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公开(公告)号：US11635415B2
公开(公告)日：2023-04-25
申请号：US17395909
申请日：2021-08-06
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zheng Ouyang
Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
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公开(公告)号：US11495448B2
公开(公告)日：2022-11-08
申请号：US16985553
申请日：2020-08-05
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , Yue Ren , Ziqing Lin
IPC: H01J49/04 , H01J49/16 , C12Q1/6806
Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.
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公开(公告)号：US20220265172A1
公开(公告)日：2022-08-25
申请号：US17692613
申请日：2022-03-11
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zheng Ouyang , Chien-hsun Chen , Ziqing Lin , Livia Schiavinato Eberlin
IPC: A61B5/1477 , A61B10/00 , H01J49/04 , A61M11/00 , A61M25/00 , H01J49/00 , H01J49/16 , H01J49/34 , G01N33/483
Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
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公开(公告)号：US20210358732A1
公开(公告)日：2021-11-18
申请号：US17179715
申请日：2021-02-19
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Ahmed Mohamed Hamid , Alan Keith Jarmusch , Zheng Ouyang
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
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公开(公告)号：US11037772B2
公开(公告)日：2021-06-15
申请号：US15577516
申请日：2016-05-27
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , Yu Xia , Xiaoxiao Ma
IPC: H01J49/04 , G01N1/30 , G01N33/92 , G01N30/00 , G01N1/40 , G01N30/72 , G01N30/88 , H01J49/00 , A61B10/02 , G01N30/02
Abstract: The invention generally relates to methods for analyzing a tissue sample. In certain aspects, the invention provides methods that involve obtaining a tissue sample including an unsaturated compound, conducting a radical reaction on the tissue sample that targets a carbon-carbon double bond within the unsaturated compound to thereby produce a plurality of compound isomers, subjecting the plurality of compound isomers to mass spectrometry analysis to identify a location of the carbon-carbon double bond within the unsaturated compound, and quantifying the plurality of compound isomers in order to distinguish normal tissue from diseased tissue.
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Patent Agency Ranking
公开(公告)号：US20200381239A1
公开(公告)日：2020-12-03
申请号：US16985553
申请日：2020-08-05
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , Yue Ren , Ziqing Lin
IPC: H01J49/16 , C12Q1/6806
Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.
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公开(公告)号：US20200340962A1
公开(公告)日：2020-10-29
申请号：US16905193
申请日：2020-06-18
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zheng Ouyang
Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
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公开(公告)号：US10777402B2
公开(公告)日：2020-09-15
申请号：US16293017
申请日：2019-03-05
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , Yue Ren , Ziqing Lin
IPC: H01J49/16 , C12Q1/6806
Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.
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公开(公告)号：US10656157B2
公开(公告)日：2020-05-19
申请号：US14862517
申请日：2015-09-23
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zheng Ouyang
IPC: G01N33/58 , H01J49/00 , G01N33/574 , G01N33/49
Abstract: The invention generally relates to methods for rare event detection using mass tags. In certain embodiments, the invention provides methods for detecting a target analyte in a sample that involve conducting an assay that specifically associates a mass tag with a target analyte in a sample, generating ions of the mass tag, and analyzing the generated ions of the mass tag, thereby detecting the target analyte from the sample.
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公开(公告)号：US20190221418A1
公开(公告)日：2019-07-18
申请号：US16293017
申请日：2019-03-05
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , Yue Ren , Ziqing Lin
IPC: H01J49/16 , C12Q1/6806
CPC classification number: H01J49/167 , C12Q1/6806 , Y10T436/24 , Y10T436/255
Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.
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