利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

81 条记录 (耗时 0.036 秒)

    Oxygen-transferable emulsion
    71.
    发明授权
    Oxygen-transferable emulsion 失效
    可转印乳液

    公开(公告)号：US3962439A

    公开(公告)日：1976-06-08

    申请号：US439638

    申请日：1974-02-04

    申请人： Kazumasa Yokoyama ,  Koichi Yamanouchi ,  Ryoichiro Murashima ,  Ryozo Watanabe

    发明人： Kazumasa Yokoyama ,  Koichi Yamanouchi ,  Ryoichiro Murashima ,  Ryozo Watanabe

    IPC分类号： A61K9/107 ,  A61K9/00 ,  A61K31/02 ,  B01F17/14 ,  A61K31/535 ,  A61K31/335 ,  A61K31/35 ,  A61K31/445

    CPC分类号： A61K9/0026 ,  A61K31/02 ,  Y10S514/832

    摘要： Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C.sub.3-5 -alkylcyclohexanes), perfluoro(C.sub.4-6 -alkyl tetrahydropyrans), perfluoro(C.sub.5-7 -alkyltetrahydrofurans), perfluoro(C.sub.5-7 -alkylmorpholins) and perfluoro(C.sub.9-11 -trialkylamines) are emulsified in a physiologically acceptable aqueons solution such as Ringer's solution by the aid of a phospholipid as emulsifier and a fatty acid of 8 to 22 carbon atoms, alkali metal salt or monoglyceride thereof as emulsifying adjuvant. The emulsion is stable for a considerable period of time and contains particles having a particle size ranging from 0.05 to 0.3 .mu.. It is usable as a blood substitute or a perfusate for preservation of the internal organs.

    摘要翻译： 可全氟（C 5-8 - 烷基环己烷），全氟（C 5-6 - 烷基四氢吡喃），全氟（C 5-7 - 烷基四氢呋喃），全氟（C 5-7 - 烷基四氢呋喃），全氟 ）和全氟（C9-11-三烷基胺）在生理学上可接受的水溶液如林格氏溶液中借助于磷脂作为乳化剂和8-22个碳原子的脂肪酸，其碱金属盐或其单甘油酯作为乳化剂乳化 。 该乳液在相当长的一段时间内是稳定的并且含有粒度范围为0.05-0.3μm的颗粒。 它可用作血液替代物或灌注液，用于保存内脏。

    Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
    72.
    发明授权
    Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same 失效
    重组人血清白蛋白，其制备方法和含有其的药物制剂

    公开(公告)号：US5986062A

    公开(公告)日：1999-11-16

    申请号：US538471

    申请日：1995-10-03

    申请人： Takao Ohmura ,  Akinori Sumi ,  Wataru Ohtani ,  Naoto Furuhata ,  Kazuya Takeshima ,  Kaeko Kamide ,  Munehiro Noda ,  Masahide Kondo ,  Syoichi Ishikawa ,  Kazuhiro Oohara ,  Kazumasa Yokoyama ,  Nagatoshi Fujiwara

    发明人： Takao Ohmura ,  Akinori Sumi ,  Wataru Ohtani ,  Naoto Furuhata ,  Kazuya Takeshima ,  Kaeko Kamide ,  Munehiro Noda ,  Masahide Kondo ,  Syoichi Ishikawa ,  Kazuhiro Oohara ,  Kazumasa Yokoyama ,  Nagatoshi Fujiwara

    IPC分类号： A61K38/00 ,  C07K14/765

    CPC分类号： C07K14/765 ,  A61K2039/545 ,  A61K38/00

    摘要： Human serum albumin obtained by gene manipulation techniques can be purified by a combination of specified steps in which a culture supernatant obtained from a human serum albumin-producing host is subjected to ultrafiltration, heat treatment, acid treatment and another ultrafiltration, followed by subsequent treatments with a cation exchanger, a hydrophobic chromatography carrier and an anion exchanger, and by salting-out to thereby obtain a pure form of human serum albumin which contains substantially no proteinous and polysaccharide contaminants, which is formulated into a pharmaceutical preparation. The thus obtained human serum albumin can further be purified by treating recombinant human serum albumin with a hydrophobic chromatography carrier at pH of 2 to 5 and a salt concentration of 0.4 to 1 and exposing the carrier to a pH of 6 to 8 and a salt concentration of 0.01 to 0.3 M, or treating the culture supernatant with boric acid or a salt thereof at pH 8 to 11 for 1 to 10 hours and recovering the supernatant. This process makes it possible to effeciently purify recombinant human serum albumin and to provide substantially pure human serum albumin which does not contain producer host-related substances and other contaminants and is sufficiently free from coloration.

    摘要翻译： 通过基因操作技术获得的人血清白蛋白可以通过特定步骤的组合来纯化，其中将得自人血清白蛋白的宿主的培养上清液进行超滤，热处理，酸处理和另一次超滤，然后用 阳离子交换剂，疏水性色谱载体和阴离子交换剂，并通过盐析，从而获得纯的形式的人血清白蛋白，其基本上不含有配制成药物制剂的蛋白质和多糖污染物。 由此获得的人血清白蛋白可以进一步通过用pH为2至5和盐浓度为0.4至1的疏水色谱载体处理重组人血清白蛋白并将载体暴露于pH6至8和盐浓度 为0.01〜0.3M，或用硼酸或其盐在pH8〜11处理培养上清1〜10小时，回收上清液。 该方法使得可以有效地纯化重组人血清白蛋白并提供基本上纯的人血清白蛋白，其不含生产者宿主相关物质和其它污染物，并且没有着色。

    Infusion preparation comprising phospholipid
    73.
    发明授权
    Infusion preparation comprising phospholipid 失效
    包含磷脂的输液制剂

    公开(公告)号：US5674527A

    公开(公告)日：1997-10-07

    申请号：US478970

    申请日：1995-06-07

    申请人： Tadaaki Inoue ,  Hideto Kodaira ,  Yoshihito Nawa ,  Ryoichiro Murashima ,  Shunichi Abe ,  Kazumasa Yokoyama

    发明人： Tadaaki Inoue ,  Hideto Kodaira ,  Yoshihito Nawa ,  Ryoichiro Murashima ,  Shunichi Abe ,  Kazumasa Yokoyama

    IPC分类号： A23L1/29 ,  A23L1/30 ,  A23L1/304 ,  A23L1/305 ,  A61K9/00 ,  A61K31/70 ,  A61K33/30 ,  A61K45/06 ,  A61K9/127

    CPC分类号： A61K33/30 ,  A23L33/115 ,  A23L33/16 ,  A23L33/175 ,  A23L33/40 ,  A61K31/70 ,  A61K45/06 ,  A61K9/0029 ,  A23V2002/00 ,  Y10S514/938 ,  Y10S514/943

    摘要： Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartments separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes. An infusion preparation containing a sugar, amino acids, electrolytes and a fat emulsion can be obtained easily and aseptically upon use, by simply removing a separation means attached to the container and mixing the two infusion liquids.

    摘要翻译： 公开了用于营养供应使用的输液制剂。 它包含糖，氨基酸，电解质和脂肪乳剂。 尽管同时存在这些组分，它具有优异的保质期而不引起沉淀，变性等。 还公开了一种装有输液的容器，其包括通过分离装置彼此分离的第一和第二隔室，其中含有脂肪乳液和糖的输注液体包含在第一隔室中，另一个输注液体含有氨基酸和 电解质被包括在第二隔室中。 还公开了包含脂肪乳剂和糖的输注制剂，以及包含氨基酸和电解质的输注制剂。 通过简单地除去附着在容器上的分离装置并混合两种输注液，可以容易地和无菌地获得含有糖，氨基酸，电解质和脂肪乳剂的输液制剂。

    Infusion preparation
    74.
    发明授权
    Infusion preparation 失效
    输液准备

    公开(公告)号：US5626880A

    公开(公告)日：1997-05-06

    申请号：US589207

    申请日：1996-01-22

    申请人： Tadaaki Inoue ,  Hideto Kodaira ,  Yoshihito Nawa ,  Ryoichiro Murashima ,  Shunichi Abe ,  Kazumasa Yokoyama

    发明人： Tadaaki Inoue ,  Hideto Kodaira ,  Yoshihito Nawa ,  Ryoichiro Murashima ,  Shunichi Abe ,  Kazumasa Yokoyama

    IPC分类号： A23L1/29 ,  A23L1/30 ,  A23L1/304 ,  A23L1/305 ,  A61K9/00 ,  A61K31/70 ,  A61K33/30 ,  A61K45/06 ,  A61K9/14

    CPC分类号： A61K33/30 ,  A23L33/115 ,  A23L33/16 ,  A23L33/175 ,  A23L33/40 ,  A61K31/70 ,  A61K45/06 ,  A61K9/0029 ,  A23V2002/00 ,  Y10S514/938 ,  Y10S514/943

    摘要： Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartments separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes. An infusion preparation containing a sugar, amino acids, electrolytes and a fat emulsion can be obtained easily and aseptically upon use, by simply removing a separation means attached to the container and mixing the two infusion liquids.

    摘要翻译： 公开了用于营养供应使用的输液制剂。 它包含糖，氨基酸，电解质和脂肪乳剂。 尽管同时存在这些组分，它具有优异的保质期而不引起沉淀，变性等。 还公开了一种装有输液的容器，其包括通过分离装置彼此分离的第一和第二隔室，其中含有脂肪乳液和糖的输注液体包含在第一隔室中，另一个输注液体含有氨基酸和 电解质被包括在第二隔室中。 还公开了包含脂肪乳剂和糖的输注制剂，以及包含氨基酸和电解质的输注制剂。 通过简单地除去附着在容器上的分离装置并混合两种输注液，可以容易地和无菌地获得含有糖，氨基酸，电解质和脂肪乳剂的输液制剂。

    Perfluoro branched alkyl ethers and emulsions
    76.
    发明授权
    Perfluoro branched alkyl ethers and emulsions 失效
    全氟支链烷基醚和乳液

    公开(公告)号：US5214214A

    公开(公告)日：1993-05-25

    申请号：US860567

    申请日：1992-03-30

    申请人： Kirby V. Scherer, Jr. ,  Kouichi Yamanouchi ,  Kazumasa Yokoyama ,  Kimie Naito

    发明人： Kirby V. Scherer, Jr. ,  Kouichi Yamanouchi ,  Kazumasa Yokoyama ,  Kimie Naito

    IPC分类号： C07C43/12 ,  C07C43/17 ,  C07C43/313

    CPC分类号： C07C43/12 ,  C07C43/123 ,  C07C43/126 ,  C07C43/17 ,  C07C43/313

    摘要： There is provided a novel perfluorochemical represented by the formula, ##STR1## wherein R.sub.F is a perfluoroalkyl group, a perfluoro alkoxyalkyl group or a perfluoroalkyloxy group, X and X' are same as or different from each other and are a fluorine atom or a perfluoroalkyl group, and Y is a perfluoroalkyloxy group or a perfluoro dialkylamino group, the total number of the carbon atoms contained being an integer of 8 to 11 inclusive. The perfluorochemical is prepared by perfluorinating the corresponding partially fluorinated compound which may have unsaturated hydrocarbon moiety, only with molecular fluorine in a stoichiometric excess amount in an inert solvent.The perfluorochemical is used for preparing a stable emulsion as blood substitutes or perfusion media.

    摘要翻译： 提供了由下式表示的新型全氟化合物，其中RF是全氟烷基，全氟烷氧基烷基或全氟烷氧基，X和X'彼此相同或不同，是氟原子或全氟烷基 基团，Y为全氟烷氧基或全氟二烷基氨基，所含碳原子总数为8〜11的整数。 全氟化合物是通过使具有不饱和烃部分的相应的部分氟化的化合物在惰性溶剂中仅以化学计量过量的分子氟全氟化来制备的。 全氟化合物用于制备稳定的乳液作为血液代用品或灌注介质。

    Perfluorochemicals and process for preparing the same
    80.
    发明授权
    Perfluorochemicals and process for preparing the same 失效
    全氟化合物及其制备方法

    公开(公告)号：US4943595A

    公开(公告)日：1990-07-24

    申请号：US582448

    申请日：1984-02-22

    申请人： Kirby V. Scherer, Jr. ,  Kouichi Yamanouchi ,  Kazumasa Yokoyama ,  Ryoichi Naito, deceased

    发明人： Kirby V. Scherer, Jr. ,  Kouichi Yamanouchi ,  Kazumasa Yokoyama ,  Ryoichi Naito, deceased

    IPC分类号： C07C43/12 ,  C07C43/17 ,  C07C43/313

    CPC分类号： C07C43/12 ,  C07C43/123 ,  C07C43/126 ,  C07C43/17 ,  C07C43/313

    摘要： There is provided a novel perfluorochemical represented by the formula, ##STR1## wherein R.sub.F is a perfluoroalkyl group, a perfluoro alkoxyalkyl group or a perfluoroalkyloxy group, X and X' are same as or different from each other and are a fluorine atom or a perfluoroalkyl group, and Y is a perfluoroalkyloxy group or a perfluoro dialkylamino group, the total number of the carbon atoms contained being an integer of 8 to 11 inclusive. The perfluorochemical is prepared by perfluorinating the corresponding partially fluorinated compound which may have unsaturated hydrocarbon moiety, only with molecular fluorine in a stoichiometric excess amount in an inert solvent.The perfluorochemical is used for preparing a stable emulsion as blood substitutes or perfusion media.

    摘要翻译： 提供了由下式表示的新型全氟化合物，其中RF是全氟烷基，全氟烷氧基烷基或全氟烷氧基，X和X'彼此相同或不同，是氟原子或全氟烷基 基团，Y为全氟烷氧基或全氟二烷基氨基，所含碳原子总数为8〜11的整数。 全氟化合物是通过使具有不饱和烃部分的相应的部分氟化的化合物在惰性溶剂中仅以化学计量过量的分子氟全氟化来制备的。 全氟化合物用于制备稳定的乳液作为血液代用品或灌注介质。