摘要:
The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, X, R1, R3, R4, R5, R6, R7, R8, and R9 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with γ-secretase activity, including Alzheimer's disease.
摘要:
Fused pyridine derivatives shown as the general formula (I), and their pharmaceutically acceptable salts, stereoisomers or solvates thereof are disclosed, which belong to the technical field of medicines. The R1, R2, R3, Q, X and Y substituents in formula (I) are defined as in the description. Also disclosed are the preparation methods, pharmaceutical compositions comprising the compounds and uses of the compounds in the manufacture of the medicine for the treatment and/or prevention of noninsulin-dependent diabetes, hyperglycemia, hyperlipidemia and insulin resistance.
摘要:
Performance of an electrohydrodynamic fluid accelerator device may be improved and adverse events such as sparking or arcing may be reduced based, amongst other things, on electrode geometries and/or positional interrelationships of the electrodes. For example, in a class of EHD devices that employ a longitudinally elongated corona discharge electrode (often, but not necessarily, a wire), a plurality of generally planar, collector electrodes may be positioned so as to present respective leading surfaces toward the corona discharge electrode. The generally planar collector electrodes may be oriented so that their major surfaces are generally orthogonal to the longitudinal extent of the corona discharge electrode. In such EHD devices, a high intensity electric field can be established in the “gap” between the corona discharge electrode and leading surfaces of the collector electrodes.
摘要:
Technologies are generally described for an enhanced Quantized Congestion Notification (QCN) congestion control approach, referred to as Fair QCN (FQCN) for enhancing fairness of multiple flows sharing link capacity in a high bandwidth, low latency data center network. QCN messages may be fed back to flow sources (e.g., servers) which send packets with a sending rate over their share of the bottleneck link capacity. By enabling the flow sources to regulate their data traffic based on the QCN messages from a congestion control component, the queue length at the bottleneck link may converge to an equilibrium queue length rapidly and TCP throughput performance may be enhanced substantially in a TCP incast circumstance.
摘要:
One embodiment of the invention comprises a fuel cell bipolar plate comprising a substrate comprising a first face, a reactant gas flow field defined in the first face, the reactant gas flow field comprising a plurality of lands and channels, and a plurality of microgrooves formed in the first face.
摘要:
The present invention relates to compounds of Formula I as shown below, wherein the definitions of Het, R0, R1 R2, R3, R4, R5, R6, R7, R8, and R9 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with γ-secretase activity, including Alzheimer's disease.
摘要:
Preparation method of aromatic boronate compound is provided, in which the is as follows: reacting aromatic amine Ar-NH2, with diboronic ester and alkyl nitrite in the presence of organic solvent, where Ar represents non-heterocyclic aryl. It enables for the first time the preparation of aromatic boronate from aromatic amine in one step by the present method.
摘要:
This invention relates to bisthiazole I and its therapeutic and prophylactic uses, wherein the variables A, R5, R6, and R7 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.
摘要:
This invention relates to tricycle I and its therapeutic and prophylactic uses, wherein the variables C1, C2, Z1, Z2, Q, J, R1, and R3 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.
摘要:
An electronic system is configurable to accommodate either of a mechanical air mover and an EHD air mover within an enclosure. At least one of a plurality of electronic components is selectively configurable to alternately accommodate the mechanical air mover or the EHD air mover within the enclosure. The mechanical fan or EHD is positioned to motivate air flow along a air flow path between inlet and outlet ventilation boundaries of the enclosure. A connector for a respective one of the electronic components allows for selective configuration in an alternate orientation of the respective one of the electronic components to accommodate a difference in geometry between the EHD air mover and the mechanical air mover.