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公开(公告)号：US09295786B2
公开(公告)日：2016-03-29
申请号：US12154935
申请日：2008-05-28
CPC分类号： A61B5/14532 , A61B5/1473 , A61B5/6849 , A61B17/3496 , A61M5/158 , A61M5/3243 , A61M25/0612 , A61M37/0069 , A61M2005/1585 , A61M2005/3247
摘要： An introducer is provided for introducing a sensor into the body of a patient. The introducer connects to a sensor hub. When the sensor hub and introducer are connected, the introducer needle is exposed. When the sensor hub and introducer are disconnected, a needle cover and the needle move with respect to each other so that the needle cover substantially covers the needle, protecting a user from being injured by the needle.
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公开(公告)号：US08795595B2
公开(公告)日：2014-08-05
申请号：US12772050
申请日：2010-04-30
申请人： Rajiv Shah
发明人： Rajiv Shah
CPC分类号： G01N21/6428 , A61B5/14532 , A61B5/14552 , A61B5/14556 , A61B5/1459 , A61B5/14865
摘要： A sensing apparatus may include a substrate having a first side for a sensing element and a second side for electronics, the substrate may have a at least one via from the first side of the substrate to the second side of the substrate, the at least one via may be hermetically sealed with an optically transmissive material.
摘要翻译： 感测装置可以包括具有用于感测元件的第一侧和用于电子器件的第二侧的衬底，衬底可以具有从衬底的第一侧到衬底的第二侧的至少一个通孔，至少一个 通孔可以用光学透射材料气密密封。
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公开(公告)号：US08795224B2
公开(公告)日：2014-08-05
申请号：US13009531
申请日：2011-01-19
IPC分类号： A61M31/00
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.
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74.发明授权公开(公告)号：US08777896B2
公开(公告)日：2014-07-15
申请号：US13009519
申请日：2011-01-19
IPC分类号： A61M31/00
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.
摘要翻译： 一种用于提供闭环输注制剂递送的系统和方法，其通过调整算法的可编程控制参数，基于感测到的生物学状态来精确地计算输送量。 该算法计算具有比例，导数和基础速率分量的传送量。 可以实时调整控制参数以补偿由日常事件导致的感测生物学状态的变化。 交付量的安全限制可能包含在算法中。 该算法可以由处理控制器内的计算元件执行，用于控制闭环灌注制剂递送。 生物状态由感测装置感测到，该感测装置向控制器提供信号。 所述控制器基于所述信号计算输注制剂输送量，并将命令发送到输送由所述命令确定的输注制剂量的输注制剂输送装置。
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75.发明申请公开(公告)号：US20140012115A1
公开(公告)日：2014-01-09
申请号：US13541262
申请日：2012-07-03
申请人： Yiwen Li , Jenn-Hann Larry Wang , Rajiv Shah
发明人： Yiwen Li , Jenn-Hann Larry Wang , Rajiv Shah
IPC分类号： A61B5/1473 , C23C16/50
CPC分类号： C12Q1/54 , C12Q1/006 , G01N27/307
摘要： Embodiments of the invention provide methods and materials for making analyte sensors having a plurality of layered elements such as amperometric glucose sensors that are used by diabetic individuals to monitor blood sugar concentrations. Embodiments of the invention utilize plasma deposition technologies to form thin films of adhesion promoting compositions useful in such sensors. Sensors that incorporate the thin film compositions formed by these processes exhibit a number of desirable characteristics.
摘要翻译： 本发明的实施方案提供了用于制备分析物传感器的方法和材料，所述分析物传感器具有多个分层元件，例如由糖尿病个体用于监测血糖浓度的电流葡萄糖传感器。 本发明的实施方案利用等离子体沉积技术形成用于这种传感器的粘合促进组合物的薄膜。 结合由这些方法形成的薄膜组合物的传感器表现出许多期望的特性。
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76.发明授权Antimicrobial coatings for medical devices and methods for making and using them 有权医疗器械的抗微生物涂层及其制造和使用方法公开(公告)号：US08512731B2
公开(公告)日：2013-08-20
申请号：US11983930
申请日：2007-11-13
申请人： Zhongping Yang , Eunjoo Jin , Laura Christoferson , Rajiv Shah
发明人： Zhongping Yang , Eunjoo Jin , Laura Christoferson , Rajiv Shah
CPC分类号： A61L27/34 , A61L27/54 , A61L2300/11 , A61L2300/208
摘要： Embodiments of the invention provide methods for using compositions to inhibit microbial growth on a surface of a medical device having the composition applied thereto, to medical devices having the composition applied to a surface thereof and to methods for using the compositions to coat medical devices.
摘要翻译： 本发明的实施方案提供了使用组合物抑制其施用组合物的医疗装置的表面上的微生物生长的方法，以及将组合物施用于其表面的医疗装置以及使用该组合物涂覆医疗装置的方法。
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公开(公告)号：US08352011B2
公开(公告)日：2013-01-08
申请号：US12264810
申请日：2008-11-04
申请人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Larry Wang , Kent L. Clark
发明人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Larry Wang , Kent L. Clark
IPC分类号： A61B5/05
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。
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公开(公告)号：US20120227737A1
公开(公告)日：2012-09-13
申请号：US13472117
申请日：2012-05-15
申请人： JOHN J. MASTROTOTARO , Rajiv Shah , Partha Ray , Kenny J. Long , Andrew C. Hayes , Nandita Patel , Cary D. Talbot , Bahar Reghabi
发明人： JOHN J. MASTROTOTARO , Rajiv Shah , Partha Ray , Kenny J. Long , Andrew C. Hayes , Nandita Patel , Cary D. Talbot , Bahar Reghabi
CPC分类号： G06F19/3456 , G16H40/63
摘要： An analyte sensor and systems for determining analyte levels in a user's body. The analyte sensor and systems are adapted to be used with single dose medication devices and include a communication system to transmit the communications from the analyte sensor to the user to notify the user of an estimated amount of fluid to deliver to the user's body. More particularly, these apparatuses and methods for use are for providing convenient monitoring of blood glucose levels in determining the appropriate amount of insulin to deliver.
摘要翻译： 分析物传感器和用于确定用户身体中的分析物水平的系统。 分析物传感器和系统适于与单剂量药物装置一起使用，并且包括通信系统，用于将来自分析物传感器的通信传输给用户，以向使用者通报估计量的流体以递送给使用者的身体。 更具体地，这些使用的装置和方法用于在确定适当量的胰岛素输送时提供对血糖水平的便利监测。
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公开(公告)号：US08187851B2
公开(公告)日：2012-05-29
申请号：US12179502
申请日：2008-07-24
申请人： Rajiv Shah , Bahar Reghabi , Rudy Montalvo , Yanan Zhang
发明人： Rajiv Shah , Bahar Reghabi , Rudy Montalvo , Yanan Zhang
CPC分类号： C07K1/1077 , C12Q1/54 , Y10S435/817
摘要： A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.
摘要翻译： 一种用于配制和固定由该方法形成的蛋白质和蛋白质基质的方法。 蛋白质基质制备方法产生物理和化学稳定的蛋白质基质，其具有低溶胀，非浸出，高活性和高机械强度性质。 该方法包括将蛋白质混合物交联并硬化，并使用模具将蛋白质形成所需的形状和尺寸。
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80.发明申请ANALYTE SENSORS COMPRISING ELECTRODES HAVING SELECTED ELECTROCHEMICAL AND MECHANICAL PROPERTIES 审中-公开包含选择电化学和机械性质的电极的分析仪传感器公开(公告)号：US20120097554A1
公开(公告)日：2012-04-26
申请号：US13276183
申请日：2011-10-18
IPC分类号： G01N33/66 , A61B5/1473 , G01N27/327
CPC分类号： C12Q1/006 , A61B5/076 , A61B5/1473 , G01N27/3274
摘要： Embodiments of the invention disclosed herein comprise amperometric glucose sensor systems that include multiple working electrodes having different material properties as well as algorithms and other elements designed for use with such systems. While embodiments of the innovation can be used in a number of contexts, typical embodiments of the invention include glucose sensors used to facilitate the management of diabetes.
摘要翻译： 本文公开的本发明的实施例包括电流葡萄糖传感器系统，其包括具有不同材料性质的多个工作电极以及被设计用于与这种系统一起使用的算法和其它元件。 尽管可以在许多情况下使用创新的实施例，但是本发明的典型实施例包括用于促进糖尿病管理的葡萄糖传感器。
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