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    Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxy lic acid
    74.
    发明授权
    Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxy lic acid 失效
    6,7-二氢-9-氟-5-甲基-1-氧代-1H，5H-苯并（ij）喹嗪-2-羧酸的方法

    公开(公告)号：US4301288A

    公开(公告)日：1981-11-17

    申请号：US122599

    申请日：1980-02-19

    申请人： Charles M. Leir ,  Kirk G. Hedberg ,  Joel R. Jacobson

    发明人： Charles M. Leir ,  Kirk G. Hedberg ,  Joel R. Jacobson

    IPC分类号： C07D215/22 ,  C07D215/18 ,  C07D215/233 ,  C07D455/04

    CPC分类号： C07D215/233 ,  C07D215/18 ,  C07D455/04

    摘要： An improved process for preparing the antimicrobial compound flumequine is disclosed. The first step of the process comprises reacting 4-fluoroaniline with crotonaldehyde under acidic conditions at a temperature between 50.degree. and 60.degree. C. In the second step, the product of the first step is slowly added to a refluxing solvent which forms a binary azeotrope with water and has a boiling point between 90.degree. and 120.degree. C. to provide a mixture of 6-fluoroquinaldine and 6-fluorotetrahydroquinaldine. This mixture is then treated with base in the presence of weak acid followed by reducing to provide 6-fluorotetrahydroquinaldine. This compound is then treated according to known procedures to form flumequine.

    摘要翻译： 公开了一种制备抗微生物化合物氟菊花的改进方法。 该方法的第一步包括在酸性条件下在50至60℃的温度下使4-氟苯胺与巴豆醛反应。在第二步中，将第一步的产物缓慢加入回流溶剂中，形成二元共沸物 用水，沸点在90〜120℃，得到6-氟喹哪啶和6-氟四氢喹喔啉的混合物。 然后将该混合物在弱酸存在下用碱处理，然后还原，得到6-氟四氢喹啉。 然后根据已知方法处理该化合物以形成氟欧喹。

    Spray on bandage and drug delivery system
    75.
    发明授权
    Spray on bandage and drug delivery system 失效
    喷在绷带和药物输送系统上

    公开(公告)号：US06958154B2

    公开(公告)日：2005-10-25

    申请号：US10619008

    申请日：2003-07-14

    申请人： Patricia J. Andolino Brandt ,  Charles M. Leir ,  David J. Wirtanen

    发明人： Patricia J. Andolino Brandt ,  Charles M. Leir ,  David J. Wirtanen

    IPC分类号： A61F13/02 ,  A61K9/70 ,  A61K47/10 ,  A61K47/30 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61L15/58 ,  A61L26/00 ,  C09J5/00 ,  C09J7/04 ,  C09J133/06 ,  C09J201/00 ,  A61K9/00

    CPC分类号： A61L26/0076 ,  A61K9/7015 ,  A61L26/0052 ,  C08L33/26 ,  C08L83/10 ,  C08L33/08

    摘要： The present invention provides novel “patch in a bottle” technology in which a fluid composition, e.g., an aerosol spray, is applied onto a surface as a fluid, but then dries to form a covering element, such as a patch, having a tack free outer surface covering an underlying adhesive that helps adhere the patch to the substrate. The fluid compositions have a unique chemical formulation that allows such composite patches to form in situ. Specifically, the fluid compositions include a tacky component, such as an adhesive, and a film-forming, non-tacky component. The non-tacky and tacky components are selected to be immiscible with each other so that the components undergo phase separation as the fluid composition dries.

    摘要翻译： 本发明提供了一种新颖的“瓶中的贴剂”技术，其中将流体组合物，例如气溶胶喷雾剂作为流体施加到表面上，然后干燥以形成具有粘性的覆盖元件，例如贴剂 自由的外表面覆盖下面的粘合剂，其有助于将贴片粘附到基底上。 流体组合物具有独特的化学制剂，其允许这样的复合斑块在原位形成。 具体地，流体组合物包括粘性组分，如粘合剂和成膜非粘性组分。 非粘性和粘性组分被选择为彼此不混溶，使得当流体组合物干燥时，组分经历相分离。

    Radiation-curable silicone elastomers and pressure sensitive adhesives
    78.
    发明授权
    Radiation-curable silicone elastomers and pressure sensitive adhesives 失效
    可辐射固化的硅氧烷弹性体和压敏粘合剂

    公开(公告)号：US5314748A

    公开(公告)日：1994-05-24

    申请号：US109004

    申请日：1993-08-16

    申请人： Mieczyslaw H. Mazurek ,  Steven S. Kantner ,  Charles M. Leir ,  Yvan A. Bogaert ,  Robert K. Galkiewicz ,  Audrey A. Sherman

    发明人： Mieczyslaw H. Mazurek ,  Steven S. Kantner ,  Charles M. Leir ,  Yvan A. Bogaert ,  Robert K. Galkiewicz ,  Audrey A. Sherman

    IPC分类号： C07F7/08 ,  C07F7/12 ,  C08F299/08 ,  C08G77/26 ,  C08G77/388 ,  C09J7/02 ,  C09J155/00 ,  C09J183/08 ,  B32B7/12 ,  B32B9/04

    CPC分类号： C07F7/12 ,  C07F7/0854 ,  C08F299/08 ,  C08G77/26 ,  C08G77/388 ,  C09J155/005 ,  C09J183/08 ,  C09J7/0207 ,  Y10T428/2809 ,  Y10T428/2852 ,  Y10T428/2896 ,  Y10T428/31663

    摘要： A composition which is curable to an elastomer comprising:A polymer or mixture of polymers of the formula ##STR1## wherein: X are monovalent moieties having ethylenic unsaturation which can be the same or different;Y are divalent linking groups which can be the same or different;m is an integer of 0 to 1;D are monovalent moieties which can be the same or different selected from the group consisting of hydrogen, an alkyl group of 1 to about 10 carbon atoms, aryl, and substituted aryl;R are divalent hydrocarbon groups which can be the same or different;R.sup.1 are monovalent moieties which can be the same or different selected from the group consisting of alkyl, substituted alkyl, aryl, and substituted aryl;R.sup.2 are monovalent moieties which can be the same or different selected from the group consisting of alkyl, substituted alkyl, aryl, and substituted aryl;R.sup.3 are monovalent moieties which can be the same or different selected from the group consisting of alkyl, substituted alkyl, vinyl, aryl, and substituted aryl;R.sup.4 are monovalent moieties which can be the same or different selenited from the group consisting of alkyl, substituted alkyl, vinyl, aryl, and substituted aryl; andn is an integer of about 270 to about 1000.A composition which is curable to a pressure sensitive adhesive comprising the above polymer and a sufficient amount of tackifier. The invention also relates to fluorosilane compounds useful in the preparation of silicone macromonomer, their preparation and the preparation of silicone macromonomer.

    摘要翻译： 可固化成弹性体的组合物，其包含：下式的聚合物或聚合物的混合物，其中：X是具有烯属不饱和度的单价部分，其可以相同或不同; Y是可以相同或不同的二价连接基团; m为0〜1的整数; D是可以相同或不同的一价部分，其选自氢，1至约10个碳原子的烷基，芳基和取代的芳基; R是可以相同或不同的二价烃基; R1是可以相同或不同的一价部分，其选自烷基，取代的烷基，芳基和取代的芳基; R2是可以相同或不同的一种选自烷基，取代的烷基，芳基和取代的芳基的一价部分; R3是可以相同或不同的一种选自烷基，取代的烷基，乙烯基，芳基和取代的芳基的一价部分; R4是可以与由烷基，取代的烷基，乙烯基，芳基和取代的芳基组成的组相同或不同的一价部分; 并且n是约270至约1000的整数。可包含上述聚合物和足够量的增粘剂的压敏粘合剂可固化的组合物。 本发明还涉及可用于制备硅氧烷大分子单体的氟硅烷化合物，其制备和硅氧烷大分子单体的制备。

    Radiation-curable silicone elastomers and pressure sensitive adhesives
    79.
    发明授权
    Radiation-curable silicone elastomers and pressure sensitive adhesives 失效
    可辐射固化的硅氧烷弹性体和压敏粘合剂

    公开(公告)号：US5237082A

    公开(公告)日：1993-08-17

    申请号：US792437

    申请日：1991-11-15

    申请人： Charles M. Leir ,  Audrey A. Sherman

    发明人： Charles M. Leir ,  Audrey A. Sherman

    IPC分类号： C07F7/08 ,  C07F7/12 ,  C08F299/08 ,  C08G77/26 ,  C08G77/388 ,  C09J7/02 ,  C09J155/00 ,  C09J183/08

    CPC分类号： C07F7/12 ,  C07F7/0854 ,  C08F299/08 ,  C08G77/26 ,  C08G77/388 ,  C09J155/005 ,  C09J183/08 ,  C09J7/0207 ,  Y10T428/2809 ,  Y10T428/2852 ,  Y10T428/2896 ,  Y10T428/31663

    摘要： The invention provides a silicone composition which is rapidly, completely, and reliably radiation curable to an elastomer comprising an organopolysiloxane polymer having terminal groups which contain ethylenic unsaturation and in addition possess both hydrogen bond donor and acceptor capabilities. The invention also provides a composition which is curable to a pressure sensitive adhesive comprising the above polymer and a sufficient amount of tackifier. The invention also relates to silicone macromonomers additives for varying the properties of the composition. The invention further relates to fluorosilane compounds useful in the preparation of silicone macromonomers, their preparation and the preparation of silicone macromonomers.

    摘要翻译： 本发明提供了一种硅氧烷组合物，其快速，完全和可靠地辐射固化到包含具有含有烯属不饱和键的端基的有机聚硅氧烷聚合物的弹性体中，并且另外具有氢键供体和受体能力。 本发明还提供一种可固化到包含上述聚合物和足够量的增粘剂的压敏粘合剂的组合物。 本发明还涉及用于改变组合物性质的硅氧烷大分子单体添加剂。 本发明还涉及可用于制备硅氧烷大分子单体的氟硅烷化合物，其制备和硅氧烷大分子单体的制备。