地附接到支撑件并且在另一端枢转地附接到承载一个或多个检查传感器的传感器块 。 第一片弹簧从支撑件延伸到手指以将手指向外偏压，并且第二片簧从支撑件延伸到载体以偏置传感器块。 偏置传感器安装在第一板簧的前缘和后缘上，以检测对应于检查传感器朝向或远离支撑件移动的第一板簧的运动。