公开(公告)号：US6008239A

公开(公告)日：1999-12-28

申请号：US135163

申请日：1998-08-17

申请人： Yasushi Kaneko ,  Sunao Takeda ,  Minoru Tokizawa ,  Hiromichi Eto ,  Kazuya Ishida ,  Kazunori Maebashi ,  Masaru Matsumoto ,  Takemitsu Asaoka ,  Susumu Sato

发明人： Yasushi Kaneko ,  Sunao Takeda ,  Minoru Tokizawa ,  Hiromichi Eto ,  Kazuya Ishida ,  Kazunori Maebashi ,  Masaru Matsumoto ,  Takemitsu Asaoka ,  Susumu Sato

IPC分类号： A01N43/653 ,  C07D249/08 ,  C07D521/00 ,  A61K31/505

CPC分类号： C07D231/12 ,  A01N43/653 ,  C07D233/56 ,  C07D249/08

摘要： Described is a triazole derivative represented by the formula (1): ##STR1## wherein R.sup.1 represents a lower alkyl group or an aralkyl group, R.sup.2 represents a hydrogen atom, a lower alkyl group, an aralkyl group or an acyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a trifluoromethyl group, n stands for an integer of 0 to 2 and m stands for an integer of 1 to 5, or salt thereof; and also a pharmaceutical comprising the derivative or salt thereof as an effective ingredient. The compound as described above has a high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.

摘要翻译： 描述了由式（1）表示的三唑衍生物：其中R1表示低级烷基或芳烷基，R2表示氢原子，低级烷基，芳烷基或酰基，X1和X2相同 或不同，各自独立地表示氢原子，卤素原子或三氟甲基，n表示0〜2的整数，m表示1〜5的整数，或其盐。 以及包含其衍生物或其盐作为有效成分的药物。 如上所述的化合物具有高的抗真菌活性，并且可用于预防和治疗哺乳动物真菌感染。

公开(公告)号：US5966195A

公开(公告)日：1999-10-12

申请号：US974994

申请日：1997-11-20

申请人： Susumu Sato ,  Ying Zhou ,  Zhan He ,  Yoshihiro Togashi

发明人： Susumu Sato ,  Ying Zhou ,  Zhan He ,  Yoshihiro Togashi

IPC分类号： G01B11/06 ,  G01J4/00 ,  G01N21/21 ,  G02B11/06 ,  G02F1/13 ,  G02F1/1337

CPC分类号： G01N21/21 ,  G01B11/0641

摘要： A method of determining a parameter of a liquid crystal cell is provided in which parameters, such as the thickness of the liquid crystal layer and the angle of the twist of liquid crystal molecule orientation in the liquid crystal cell, are accurately determined in a short time with a simple apparatus. Light from a light source 1 is transmitted through a polarizing plate 2 and incident to a liquid crystal cell 3. The light is transmitted by a polarizing plate 4 and the intensity of the transmitted light is measured by a photodetector 6. Then, the outputs of the photodetector 6 for the following cases are measured: when the polarization direction of the polarizing plate 4 is set (1) in the direction of the X axis, (2) in the direction of Y axis and (3) at 45 degrees to the X and Y axes and (4) when, with the polarization direction of the polarizing plate 4 being at 45 degrees to the X and Y axes, a quarter wavelength plate 5 is inserted between the polarizing plate 4 and the liquid crystal cell 3 so that its axial direction is tilted at 45 degrees to the polarization direction of the polarizing plate 4. Stokes parameters are obtained from the measurement values, and the thickness of the liquid crystal layer and the angle of twist of liquid crystal molecule orientation are calculated from the measured Stokes parameters.

摘要翻译： 提供一种确定液晶单元的参数的方法，其中在短时间内精确地确定诸如液晶层的厚度和液晶单元中液晶分子取向的扭转角度的参数 用简单的装置。 来自光源1的光通过偏振板2透射并入射到液晶单元3.光被偏振板4透射，透射光的强度由光电检测器6测量。然后，输出 测量以下情况的光检测器6：当偏振板4的偏振方向在X轴方向上被设定为（1）时，（2）沿Y轴方向和（3）相对于 X轴和Y轴以及（4）当偏振板4的偏振方向与X轴和Y轴成45度时，四分之一波片5被插入到偏振板4和液晶单元3之间， 其轴向方向与偏光板4的偏振方向倾斜45度。从测量值获得斯托克斯参数，计算液晶层的厚度和液晶分子取向的扭转角f 测量斯托克斯参数。

公开(公告)号：US5902826A

公开(公告)日：1999-05-11

申请号：US997061

申请日：1997-12-23

申请人： Kinichi Mogi ,  Hidehiko Koya ,  Mari Ohtsuka ,  Hiroyuki Mizuno ,  Susumu Sato

发明人： Kinichi Mogi ,  Hidehiko Koya ,  Mari Ohtsuka ,  Hiroyuki Mizuno ,  Susumu Sato

IPC分类号： A61K31/55 ,  C07F15/00 ,  A61K31/28

CPC分类号： C07F15/0093

摘要： A diamine-platinum (IV) complex represented by the following formula (1): ##STR1## wherein R.sup.1 and R.sup.2 together represent R.sup.5 O--CH(CH.sub.2 NH.sub.2).sub.2 (R.sup.5 represents hydrogen, acetyl, trifluoroacetyl, benzoyl, cycloalkylcarbonyl or methanesulfonyl) or a C.sub.5-8 1,2-cycloalkanediamine; R.sup.3 and R.sup.4 each represents hydrogen or R.sup.6 CO-- (R.sup.6 represents alkyl, halogenoalkyl, cycloalkyl, aryl or aralkyl); and two X's together represent a malonic acid residue or glycolic acid residue which may have a substituent capable of coordinating to the platinum in formula (1) by an O,O-coordination or an N-acylamino acid residue coordinating to the platinum in formula (1) by an O,N-coordination; and a pharmaceutical composition comprising as an active ingredient the above-described diamine-platinum (IV) complex.

摘要翻译： 由下式（1）表示的二胺 - 铂（IV）络合物：其中R1和R2一起表示R5O-CH（CH2NH2）2（R5代表氢，乙酰基，三氟乙酰基，苯甲酰基，环烷基羰基或甲磺酰基）或C5-8 1,2-环烷二胺; R3和R4各自表示氢或R6CO-（R6表示烷基，卤代烷基，环烷基，芳基或芳烷基）; 两个X一起代表丙二酸残基或乙醇酸残基，其可以具有能够通过与式（1）中的铂配位的O，O-配位体或N-酰基氨基酸残基与式（1）中的铂配位的取代基， 1）通过O，N-配位; 以及包含上述二胺 - 铂（IV）络合物作为活性成分的药物组合物。

公开(公告)号：US5866609A

公开(公告)日：1999-02-02

申请号：US899647

申请日：1997-07-24

申请人： Yoshihiko Kanamaru ,  Hiroyuki Hirota ,  Akihiro Shibata ,  Teruo Komoto ,  Hiroyuki Naito ,  Koichi Tachibana ,  Mari Ohtsuka ,  Fumio Ishii ,  Susumu Sato

发明人： Yoshihiko Kanamaru ,  Hiroyuki Hirota ,  Akihiro Shibata ,  Teruo Komoto ,  Hiroyuki Naito ,  Koichi Tachibana ,  Mari Ohtsuka ,  Fumio Ishii ,  Susumu Sato

IPC分类号： C07C275/28 ,  C07C275/30 ,  C07C275/34 ,  C07C275/40 ,  C07C275/42 ,  C07C317/42 ,  C07C323/44 ,  C07D211/58 ,  C07D317/58 ,  C07D317/66 ,  A61K31/17 ,  C07C275/04

CPC分类号： C07C317/42 ,  C07C275/28 ,  C07C275/30 ,  C07C275/34 ,  C07C275/40 ,  C07C275/42 ,  C07C323/44 ,  C07D211/58 ,  C07D317/58 ,  C07D317/66 ,  C07C2101/14

摘要： Disclosed herein are substituted vinylurea derivatives represented by the following general formula (1): ##STR1## wherein R.sup.1 and R.sup.3 are independently a phenyl group which may be substituted, R.sup.2 is a phenyl group which may be substituted, or a cycloalkyl group, and wave lines mean that the bonding state may be either E or Z, with the proviso that the cases where R.sup.1, R.sup.2 and R.sup.3 are unsubstituted phenyl groups, and where R.sup.1 and R.sup.2 are unsubstituted phenyl groups and R.sup.3 is a 4-ethoxyphenyl group are excluded, or salt thereof, and medicines comprising such a derivative as an active ingredient as well as a method of preventing and treating arteriosclerosis with such a medicine. The derivatives or salts thereof selectively and strongly inhibit ACAT in macrophages and are hence useful as prophylactic and therapeutic agents for arteriosclerosis.

摘要翻译： 本文公开了由以下通式（1）表示的取代的乙烯基脲衍生物：其中R 1和R 3独立地为可被取代的苯基，R 2为可被取代的苯基或环烷基 并且波线意味着键合状态可以是E或Z，条件是其中R1，R2和R3是未取代的苯基，R1和R2是未取代的苯基，R3是4-乙氧基苯基的情况 或其盐，以及包含这样的衍生物作为活性成分的药物，以及用这种药物预防和治疗动脉硬化的方法。 其衍生物或其盐在巨噬细胞中选择性且强烈地抑制ACAT，因此可用作动脉硬化的预防和治疗剂。

公开(公告)号：US5719703A

公开(公告)日：1998-02-17

申请号：US692228

申请日：1996-08-07

申请人： Susumu Sato

发明人： Susumu Sato

IPC分类号： G02B13/02 ,  G02B15/173 ,  G02B27/64 ,  G02B15/14

CPC分类号： G02B13/02 ,  G02B15/173 ,  G02B27/646

摘要： An optical system includes a first lens group having a positive refractive power, a second lens group having a negative refractive power, and a third lens group having a positive refractive power. The third lens group comprises at least one positive lens and at least one negative lens. The second lens group is movable along a direction of an optical axis, and the third lens group is movable in a direction substantially perpendicular to the optical axis. The optical system satisfies: 0.25

摘要翻译： 光学系统包括具有正折光力的第一透镜组，具有负折光力的第二透镜组和具有正折光力的第三透镜组。 第三透镜组包括至少一个正透镜和至少一个负透镜。 第二透镜组可以沿着光轴的方向移动，并且第三透镜组可以在基本上垂直于光轴的方向上移动。 光学系统满足：0.25

公开(公告)号：US5613920A

公开(公告)日：1997-03-25

申请号：US388578

申请日：1995-02-14

申请人： Shigeo Uno ,  Masahiko Ibamoto ,  Mitsuhiro Masuda ,  Kazuhiko Sato ,  Susumu Sato ,  Hiroshi Kuroiwa ,  Mitsuyoshi Okada

发明人： Shigeo Uno ,  Masahiko Ibamoto ,  Mitsuhiro Masuda ,  Kazuhiko Sato ,  Susumu Sato ,  Hiroshi Kuroiwa ,  Mitsuyoshi Okada

IPC分类号： B60W10/04 ,  B60W10/06 ,  B60W10/10 ,  B60W10/11 ,  B60W30/18 ,  F02D29/00 ,  F16H59/14 ,  F16H59/16 ,  F16H59/46 ,  F16H61/00 ,  F16H61/04 ,  F16H63/50 ,  F16H59/00

CPC分类号： B60W10/06 ,  B60W10/04 ,  B60W10/11 ,  B60W30/18 ,  B60W30/1819 ,  B60W30/19 ,  F16H63/502 ,  B60W2510/105 ,  B60W2710/0605 ,  B60W2710/0616 ,  B60W2710/0666 ,  B60W2710/105 ,  F16H2059/148 ,  F16H2059/467 ,  F16H2061/0078 ,  F16H2061/0096 ,  F16H59/14 ,  F16H59/16 ,  Y10T477/677 ,  Y10T477/679

摘要： The invention provides a torque feedback shift control device for an engine control system including an engine, an engine torque controller, an automatic transmission for changing output speed of the engine, and a transmission controller for controlling gear shifting in the transmission. A target torque generator is provided for generating a signal indicative of a target torque pattern in shifting of the automatic transmission according to a shifting signal from the transmission controller. A drive shaft torque detector detects an output torque of the automatic transmission, and the engine controller performs feedback control of the engine torque so that the output torque detected by the drive shaft torque detector in downshifting of the automatic transmission follows up the target torque pattern.

摘要翻译： 本发明提供了一种用于发动机控制系统的扭矩反馈换档控制装置，其包括发动机，发动机转矩控制器，用于改变发动机的输出速度的自动变速器，以及用于控制变速器中的换档的变速器控制装置。 提供了一种目标扭矩发生器，用于根据来自变速器控制器的换档信号产生指示自动变速器移位中的目标转矩模式的信号。 驱动轴扭矩检测器检测自动变速器的输出转矩，并且发动机控制器执行发动机转矩的反馈控制，使得由自动变速器降档中的驱动轴转矩检测器检测到的输出转矩跟随目标转矩模式。

公开(公告)号：US5530589A

公开(公告)日：1996-06-25

申请号：US315679

申请日：1994-09-30

申请人： Susumu Sato

发明人： Susumu Sato

IPC分类号： G02B15/16 ,  G02B27/64 ,  G02B15/14

CPC分类号： G02B27/646 ,  G02B15/161 ,  G02B15/173

摘要： A zoom lens has a first group of a positive refractive power and a second group of a negative refractive power in sequence as seen from an object. The first group of the positive refractive power comprises a front group of a positive refractive power arranged to face the object and in front of an aperture iris and a rear group of a positive refractive power arranged between the aperture iris and an image plane. The rear group includes displacement means to drive it across an optical axis for vibration correction.

摘要翻译： 从物体看，变焦透镜具有正折射光焦度的第一组和负折射光焦度的第二组。 正折射光焦度的第一组包括布置成面对物体的正折射力的正面组和布置在孔径光阑和像面之间的孔眼光圈和正折射光焦度的前面。 后组包括位移装置，以驱动它穿过光轴进行振动校正。

公开(公告)号：US5498780A

公开(公告)日：1996-03-12

申请号：US454825

申请日：1995-05-31

申请人： Koichi Yokoi ,  Kinichi Mogi ,  Hidehiko Kohya ,  Mari Ohtsuka ,  Hiroyuki Mizuno ,  Susumu Sato ,  Tadayuki Kuraishi

发明人： Koichi Yokoi ,  Kinichi Mogi ,  Hidehiko Kohya ,  Mari Ohtsuka ,  Hiroyuki Mizuno ,  Susumu Sato ,  Tadayuki Kuraishi

IPC分类号： A61K33/24 ,  A61K31/28 ,  A61K31/282 ,  A61P35/00 ,  C07C239/08 ,  C07F15/00

CPC分类号： C07F15/0093

摘要： A diamine-platinum complex represented by the following formula (1): ##STR1## wherein the all definitions are defined in the disclosure, and a malignant tumor treating drug which contains the above complex as an active ingredient. The diamine-platinum complex has a high water solubility and an excellent antitumor effect.

摘要翻译： 由下式（1）表示的二胺 - 铂络合物：其中全部定义在本公开中定义，以及含有上述络合物作为活性成分的恶性肿瘤治疗药物。 二胺 - 铂络合物具有高水溶性和优异的抗肿瘤效果。

公开(公告)号：US5442486A

公开(公告)日：1995-08-15

申请号：US291505

申请日：1994-08-17

申请人： Susumu Sato

发明人： Susumu Sato

IPC分类号： G02B15/16 ,  G02B15/173 ,  G03B17/14 ,  G02B15/14

CPC分类号： G02B15/173

摘要： An internal focus super-telephoto zoom lens comprises, in succession from the object side, a first lens unit having positive refractive power, a second lens unit having negative refractive power, and a third lens unit having positive refractive power. During vari-focusing from the wide angle end to the telephoto end, the first lens unit is fixed relative to the image plane and the second lens unit and the third lens unit are moved on the optical axis thereof so as to narrow the air gap therebetween. The first lens unit has, in succession from the object side, a lens group having positive refractive power, a lens group having negative refractive power, and a lens group having positive refractive power. The lens group having negative refractive power is moved on the optical axis to thereby effect focusing. The super-telephoto zoom lens satisfies various predetermined conditions.

摘要翻译： 内部聚焦超远摄变焦透镜从物体侧依次包括具有正折光力的第一透镜单元，具有负折光力的第二透镜单元和具有正折光力的第三透镜单元。 在从广角端到远摄端的变焦聚焦期间，第一透镜单元相对于图像平面固定，并且第二透镜单元和第三透镜单元在其光轴上移动，以使其间的气隙变窄 。 第一透镜单元从物体侧连续地具有正屈光力的透镜组，具有负屈光力的透镜组和具有正折光力的透镜组。 具有负屈光力的透镜组在光轴上移动，从而实现聚焦。 超长焦变焦透镜满足各种预定条件。

公开(公告)号：US5159091A

公开(公告)日：1992-10-27

申请号：US596323

申请日：1990-10-12

申请人： Tadatoshi Kuriyama ,  Masaki Ogawa ,  Susumu Sato ,  Naokata Taido ,  Tadayuki Kuraishi

发明人： Tadatoshi Kuriyama ,  Masaki Ogawa ,  Susumu Sato ,  Naokata Taido ,  Tadayuki Kuraishi

IPC分类号： C07J5/00 ,  C07J7/00 ,  C07J21/00 ,  C07J31/00 ,  C07J75/00

CPC分类号： C07J7/0045 ,  C07J21/00 ,  C07J31/006 ,  C07J5/0053

摘要： A process for preparing 21-desoxyprednisolone 17-esters of formula (IV) is disclosed. ##STR1## The process comprises reacting a prednisolone 17.alpha.,21-cyclic orthoester with an acid in a 40-60% lower alcohol solution to produce a prednisolone 17-ester, sulfonylating the prednisolone 17-ester into a prednisolone 17-ester 21-sulfonate, and reacting the sulfonate with an alkali metal iodide in methyl ethyl ketone in the presence of a lower fatty acid to produce the compound of formula (IV). The process ensures economical industrial production of high purity 21-desoxyprednisolone 17-esters, an excellent local anti-inflammatory medicine, in a high yield by simple procedures.