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公开(公告)号：US06416511B1
公开(公告)日：2002-07-09
申请号：US09642614
申请日：2000-08-17
Applicant: Michael D. Lesh , Michael Ronald Ross , Jonathan J. Langberg , James C. Peacock, III
Inventor： Michael D. Lesh , Michael Ronald Ross , Jonathan J. Langberg , James C. Peacock, III
IPC: A61B1818
CPC classification number: A61B18/1492 , A61B18/00 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/0016 , A61B2018/00214 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00369 , A61B2018/00375 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2218/002 , A61N7/02
Abstract: This invention is a circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein. The assembly includes a circumferential ablation element which is adapted to ablate a circumferential region of tissue along a pulmonary vein wall which circumscribes the pulmonary vein lumen, thereby transecting the electrical conductivity of the pulmonary vein against conduction along its longitudinal axis and into the left atrium. The circumferential ablation element includes an expandable member with a working length that is adjustable from a radially collapsed position to a radially expanded position. An equatorial band circumscribes the outer surface of the working length and is adapted to ablate tissue adjacent thereto when actuated by an ablation actuator. The equatorial band has a length relative to the longitudinal axis of the expandable member that is narrow relative to the working length, and is also substantially shorter than its circumference when the working length is in the radially expanded position. A pattern of insulators may be included over an ablation element which otherwise spans the working length in order to form the equatorial band described. The expandable member is also adapted to conform to the pulmonary vein in the region of its ostium, such as by providing a great deal of radial compliance or by providing a taper along the working length which has a distally reducing outer diameter. A linear ablation element is provided adjacent to the circumferential ablation element in a combination assembly which is adapted for use in a less-invasive “maze”-type procedure in the region of the pulmonary vein ostia in the left ventricle.
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公开(公告)号：US6024740A
公开(公告)日：2000-02-15
申请号：US889798
申请日：1997-07-08
Applicant: Michael D. Lesh , Michael Ronald Ross , Jonathan J. Langberg , James C. Peacock, III
Inventor： Michael D. Lesh , Michael Ronald Ross , Jonathan J. Langberg , James C. Peacock, III
CPC classification number: A61B18/1492 , A61B18/00 , A61N7/02 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/0016 , A61B2018/00214 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00369 , A61B2018/00375 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2218/002
Abstract: This invention is a circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein. The assembly includes a circumferential ablation element which is adapted to ablate a circumferential region of tissue along a pulmonary vein wall which circumscribes the pulmonary vein lumen, thereby transecting the electrical conductivity of the pulmonary vein against conduction along its longitudinal axis and into the left atrium. The circumferential ablation element includes an expandable member with a working length that is adjustable from a radially collapsed position to a radially expanded position. An equatorial band circumscribes the outer surface of the working length and is adapted to ablate tissue adjacent thereto when actuated by an ablation actuator. The equatorial band has a length relative to the longitudinal axis of the expandable member that is narrow relative to the working length, and is also substantially shorter than its circumference when the working length is in the radially expanded position. A pattern of insulators may be included over an ablation element which otherwise spans the working length in order to form the equatorial band described. The expandable member is also adapted to conform to the pulmonary vein in the region of its ostium, such as by providing a great deal of radial compliance or by providing a taper along the working length which has a distally reducing outer diameter. A linear ablation element is provided adjacent to the circumferential ablation element in a combination assembly which is adapted for use in a less-invasive "maze"-type procedure in the region of the pulmonary vein ostia in the left ventricle.
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公开(公告)号：US5971983A
公开(公告)日：1999-10-26
申请号：US853861
申请日：1997-05-09
Applicant: Michael D. Lesh
Inventor： Michael D. Lesh
CPC classification number: A61B18/1492 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/0016 , A61B2018/00214 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00369 , A61B2018/00375 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2218/002
Abstract: A tissue ablation device creates long linear lesions along a body space wall of an animal, and primarily between adjacent pulmonary vein ostia in a left atrial wall. An ablation element includes first and second ends that are bordered by first and second anchors. The anchors are adapted to secure the ablation element ends at predetermined first and second locations along the body space wall such that the ablation element is adapted to ablate an elongate region of tissue between those locations. The anchors may be guidewire tracking members, each including a bore adapted to receive and track over a guidewire, and may anchor within adjacent pulmonary vein ostia when the engaged guidewires are positioned within the respective veins. Stop members may be provided on the guidewires and may be adapted for positioning the relative anchors or for forcing the anchors to fit snugly within the vein ostia. A conduit passageway through the catheter houses a stiffening stylet which may be advanced into the region of the ablation element in order to impart a shape to that element to conform it to a predetermined region of anatomy, or to stiffen the underlying catheter in order to advance the assembly into remote anatomy.
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公开(公告)号：US5385148A
公开(公告)日：1995-01-31
申请号：US99995
申请日：1993-07-30
Applicant: Michael D. Lesh , Patrick M. Owens , Jerome Jackson
Inventor： Michael D. Lesh , Patrick M. Owens , Jerome Jackson
CPC classification number: A61B18/1492 , A61B8/12 , A61B8/445 , A61B2018/00982 , A61B2034/2063 , A61B2090/3782 , A61B2090/3929
Abstract: Method and apparatus for ablation of cardiac tissue includes a catheter (2, 60) having an elongated flexible body (6, 64), a tissue characterization assembly including a transducer (34) at the distal end (16) of the body and a tissue ablation assembly having a tissue ablation tip (32) at the distal end of the body. The tissue ablation tip is positioned adjacent the tissue to be ablated using the visualization assembly and then activated.
Abstract translation: 用于消融心脏组织的方法和装置包括具有细长柔性体（6,64）的导管（2,60），组织表征组件，其包括位于身体的远端（16）处的换能器（34）和组织 消融组件，其具有在身体远端的组织消融尖端（32）。 组织消融尖端使用可视化组件定位在要消融的组织附近，然后被激活。
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75.发明授权Device, system, and method for transcatheter treatment of valve regurgitation 有权用于经导管治疗瓣膜反流的装置，系统和方法公开(公告)号：US08888843B2
公开(公告)日：2014-11-18
申请号：US13531407
申请日：2012-06-22
Applicant: Alex Khairkhahan , Michael D. Lesh
Inventor： Alex Khairkhahan , Michael D. Lesh
IPC: A61F2/24 , A61F2/00 , A61B17/04 , A61B17/068 , A61B17/064 , A61B19/00
CPC classification number: A61F2/2457 , A61B17/0401 , A61B17/068 , A61B2017/0406 , A61B2017/0409 , A61B2017/0414 , A61B2017/0443 , A61B2017/0448 , A61B2017/0649 , A61B2090/08021 , A61F2/2418 , A61F2/2454 , A61F2/2466 , A61F2210/0014 , A61F2220/0008 , A61L27/042 , A61L27/06 , A61L27/3625 , A61L27/50 , A61L2400/16 , A61L2430/20
Abstract: The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation enhancement element for implantation across the valve; a system including the coaptation enhancement element and anchors for implantation; a system including the coaptation enhancement element, catheter and driver; and a method for transcatheter implantation of a coaptation element across a heart valve.
Abstract translation: 本发明涉及一种用于经导管治疗二尖瓣反流的装置，特别是用于跨瓣膜植入的接合增强元件。 包括接合增强元件和用于植入的锚的系统; 包括接合增强元件，导管和驱动器的系统; 以及穿过心脏瓣膜的经导管植入接合元件的方法。
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Patent Agency Ranking
公开(公告)号：US08603108B2
公开(公告)日：2013-12-10
申请号：US13477404
申请日：2012-05-22
Applicant: Chad C. Roue , Andrew G. C. Frazier , Michael D. Lesh , Erik J. van der Burg
Inventor： Chad C. Roue , Andrew G. C. Frazier , Michael D. Lesh , Erik J. van der Burg
IPC: A61B17/10
CPC classification number: A61B17/0057 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0644 , A61B17/12122 , A61B2017/00243 , A61B2017/00292 , A61B2017/00575 , A61B2017/00579 , A61B2017/00632 , A61B2017/00668 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0417 , A61B2017/042 , A61B2017/0437 , A61B2017/0445 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0472 , A61B2017/0477 , A61B2017/048 , A61B2017/0488 , A61B2017/0645 , A61B2017/0647 , A61F2/24 , A61F2/2427 , A61F2/2487 , Y10S606/907
Abstract: Disclosed is a closure catheter, for closing a tissue opening such as an atrial septal defect, patent foreman ovale, or the left atrial appendage of the heart. The closure catheter carries a plurality of tissue anchors, which may be deployed into tissue surrounding the opening, and used to draw the opening closed. Methods are also disclosed.
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公开(公告)号：US08523897B2
公开(公告)日：2013-09-03
申请号：US11529707
申请日：2006-09-27
Applicant: Erik J. van der Burg , Dino De Cicco , Andrew G. C. Frazier , Alex K. Khairkahan , Marc S. Kriedler , Michael D. Lesh , Chad C. Roue
Inventor： Erik J. van der Burg , Dino De Cicco , Andrew G. C. Frazier , Alex K. Khairkahan , Marc S. Kriedler , Michael D. Lesh , Chad C. Roue
CPC classification number: A61B17/12122 , A61B17/0057 , A61B17/12022 , A61B17/12031 , A61B17/12136 , A61B17/12172 , A61B17/12186 , A61B17/12195 , A61B17/122 , A61B2017/00243 , A61B2017/00557 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00615 , A61B2017/00619 , A61B2017/00632 , A61B2017/00867 , A61B2017/081 , A61B2017/1205 , A61F2/01 , A61F2002/018 , A61F2230/0006 , A61F2230/0069 , A61F2230/0071 , A61F2230/008 , A61M25/10 , A61M2025/1054 , A61M2210/125
Abstract: An implantable device for containing emboli within an atrial appendage may include an expandable frame having a plurality of supports projecting distally from a proximal hub, a mesh barrier provided on proximal sections of the supports, and a plurality of tissue anchors provided on the supports for engaging tissue when the device is positioned in an atrial appendage.
Abstract translation: 用于在耳附件内容纳栓塞的可植入装置可以包括具有多个从近侧毂向远侧突出的支撑件的可扩张框架，设置在支撑件的近侧部分上的网状屏障，以及设置在支撑件上的多个组织锚， 当装置位于心房附近时的组织。
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公开(公告)号：US20130023985A1
公开(公告)日：2013-01-24
申请号：US13531407
申请日：2012-06-22
Applicant: Alex Khairkhahan , Michael D. Lesh
Inventor： Alex Khairkhahan , Michael D. Lesh
IPC: A61F2/24
CPC classification number: A61F2/2457 , A61B17/0401 , A61B17/068 , A61B2017/0406 , A61B2017/0409 , A61B2017/0414 , A61B2017/0443 , A61B2017/0448 , A61B2017/0649 , A61B2090/08021 , A61F2/2418 , A61F2/2454 , A61F2/2466 , A61F2210/0014 , A61F2220/0008 , A61L27/042 , A61L27/06 , A61L27/3625 , A61L27/50 , A61L2400/16 , A61L2430/20
Abstract: The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation enhancement element for implantation across the valve; a system including the coaptation enhancement element and anchors for implantation; a system including the coaptation enhancement element, catheter and driver; and a method for transcatheter implantation of a coaptation element across a heart valve.
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公开(公告)号：US08221384B2
公开(公告)日：2012-07-17
申请号：US13270703
申请日：2011-10-11
Applicant: Andrew G. C. Frazier , Michael D. Lesh , Chad C. Roue , Erik J. van der Burg
Inventor： Andrew G. C. Frazier , Michael D. Lesh , Chad C. Roue , Erik J. van der Burg
IPC: A61M31/00
CPC classification number: A61B17/0057 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0644 , A61B17/12122 , A61B2017/00243 , A61B2017/00292 , A61B2017/00575 , A61B2017/00579 , A61B2017/00632 , A61B2017/00668 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0417 , A61B2017/042 , A61B2017/0437 , A61B2017/0445 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0472 , A61B2017/0477 , A61B2017/048 , A61B2017/0488 , A61B2017/0645 , A61B2017/0647 , A61F2/24 , A61F2/2427 , A61F2/2487 , Y10S606/907
Abstract: Disclosed is an anastomosis catheter, for achieving a tissue to tissue or synthetic graft to tissue attachment. The catheter includes a plurality of deployable tissue anchors, which may be laterally deployed into surrounding tissue. The anchors may be used to achieve end to end or end to side anastomoses. Methods are also disclosed.
Abstract translation: 公开了一种用于实现组织到组织或合成移植物到组织附着的吻合导管。 导管包括多个可展开的组织锚，其可以横向地布置到周围组织中。 锚可以用于实现端对端或端到端吻合。 还公开了方法。
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公开(公告)号：US20120029541A1
公开(公告)日：2012-02-02
申请号：US13270703
申请日：2011-10-11
Applicant: Andrew G.C. Frazier , Michael D. Lesh , Chad C. Roue , Erik J. van der Burg
Inventor： Andrew G.C. Frazier , Michael D. Lesh , Chad C. Roue , Erik J. van der Burg
IPC: A61B17/11
CPC classification number: A61B17/0057 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0644 , A61B17/12122 , A61B2017/00243 , A61B2017/00292 , A61B2017/00575 , A61B2017/00579 , A61B2017/00632 , A61B2017/00668 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0417 , A61B2017/042 , A61B2017/0437 , A61B2017/0445 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0472 , A61B2017/0477 , A61B2017/048 , A61B2017/0488 , A61B2017/0645 , A61B2017/0647 , A61F2/24 , A61F2/2427 , A61F2/2487 , Y10S606/907
Abstract: Disclosed is an anastomosis catheter, for achieving a tissue to tissue or synthetic graft to tissue attachment. The catheter includes a plurality of deployable tissue anchors, which may be laterally deployed into surrounding tissue. The anchors may be used to achieve end to end or end to side anastomoses. Methods are also disclosed.
Abstract translation: 公开了一种用于实现组织到组织或合成移植物到组织附着的吻合导管。 导管包括多个可展开的组织锚，其可以横向地布置到周围组织中。 锚可以用于实现端对端或端到端吻合。 还公开了方法。
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