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    Apparatus comprising an ion mobility spectrometer
    71.
    发明授权
    Apparatus comprising an ion mobility spectrometer 有权
    装置包括离子迁移谱仪

    公开(公告)号：US08334502B2

    公开(公告)日：2012-12-18

    申请号：US13297791

    申请日：2011-11-16

    申请人： Kevin Giles

    发明人： Kevin Giles

    IPC分类号： B01D59/44 ,  H01J49/40

    CPC分类号： H01J49/0481 ,  G01N27/622 ,  H01J49/004 ,  H01J49/062

    摘要： A mass spectrometer is disclosed comprising a first chamber and a second chamber. The second chamber is located downstream of the first chamber and an inter-chamber aperture is provided between the two chambers. An ion guide is located in the first chamber and an ion mobility spectrometer is located in the second chamber. Helium gas is provided to the first chamber. As ions are accelerated towards the ion mobility spectrometer from a relatively low pressure region they pass initially into the first chamber. The helium gas provided in the first chamber minimizes ion fragmentation and ion discrimination effects as ions are accelerated into a relatively high pressure region. The ions are then transmitted by the ion guide and are subsequently transmitted to the ion mobility spectrometer located in the second chamber.

    摘要翻译： 公开了一种质谱仪，其包括第一室和第二室。 第二室位于第一室的下游，并且在两个室之间设置室间孔。 离子导向器位于第一室中，离子迁移谱仪位于第二室中。 氦气被提供到第一室。 当离子从相对低的压力区域向离子迁移谱仪加速时，它们最初通入第一室。 当离子加速到相对高的压力区域时，设置在第一室中的氦气最小化离子碎片和离子鉴别效应。 然后离子通过离子导向器传输并随后传输到位于第二室中的离子迁移谱仪。

    Mass Spectrometer
    72.
    发明申请
    Mass Spectrometer 有权
    质谱仪

    公开(公告)号：US20110127416A1

    公开(公告)日：2011-06-02

    申请号：US12528203

    申请日：2008-02-25

    申请人： Iain Campuzano ,  Kevin Giles ,  Chris Hughes

    发明人： Iain Campuzano ,  Kevin Giles ,  Chris Hughes

    IPC分类号： B01D59/44 ,  H01J49/04

    CPC分类号： H01J49/0481 ,  H01J49/0431 ,  H01J49/067

    摘要： A mass spectrometer is disclosed comprising a sampling cone (3) and a cone-gas cone (4) wherein, in use, sulphur hexa fluoride (‘SF6’) is supplied as a cone gas (5) to the annulus between the cone-gas cone (4) and the sampling cone (3) in order to improve the transmission of high molecular mass ions passing through the sampling cone (3) into and through subsequent stages of the mass spectrometer.

    摘要翻译： 公开了一种质谱仪，其包括采样锥体（3）和锥形气体锥体（4），其中在使用中将六氟化硫（“SF 6”）作为锥形气体（5）供应到圆锥体 气体锥体（4）和采样锥体（3），以改善通过采样锥体（3）进入质谱仪后续阶段的高分子量离子的透射。

    Mass spectrometer
    73.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US07829849B2

    公开(公告)日：2010-11-09

    申请号：US11816221

    申请日：2006-02-14

    申请人： Kevin Giles

    发明人： Kevin Giles

    IPC分类号： H01J49/00

    CPC分类号： H01J49/065 ,  G01N27/624

    摘要： A device (6) for separating ions according to differences in their ion mobility as a function of electric field strength is disclosed. The device (6) comprises an upper electrode (7a), a lower electrode (7b) and a plurality of intermediate electrodes (8). An asymmetric voltage waveform is applied to the upper electrode (7a) and a DC compensating voltage is applied to the lower electrode (7b).

    摘要翻译： 公开了一种用于根据离子迁移率的差异分离离子作为电场强度的函数的装置（6）。 装置（6）包括上电极（7a），下电极（7b）和多个中间电极（8）。 对上部电极（7a）施加非对称电压波形，向下部电极（7b）施加直流补偿电压。

    Mass Spectrometer
    74.
    发明申请
    Mass Spectrometer 有权
    质谱仪

    公开(公告)号：US20100108878A1

    公开(公告)日：2010-05-06

    申请号：US11720771

    申请日：2005-12-07

    申请人： Robert Harold Bateman ,  Kevin Giles

    发明人： Robert Harold Bateman ,  Kevin Giles

    IPC分类号： H01J49/26 ,  H01J49/34

    CPC分类号： H01J49/0045 ,  G01N27/622 ,  H01J49/004 ,  H01J49/022 ,  H01J49/062

    摘要： A mass spectrometer is disclosed comprising a first quadrupole rod set mass filter (7), a collision cell (8), an ion mobility spectrometer or separator, an ion guide or collision cell (13) arranged downstream of the ion mobility spectrometer or separator, a second quadrupole rod set mass filter (16) and an ion detector (15).

    摘要翻译： 公开了一种质谱仪，其包括第一四极杆组质量过滤器（7），碰撞池（8），离子迁移谱仪或分离器，位于离子迁移谱仪或分离器下游的离子导向器或碰撞池（13） 第二四极杆组质量过滤器（16）和离子检测器（15）。

    Mass spectrometer
    75.
    发明申请
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US20070023638A1

    公开(公告)日：2007-02-01

    申请号：US11472278

    申请日：2006-06-22

    申请人： Robert Bateman ,  Kevin Giles ,  John Hoyes ,  Steve Pringle ,  Jeff Brown

    发明人： Robert Bateman ,  Kevin Giles ,  John Hoyes ,  Steve Pringle ,  Jeff Brown

    IPC分类号： H01J49/00

    CPC分类号： H01J49/4225

    摘要： A mass spectrometer is disclosed comprising an ion trap wherein ions which have been temporally separated according to their mass to charge ratio or ion mobility enter the ion trap. Once at least some of the ions have entered the ion trap, a plurality of ion trapping regions are created along the length of the ion trap in order to fractionate the ions. Alternatively, the ions may be received within one or more axial trapping regions which are translated along the ion trap with a velocity which is progressively reduced to zero.

    摘要翻译： 公开了一种质谱仪，其包括离子阱，其中根据其质荷比或离子迁移率暂时分离的离子进入离子阱。 一旦至少一些离子已经进入离子阱，沿着离子阱的长度产生多个离子捕获区域，以分离离子。 或者，离子可以被接收在一个或多个沿着离子阱平移的轴向捕获区域中，其速度逐渐减小到零。

    Mass spectrometer
    78.
    发明申请
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US20050023453A1

    公开(公告)日：2005-02-03

    申请号：US10633702

    申请日：2003-08-05

    申请人： Robert Bateman ,  Kevin Giles ,  John Hoyes ,  Steve Pringle ,  Jeff Brown

    发明人： Robert Bateman ,  Kevin Giles ,  John Hoyes ,  Steve Pringle ,  Jeff Brown

    IPC分类号： H01J49/00 ,  H01J49/42

    CPC分类号： H01J49/4225

    摘要： A mass spectrometer is disclosed comprising an ion trap wherein ions which have been temporally separated according to their mass to charge ratio or ion mobility enter the ion trap. Once at least some of the ions have entered the ion trap, a plurality of ion trapping regions are created along the length of the ion trap in order to fractionate the ions. Alternatively, the ions may be received within one or more axial trapping regions which are translated along the ion trap with a velocity which is progressively reduced to zero.

    摘要翻译： 公开了一种质谱仪，其包括离子阱，其中根据其质荷比或离子迁移率暂时分离的离子进入离子阱。 一旦至少一些离子已经进入离子阱，沿着离子阱的长度产生多个离子捕获区域，以分离离子。 或者，离子可以被接收在一个或多个沿着离子阱平移的轴向捕获区域中，其速度逐渐减小到零。

    Mass spectrometer
    79.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US06794641B2

    公开(公告)日：2004-09-21

    申请号：US10448059

    申请日：2003-05-30

    申请人： Robert Harold Bateman ,  Kevin Giles ,  Steve Pringle

    发明人： Robert Harold Bateman ,  Kevin Giles ,  Steve Pringle

    IPC分类号： H01J4940

    CPC分类号： H01J49/062 ,  H01J49/004

    摘要： A mass spectrometer is disclosed wherein ions from a pulsed ion source are dispersed in a drift region so that the ions become separated according to their mass to charge ratios. The ions are then received by an ion guide in which multiple trapping regions are created and wherein the multiple trapping regions are translated along the length of the ion guide. The ion guide receives the ions so that all the ions trapped in a particular trapping region have substantially the same or similar mass to charge ratios. The ions are released from the exit of the ion guide and the pusher/puller electrode of an orthogonal acceleration Time of Flight mass analyzer is arranged to be energised in synchronization with the ions emerging from the ion guide. The trapping regions may be translated along the ion guide with a velocity which becomes progressively slower and the delay time of the pusher/puller electrode may be progressively increased.

    摘要翻译： 公开了一种质谱仪，其中来自脉冲离子源的离子分散在漂移区域中，使得离子根据其质荷比分离。 然后由离子导向器接收离子，其中产生多个俘获区域，并且其中多个俘获区域沿离子导向件的长度平移。 离子导向器接收离子，使得捕获在特定捕获区域中的所有离子具有基本上相同或相似的质荷比。 离子从离子导向器的出口释放，并且正交加速时间飞行质量分析器的推动器/牵引电极被布置成与从离子导向器出射的离子同步地通电。 俘获区域可以沿着离子导向器平移，速度逐渐变慢，并且推动器/拉电极的延迟时间可以逐渐增加。

    Mass spectrometer
    80.
    发明授权
    Mass spectrometer 有权

    公开(公告)号：US09620346B2

    公开(公告)日：2017-04-11

    申请号：US11721729

    申请日：2005-12-16

    申请人： Kevin Giles

    发明人： Kevin Giles

    IPC分类号： H01J49/26 ,  H01J49/06

    CPC分类号： H01J49/062 ,  Y10T29/49165

    摘要： A mass spectrometer is disclosed comprising an ion guide. The ion guide comprises a hollow tubular conductor having a wall. One or more electrodes are provided in the wall of the tubular conductor. An exit aperture is provided in the wall of the tubular conductor downstream of the one or more electrodes. An AC or RF voltage is applied to the one or more electrodes and a DC potential difference is maintained between the wall of the tubular conductor and the one or more electrodes. The combination of a DC voltage gradient and applying an AC or RF voltage to the electrodes is that ions are confined radially to a region which is preferably close to the one or more electrodes. Ions are preferably extracted from the ion guide via the exit aperture.