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221 条记录 (耗时 0.044 秒)

    4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
    71.
    发明授权
    4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders 失效
    4-（苯基 - （哌啶-4-基） - 氨基） - 苯甲酰胺衍生物及其用于治疗疼痛，焦虑或胃肠道疾病

    公开(公告)号：US07008952B2

    公开(公告)日：2006-03-07

    申请号：US10477636

    申请日：2002-05-16

    申请人： William Brown ,  Andrew Griffin ,  Christopher Walpole

    发明人： William Brown ,  Andrew Griffin ,  Christopher Walpole

    IPC分类号： A61K31/55 ,  C07D211/58

    CPC分类号： C07D401/06 ,  C07D211/58 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

    摘要： Compounds of general formula I[Chemical formula should be inserted here. Please see paper copy] R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6alkyl, NO2, CF3, C1–C6alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.

    摘要翻译： 通式Ⅰ化合物[化学式应在此插入。 R 1选自苯基，吡啶基，噻吩基，呋喃基，咪唑基，吡咯基，三唑基，噻唑基和吡啶N-氧化物中的任何一种。 其中每个R 1苯基环和R 1个杂芳族环可以任选和独立地被1,2或3个选自直链和支链C 1〜 C 1 -C 6烷基，NO 2，CF 3，C 1 -C 6烷基，C 1 -C 6烷基， 烷氧基，氯，氟，溴和碘。 苯环上和杂芳环上的取代可以在所述环体系上的任何位置进行; 在本申请中公开和要求保护，以及包含新化合物的盐和药物组合物及其在治疗中的用途，特别是在治疗疼痛，焦虑和功能性胃肠道疾病中的用途。

    Automatic flavor-injected blending apparatus and method
    76.
    发明授权
    Automatic flavor-injected blending apparatus and method 失效
    自动注香混合装置及方法

    公开(公告)号：US06945157B2

    公开(公告)日：2005-09-20

    申请号：US10120772

    申请日：2002-04-11

    申请人： William Brown ,  Eric R. Miller

    发明人： William Brown ,  Eric R. Miller

    IPC分类号： A23G9/04 ,  A23G9/22 ,  A23G9/28 ,  A47J31/41 ,  A47J43/042 ,  A47J43/044 ,  A23L2/00 ,  B02C19/00 ,  B67D5/00

    CPC分类号： A47J43/042 ,  A23G9/04 ,  A23G9/045 ,  A23G9/225 ,  A23G9/28 ,  A23G9/283 ,  A47J31/41 ,  A47J2043/04463

    摘要： An automatic flavor-injected blending apparatus includes a base, a processor, and a user input in signal communication with the processor. A blending spindle is rotatably affixed at an upper end to the base and is rotatable under processor control. A container support is movably affixed to the base and is movable between a lower position for placing a container thereon and an upper position closer to the spindle's upper end. A selected flavor is injectable into the container. Software is resident in the processor that is adapted to receive the flavor selection and actuate the injection. The software is further adapted to actuate the spindle rotation. Since the blending process is automated, the server can start the apparatus, step away and attend to other duties while the apparatus is functioning, and return at a later time after a timer has turned off the spindle rotator.

    摘要翻译： 自动注香混合装置包括基座，处理器和与处理器进行信号通信的用户输入。 混合轴可旋转地固定在基座的上端，并可在处理器控制下旋转。 容器支撑件可移动地固定到基座并且可在用于放置容器的下部位置和更靠近主轴的上端的上部位置之间移动。 选择的香料可注入容器。 软件驻留在处理器中，适于接收风味选择并启动注射。 该软件还适于致动主轴旋转。 由于混合过程是自动化的，服务器可以在设备运行时启动设备，离开并参与其他任务，并在定时器关闭主轴旋转器之后的较晚时间返回。

    Flame retardant, additive compositions, and flame retardant polyurethanes
    77.
    发明申请
    Flame retardant, additive compositions, and flame retardant polyurethanes 失效
    阻燃剂，添加剂组合物和阻燃聚氨酯

    公开(公告)号：US20050113495A1

    公开(公告)日：2005-05-26

    申请号：US10719948

    申请日：2003-11-21

    申请人： Saadat Hussain ,  Jeffrey Aplin ,  William Brown ,  Charles Kolich ,  Arthur Mack

    发明人： Saadat Hussain ,  Jeffrey Aplin ,  William Brown ,  Charles Kolich ,  Arthur Mack

    IPC分类号： C08G18/32 ,  C08K5/00 ,  C08K5/51 ,  C08K5/521 ,  C08K5/5398 ,  C09K21/14 ,  C09K21/00 ,  C08K5/49

    CPC分类号： C08K5/0066 ,  C08K5/521 ,  C09K21/14 ,  C08L75/04

    摘要： Provided are new flame retardants and liquid flame retardant additive compositions of low viscosity for use in flexible polyurethane foams. The new flame retardants are the reaction product of at least one brominated aromatic diester diol with at least one alcohol-reactive agent. Preferred liquid flame retardant additive compositions are capable of minimizing visible scorching of the foam during its production. Flexible flame retardant polyurethane foams and methods for their production are also provided. The flame retardant additive compositions are formed at least from a) at least one reaction product of a brominated aromatic diester diol and an alcohol-reactive agent; b) at least one hindered amine antioxidant; and c) at least one phenolic antioxidant in which the phenolic ring is substituted by an alkanoic acid alkyl ester group in which alkanoic acid moiety has in the range of 2 to about 4 carbon atoms and the alkyl group has in the range of about 6 to about 16 carbon atoms.

    摘要翻译： 提供了用于柔性聚氨酯泡沫的新型阻燃剂和低粘度的液体阻燃添加剂组合物。 新的阻燃剂是至少一种溴化芳族二酯与至少一种醇反应剂的反应产物。 优选的液体阻燃添加剂组合物能够使泡沫在其生产过程中的可见焦化最小化。 还提供了柔性阻燃聚氨酯泡沫及其生产方法。 所述阻燃添加剂组合物至少由a）至少一种溴化芳族二酯二醇和醇反应剂的反应产物形成; b）至少一种受阻胺抗氧化剂; 和c）至少一种酚类抗氧化剂，其中酚环被其中链烷酸部分具有2至约4个碳原子的链烷酸烷基酯基团取代，并且烷基具有约6至 约16个碳原子。

    Hook and loop disposable undergarment
    79.
    发明申请
    Hook and loop disposable undergarment 审中-公开
    钩和环一次性内衣

    公开(公告)号：US20050027280A1

    公开(公告)日：2005-02-03

    申请号：US10627781

    申请日：2003-07-28

    申请人： La'Tanya Patty-Brown ,  William Brown

    发明人： La'Tanya Patty-Brown ,  William Brown

    IPC分类号： A61F13/15 ,  A61F13/70

    CPC分类号： A61F13/70 ,  A61F2013/425

    摘要： A hook and loop disposable undergarment for use by toilet training toddlers and incontinent adults. The hook and loop disposable undergarment has a generally rectangular flap portion, a belt portion and elastic supports. The generally rectangular flap portion can be folded back and releasably secured from the back of the belt portion, allowing the user to sit on a toilet and go to the bathroom without taking the hook and loop disposable undergarment off or pulling it down.

    摘要翻译： 一个钩和环一次性内衣，用于厕所训练幼儿和失禁的成年人。 钩环一次性内衣具有大致矩形的翼片部分，皮带部分和弹性支撑件。 大致矩形的翼片部分可以从皮带部分的背面向后折叠并可松脱地固定，从而允许使用者坐在马桶上，而不用将钩和环的一次性内衣脱下或将其拉下来。

    Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain
    80.
    发明授权
    Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain 失效
    羟苯基 - 哌啶-4-亚基 - 甲基 - 苯甲酰胺衍生物用于治疗疼痛

    公开(公告)号：US06756387B2

    公开(公告)日：2004-06-29

    申请号：US10240038

    申请日：2003-01-16

    申请人： William Brown ,  Christopher Walpole ,  Zhongyong Wei

    发明人： William Brown ,  Christopher Walpole ,  Zhongyong Wei

    IPC分类号： A61K314545

    CPC分类号： C07D401/06 ,  C07D211/70 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

    摘要： Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, triazolyl and thiazolyl; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.

    摘要翻译： 通式IR 1的化合物选自苯基，吡啶基，噻吩基，呋喃基，咪唑基，三唑基和噻唑基中的任一个;其中每个R 1苯环和R 1杂芳环可以任选和独立地进一步被取代 选自直链和支链C 1 -C 6烷基，NO 2，CF 3，C 1 -C 6烷氧基，氯，氟，溴和碘的1,2或3个取代基。 苯环上和杂芳环上的取代可以在所述环体系上的任何位置进行;在本申请中公开和要求保护的，以及包含新化合物的盐和药物组合物及其在治疗中的用途，特别是 在痛苦的管理中。