公开(公告)号：US5922767A

公开(公告)日：1999-07-13

申请号：US946098

申请日：1997-10-07

申请人： Yoshihiko Kanamaru ,  Hiroyuki Hirota ,  Akihiro Shibata ,  Teruo Komoto ,  Hiroyuki Naito ,  Koichi Tachibana ,  Mari Ohtsuka ,  Fumio Ishii ,  Susumu Sato

发明人： Yoshihiko Kanamaru ,  Hiroyuki Hirota ,  Akihiro Shibata ,  Teruo Komoto ,  Hiroyuki Naito ,  Koichi Tachibana ,  Mari Ohtsuka ,  Fumio Ishii ,  Susumu Sato

IPC分类号： C07C275/28 ,  C07D213/30 ,  C07D307/42 ,  C07D333/16 ,  A61K31/17 ,  C07C275/06

CPC分类号： C07D213/30 ,  C07C275/28 ,  C07D307/42 ,  C07D333/16

摘要： Disclosed herein are substituted benzylurea derivatives represented by the following general formula (1): ##STR1## wherein R.sup.1 and R.sup.2 are independently H, a halogen atom, or an alkyl or alkoxyl group, R.sup.3 is a phenyl or heterocyclic group which may be substituted, n is an integer of 1-6, and R.sup.4 is a phenyl group which may be substituted, or salts thereof, and medicines comprising such a derivative as an active ingredient. The derivatives or salts thereof strongly inhibit only ACAT in macrophages and are hence useful as prophylactic and therapeutic agents for arteriosclerosis.

摘要翻译： 本文公开了由以下通式（1）表示的取代的苄基脲衍生物：其中R 1和R 2独立地为H，卤素原子或烷基或烷氧基，R 3为可被取代的苯基或杂环基，n为 1-6的整数，R4是可被取代的苯基或其盐，以及包含这种衍生物作为活性成分的药物。 其衍生物或盐在巨噬细胞中仅强烈地抑制ACAT，因此可用作动脉硬化的预防和治疗剂。

公开(公告)号：US5866609A

公开(公告)日：1999-02-02

申请号：US899647

申请日：1997-07-24

申请人： Yoshihiko Kanamaru ,  Hiroyuki Hirota ,  Akihiro Shibata ,  Teruo Komoto ,  Hiroyuki Naito ,  Koichi Tachibana ,  Mari Ohtsuka ,  Fumio Ishii ,  Susumu Sato

发明人： Yoshihiko Kanamaru ,  Hiroyuki Hirota ,  Akihiro Shibata ,  Teruo Komoto ,  Hiroyuki Naito ,  Koichi Tachibana ,  Mari Ohtsuka ,  Fumio Ishii ,  Susumu Sato

IPC分类号： C07C275/28 ,  C07C275/30 ,  C07C275/34 ,  C07C275/40 ,  C07C275/42 ,  C07C317/42 ,  C07C323/44 ,  C07D211/58 ,  C07D317/58 ,  C07D317/66 ,  A61K31/17 ,  C07C275/04

CPC分类号： C07C317/42 ,  C07C275/28 ,  C07C275/30 ,  C07C275/34 ,  C07C275/40 ,  C07C275/42 ,  C07C323/44 ,  C07D211/58 ,  C07D317/58 ,  C07D317/66 ,  C07C2101/14

摘要： Disclosed herein are substituted vinylurea derivatives represented by the following general formula (1): ##STR1## wherein R.sup.1 and R.sup.3 are independently a phenyl group which may be substituted, R.sup.2 is a phenyl group which may be substituted, or a cycloalkyl group, and wave lines mean that the bonding state may be either E or Z, with the proviso that the cases where R.sup.1, R.sup.2 and R.sup.3 are unsubstituted phenyl groups, and where R.sup.1 and R.sup.2 are unsubstituted phenyl groups and R.sup.3 is a 4-ethoxyphenyl group are excluded, or salt thereof, and medicines comprising such a derivative as an active ingredient as well as a method of preventing and treating arteriosclerosis with such a medicine. The derivatives or salts thereof selectively and strongly inhibit ACAT in macrophages and are hence useful as prophylactic and therapeutic agents for arteriosclerosis.

摘要翻译： 本文公开了由以下通式（1）表示的取代的乙烯基脲衍生物：其中R 1和R 3独立地为可被取代的苯基，R 2为可被取代的苯基或环烷基 并且波线意味着键合状态可以是E或Z，条件是其中R1，R2和R3是未取代的苯基，R1和R2是未取代的苯基，R3是4-乙氧基苯基的情况 或其盐，以及包含这样的衍生物作为活性成分的药物，以及用这种药物预防和治疗动脉硬化的方法。 其衍生物或其盐在巨噬细胞中选择性且强烈地抑制ACAT，因此可用作动脉硬化的预防和治疗剂。

公开(公告)号：US5532371A

公开(公告)日：1996-07-02

申请号：US377965

申请日：1995-01-25

申请人： Teruo Komoto ,  Hiroyuki Hirota ,  Susumu Sato ,  Mari Ohtsuka ,  Hidehiko Koya ,  Hiroyuki Mizuno ,  Tadayuki Kuraishi

发明人： Teruo Komoto ,  Hiroyuki Hirota ,  Susumu Sato ,  Mari Ohtsuka ,  Hidehiko Koya ,  Hiroyuki Mizuno ,  Tadayuki Kuraishi

IPC分类号： C07D211/22 ,  C07D211/52 ,  C07D211/70 ,  C07D213/82 ,  C07D295/192 ,  C07D333/38 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D401/10

CPC分类号： C07D213/82 ,  C07D211/22 ,  C07D211/52 ,  C07D211/70 ,  C07D295/192 ,  C07D333/38 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06

摘要： An arylamide derivative of formula (1), a salt thereof and a therapeutic agent for hyperlipemia which comprises the derivative or salt: ##STR1## wherein Ar represents a group ##STR2## a naphthyl group, a pyridinyl group, a furyl group, a thienyl group, a quinolyl group or an indolyl group; Y represents a group ##STR3## and Q represents --O-- or a single bond, Z represents an alkylene group, and R.sup.4 represents a hydroxyl group, an alkoxy group or a group --NH(CH.sub.2).sub.m COOH.

摘要翻译： 式（1）的芳基酰胺衍生物，其盐和含有该衍生物或盐的高脂血症治疗剂：其中Ar表示基团，萘基，吡啶基，呋喃基 噻吩基，喹啉基或吲哚基; Y表示基团，Q表示-O-或单键，Z表示亚烷基，R4表示羟基，烷氧基或基团-NH（CH2）mCOOH。

公开(公告)号：US5411972A

公开(公告)日：1995-05-02

申请号：US158398

申请日：1993-11-29

申请人： Teruo Komoto ,  Hiroyuki Hirota ,  Susumu Sato ,  Mari Ohtsuka ,  Hidehiko Koya ,  Hiroyuki Mizuno ,  Tadayuki Kuraishi

发明人： Teruo Komoto ,  Hiroyuki Hirota ,  Susumu Sato ,  Mari Ohtsuka ,  Hidehiko Koya ,  Hiroyuki Mizuno ,  Tadayuki Kuraishi

IPC分类号： C07D211/22 ,  C07D211/52 ,  C07D211/70 ,  C07D213/82 ,  C07D295/192 ,  C07D333/38 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  A61K31/445 ,  C07D211/40 ,  C07D211/74 ,  C07D295/10

CPC分类号： C07D213/82 ,  C07D211/22 ,  C07D211/52 ,  C07D211/70 ,  C07D295/192 ,  C07D333/38 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06

摘要： An arylamide derivative of formula (1), a salt thereof and a therapeutic agent for hyperlipemia which comprises the derivative or salt: ##STR1## wherein Ar represents a group ##STR2## a naphthyl group, a pyridinyl group, a furyl group, a thienyl group, a quinolyl group or an indolyl group; Y represents a group ##STR3## and Q represents --O-- or a single bond, Z represents an alkylene group, and R.sup.4 represents a hydroxyl group, an alkoxy group or a group --NH(CH.sub.2).sub.m COOH, useful for the treatment and prevention of hyperlipemia due to their excellent cholesterol reducing action, triglyceride reducing action and high safety.

摘要翻译： 式（1）的芳基酰胺衍生物，其盐和含有该衍生物或盐的高脂血症治疗剂：其中Ar表示基团，萘基，吡啶基，呋喃基 噻吩基，喹啉基或吲哚基; Y表示 ，Q表示-O-或单键，Z表示亚烷基，R4表示羟基，烷氧基或-NH（CH2）mCOOH基团，可用于 治疗和预防高脂血症由于其优异的胆固醇降低作用，甘油三酯降低作用和高安全性。

公开(公告)号：US06958353B2

公开(公告)日：2005-10-25

申请号：US10258610

申请日：2001-06-08

申请人： Fujiko Konno ,  Yoshihiro Nagao ,  Kazuo Isomae ,  Mari Ohtsuka ,  Yoshiyuki Takahashi ,  Fumio Ishii ,  Hiroyuki Hirota ,  Sunao Takeda ,  Noriyuki Kawamoto ,  Haruyoshi Honda ,  Susumu Sato

发明人： Fujiko Konno ,  Yoshihiro Nagao ,  Kazuo Isomae ,  Mari Ohtsuka ,  Yoshiyuki Takahashi ,  Fumio Ishii ,  Hiroyuki Hirota ,  Sunao Takeda ,  Noriyuki Kawamoto ,  Haruyoshi Honda ,  Susumu Sato

IPC分类号： A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P43/00 ,  C07D233/22 ,  C07D233/60 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D521/00 ,  A61K31/4178 ,  A61K31/444

CPC分类号： C07D401/14 ,  C07D231/12 ,  C07D233/22 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14

摘要： The invention is directed to an imidazole derivative represented by formula (1): wherein each of R1 and R2 represents an aryl group, a heteroaryl group, etc.; each of A, X1, and X2 represents N or CH; each of Y and Z represents O, S, etc.; each of R3, R4, and R5 represents a hydrogen atom, an alkyl group, etc.; m is a number of 1 to 4; and n is a number of 0 to 4, or a salt thereof. The invention is also directed to a drug containing the derivative or the salt as an active ingredient. These compounds exert excellent effects of inhibiting production of NO and IL-6 and are useful for preventing or treating diseases induced by overproduction of NO and IL-6.

摘要翻译： 本发明涉及由式（1）表示的咪唑衍生物：其中R 1和R 2各自表示芳基，杂芳基等; A，X 1和X 2各自表示N或CH; Y和Z各自表示O，S等; R 3，R 4和R 5各自表示氢原子，烷基等; m是1到4的数字; n为0〜4的数，或其盐。 本发明还涉及含有衍生物或盐作为活性成分的药物。 这些化合物具有抑制NO和IL-6产生的优异效果，可用于预防或治疗由过量产生NO和IL-6引起的疾病。

公开(公告)号：US10007194B2

公开(公告)日：2018-06-26

申请号：US12289515

申请日：2008-10-29

申请人： Osamu Tanitsu ,  Koji Shigematsu ,  Hiroyuki Hirota ,  Tomoyuki Matsuyama

发明人： Osamu Tanitsu ,  Koji Shigematsu ,  Hiroyuki Hirota ,  Tomoyuki Matsuyama

IPC分类号： G03F7/20 ,  G02B27/28 ,  F21V9/14 ,  F21V13/02

CPC分类号： G03F7/70566 ,  F21V9/14 ,  F21V13/02 ,  F21V13/12 ,  G02B5/3025 ,  G02B27/0977 ,  G02B27/286 ,  G03F7/701 ,  G03F7/70191 ,  G03F7/70308

摘要： There is disclosed a polarization-modulating element for modulating a polarization state of incident light into a predetermined polarization state, the polarization-modulating element being made of an optical material with optical activity and having a circumferentially varying thickness profile.

公开(公告)号：US09140990B2

公开(公告)日：2015-09-22

申请号：US13067958

申请日：2011-07-11

申请人： Osamu Tanitsu ,  Koji Shigematsu ,  Hiroyuki Hirota ,  Tomoyuki Matsuyama

发明人： Osamu Tanitsu ,  Koji Shigematsu ,  Hiroyuki Hirota ,  Tomoyuki Matsuyama

IPC分类号： G01J4/00 ,  G03F7/20 ,  G02B27/28 ,  F21V9/14 ,  F21V13/02

CPC分类号： G03F7/70566 ,  F21V9/14 ,  F21V13/02 ,  G02B27/286 ,  G03F7/701 ,  G03F7/70191 ,  G03F7/70308

摘要： There is disclosed a polarization-modulating element for modulating a polarization state of incident light into a predetermined polarization state, the polarization-modulating element being made of an optical material with optical activity and having a circumferentially varying thickness profile.

公开(公告)号：US08765633B2

公开(公告)日：2014-07-01

申请号：US13070087

申请日：2011-03-23

申请人： Hiroyuki Hirota ,  Hiromi Yunoki ,  Kenichi Ochiai

发明人： Hiroyuki Hirota ,  Hiromi Yunoki ,  Kenichi Ochiai

IPC分类号： B01J23/58 ,  B01J23/48 ,  C07D301/10 ,  C07D301/03

CPC分类号： B01J37/0203 ,  B01J21/04 ,  B01J23/66 ,  B01J35/0026 ,  B01J35/0066 ,  B01J35/0093 ,  B01J35/026 ,  B01J35/1009 ,  B01J37/0207 ,  B01J37/0213 ,  B01J37/04 ,  B01J37/06 ,  B01J37/18 ,  C07D301/10 ,  Y02P20/52

摘要： A catalyst for the production of ethylene oxide in high efficiency and high selectivity, as well as stably for a long period of time is provided.A catalyst for the production of ethylene oxide comprising silver and a reaction promoter supported on a porous carrier comprising α-alumina as a main component, characterized in that a relative standard deviation of silver supporting rate of each particle of the catalyst is 0.001 or more and 0.1 or less.

摘要翻译： 提供了一种以高效率和高选择性生产环氧乙烷以及长时间稳定生产的催化剂。 一种用于生产包含银的催化剂和负载在包含α-氧化铝作为主要成分的多孔载体上的反应促进剂的催化剂，其特征在于，催化剂的每种颗粒的银支持速率的相对标准偏差为0.001以上， 0.1以下。

公开(公告)号：US20120013877A1

公开(公告)日：2012-01-19

申请号：US13166316

申请日：2011-06-22

申请人： Hirohisa Tanaka ,  Hiroyuki Hirota

发明人： Hirohisa Tanaka ,  Hiroyuki Hirota

IPC分类号： G03B27/54

CPC分类号： G02B27/0961 ,  G02B26/008 ,  G03F7/70091 ,  G03F7/70191

摘要： According to one embodiment, an illumination optical system comprises an optical integrator which forms a secondary light source on an illumination pupil plane in an illumination optical path of the illumination optical system with incidence of exposure light from a light source device thereinto; a first transmission filter arranged in an optical path of the exposure light emitted from a first surface illuminant of the secondary light source and having a transmittance characteristic varying according to angles of incidence of the exposure light; a second transmission filter arranged in an optical path of the exposure light emitted from a second surface illuminant of the secondary light source and having a transmittance characteristic varying according to the angles of incidence of the exposure light; and a rotation mechanism which rotates the first and second transmission filters so as to vary an angle of inclination thereof relative to the optical axis of the illumination optical system.

摘要翻译： 根据一个实施例，照明光学系统包括光学积分器，其在照明光学系统的照明光路中的照明光瞳平面上形成二次光源，其中光源装置的曝光光入射到照明光学系统中; 第一透射滤光器，其布置在从所述次级光源的第一表面光源发射的曝光光的光路中，并且具有根据所述曝光光的入射角度而变化的透射特性; 第二透射滤光器，其布置在从所述次级光源的第二表面光源发射的曝光光的光路中，并且具有根据所述曝光光的入射角度而变化的透射特性; 以及旋转机构，其使第一和第二透射滤光片旋转以改变其相对于照明光学系统的光轴的倾斜角。

公开(公告)号：US06636018B2

公开(公告)日：2003-10-21

申请号：US10033762

申请日：2001-12-28

申请人： Hiroyuki Hirota

发明人： Hiroyuki Hirota

IPC分类号： H02J700

CPC分类号： H01M2/1066 ,  B29C51/00 ,  B29L2031/3431 ,  H01M2/0207 ,  H04M1/0262

摘要： A battery module is provided by coating selected sides of a battery cell having a rectangular shape with a prescribed resin material. The resin material is selected from among polyamide resin, polyurethane resin. Module side surfaces are provided with slopes having the slope angle of 5° or more in the thickness direction. A positioning structure is provided for establishing the prescribed positioning between the battery module and its counterpart unit such as a cellular phone having a hollow space. A plurality of slopes are formed along side walls of the hollow space to provide complementary shapes to the sloped module side surfaces. When the battery module is installed in the hollow space, the module side surfaces slide along and come in close contact with the slopes of the side walls of the hollow space.