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公开(公告)号：US20120134980A1
公开(公告)日：2012-05-31
申请号：US13174963
申请日：2011-07-01
申请人： Donald G. Wallace , Cary J. Reich , Narinder S. Shargill , Felix Vega , A. Edward Osawa , Zhen Qian-Wallis
发明人： Donald G. Wallace , Cary J. Reich , Narinder S. Shargill , Felix Vega , A. Edward Osawa , Zhen Qian-Wallis
CPC分类号： A61K38/4833 , A61K9/0002 , A61L2/081 , A61L2/087 , A61L24/0015 , A61L24/0031 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/418 , A61L2300/604 , A61L2400/04
摘要： Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extruding the hydrogel through an orifice at the target site. Alternatively, the hydrogels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for controlled release drug delivery, for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.
摘要翻译： 交联水凝胶包含各种生物和非生物聚合物，如蛋白质，多糖和合成聚合物。 这种水凝胶优选不含游离水相，并且可以通过在目标部位的孔口挤出水凝胶而将其施加到患者体内的靶位点。 或者，水凝胶可以被机械破坏并用于可植入制品，例如乳房植入物。 当在体内使用时，组合物可用于控释药物递送，用于抑制手术后脊柱和其他组织粘连，用于填充组织切口，组织束，体腔，手术缺陷等。
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公开(公告)号：US20110223231A1
公开(公告)日：2011-09-15
申请号：US13114784
申请日：2011-05-24
IPC分类号： A61M5/178
CPC分类号： A61L24/0015 , A61L24/0031 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/418 , A61L2300/604 , Y10S524/916
摘要： Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extruding the hydrogel through an orifice at the target site. Alternatively, the hydrogels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for controlled release drug delivery, for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.
摘要翻译： 交联水凝胶包含各种生物和非生物聚合物，如蛋白质，多糖和合成聚合物。 这种水凝胶优选不含游离水相，并且可以通过在目标部位的孔口挤出水凝胶而将其施加到患者体内的靶位点。 或者，水凝胶可以被机械破坏并用于可植入制品，例如乳房植入物。 当在体内使用时，组合物可用于控释药物递送，用于抑制手术后脊柱和其他组织粘连，用于填充组织切口，组织束，体腔，手术缺陷等。
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公开(公告)号：US08357378B2
公开(公告)日：2013-01-22
申请号：US13114784
申请日：2011-05-24
CPC分类号： A61L24/0015 , A61L24/0031 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/418 , A61L2300/604 , Y10S524/916
摘要： Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extruding the hydrogel through an orifice at the target site. Alternatively, the hydrogels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for controlled release drug delivery, for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.
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公开(公告)号：US6066325A
公开(公告)日：2000-05-23
申请号：US32370
申请日：1998-02-27
CPC分类号： A61L24/0015 , A61L24/0031 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/418 , A61L2300/604 , Y10S524/916
摘要： Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extruding the hydrogel through an orifice at the target site. Alternatively, the hydrogels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for controlled release drug delivery, for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.
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公开(公告)号：US08303981B2
公开(公告)日：2012-11-06
申请号：US13174963
申请日：2011-07-01
申请人： Donald G. Wallace , Cary J. Reich , Narinder S. Shargill , Felix Vega , A. Edward Osawa , Zhen Qian-Wallis
发明人： Donald G. Wallace , Cary J. Reich , Narinder S. Shargill , Felix Vega , A. Edward Osawa , Zhen Qian-Wallis
CPC分类号： A61K38/4833 , A61K9/0002 , A61L2/081 , A61L2/087 , A61L24/0015 , A61L24/0031 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/418 , A61L2300/604 , A61L2400/04
摘要： Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extruding the hydrogel through an orifice at the target site. Alternatively, the hydrogels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for controlled release drug delivery, for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.
摘要翻译： 交联水凝胶包含各种生物和非生物聚合物，如蛋白质，多糖和合成聚合物。 这种水凝胶优选不含游离水相，并且可以通过在目标部位的孔口挤出水凝胶而将其施加到患者体内的靶位点。 或者，水凝胶可以被机械破坏并用于可植入制品，例如乳房植入物。 当在体内使用时，组合物可用于控释药物递送，用于抑制手术后脊柱和其他组织粘连，用于填充组织切口，组织束，体腔，手术缺陷等。
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公开(公告)号：US07871637B2
公开(公告)日：2011-01-18
申请号：US11859312
申请日：2007-09-21
申请人： Zhen Qian , A. Edward Osawa , Cary J. Reich , Donald G. Wallace , Narinder S. Shargill , Felix Vega
发明人： Zhen Qian , A. Edward Osawa , Cary J. Reich , Donald G. Wallace , Narinder S. Shargill , Felix Vega
CPC分类号： A61L24/0031 , A61L24/043 , A61L24/104 , A61L2400/04 , C08L89/00
摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.
摘要翻译： 制备干燥的交联明胶组合物，其快速再水化以产生适合作为止血密封剂的明胶水凝胶。 在某些再水化助剂如聚乙二醇，聚乙烯基丙基吡咯烷酮和葡聚糖存在下，明胶是交联的，以产生干燥的交联明胶粉末。 已经发现使用再水合助剂在含水的再水合介质（通常为含有凝血酶的盐水）的存在下显着增加再水合速率。
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公开(公告)号：US6063061A
公开(公告)日：2000-05-16
申请号：US903674
申请日：1997-07-31
IPC分类号： A61K47/42 , A01K1/015 , A61F2/00 , A61K9/00 , A61L20060101 , A61L24/00 , A61L27/00 , A61L27/52 , A61L27/54 , A61L31/00 , A61L31/14 , A61L31/16 , A61M5/00 , A61P17/02 , A61P41/00 , C08J3/075 , C08L1/00 , C08L3/00 , C08L5/00 , C08L89/00 , C08L101/00 , C08L101/16
CPC分类号： A61L24/0015 , A61L24/0031 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/418
摘要： Molecular cross-linked gels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such molecular gels may be applied to target sites in a patient's body by extruding the gel through an orifice at the target site. Alternatively, the gels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.
摘要翻译： 分子交联凝胶包含多种生物和非生物聚合物，如蛋白质，多糖和合成聚合物。 这种分子凝胶可以通过在目标部位的孔口挤出凝胶而施加到患者体内的靶位点。 或者，凝胶可能被机械破坏并用于可植入制品，例如乳房植入物。 当在体内使用时，组合物可用于抑制手术后脊柱和其他组织粘连，用于填充组织斑点，组织束，体腔，手术缺陷等。
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公开(公告)号：US08962025B2
公开(公告)日：2015-02-24
申请号：US11832380
申请日：2007-08-01
申请人： Woonza M. Rhee , Cary J. Reich , A. Edward Osawa , Felix Vega
发明人： Woonza M. Rhee , Cary J. Reich , A. Edward Osawa , Felix Vega
IPC分类号： A61K9/14 , A61K38/39 , A61L31/12 , A61L24/10 , A61L24/06 , A61K47/42 , A61L24/00 , A61L31/04 , A61L31/14 , A61K9/70 , A61K38/36 , A61K38/48 , A61K47/34
CPC分类号： A61K47/42 , A61K9/70 , A61K38/363 , A61K38/4833 , A61K47/34 , A61L24/001 , A61L24/0031 , A61L24/06 , A61L31/044 , A61L31/145 , A61L31/146 , Y10T428/249983 , C08L71/02
摘要： Compositions, methods, and kits are provided for sealing applications. Compositions are prepared by combining a first cross-linkable component with a second cross-linkable component to form a porous matrix having interstices, and combining the porous matrix with a hydrogel-forming component to fill at least some of the interstices. The compositions exhibit minimal swelling properties.
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公开(公告)号：US20080187591A1
公开(公告)日：2008-08-07
申请号：US11832380
申请日：2007-08-01
申请人： Woonza M. Rhee , Cary J. Reich , A. Edward Osawa , Felix Vega
发明人： Woonza M. Rhee , Cary J. Reich , A. Edward Osawa , Felix Vega
CPC分类号： A61K47/42 , A61K9/70 , A61K38/363 , A61K38/4833 , A61K47/34 , A61L24/001 , A61L24/0031 , A61L24/06 , A61L31/044 , A61L31/145 , A61L31/146 , Y10T428/249983 , C08L71/02
摘要： Compositions, methods, and kits are provided for sealing applications. Compositions are prepared by combining a first cross-linkable component with a second cross-linkable component to form a porous matrix having interstices, and combining the porous matrix with a hydrogel-forming component to fill at least some of the interstices. The compositions exhibit minimal swelling properties.
摘要翻译： 提供组合物，方法和试剂盒用于密封应用。 通过将第一可交联组分与第二可交联组分组合以形成具有间隙的多孔基质并将多孔基质与形成水凝胶的组分相结合以填充至少一些间隙来制备组合物。 组合物表现出最小的溶胀特性。
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公开(公告)号：US08092820B2
公开(公告)日：2012-01-10
申请号：US12468316
申请日：2009-05-19
申请人： Zhen Qian , A. Edward Osawa , Cary J. Reich
发明人： Zhen Qian , A. Edward Osawa , Cary J. Reich
CPC分类号： A61K38/4833 , A61L24/0031 , A61L24/104 , A61L2400/04
摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.
摘要翻译： 制备干燥的交联明胶组合物，其快速再水化以产生适合作为止血密封剂的明胶水凝胶。 在某些再水化助剂如聚乙二醇，聚乙烯基丙基吡咯烷酮和葡聚糖存在下，明胶是交联的，以产生干燥的交联明胶粉末。 已经发现使用再水合助剂在含水的再水合介质（通常为含有凝血酶的盐水）的存在下显着增加再水合速率。
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