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公开(公告)号：US07294841B2
公开(公告)日：2007-11-13
申请号：US11051609
申请日：2005-02-04
IPC分类号： H01J27/00
CPC分类号： H01J49/165 , H01J49/044 , H01J49/045 , H01J49/0468 , H01J49/168
摘要： An Electrospray Ionisation ion source and an Atmospheric Pressure Chemical Ionisation ion source are disclosed which comprise a probe 1 comprising three co-axial capillary tubes 2,3,3′. A blue-flame gas torch 6 is provided downstream of the probe 1 as a combustion source. An analyte solution is sprayed from an inner capillary tube 2 of the probe 1, a combustible gas is supplied to an intermediate capillary tube 3 of the probe 1 and oxygen or air is supplied to an outer capillary tube 3′ of the probe 1. The combustible gas supplies heat to aid desolvation of the droplets emerging from the probe 1 via combustion with the surrounding oxygen-containing atmosphere when combusted by the blue flame torch 6.
摘要翻译： 公开了一种电喷雾离子源和大气压化学离子源，其包括包含三个同轴毛细管2,3,3'的探针1。 蓝色火焰焰炬6设置在探头1的下游，作为燃烧源。 从探针1的内部毛细管2喷射分析物溶液，向探针1的中间毛细管3供给可燃性气体，将氧气或空气供给到探针1的外部毛细管3'。 当由蓝色火焰焰炬6燃烧时，可燃气体通过与周围的含氧气氛的燃烧而提供热量以帮助从探针1出来的液滴的去溶剂化。
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公开(公告)号：US07202473B2
公开(公告)日：2007-04-10
申请号：US10821548
申请日：2004-04-09
申请人： Robert Harold Bateman , Jeff Brown , Martin Green
发明人： Robert Harold Bateman , Jeff Brown , Martin Green
CPC分类号： H01J49/0036
摘要： A mass spectrometer is disclosed wherein the experimentally determined mass to charge ratios of ions are reported together with an error band for each mass to charge ratio determination. The error band may, for example, reflect a 95% probability or confidence that the real, true, actual or accepted mass to charge ratio of the ion lies within the error band. By accurately determining the error band the possible candidate ions in a database can be accurately restricted whilst also guarding against over restriction.
摘要翻译： 公开了一种质谱仪，其中实验确定的离子质量与电荷比率与每个质荷比确定的误差带一起报告。 例如，误差带可以反映出真实的，真实的，实际的或接受的离子质量与电荷比在误差带内的概率或置信度。 通过精确地确定误差带，可以准确地限制数据库中的可能候选离子，同时也防止过度限制。
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公开(公告)号：US07157697B2
公开(公告)日：2007-01-02
申请号：US10734055
申请日：2003-12-11
CPC分类号： H01J43/246
摘要： An ion detector for a mass spectrometer is disclosed comprising one or more microchannel plates and an anode arranged to receive electrons emitted from the one or more microchannel plates. The anode preferably has a smaller diameter than the microchannel plates and is preferably arranged at a distance of at least 15 mm from the microchannel plates. One or more focusing lenses may be provided intermediate the microchannel plates and the anode. The anode preferably comprises two portions separated by an electrically insulated layer.
摘要翻译： 公开了一种用于质谱仪的离子检测器，其包括一个或多个微通道板和布置成接收从一个或多个微通道板发射的电子的阳极。 阳极优选具有比微通道板更小的直径，并且优选地布置在距离微通道板至少15mm的距离处。 可以在微通道板和阳极之间提供一个或多个聚焦透镜。 阳极优选包括由电绝缘层分开的两个部分。
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公开(公告)号：US06642514B2
公开(公告)日：2003-11-04
申请号：US09930227
申请日：2001-08-16
申请人： Robert Harold Bateman , Kevin Giles
发明人： Robert Harold Bateman , Kevin Giles
IPC分类号： B01D5944
CPC分类号： H01J49/065
摘要： A mass spectrometer is disclosed comprising an ion guide which spans two or more vacuum chambers. The ion guide comprises a plurality of electrodes having apertures. Preferably, one of the electrodes also forms a differential pumping aperture which separates two vacuum chambers.
摘要翻译： 公开了一种质谱仪，其包括跨越两个或更多个真空室的离子导向器。 离子导向器包括具有孔的多个电极。 优选地，电极中的一个还形成分离两个真空室的差分泵浦孔。
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75.发明授权Time of flight mass spectrometer with analog to digital converter and method of using 有权具有模数转换器的飞行时间质谱仪及其使用方法公开(公告)号：US08809767B2
公开(公告)日：2014-08-19
申请号：US12302168
申请日：2007-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
CPC分类号： H01J49/0036 , G06K9/0053
摘要： A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined.
摘要翻译： 公开了一种飞行时间质量分析仪，其包括离子检测器，该离子检测器包括模数转换器。 来自离子检测器的输出信号被数字化，确定与离子到达事件有关的到达时间和强度值。 如果从两个信号确定的到达时间落在相同的时间窗口内，则以加权的方式将到达时间相加在一起并且强度值被组合。
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公开(公告)号：US08633435B2
公开(公告)日：2014-01-21
申请号：US12445774
申请日：2007-10-16
申请人： Daniel James Kenny , Robert Harold Bateman , Martin Green , Jason Lee Wildgoose , Steven Derek Pringle
发明人： Daniel James Kenny , Robert Harold Bateman , Martin Green , Jason Lee Wildgoose , Steven Derek Pringle
CPC分类号： H01J49/005 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/065 , H01J49/34 , H01J49/4235
摘要： A collision or fragmentation cell is disclosed comprising a plurality of electrodes wherein a first RF voltage is applied to an upstream group of electrodes and a second different RF voltage is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell is optimized by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell is optimized by the second different RF voltage applied to the downstream group of electrodes.
摘要翻译： 公开了包括多个电极的碰撞或分裂单元，其中将第一RF电压施加到上游电极组，并且将第二不同的RF电压施加到下游电极组。 通过施加到上游电极组的第一RF电压来优化进入碰撞或破碎电池的母体离子的径向约束，并且通过第二不同RF电压优化在碰撞或断裂电池内产生的子或碎片离子的径向约束 应用于下游电极组。
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公开(公告)号：US08299422B2
公开(公告)日：2012-10-30
申请号：US12917720
申请日：2010-11-02
CPC分类号： G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/02 , H01J49/062 , H01J49/065 , H01J49/066 , H01J49/40 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide.
摘要翻译： 公开了一种质谱仪，其包括离子迁移谱仪或分离器，以及布置在离子迁移谱仪或分离器下游的离子导向器。 在离子导向器中产生多个轴向势阱，使得从离子迁移谱仪或分离器接收的离子变得限制在单独的轴向势阱中。 潜在的孔保持从离子迁移谱仪或分离器接收的离子的保真度和/或组成。 势阱沿离子导向器的长度平移。
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公开(公告)号：US08063358B2
公开(公告)日：2011-11-22
申请号：US11916430
申请日：2006-06-01
IPC分类号： H01J49/26
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analyzed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.
摘要翻译： 公开了一种质谱法，其中分析了来自离子检测器的电压信号。 获得每个电压信号的第二差分，并且确定观察到的电压峰值的开始和结束时间。 然后确定每个电压峰值的强度和平均时间，并存储强度和时间值。 然后通过组合与多个实验运行中观察到的每个电压峰值相关的强度和时间值来形成中间复合质谱。 然后将各种时间和强度数据对被整合以产生平滑的连续质谱。 然后可以通过确定连续质谱的第二差分来进一步处理连续质谱。 可以确定在连续质谱中观察到的质量峰的开始和结束时间。 然后可以确定在连续质谱中观察到的每个质量峰的强度和质荷比。 然后可以显示或输出包括仅每个离子种类的强度值和质荷比的最终离散质谱。
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公开(公告)号：US20100294923A1
公开(公告)日：2010-11-25
申请号：US12445774
申请日：2007-10-16
申请人： Daniel James Kenny , Robert Harold Bateman , Martin Green , Jason Lee Wildgoose , Steven Derek Pringle
发明人： Daniel James Kenny , Robert Harold Bateman , Martin Green , Jason Lee Wildgoose , Steven Derek Pringle
CPC分类号： H01J49/005 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/065 , H01J49/34 , H01J49/4235
摘要： A collision or fragmentation cell (4) is disclosed comprising a plurality of electrodes wherein a first RF voltage (7a) is applied to an upstream group of electrodes and a second different RF voltage (7b) is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell (4) is optimised by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell (4) is optimised by the second different RF voltage applied to the downstream group of electrodes.
摘要翻译： 公开了一种碰撞或分裂单元（4），其包括多个电极，其中将第一RF电压（7a）施加到上游电极组，并且将第二不同RF电压（7b）施加到下游电极组。 通过施加到上游电极组的第一RF电压来优化进入碰撞或破碎电池（4）的母体离子的径向约束，并且优化在碰撞或断裂电池（4）内产生的子或碎片离子的径向约束 通过施加到下游组电极的第二不同RF电压。
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公开(公告)号：US07820966B2
公开(公告)日：2010-10-26
申请号：US11909996
申请日：2006-04-03
CPC分类号： B01D59/44 , G01N30/724 , G01N2030/8447 , G01N2030/8868 , H01J49/004 , H01J49/04
摘要： A mass spectrometer is disclosed comprising a High Pressure Liquid Chromatography system (10) which is interfaced to a combustion chamber (16) and isotope ratio mass analyser (19) by means of an Electrospray Ionisation ion source (11) and a Field Asymmetric Ion Mobility Spectrometry device (13). Analyte and solvent molecules are ionised by the ion source (11). Desired analyte ions are substantially onwardly transmitted by the Field Asymmetric Ion Mobility Spectrometry device (13) to the combustion chamber (16) whereas undesired solvent ions are substantially attenuated by the Field Asymmetric Ion Mobility Spectrometry device (13).
摘要翻译： 公开了一种质谱仪，其包括通过电喷雾离子源（11）和场非对称离子迁移率（11）与燃烧室（16）和同位素比质量分析器（19）相连的高压液相色谱系统（10） 光谱测定装置（13）。 分析物和溶剂分子被离子源（11）电离。 期望的分析物离子通过场非对称离子迁移率分析装置（13）基本向上传输到燃烧室（16），而不期望的溶剂离子被场非对称离子迁移率装置（13）基本上衰减。
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