公开(公告)号：US11732289B2

公开(公告)日：2023-08-22

申请号：US17878580

申请日：2022-08-01

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  Norbert D. Hagen ,  David Opalsky

IPC: B01L3/00 ,  B01L7/00 ,  G01N35/04 ,  C12Q1/6806 ,  C12Q1/686

CPC classification number: C12Q1/6806 ,  B01L3/50825 ,  B01L3/565 ,  B01L7/5255 ,  C12Q1/686 ,  G01N35/04 ,  B01L3/527 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/046 ,  G01N2035/0418 ,  G01N2035/0436

Abstract: A receptacle distribution system includes a rotary distributor and a receptacle handoff device. The rotary distributor includes a motorized turntable with an upright wall, a distributor head for holding a receptacle, a hook configured to engage a receptacle for moving the receptacle into or out of the distributor head, and an a system for powered elevation of the distributor head. The receptacle handoff device is configured to transfer a receptacle from a first receptacle distributor to the rotary distributor and includes a receptacle yoke configured to hold a receptacle placed in the receptacle yoke with the first receptacle distributor, the receptacle yoke being rotatable between a first position to receive the receptacle and a second position to present the receptacle to the rotary distributor to enable the hook of the rotary distributor to pull the receptacle from the receptacle yoke and into the distributor head.

公开(公告)号：US11732288B2

公开(公告)日：2023-08-22

申请号：US17877832

申请日：2022-07-29

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  Norbert D. Hagen ,  David Opalsky

IPC: B01L3/00 ,  B01L7/00 ,  G01N35/04 ,  C12Q1/6806 ,  C12Q1/686

CPC classification number: C12Q1/6806 ,  B01L3/50825 ,  B01L3/565 ,  B01L7/5255 ,  C12Q1/686 ,  G01N35/04 ,  B01L3/527 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/046 ,  G01N2035/0418 ,  G01N2035/0436

Abstract: An assembly includes a bracket, a magnetic elution slot, and a reagent pack loading station. The elution slot receives a multiple receptacle device having multiple receptacles interconnected by a connecting rib defining shoulders along either side of the receptacle device. The elution slot includes opposed walls attached to the bracket below a top surface of the bracket with the opposed walls disposed on either side of a slot formed in the bracket. The downwardly facing shoulders of the receptacle device are supported on the top surface of the bracket on opposed sides of the slot, and one or more magnets are attached to or embedded in one or both walls. The reagent pack loading station holds a multi-well reagent pack such that the wells of the reagent pack are accessible by a pipettor, and the reagent pack holding station includes spaced apart hold down features extending above the top surface of the bracket.

公开(公告)号：USD982177S1

公开(公告)日：2023-03-28

申请号：US29751801

申请日：2020-09-23

Applicant: GEN-PROBE INCORPORATED

Designer： Byron J. Knight ,  David A. Buse ,  David Opalsky ,  Norbert D. Hagen ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

公开(公告)号：US20210079452A1

公开(公告)日：2021-03-18

申请号：US17033395

申请日：2020-09-25

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Tyler Moore ,  Byron J. Knight

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A receptacle cap includes a probe recess configured to receive a probe inserted therein to thereby frictionally secure the receptacle cap to the probe, and a closed lower end of the receptacle is insertable into an open end of a reaction receptacle to close the reaction receptacle. The receptacle cap and the reaction receptacle include interlocking features for securing the receptacle cap to the reaction receptacle.

公开(公告)号：US10719677B2

公开(公告)日：2020-07-21

申请号：US16208186

申请日：2018-12-03

Applicant: GEN-PROBE INCORPORATED

Inventor： Norbert D. Hagen ,  David Opalsky ,  Rolf Silbert

IPC: G06K7/10 ,  G01N35/00 ,  G01N35/02 ,  G06K7/14 ,  G06K19/06 ,  G01N35/04

Abstract: A method of reading machine-readable labels on sample receptacles held by a sample rack. In the method, an absolute position of the sample rack is measured as the sample rack moves between first and second positions in a housing. During movement between the first and second positions, an image is acquired of a machine-readable label associated with each sample receptacle held by the sample rack. The image of each machine-readable label is thereafter decoded.

公开(公告)号：US10711297B2

公开(公告)日：2020-07-14

申请号：US15675206

申请日：2017-08-11

Applicant: GEN-PROBE INCORPORATED

Inventor： David A. Buse ,  David Opalsky ,  Jason F. Rhubottom ,  Norbert D. Hagen ,  Jennifer L. Tidd

IPC: C12Q1/68 ,  B01L3/00 ,  B01L7/00 ,  G01N35/04 ,  C12Q1/6806 ,  C12Q1/686

Abstract: An automated method for analyzing a plurality of samples within a housing of a self-contained system. The system is loaded with a plurality of samples, after which a first assay is performed on a first sample subset and a second assay performed on a second sample subset. The two assays include exposing the samples to a target capture reagent having a solid support for directly or indirectly immobilizing a target nucleic acid that may be present in one or more of the samples. The two assays may be performed with the same or different target capture reagents and target nucleic acids, but the receptacles for performing the exposing step have substantially identical geometries. Following the exposing step, an amplification reaction for amplifying a region of the target nucleic acid is performed with each sample. The amplification reactions of the two assays are performed in receptacles having different geometries.

公开(公告)号：US10656077B2

公开(公告)日：2020-05-19

申请号：US15709200

申请日：2017-09-19

Applicant: GEN-PROBE INCORPORATED

Inventor： Norbert D. Hagen ,  Byron J. Knight ,  David Opalsky

IPC: G01N21/15 ,  G01N35/00 ,  B08B1/00 ,  B08B9/00 ,  G02B6/38

Abstract: A sample testing system includes a test receptacle support structure, an optical element positioned for transmitting electromagnetic radiation emitted or reflected by a sample disposed in a test receptacle supported by the test receptacle support structure, a cleaning member, and an automated transport arm configured to (i) detachably couple the cleaning member, (ii) move the detachably-coupled cleaning member into a position proximate to and/or contacting the optical element, and (iii) decouple the cleaning member.

公开(公告)号：US10563251B2

公开(公告)日：2020-02-18

申请号：US15951818

申请日：2018-04-12

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  David Howard Combs ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Keith Moravick ,  Tyler Moore

IPC: C12Q1/686 ,  B01L7/00 ,  G01N21/64 ,  B01L9/06

Abstract: First and second sets of receptacles containing reagents for first and second amplification reactions, respectively, are placed in first and second receptacle holders, each associated with a thermal element. The receptacles are subjected to different first and second incubation processes resulting in the first and second amplification reactions in each of the first and second sets of receptacles that contain a first or a second target nucleic acid, respectively. The presence or absence of the first or second target nucleic acid, if any, is determined for each receptacle of the first and second sets of receptacles.

公开(公告)号：US20190284612A1

公开(公告)日：2019-09-19

申请号：US16363671

申请日：2019-03-25

Applicant: Gen-Probe Incorporated

Inventor： David A. BUSE ,  David Opalsky ,  Jason F. Rhubottom ,  Norbert D. Hagen ,  Jennifer L. Tidd

IPC: C12Q1/6806 ,  C12Q1/686 ,  B01L7/00 ,  B01L3/00 ,  G01N35/04

Abstract: An automated method for analyzing a plurality of samples within a housing of a self-contained system. The system is loaded with a plurality of samples, after which a first assay is performed on a first sample subset and a second assay performed on a second sample subset. The two assays include exposing the samples to a target capture reagent having a solid support for directly or indirectly immobilizing a target nucleic acid that may be present in one or more of the samples. The two assays may be performed with the same or different target capture reagents and target nucleic acids, but the receptacles for performing the exposing step have substantially identical geometries. Following the exposing step, an amplification reaction for amplifying a region of the target nucleic acid is performed with each sample. The amplification reactions of the two assays are performed in receptacles having different geometries.

公开(公告)号：US10132821B2

公开(公告)日：2018-11-20

申请号：US15054943

申请日：2016-02-26

Applicant: GEN-PROBE INCORPORATED

Inventor： Rolf Silbert ,  David Opalsky ,  David Aaron Buse ,  Robert J. Rosati ,  Olev Tammer ,  Richard Capella ,  Matthias Merten

IPC: G01N35/00 ,  G01N35/10 ,  G01F23/26 ,  G01N1/28 ,  C40B60/12 ,  G01N35/04

Abstract: The present invention provides a processing station for automatically processing a biological sample, a system for automated real-time inventory control of consumables within a biological sample handling or assay instrument, a high throughput random access automated instrument for processing biological samples, an automated instrument for processing or analysis of a sample, and processes for automated mucoid detection and elimination. Methods of using the disclosed instruments, mucoid detection processes, and systems to process and/or analyze samples are also disclosed.