公开(公告)号：US20060120204A1

公开(公告)日：2006-06-08

申请号：US11235938

申请日：2005-09-27

申请人： Yama Abassi ,  Josephine Atienza ,  Xiao Xu ,  Xiaobo Wang

发明人： Yama Abassi ,  Josephine Atienza ,  Xiao Xu ,  Xiaobo Wang

IPC分类号： G11C8/02

CPC分类号： G01N29/036 ,  G01N2291/0257

摘要： The present invention includes devices and methods for dynamically monitoring cell adhesion and cell spreading. Cells are added to a microelectronic cell sensor array operably connected to an impedance analyzer. The device also includes a coating including biological molecule or organic compound capable of interacting with the cell. Cell adhesion and cell mobility is determined by detecting changes in impedance and comparing impedance or cell index values between samples.

摘要翻译： 本发明包括用于动态监测细胞粘附和细胞扩散的装置和方法。 将细胞添加到可操作地连接到阻抗分析器的微电子单元传感器阵列。 该装置还包括包含能够与细胞相互作用的生物分子或有机化合物的涂层。 通过检测阻抗变化并比较样品之间的阻抗或细胞指数值来确定细胞粘附和细胞迁移率。

公开(公告)号：US20060023559A1

公开(公告)日：2006-02-02

申请号：US11197994

申请日：2005-08-04

申请人： Xiao Xu ,  Yama Abassi ,  Xiaobo Wang

发明人： Xiao Xu ,  Yama Abassi ,  Xiaobo Wang

IPC分类号： G11C8/00

CPC分类号： G01N33/5438 ,  G01N33/5014 ,  G01N2333/4716

摘要： The present invention includes a method of measuring cytolytic activity including providing a device capable of monitoring cell-substrate impedance operably connected to an impedance analyzer, adding target cells to at least one well of the device, adding effector cells to the at least one well, monitoring impedance of the at least one well and optionally determining a cell index from the impedance, wherein monitoring impedance includes measuring impedance during at least one time point before and at least one time point after adding effector cells, and determining viability of said target cells after adding effector cells by comparing the impedance or optionally the cell index at the at least one time point after adding effector cells to the impedance or optionally the cell index at the at least one time point before adding effector cells

摘要翻译： 本发明包括一种测量溶细胞活性的方法，包括提供能够监测可操作地连接到阻抗分析仪的细胞 - 基底阻抗的装置，将靶细胞添加到装置的至少一个孔中，将效应细胞添加到至少一个孔， 监测所述至少一个井的阻抗并且可选地从所述阻抗确定细胞指数，其中监测阻抗包括在加入效应细胞之前和至少一个时间点之前的至少一个时间点内测量阻抗，以及在确定所述靶细胞之后的存活力 通过在添加效应细胞之前在至少一个时间点将效应细胞添加到阻抗或任选地在至少一个时间点的细胞指数之后比较阻抗或任选的细胞指数来添加效应细胞，

公开(公告)号：US08852457B2

公开(公告)日：2014-10-07

申请号：US14125857

申请日：2012-05-24

申请人： Xiaobo Wang ,  Zengli Zhao ,  Haibin Li ,  Anqi Liu ,  Hongxiang Wu

发明人： Xiaobo Wang ,  Zengli Zhao ,  Haibin Li ,  Anqi Liu ,  Hongxiang Wu

IPC分类号： C01B3/38 ,  C10K1/00 ,  C10K3/00 ,  C10K1/02 ,  C10K3/04 ,  C10K3/02 ,  B01D53/68 ,  C01B3/56 ,  C10K3/06 ,  B01D53/48 ,  C01B3/50 ,  C10K1/34

CPC分类号： C01B3/56 ,  B01D53/48 ,  B01D53/68 ,  B01D2251/304 ,  B01D2251/306 ,  B01D2251/604 ,  B01D2251/606 ,  B01D2256/16 ,  B01D2256/20 ,  B01D2257/2045 ,  B01D2257/30 ,  B01D2257/304 ,  B01D2257/308 ,  B01D2257/408 ,  C01B3/50 ,  C10K1/002 ,  C10K1/004 ,  C10K1/02 ,  C10K1/024 ,  C10K1/32 ,  C10K1/34 ,  C10K3/00 ,  C10K3/001 ,  C10K3/006 ,  C10K3/026 ,  C10K3/04 ,  C10K3/06

摘要： A method for purification and conditioning of crude syngas based on properties of molten salts, includes removing particles at a high-temperature by enabling the high-temperature crude syngas produced by a gasification device to firstly pass through a high-temperature particle removal device to remove solid particles in the gas; removing hydrocarbons in the presence of oxygen by introducing an oxidant into the crude syngas after treatment, selectively removing the hydrocarbons in the crude syngas and simultaneously utilizing high temperature produced by oxidation of the hydrocarbons to crack tar; and removing gas pollutants and conditioning by introducing the obtained crude syngas into molten salts medium, removing pollutants containing sulfur and chlorine in the crude syngas, and simultaneously adjusting the H2/CO ratio of the syngas to obtain purified syngas.

摘要翻译： 基于熔融盐的性质对粗合成气进行净化和调理的方法包括通过使由气化装置产生的高温粗合成气首先通过高温颗粒去除装置除去高温下的高温脱除颗粒， 气体中的固体颗粒; 通过在处理后将氧化剂引入粗合成气中，在氧气存在下除去碳氢化合物，选择性地除去粗合成气中的烃，同时利用烃氧化产生的高温裂解焦油; 通过将所得粗合成气引入熔盐介质中除去气体污染物和调节物质，除去粗合成气中含有硫和氯的污染物，同时调节合成气的H 2 / CO比，得到纯化合成气。

公开(公告)号：US08676888B2

公开(公告)日：2014-03-18

申请号：US12615886

申请日：2009-11-10

申请人： Guojun Xu ,  Xiaobo Wang

发明人： Guojun Xu ,  Xiaobo Wang

IPC分类号： G06F15/16

CPC分类号： H04L65/1069 ,  H04L29/12594 ,  H04L61/30 ,  H04L61/309 ,  H04L65/80 ,  H04L67/14

摘要： A method for a multi-terminal session, and a communication system and related devices thereof are disclosed according to the present invention. Accordingly, the user experience is improved. The method of the present invention includes setting up a connection between each terminal of a multi-terminal user and a session transfer server; setting up a connection between the session transfer server and a peer user; conducting a session between each terminal of the multi-terminal user and the peer user via the session transfer server.

摘要翻译： 根据本发明公开了一种多终端会话的方法，以及通信系统及其相关装置。 因此，提高了用户体验。 本发明的方法包括建立多终端用户的每个终端与会话传送服务器之间的连接; 建立会话转移服务器和对等体用户之间的连接; 通过会话转移服务器在多终端用户的每个终端和对等体用户之间进行会话。

公开(公告)号：US08620899B2

公开(公告)日：2013-12-31

申请号：US12702384

申请日：2010-02-09

申请人： Dongsheng Chen ,  Hong Min ,  Terence P. Purcell ,  Yefim Shuf ,  Xiaobo Wang ,  Zhongliang Zhang

发明人： Dongsheng Chen ,  Hong Min ,  Terence P. Purcell ,  Yefim Shuf ,  Xiaobo Wang ,  Zhongliang Zhang

IPC分类号： G06F17/30 ,  G06F7/00

CPC分类号： G06F17/30457

摘要： Techniques for generating a set of one or more materialized query table (MQT) candidates for a workload are provided. The techniques include receiving a workload, wherein the workload comprises a set of one or more queries, generating one or more best matching MQTs (BMQTs) based on one or more query blocks of the one or more queries by removing syntax that is not qualified for a MQT re-write, determining one or more frequently used multi-joins in the workload, using the one or more BMQTs and the one or more frequently used multi-joins to generate a set of one or more workload MQTs (WMQTs), and grouping one or more WMQTs and one or more BMQTs into one or more groups to merge into a set of a smaller number of MQTs and to cover the workload.

摘要翻译： 提供了用于生成用于工作负载的一个或多个物化查询表（MQT）候选的集合的技术。 所述技术包括接收工作负载，其中所述工作负载包括一组一个或多个查询，基于所述一个或多个查询的一个或多个查询块生成一个或多个最佳匹配MQT（BMQT），通过除去不符合 MQT重写，使用所述一个或多个BMQT和所述一个或多个频繁使用的多连接来生成一组一个或多个工作负载MQT（WMQT）来确定所述工作负载中的一个或多个频繁使用的多连接，以及 将一个或多个WMQT和一个或多个BMQT分组成一个或多个组合并成一组较少数量的MQT并覆盖工作负载。

公开(公告)号：US20130143254A1

公开(公告)日：2013-06-06

申请号：US13309209

申请日：2011-12-01

申请人： Donald Thomas ,  Wei Li ,  Ning Ke ,  Nan Li ,  Adrian Papas ,  Manfred Watzele ,  Alexander Seiler ,  Tianxing Wang ,  Yama Abassi ,  Xiaobo Wang

发明人： Donald Thomas ,  Wei Li ,  Ning Ke ,  Nan Li ,  Adrian Papas ,  Manfred Watzele ,  Alexander Seiler ,  Tianxing Wang ,  Yama Abassi ,  Xiaobo Wang

IPC分类号： G01N27/02 ,  G01N21/00 ,  C12M1/34 ,  C12Q1/02 ,  C12M1/12 ,  C12M1/00

CPC分类号： C12M25/04 ,  C12Q1/02 ,  G01N21/253 ,  G01N21/6452 ,  G01N33/48735 ,  G01N33/54373

摘要： An insert device and co-culture device assembly incorporating the insert device, which includes an insert chamber with two fluid impermeable side walls that extend from a microporous bottom to an open top to form an inner cavity. The first side wall is shaped to form a convex arc that follows between about half of a circumference of the well and less than an entire circumference of the well. The second side wall joins ends of the first side wall and protrudes inward towards a center of the convex arc. A flange extends outward from or beneath the top and is notched to form a gap adjacent to the second side wall, which forms an access port allowing access to the lower chamber with a micropipette tip when the insert device is inserted into a well of a single or multi-well plate.

摘要翻译： 包括插入装置的插入装置和共培养装置组件，其包括具有从微孔底部延伸到开口顶部以形成内腔的两个流体不可渗透侧壁的插入室。 第一侧壁成形为形成沿着井的圆周的大约一半且小于井的整个圆周的凸弧。 第二侧壁连接第一侧壁的端部并朝向凸弧的中心向内突出。 凸缘从顶部向下或从顶部向外延伸并且被切口以形成与第二侧壁相邻的间隙，当形成插入装置插入到单个孔中时，形成允许通过微量移液管尖端进入下腔室的进入口 或多孔板。

公开(公告)号：US20130118903A1

公开(公告)日：2013-05-16

申请号：US13545775

申请日：2012-07-10

申请人： Frederick F. Becker ,  Peter Gascoyne ,  Xiaobo Wang ,  Jody Valentine Vykoukal ,  Giovanni De Gasperis

发明人： Frederick F. Becker ,  Peter Gascoyne ,  Xiaobo Wang ,  Jody Valentine Vykoukal ,  Giovanni De Gasperis

IPC分类号： G01N27/447

CPC分类号： G01N27/44773 ,  B01F13/0076 ,  B01F2215/0404 ,  B01L3/502715 ,  B01L3/502761 ,  B01L3/502792 ,  B01L2200/143 ,  B01L2300/089 ,  B01L2400/0421 ,  B01L2400/0424 ,  B01L2400/0454 ,  B03C5/005 ,  B03C5/024 ,  B03C5/026 ,  B03C5/028 ,  G01N27/447

摘要： A method and apparatus for microfluidic processing by programmably manipulating a packet. A material is introduced onto a reaction surface and compartmentalized to form a packet. A position of the packet is sensed with a position sensor. A programmable manipulation force is applied to the packet at the position. The programmable manipulation force is adjustable according to packet position by a controller. The packet is programmably moved according to the programmable manipulation force along arbitrarily chosen paths.

摘要翻译： 用于通过可编程地操纵分组的微流体处理的方法和装置。 将材料引入反应表面并分隔成形成包装。 用位置传感器检测分组的位置。 可编程操纵力被施加到该位置处的分组。 可编程操纵力可根据控制器的分组位置进行调节。 根据可编程操纵力沿着任意选择的路径可编程地移动分组。

公开(公告)号：US08420363B2

公开(公告)日：2013-04-16

申请号：US12325530

申请日：2008-12-01

申请人： Xiaobo Wang ,  Xiao Xu

发明人： Xiaobo Wang ,  Xiao Xu

IPC分类号： C12N13/00 ,  B05D3/00

CPC分类号： G01N27/02 ,  C12M23/12 ,  C12M41/36 ,  G01N27/3276 ,  Y10T29/49117

摘要： A device for detecting cells and/or molecules on an electrode surface is disclosed. The device detects cells and/or molecules through measurement of impedance changes resulting from the cells and/or molecules. A disclosed embodiment of the device includes a substrate having two opposing ends along a longitudinal axis. A plurality of electrode arrays are positioned on the substrate. Each electrode array includes at least two electrodes, and each electrode is separated from at least one adjacent electrode in the electrode array by an expanse of non-conductive material. The electrode has a width at its widest point of more than about 1.5 and less than about 10 times the width of the expanse of non-conductive material. The device also includes electrically conductive traces extending substantially longitudinally to one of the two opposing ends of the substrate without intersecting another trace. Each trace is in electrical communication with at least one of the electrode arrays.

摘要翻译： 公开了一种用于检测电极表面上的电池和/或分子的装置。 该装置通过测量由细胞和/或分子产生的阻抗变化来检测细胞和/或分子。 所述装置的公开实施例包括具有沿着纵向轴线的两个相对端部的基板。 多个电极阵列位于基板上。 每个电极阵列包括至少两个电极，并且每个电极由电极阵列中的至少一个相邻的电极通过一片非导电材料分开。 电极的最宽点处的宽度大于非导电材料的宽度的大约1.5倍且小于约10倍。 该器件还包括基本上纵向延伸到衬底的两个相对端之一的导电迹线，而不与另一迹线相交。 每个迹线与至少一个电极阵列电连通。

公开(公告)号：US08252822B2

公开(公告)日：2012-08-28

申请号：US12175154

申请日：2008-07-17

申请人： Haoyun An ,  Biao Xi ,  Yama Abassi ,  Xiaobo Wang ,  Xiao Xu

发明人： Haoyun An ,  Biao Xi ,  Yama Abassi ,  Xiaobo Wang ,  Xiao Xu

IPC分类号： A61K31/429 ,  C07D513/04

CPC分类号： C07D487/04 ,  C07D498/04 ,  C07D513/04

摘要： Novel compounds having a fused bicyclic heteroaromatic ring system substituted with a heteroaryl five-membered ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.

摘要翻译： 公开了具有被杂芳基五元环取代的稠合双环杂芳环系的新型化合物。 这些化合物抑制多种类型的癌细胞的生长，因此可用于治疗癌症。 通过用于监测细胞生长/迁移的系统来证明这些化合物的功效，这表明它们是癌细胞的生长和/或迁移的有效抑制剂。 此外，本发明的化合物被证明可以在体内停止肿瘤生长，并减少体内肿瘤的大小。 公开了包含这些化合物的组合物，以及使用这些化合物和用于治疗癌症的组合物的方法。

公开(公告)号：US20110039294A1

公开(公告)日：2011-02-17

申请号：US12774709

申请日：2010-05-05

申请人： Xiaobo Wang ,  Wei Ouyang ,  Nan Li ,  Biao Xi ,  Yama A. Abassi ,  Xiao Xu

发明人： Xiaobo Wang ,  Wei Ouyang ,  Nan Li ,  Biao Xi ,  Yama A. Abassi ,  Xiao Xu

IPC分类号： C12Q1/02 ,  C12M1/34

CPC分类号： G01N33/48735

摘要： Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the recording electrode is accessible to cells when a cell sample is added to the device; and a reference electrode positioned within the well in a cell-free zone, the cell-free zone characterized as free from contact with cells when the cell sample is added to the device, thereby preventing contact between cells and the reference electrode.

摘要翻译： 提供了用于进行细胞的细胞外记录的装置和方法，例如可兴奋细胞，心肌细胞和心肌细胞前体细胞。 示例性装置包括形成或提供为一个或多个孔的基底的非导电基底; 记录电极，其位于所述阱内的所述衬底上，其中当将细胞样品添加到所述装置时，所述记录电极可接近细胞; 以及位于无细胞区域内的阱内的参比电极，当将细胞样品添加到器件时，无细胞区域表征为不与细胞接触，从而防止细胞与参比电极之间的接触。