公开(公告)号：US20130288278A1

公开(公告)日：2013-10-31

申请号：US13993126

申请日：2011-12-08

申请人： Eiji Inoue

发明人： Eiji Inoue

IPC分类号： C12Q1/37

CPC分类号： C12Q1/37 ,  C12Q1/485 ,  G01N2333/91205 ,  G01N2333/96494 ,  G01N2500/02

摘要： The object of the present invention is to provide a method for screening a substance that affects gelatinase-mediated EphA4 processing. The present invention provides a method for screening a substance that affects gelatinase-mediated EphA4 processing, which comprises the steps of: (a) allowing a first biological composition containing gelatinase or a biologically active fragment thereof to be contacted with a second biological composition containing EphA4 in the presence and absence of a candidate substance; (b) measuring the presence or amount of the EphA4 ectodomain and/or endodomain fragment; and (c) selecting the candidate substance as a substance that affects gelatinase-mediated EphA4 processing if the results of the step (b) measured in the presence of the candidate substance are changed in comparison with the results of the step (b) measured in the absence of the candidate substance.

摘要翻译： 本发明的目的是提供一种筛选影响明胶酶介导的EphA4处理的物质的方法。 本发明提供一种筛选影响明胶酶介导的EphA4处理的物质的方法，其包括以下步骤：（a）使含有明胶酶或其生物活性片段的第一生物组合物与含有EphA4的第二生物组合物接触 在候选物质的存在和不存在的情况下; （b）测量EphA4胞外域和/或endodomain片段的存在或量; 如果在候选物质存在下测量的步骤（b）的结果与步骤（b）中测得的步骤（b）的结果相比改变，则将候选物质选择为影响明胶酶介导的EphA4处理的物质; 没有候选物质。

公开(公告)号：US20110111444A1

公开(公告)日：2011-05-12

申请号：US13009127

申请日：2011-01-19

申请人： Eiji Inoue

发明人： Eiji Inoue

IPC分类号： C12Q1/37 ,  C12N9/12 ,  C07K14/47

CPC分类号： C12Q1/37 ,  G01N2500/02 ,  Y10S435/975

摘要： The present invention provides a method of screening for compounds which affect the processing of EphA4 by γ-secretase, comprising the following steps: (i) contacting a first biological composition containing γ-secretase or a biologically active fragment thereof with a second biological composition containing EphA4 in the presence and absence of a candidate compound; (ii) measuring the cleavage of the EphA4 in the presence and absence of the candidate compound; (iii) selecting those candidate compounds which affect the cleavage of the EphA4 by γ-secretase; and (iv) identifying the candidate compounds selected in step (iii) as compounds which affect the processing of EphA4 by γ-secretase.

摘要翻译： 本发明提供一种筛选影响通过γ-分泌酶处理EphA4的化合物的方法，包括以下步骤：（i）使含有γ-分泌酶或其生物活性片段的第一生物组合物与含有 EphA4在候选化合物的存在和不存在下; （ii）在存在和不存在候选化合物的情况下测量EphA4的切割; （iii）通过γ-分泌酶选择影响EphA4切割的候选化合物; 和（iv）将步骤（iii）中选择的候选化合物鉴定为影响γ-分泌酶对EphA4加工的化合物。

公开(公告)号：US07892769B2

公开(公告)日：2011-02-22

申请号：US12325418

申请日：2008-12-01

申请人： Eiji Inoue ,  Maki Tawarada ,  Aki Togawa ,  Emiko Kamakura

发明人： Eiji Inoue ,  Maki Tawarada ,  Aki Togawa ,  Emiko Kamakura

IPC分类号： G01N33/567 ,  G01N33/48 ,  G01N33/53 ,  C12N15/63

CPC分类号： C07K14/71 ,  C07K14/715 ,  C12Q1/37 ,  G01N33/5058 ,  G01N2333/96425

摘要： The present invention provides EphA4 polypeptides which encode EphA4 fragments cleaved by γ-secretase, especially intracellular fragments of such cleaved fragments, polynucleotides which encode such polypeptides, and antibodies specific to such polypeptides. Also disclosed is a method of screening for compounds which affect the processing of EphA4 by γ-secretase; a method of screening for compounds which affect dendritic spine formation by EphA4 processed by γ-secretase (γ-secretase-processed EphA4); and a method of screening for compounds which affect Rac activity mediated by γ-secretase-processed EphA4.

摘要翻译： 本发明提供编码由γ-分泌酶切割的EphA4片段的EphA4多肽，特别是这种切割片段的细胞内片段，编码这种多肽的多核苷酸，以及对这些多肽特异的抗体。 还公开了筛选通过γ-分泌酶影响EphA4处理的化合物的方法; 通过γ-分泌酶（γ-分泌酶处理的EphA4）处理的EphA4影响树突棘形成的化合物的方法; 以及筛选影响由γ-分泌酶处理的EphA4介导的Rac活性的化合物的方法。

公开(公告)号：US07803039B2

公开(公告)日：2010-09-28

申请号：US10872149

申请日：2004-06-18

申请人： Eiji Inoue ,  Akira Umehara ,  Makoto Sakamaki

发明人： Eiji Inoue ,  Akira Umehara ,  Makoto Sakamaki

IPC分类号： B60H1/24 ,  G01N7/00

CPC分类号： B60H3/0085 ,  B60H1/008 ,  B60H1/00849

摘要： A method for controlling air intake into an air conditioned enclosure includes generating a plurality of sensor output voltages using a NOx sensor. A NOx voltage ratio is calculated from the sensor output voltages. A determination is made when the NOx voltage ratio one of equals and exceeds a NOx threshold. The NOx voltage ratio is reset to a unitary value for a predetermined length of time.

摘要翻译： 用于控制进入空调壳体的进气的方法包括使用NOx传感器产生多个传感器输出电压。 根据传感器输出电压计算NOx电压比。 当NOx电压比等于并超过NOx阈值时，进行判定。 NOx电压比在预定的时间长度内重置为单一值。

公开(公告)号：US20090275049A1

公开(公告)日：2009-11-05

申请号：US12325418

申请日：2008-12-01

申请人： Eiji Inoue ,  Maki Tawarada ,  Aki Togawa ,  Emiko Kamakura

发明人： Eiji Inoue ,  Maki Tawarada ,  Aki Togawa ,  Emiko Kamakura

IPC分类号： G01N33/53 ,  C07H21/00 ,  C07K14/00 ,  C07K16/00

CPC分类号： C07K14/71 ,  C07K14/715 ,  C12Q1/37 ,  G01N33/5058 ,  G01N2333/96425

摘要： The present invention provides a polynucleotide which consists of a partial sequence of a polynucleotide encoding the amino acid sequence as shown in SEQ ID NO: 2, wherein the former polynucleotide encodes a polypeptide consisting of a partial amino acid sequence of SEQ ID NO: 2 whose N-terminus starts between positions 564 and 621 of SEQ ID NO: 2.

摘要翻译： 本发明提供了由编码如SEQ ID NO：2所示的氨基酸序列的多核苷酸的部分序列组成的多核苷酸，其中前一个多核苷酸编码由SEQ ID NO：2的部分氨基酸序列组成的多肽， N末端从SEQ ID NO：2的位置564和621开始。

公开(公告)号：US07520832B2

公开(公告)日：2009-04-21

申请号：US11434244

申请日：2006-05-16

申请人： Toshiro Toyoda ,  Eiji Inoue ,  Takashi Imanishi ,  Takumi Sinojima

发明人： Toshiro Toyoda ,  Eiji Inoue ,  Takashi Imanishi ,  Takumi Sinojima

IPC分类号： F16H37/02

CPC分类号： F16H61/6648 ,  Y10T477/6197 ,  Y10T477/6217

摘要： A sleeve 28 making up a gear ratio control valve 21 is driven by not only a stepping motor 29 but also a secondary actuator 47. Pressure oil is made free to be introduced into the secondary actuator 47 through a manual oil pressure switching valve 37 which is switched over by a gearshift. Then, when the gearshift is operated from a non-running state to a running state, a gear ratio of a toroidal type continuously variable transmission is corrected by a predetermined amount by driving the sleeve 28 by the secondary actuator 47. As a result, while improving characteristic of a vehicle when starting from rest, the vehicle can be prevented from being reduced in speed unintentionally excessively even when the gearshift is operated while running.

摘要翻译： 组成齿轮比控制阀21的套筒28不仅由步进马达29驱动，而且还辅助辅助致动器47驱动。压力油通过手动油压切换阀37而被自由地引入辅助致动器47，手动油压切换阀37 换档换乘。 然后，当变速从非行驶状态运行到行驶状态时，环形无级变速器的齿轮比通过二次致动器47驱动套筒28来校正预定量。结果，当 改善从休息开始时的车辆的特性，即使在行驶时变速操作时，也能够防止车辆的意外地过度减速。

公开(公告)号：US07326146B2

公开(公告)日：2008-02-05

申请号：US10421803

申请日：2003-04-24

申请人： Shinji Miyata ,  Eiji Inoue

发明人： Shinji Miyata ,  Eiji Inoue

IPC分类号： F16H15/38

CPC分类号： F16H37/086 ,  F16H2037/0886

摘要： A toroidal-type continuously variable transmission has a casing; a rotary shaft; a pair of outside disks each including an axial-direction one-side surface and supported on the rotary shaft so as to be rotated in synchronization with the rotary shaft; an inside disk including axial-direction two-side surfaces and rotatably supported on the periphery of the middle portion of the rotary shaft so as to be rotated with respect to the rotary shaft; support members disposed between the one side axial-direction surface and the axial-direction one-side surface so as to be swung and shifted about pivot shafts thereof; power rollers rotatably supported on the support members, the peripheral surface of the power rollers being contacted with the axial-direction two-side surface and the axial-direction one-side surface; and ball bearings for supporting the inside disk in such a manner that the inside disk is rotated with respect to the casing.

摘要翻译： 环形无级变速器具有壳体; 旋转轴; 一对外圆盘，每个外圆盘均包括轴向一侧表面，并支撑在所述旋转轴上以与所述旋转轴同步旋转; 包括轴向两侧表面的内圆盘，并且可旋转地支撑在所述旋转轴的中部的周边上以相对于所述旋转轴旋转; 支撑构件设置在所述一个侧面轴向表面和所述轴向单侧表面之间，以便绕其枢轴摆动和偏移; 动力辊可旋转地支撑在支撑构件上，动力辊的周面与轴向两侧表面和轴向单侧表面接触; 以及用于以内侧盘相对于壳体旋转的方式支撑内侧盘的球轴承。

公开(公告)号：US07297773B2

公开(公告)日：2007-11-20

申请号：US10747065

申请日：2003-12-30

申请人： Toshihisa Ohtsuka ,  Etsuko Rikitsu ,  Marie Inoue ,  Eiji Inoue

发明人： Toshihisa Ohtsuka ,  Etsuko Rikitsu ,  Marie Inoue ,  Eiji Inoue

IPC分类号： C07K1/00 ,  C07K14/00 ,  C12P21/06 ,  C12N15/00 ,  C12N5/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K14/47

摘要： The present invention enabled the detection and quantification of CAST, which is localized to synapses and tightly bound to the cytomatrix, and of the mRNA encoding the CAST. Furthermore, it was revealed that CAST functions as a protein scaffold for localizing RIM1 to synapses, contributing as a molecular basis for active zone formation.

摘要翻译： 本发明能够检测和定量CAST，其定位于突触并紧密结合至细胞基质上，以及编码CAST的mRNA。 此外，据透露，CAST作为将RIM1定位于突触的蛋白质支架起作用，作为活性区形成的分子基础。

公开(公告)号：US07273440B2

公开(公告)日：2007-09-25

申请号：US10874539

申请日：2004-06-24

申请人： Takashi Imanishi ,  Eiji Inoue ,  Takumi Sinojima ,  Toshiro Toyoda

发明人： Takashi Imanishi ,  Eiji Inoue ,  Takumi Sinojima ,  Toshiro Toyoda

IPC分类号： B60W10/00

CPC分类号： F16H61/6648 ,  F16H37/086 ,  F16H2037/0886 ,  F16H2061/6609 ,  Y10T477/6203 ,  Y10T477/638

摘要： A continuously variable transmission apparatus includes a toroidal-type continuously variable transmission, a planetary gear type transmission and a clutch apparatus that connects the toroidal-type continuously variable transmission and the planetary gear type transmission. The clutch apparatus includes: a low speed clutch engaged for realizing a low speed mode and disengaged for realizing a high speed, a high speed clutch engaged for realizing the high speed mode and disengaged for realizing the low speed mode and a controller. The controller controls the transmission ratio of the toroidal-type continuously variable transmission so that rotational speeds of members connected via the clutch apparatus equals with each other, and then disengages the one of the low speed clutch and the high speed clutch after engaging the other.

摘要翻译： 无级变速传动装置包括环形无级变速器，行星齿轮式变速器和连接环形无级变速器和行星齿轮式变速器的离合器装置。 离合器装置包括：低速离合器，用于实现低速模式并脱离以实现高速;接合的高速离合器，用于实现高速模式和脱离以实现低速模式;以及控制器。 控制器控制环形无级变速器的传动比，使得通过离合器装置连接的构件的转速彼此相等，然后在接合另一个之后使低速离合器和高速离合器中的一个离合。

公开(公告)号：US07077781B2

公开(公告)日：2006-07-18

申请号：US10653256

申请日：2003-09-03

申请人： Kouji Ishikawa ,  Eiji Inoue

发明人： Kouji Ishikawa ,  Eiji Inoue

IPC分类号： F16H15/38

CPC分类号： F16H15/38

摘要： A power roller unit for a toroidal-type continuously variable transmission, has: a trunnion including a support plate portion, a pair of bent wall portions, two pivot shafts, and a connecting member; a displacement shaft; a power roller; a thrust ball bearing including an outer ring, a ball, and a retainer; a thrust bearing, wherein the thrust bearing is held by a hold portion disposed in the support plate portion, and wherein, where the distance between the small end face of the power roller and the connecting member is expressed as a, the distance between the outer ring and the opposed surface of the hold portion opposed to the outer ring is expressed as b, and the thickness of the thrust bearing is expressed as c, the sum of a and b is set smaller than c.

摘要翻译： 一种用于环形无级变速器的动力辊单元，具有：包括支撑板部分，一对弯曲壁部分，两个枢转轴和连接部件的耳轴; 位移轴; 动力辊; 包括外圈，球和保持器的推力球轴承; 推力轴承，其中所述止推轴承由设置在所述支撑板部分中的保持部分保持，并且其中，当所述动力辊的小端面与所述连接构件之间的距离表示为a时，所述外部 并且与外圈相对的保持部的相对面被表示为b，推力轴承的厚度表示为c，将a和b的和设定为小于c。