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公开(公告)号：US20110293638A1
公开(公告)日：2011-12-01
申请号：US12789365
申请日：2010-05-27
申请人： Leopold Bruckschwaiger , Sonja Svatos , Julia N+e,uml u+ee rnberger , Wolfgang Teschner , Harald Arno Butterweck , Hans-Peter Schwarz , Thomas Gundinger , Bernhard Koelbl , Reinhard Grausenberger , Azra Pljevljakovic
发明人： Leopold Bruckschwaiger , Sonja Svatos , Julia N+e,uml u+ee rnberger , Wolfgang Teschner , Harald Arno Butterweck , Hans-Peter Schwarz , Thomas Gundinger , Bernhard Koelbl , Reinhard Grausenberger , Azra Pljevljakovic
IPC分类号： A61K39/395 , A61P37/00 , A61P31/00
CPC分类号： C07K1/36 , A61K9/0019 , A61K9/08 , A61K35/16 , A61K38/1709 , A61K47/183 , C07K1/14 , C07K1/18 , C07K1/30 , C07K1/34 , C07K16/065
摘要： The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.
摘要翻译： 本发明提供了用于制造IVIG产品的改进方法。 这些方法提供各种优点，例如在净化期间减少IgG的损失并提高最终产品的质量。 在其它方面，本发明提供适用于静脉内，皮下和/或肌内给药的水性和药物组合物。 在其它实施方案中，本发明提供了治疗疾病或病症的方法，包括施用本文提供的IgG组合物。
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72.发明授权IVIG modulation of chemokines for treatment of multiple sclerosis, alzheimer's disease, and parkinson's disease 有权用于治疗多发性硬化，阿尔茨海默氏病和帕金森病的趋化因子的IVIG调节公开(公告)号：US07968293B2
公开(公告)日：2011-06-28
申请号：US12189367
申请日：2008-08-11
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： The present invention provides methods for providing a prognosis of treatment of diseases associated with inflammatory disease of the brain, including MS, e.g., relapsing-remitting multiple sclerosis (RRMS), Alzheimer's disease, and Parkinson's disease using molecular markers that are shown to be overexpressed or underexpressed in patients treated with intravenous immunoglobulins (IVIG). Also provided are methods to identify compounds that are useful for the treatment or prevention of MS, e.g., relapsing-remitting multiple sclerosis (RRMS), Alzheimer's disease, and Parkinson's disease.
摘要翻译： 本发明提供用于提供治疗与脑炎性疾病相关疾病（包括MS）的预后的方法，例如使用显示为过表达的分子标记物复发性缓解多发性硬化（RRMS），阿尔茨海默氏病和帕金森病 或在静脉注射免疫球蛋白（IVIG）治疗的患者中未表达。 还提供了鉴定可用于治疗或预防MS的化合物的方法，例如复发缓解多发性硬化症（RRMS），阿尔茨海默病和帕金森病。
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73.发明申请Stable co-formulation of hyaluronidase and immunoglobulin, and methods of use thereof 有权透明质酸酶和免疫球蛋白的稳定共配方及其使用方法公开(公告)号：US20110066111A1
公开(公告)日：2011-03-17
申请号：US12807991
申请日：2010-09-16
申请人： Wolfgang Teschner , Sonja Svatos , Leopold Bruckschwaiger , Alfred Weber , Hans-Peter Schwarz , Laura Lei
发明人： Wolfgang Teschner , Sonja Svatos , Leopold Bruckschwaiger , Alfred Weber , Hans-Peter Schwarz , Laura Lei
CPC分类号： A61K39/00 , A61K9/0021 , A61K39/39591 , A61K47/42 , A61K2039/505 , C07K16/00 , C07K16/06 , C07K2317/21 , C12N9/2474 , C12Y302/01035 , Y02A50/464
摘要： Provided herein are stable co-formulations of immunoglobulin and hyaluronidase that are stable to storage in liquid form at room temperature for at least 6 months and at standard refrigerator temperatures for 1-2 years. Such co-formulations can be used in methods of treating IG-treatable diseases or conditions by subcutaneous administration.
摘要翻译： 本文提供了免疫球蛋白和透明质酸酶的稳定共配方，其在室温下以液体形式储存至少6个月，并在标准冰箱温度下保存1-2年。 这种共同制剂可用于通过皮下给药治疗IG治疗性疾病或病症的方法。
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74.发明申请IVIG MODULATION OF CHEMOKINES FOR TREATMENT OF MULTIPLE SCLEROSIS, ALZHEIMER'S DISEASE, AND PARKINSON'S DISEASE 有权用于治疗多发性硬化症，阿尔茨海默病和帕金森病的化疗药物的IVIG调节公开(公告)号：US20090148463A1
公开(公告)日：2009-06-11
申请号：US12189367
申请日：2008-08-11
IPC分类号： A61K39/395 , G01N33/53 , A61P25/00 , A61P37/06 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： The present invention provides methods for providing a prognosis of treatment of diseases associated with inflammatory disease of the brain, including MS, e.g., relapsing-remitting multiple sclerosis (RRMS), Alzheimer's disease, and Parkinson's disease using molecular markers that are shown to be overexpressed or underexpressed in patients treated with intravenous immunoglobulins (IVIG). Also provided are methods to identify compounds that are useful for the treatment or prevention of MS, e.g., relapsing-remitting multiple sclerosis (RRMS), Alzheimer's disease, and Parkinson's disease.
摘要翻译： 本发明提供用于提供治疗与脑炎性疾病相关疾病（包括MS）的预后的方法，例如使用显示为过表达的分子标记物复发性缓解多发性硬化（RRMS），阿尔茨海默氏病和帕金森病 或在静脉注射免疫球蛋白（IVIG）治疗的患者中未表达。 还提供了鉴定可用于治疗或预防MS的化合物的方法，例如复发缓解多发性硬化症（RRMS），阿尔茨海默病和帕金森病。
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75.发明授权公开(公告)号：US07033590B1
公开(公告)日：2006-04-25
申请号：US09661992
申请日：2000-09-14
申请人： Friedrich Scheiflinger , Randolf Kerschbaumer , Falko-Guenter Falkner , Friedrich Dorner , Hans-Peter Schwarz
发明人： Friedrich Scheiflinger , Randolf Kerschbaumer , Falko-Guenter Falkner , Friedrich Dorner , Hans-Peter Schwarz
IPC分类号： A61K39/395 , A61K38/04 , C12N5/20 , C07K16/00 , C07K16/34
CPC分类号： C07K16/40 , A61K2039/505
摘要： An antibody or antibody derivative against factor IX/activated factor IX (FIXa) which increases the procoagulant activity of FIXa.
摘要翻译： 针对因子IX /活化因子IX（FIXa）的抗体或抗体衍生物，其增加FIXa的促凝血活性。
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公开(公告)号：US08772462B2
公开(公告)日：2014-07-08
申请号：US13117028
申请日：2011-05-26
申请人： Wolfgang Teschner , Hans-Peter Schwarz , Ruth Madlener , Sonja Svatos , Azra Pljevljakovic , Alfred Weber
发明人： Wolfgang Teschner , Hans-Peter Schwarz , Ruth Madlener , Sonja Svatos , Azra Pljevljakovic , Alfred Weber
CPC分类号： C07K16/065 , A61K9/0019 , A61K9/08 , A61K35/16 , A61K38/1709 , A61K39/39525 , A61K47/183 , B01D15/12 , B01D15/362 , B01D15/363 , B01D15/424 , C07K1/30 , C07K1/36
摘要： The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and\or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.
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公开(公告)号：US08546548B2
公开(公告)日：2013-10-01
申请号：US12789345
申请日：2010-05-27
申请人： Wolfgang Teschner , Harald Arno Butterweck , Azra Pljevljakovic , Theresa Friederike Bauer , Bernhard Koelbl , Hans-Peter Schwarz , Nebojsa Nikolic , Gerhard Poelsler , Johanna Kindermann
发明人： Wolfgang Teschner , Harald Arno Butterweck , Azra Pljevljakovic , Theresa Friederike Bauer , Bernhard Koelbl , Hans-Peter Schwarz , Nebojsa Nikolic , Gerhard Poelsler , Johanna Kindermann
IPC分类号： A23J1/00
CPC分类号： C07K16/18 , A61K39/39591 , A61K2039/505 , A61K2039/54 , B01D61/142 , B01D61/145 , B01D2315/16 , C07K16/00 , C07K16/065 , C07K2317/10 , C07K2317/21
摘要： The present invention relates to a new and improved method for preparing a highly concentrated immunoglobulin composition from pooled plasma for subcutaneous injection. A composition comprising 20% or more immunoglobulin suitable for subcutaneous use is also described.
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公开(公告)号：US08304524B2
公开(公告)日：2012-11-06
申请号：US12842944
申请日：2010-07-23
申请人： Shawn F. Bairstow , Richard Johnson , Sindhu Ramachandran , Ruth Madlener , Wolfgang Teschner , Hans-Peter Schwarz
发明人： Shawn F. Bairstow , Richard Johnson , Sindhu Ramachandran , Ruth Madlener , Wolfgang Teschner , Hans-Peter Schwarz
CPC分类号： C07K14/472 , A61K38/1709 , A61K38/1725 , C07K1/36
摘要： The present invention provides compositions and pharmaceutical formulations of Factor H derived from plasma. Also provided are methods for the manufacture of the Factor H compositions and formulations, as well as methods for the treatment of diseases associated with Factor H dysfunction.
摘要翻译： 本发明提供衍生自血浆的因子H的组合物和药物制剂。 还提供了用于制备因子H组合物和制剂的方法，以及用于治疗与因子H功能障碍相关的疾病的方法。
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79.发明申请STABILIZATION OF IMMUNOGLOBULINS THROUGH AQUEOUS FORMULATION WITH HISTIDINE AT WEAK ACIDIC TO NEUTRAL PH 有权通过水性配方与弱酸对中性PH的稳定化免疫球蛋白公开(公告)号：US20120076772A1
公开(公告)日：2012-03-29
申请号：US13235314
申请日：2011-09-16
申请人： Harald Arno Butterweck , Bernhard Kölbl , Lucia Hofbauer , Wolfgang Teschner , Hans-Peter Schwarz
发明人： Harald Arno Butterweck , Bernhard Kölbl , Lucia Hofbauer , Wolfgang Teschner , Hans-Peter Schwarz
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： A61K39/39591 , A61K9/0019 , A61K47/02 , A61K47/183
摘要： The present invention provides, among other aspects, storage stabile aqueous formulations of immunoglobulins with histidine at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing immunoglobulin compositions by formulating with histidine at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of immunoglobulins at mildly acidic to neutral pH useful for parenteral administration.
摘要翻译： 除其他方面之外，本发明提供了在轻度酸性至中性pH下具有组氨酸的免疫球蛋白的储存稳定水性制剂。 本发明还提供了通过在轻度酸性至中性pH下配制组氨酸来稳定免疫球蛋白组合物的方法。 有利地，本文提供的方法和制剂允许稳定的免疫球蛋白水溶液组合物，其具有适用于胃肠外给药的中等pH至中性pH。
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80.发明申请公开(公告)号：US20110070592A1
公开(公告)日：2011-03-24
申请号：US12786641
申请日：2010-05-25
申请人： Christian Lubich , Juergen Siekmann , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
发明人： Christian Lubich , Juergen Siekmann , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
IPC分类号： G01N33/566
CPC分类号： G01N33/6854
摘要： The present invention provides analytical methods for detecting anti-polymer antibody in an individual. The methods involve contacting a sample from the individual with a water soluble polymer-modified carrier and detecting binding of antibody to the water soluble polymer on the water soluble polymer-modified carrier wherein binding is indicative of the presence of antibody to the water polymer-modified polypeptide. Antibody may be detected to water soluble polymers such as polyethylene glycol, polysialic acid, dextran, hydroxyalkyl starch, or hydroxyethyl starch. When antibody to the water soluble polymer polyethylene glycol is to be detected, the carrier is modified with a non-linear polyethylene glycol derivative.
摘要翻译： 本发明提供了检测个体抗体抗体的分析方法。 所述方法包括使来自个体的样品与水溶性聚合物修饰的载体接触并检测抗体与水溶性聚合物修饰的载体上的水溶性聚合物的结合，其中结合指示抗体存在于聚合物修饰的水 多肽。 可以对水溶性聚合物如聚乙二醇，聚唾液酸，葡聚糖，羟烷基淀粉或羟乙基淀粉检测抗体。 当检测到对水溶性聚合物聚乙二醇的抗体时，用非线性聚乙二醇衍生物修饰载体。
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