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公开(公告)号：US08092820B2
公开(公告)日：2012-01-10
申请号：US12468316
申请日：2009-05-19
申请人： Zhen Qian , A. Edward Osawa , Cary J. Reich
发明人： Zhen Qian , A. Edward Osawa , Cary J. Reich
CPC分类号： A61K38/4833 , A61L24/0031 , A61L24/104 , A61L2400/04
摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.
摘要翻译： 制备干燥的交联明胶组合物，其快速再水化以产生适合作为止血密封剂的明胶水凝胶。 在某些再水化助剂如聚乙二醇，聚乙烯基丙基吡咯烷酮和葡聚糖存在下，明胶是交联的，以产生干燥的交联明胶粉末。 已经发现使用再水合助剂在含水的再水合介质（通常为含有凝血酶的盐水）的存在下显着增加再水合速率。
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公开(公告)号：US20080286376A1
公开(公告)日：2008-11-20
申请号：US12176945
申请日：2008-07-21
申请人： Zhen Qian , A. Edward Osawa , Cary J. Reich
发明人： Zhen Qian , A. Edward Osawa , Cary J. Reich
CPC分类号： A61K38/4833 , A61L24/0031 , A61L24/104 , A61L2400/04
摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.
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公开(公告)号：US06613070B2
公开(公告)日：2003-09-02
申请号：US09882296
申请日：2001-06-14
申请人： Russell J. Redmond , Claude Vidal , Cary J. Reich , Felix Vega , Michael Collinson , Joseph F. Rondinone
发明人： Russell J. Redmond , Claude Vidal , Cary J. Reich , Felix Vega , Michael Collinson , Joseph F. Rondinone
IPC分类号： A61B1708
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00637 , A61B2017/0065 , A61B2017/00654
摘要： Systems and method for sealing vascular penetrations rely on placement of a temporary barrier on the posterior side of the penetration. Penetrations are then sealed by delivering a hemostatic gel to a region over the penetration, where the barrier both inhibits loss of the gel and promotes back flow of blood into the gel. A combination of natural clotting factors in the blood and hemostatic agents in the gel promote rapid and effective sealing of the vascular penetration. Specific systems for performing the method include a barrier carrier for temporary placement of the barrier within the blood vessel and a gel delivery tube which may be positioned within a tissue tract or line of penetration simultaneously with the barrier carrier to deliver the hemostatic gel.
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74.发明授权
公开(公告)号：US5474562A
公开(公告)日：1995-12-12
申请号：US208029
申请日：1994-03-09
申请人： Michael W. Orchowski , Bradley S. Stone , Cary J. Reich , Todd A. Mendelson , Robert J. Sullivan , Alok Nigam
发明人： Michael W. Orchowski , Bradley S. Stone , Cary J. Reich , Todd A. Mendelson , Robert J. Sullivan , Alok Nigam
CPC分类号： A61F2/167 , A61F2/1664 , A61F2/1667 , A61F2/1675
摘要： An apparatus in which a deformable or compressible intraocular lens can be received and staged for insertion into a patient's eye. The apparatus has an elongated compression chamber with proximal and distal ends and a longitudinal passageway, having an inner surface, extending between the ends. The portion of the passageway adjacent to the proximal end forms a loading area in which the passageway gradually decreases in size for causing an intraocular lens to be deformed or compressed as the lens is moved along the passageway. A staging area having a top and bottom passageway wall, communicates with the loading area with the passageway wall including alignment means for retaining the intraocular lens in a deformed or compressed condition. A portion of the passageway is sized to retain the intraocular lens in the deformed or compressed condition. A portion of the passageway defining the loading area comprises a surface which includes an opening and a slot or groove for permitting withdrawal of forceps used for pushing the intraocular lens through the loading area and into the staging area for deforming or compressing the lens.
摘要翻译： 可变形或可压缩的眼内透镜可以被接收并分级以插入患者眼睛的装置。 该装置具有细长的压缩室，其具有近端和远端以及纵向通道，其具有在端部之间延伸的内表面。 与近端相邻的通道部分形成一个装载区域，其中通道在尺寸上逐渐减小，以致随着透镜沿着通道移动而使眼内透镜变形或压缩。 具有顶部和底部通道壁的分段区域与装载区域连通，通道壁包括对准装置，用于将眼内透镜保持在变形或压缩状态。 通道的一部分的尺寸被设计成将眼内透镜保持在变形或压缩状态。 限定加载区域的通道的一部分包括一个表面，该表面包括开口和槽或凹槽，用于允许撤回用于将眼内透镜推动穿过装载区域并进入到用于变形或压缩透镜的分段区域中的镊子。
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公开(公告)号：US5336261A
公开(公告)日：1994-08-09
申请号：US15984
申请日：1993-02-10
IPC分类号： A61F2/14
CPC分类号： A61F2/145 , A61F2/1451 , G02C7/041 , A61F2250/0053
摘要： A low or high refractive index corneal inlay optical lens adapted to be inserted singly or multiply between the layers of a cornea to correct refractive errors in eyesight, wherein the implanted lens is a solid transparent uncoated lens having no apertures therethrough, of a diameter less than that of the optic zone of the eye under normal light or bright light conditions, such that the movement of fluids, nutrients and gases throughout the corneal layers is unimpeded, and wherein the composition of the lens or lenses relative to that of the surrounding stromal tissue are such that multiple refractive indices may be created and multiple focal corrections are possible.
摘要翻译： 一种低或高折射率角膜镶嵌光学透镜，适合于单独或多次插入角膜之间以矫正视力中的屈光不正，其中植入的透镜是透明的透明未透光透镜，其直径小于 在正常光线或明亮的光线条件下眼睛的视觉区域，使得流体，营养物质和气体在整个角膜层中的移动是不受阻碍的，并且其中透镜或透镜的组成相对于周围基质组织的组成 可以产生多个折射率并且可以进行多次焦点校正。
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公开(公告)号：US4746751A
公开(公告)日：1988-05-24
申请号：US47690
申请日：1987-05-07
CPC分类号： C09B69/008 , C07F7/0809 , C07F7/1836 , C08K5/54
摘要： The preparation of particular fluorescent silane dye compositions is disclosed. These silane dye compositions have particular utility as reactants in the preparation of silicone polymeric fluorescent dyes which can be ideally used as chemical indicators in biological sensors.
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公开(公告)号：US09408945B2
公开(公告)日：2016-08-09
申请号：US13150809
申请日：2011-06-01
CPC分类号： A61L24/104 , A61K38/4833 , A61L24/10 , A61L24/106 , A61L2400/04
摘要： Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a first component comprising a dry preparation of a coagulation inducing agent, b) providing a second component comprising a dry preparation of a biocompatible polymer suitable for use in hemostasis, c) mixing said first component and said second component under conditions effective to form a wet paste while essentially preventing degradation of the second component by said first component in a final container or transferring said wet paste into a final container, d) freezing and lyophilizing said paste in said container thereby obtaining a dry and stable hemostatic composition comprising said first and said second component in lyophilized form, and e) finishing said dry and stable hemostatic composition in said final container to a storable pharmaceutical device containing said first component and said second component in a combined form as a dry and stable hemostatic composition.
摘要翻译： 描述了制备干燥和稳定的止血组合物的方法，所述方法包括a）提供包含凝结诱导剂的干制剂的第一组分，b）提供第二组分，其包含适于用于 止血，c）在有效形成湿糊剂的条件下混合所述第一组分和所述第二组分，同时基本上防止所述第一组分在最终容器中降解第二组分或将所述湿糊剂转移到最终容器中，d）冷冻和 将所述糊剂冻干在所述容器中，从而获得干燥且稳定的止血组合物，其包含冻干形式的所述第一和所述第二组分，和e）将所述最终容器中的所述干燥稳定的止血组合物整理成含有所述第一组分和 组合形式的第二组分作为干燥和稳定的止血组合物 游戏
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公开(公告)号：US08357378B2
公开(公告)日：2013-01-22
申请号：US13114784
申请日：2011-05-24
CPC分类号： A61L24/0015 , A61L24/0031 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/418 , A61L2300/604 , Y10S524/916
摘要： Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extruding the hydrogel through an orifice at the target site. Alternatively, the hydrogels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for controlled release drug delivery, for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.
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公开(公告)号：US20090227779A1
公开(公告)日：2009-09-10
申请号：US12468316
申请日：2009-05-19
申请人： Zhen Qian , A. Edward Osawa , Cary J. Reich
发明人： Zhen Qian , A. Edward Osawa , Cary J. Reich
IPC分类号： C07K14/78
CPC分类号： A61K38/4833 , A61L24/0031 , A61L24/104 , A61L2400/04
摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.
摘要翻译： 制备干燥的交联明胶组合物，其快速再水化以产生适合作为止血密封剂的明胶水凝胶。 在某些再水化助剂如聚乙二醇，聚乙烯基丙基吡咯烷酮和葡聚糖存在下，明胶是交联的，以产生干燥的交联明胶粉末。 已经发现使用再水合助剂在含水的再水合介质（通常为含有凝血酶的盐水）的存在下显着增加再水合速率。
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公开(公告)号：US20080187591A1
公开(公告)日：2008-08-07
申请号：US11832380
申请日：2007-08-01
申请人： Woonza M. Rhee , Cary J. Reich , A. Edward Osawa , Felix Vega
发明人： Woonza M. Rhee , Cary J. Reich , A. Edward Osawa , Felix Vega
CPC分类号： A61K47/42 , A61K9/70 , A61K38/363 , A61K38/4833 , A61K47/34 , A61L24/001 , A61L24/0031 , A61L24/06 , A61L31/044 , A61L31/145 , A61L31/146 , Y10T428/249983 , C08L71/02
摘要： Compositions, methods, and kits are provided for sealing applications. Compositions are prepared by combining a first cross-linkable component with a second cross-linkable component to form a porous matrix having interstices, and combining the porous matrix with a hydrogel-forming component to fill at least some of the interstices. The compositions exhibit minimal swelling properties.
摘要翻译： 提供组合物，方法和试剂盒用于密封应用。 通过将第一可交联组分与第二可交联组分组合以形成具有间隙的多孔基质并将多孔基质与形成水凝胶的组分相结合以填充至少一些间隙来制备组合物。 组合物表现出最小的溶胀特性。
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