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    Methods and reagents for modulating TGF-&bgr; superfamily signalling
    71.
    发明授权
    Methods and reagents for modulating TGF-&bgr; superfamily signalling 失效
    用于调节TGF-β超家族信号传导的方法和试剂

    公开(公告)号：US06365711B1

    公开(公告)日：2002-04-02

    申请号：US09087134

    申请日：1998-05-28

    Applicant: Malcolm Whitman ,  Xin Chen

    Inventor： Malcolm Whitman ,  Xin Chen

    IPC: C07K1447

    CPC classification number: C07K14/4702 ,  A61K38/00 ,  C07K14/463 ,  C07K2319/00 ,  C12Q1/6897 ,  G01N2333/495

    Abstract: FAST-1 and Smad2 or Smad3 form a complex that is specifically induced by signals generated by a TGF-&bgr; superfamily member. We have shown that a domain of FAST-1 directly interacts with Smad2 or Smad3, and that this interaction is mediated by specific domains of the two interacting molecules, namely, the MH2 domain of Smad2 or Smad3 and the Smad Interaction Domain (SID) of FAST-1. This result allows the development of methods and reagents for the isolation of compounds that are involved in, and/or modulate, TGF-&bgr; superfamily signalling.

    Abstract translation: FAST-1和Smad2或Smad3形成由TGF-β超家族成员产生的信号特异性诱导的复合物。 我们已经表明，FAST-1的结构域与Smad2或Smad3直接相互作用，并且这种相互作用由两个相互作用的分子的特定结构域介导，即Smad2或Smad3的MH2结构域和Smad2的Smad相互作用域（SID） FAST-1。 该结果允许开发用于分离参与和/或调节TGF-β超家族信号传导的化合物的方法和试剂。

    Plank abdominal wheel
    74.
    外观设计
    Plank abdominal wheel 有权

    公开(公告)号：USD997268S1

    公开(公告)日：2023-08-29

    申请号：US29886911

    申请日：2023-03-15

    Applicant: Xin Chen

    Designer： Xin Chen

    Abstract: FIG. 1 is a front, right and top perspective view of an plank abdominal wheel, showing my design.
    FIG. 2 is a rear, left and bottom perspective view thereof.
    FIG. 3 is a front elevation view thereof.
    FIG. 4 is a rear elevation view thereof.
    FIG. 5 is a left side elevation view thereof.
    FIG. 6 is a right side elevation view thereof.
    FIG. 7 is a top plan view thereof.
    FIG. 8 is a bottom plan view thereof.
    FIG. 9 is an enlarged view of detail 9 in FIG. 1.
    FIG. 10 is an enlarged view of detail 10 in FIG. 2; and,
    FIG. 11 is another front, right and top perspective view of the plank abdominal wheel, wherein the two parts of the plank abdominal wheel are separated from each other.
    The dash-dash lines depict portions of the plank abdominal wheel that form no part of the claimed design. The dot-dash broken lines in FIGS. 1, 2, 9, and 10 depict the boundaries of the enlargements and form no part of the claimed design.

    Cervical pillow
    75.
    外观设计
    Cervical pillow 有权

    公开(公告)号：USD993668S1

    公开(公告)日：2023-08-01

    申请号：US29820588

    申请日：2021-12-22

    Applicant: Xin Chen

    Designer： Xin Chen

    Abstract: FIG. 1 is a front, right side, top perspective view of a cervical pillow showing my new design;
    FIG. 2 is a front elevational view thereof;
    FIG. 3 is a rear elevational view thereof;
    FIG. 4 is a left side elevational view thereof;
    FIG. 5 is a right side elevational view thereof;
    FIG. 6 is a top plan view thereof; and,
    FIG. 7 is a bottom plan view thereof.

    Cervical pillow
    77.
    外观设计
    Cervical pillow 有权

    公开(公告)号：USD970925S1

    公开(公告)日：2022-11-29

    申请号：US29843075

    申请日：2022-06-17

    Applicant: Xin Chen

    Designer： Xin Chen

    Measuring Tissue Shear Wave Properties using One Excitation Pulse and Excitation Pulses having Different Widths and Shapes
    78.
    发明申请
    Measuring Tissue Shear Wave Properties using One Excitation Pulse and Excitation Pulses having Different Widths and Shapes 审中-公开

    公开(公告)号：US20170367683A1

    公开(公告)日：2017-12-28

    申请号：US15090357

    申请日：2016-04-04

    Applicant: Yi Zheng ,  Siping Chen ,  Tianfu Wang ,  Xin Chen ,  Haoming Lin

    Inventor： Yi Zheng ,  Siping Chen ,  Tianfu Wang ,  Xin Chen ,  Haoming Lin

    IPC: A61B8/08 ,  G01S7/52 ,  G01S7/62

    CPC classification number: A61B8/485 ,  A61B8/5223 ,  G01S7/52022 ,  G01S7/52038 ,  G01S7/52042 ,  G01S7/52071 ,  G01S7/6263

    Abstract: Methods and apparatus measuring tissue nonlinear shear wave property are disclosed. When tissue shear responses are different to ultrasound radiation forces generated by pulses having different shapes, its nonlinear effect can be used to estimate tissue property at single location without measurements of group velocities or phase velocities. Ultrasound radiation force using a single tone burst pulse is applied to a selected location in a tissue region. The induced shear wave is detected in the region and its spectral distribution is calculated and analyzed. This detection may be repeated with other excitation pulses having different widths or different shapes at the same location. The spectral analysis of the detected shear wave is performed according to a nonlinear shear model for solving nonlinearity and viscoelasticity of the tissue at a single location in a tissue region. The detection location can be at one point at a time for imaging two-dimensional or three-dimensional tissue nonlinearities and shear wave properties. The property includes nonlinear magnitude variations, nonlinear phase variations, nonlinear coefficients, and viscoelasticity. The induced shear wave are detected at multiple locations along the shear propagation directions in the tissue region for calculating different shear group velocities and different shear phase velocities using different excitation pulses, and calculating nonlinearity and viscoelasticity. A difference between certain aspects of this disclosure and the prior art of ultrasound elastography is the utilization of nonlinear responses of the tissue shear property.

    Method of packaging and displaying an E-mail
    79.
    发明授权
    Method of packaging and displaying an E-mail 有权

    公开(公告)号：US09660831B2

    公开(公告)日：2017-05-23

    申请号：US12991160

    申请日：2009-05-04

    Applicant: Xin Chen ,  Wan Kei Ricky Ha

    Inventor： Xin Chen ,  Wan Kei Ricky Ha

    IPC: G06F15/16 ,  H04L12/58 ,  G06Q10/10

    CPC classification number: H04L51/22 ,  G06Q10/107 ,  H04L51/08 ,  H04L51/10

    Abstract: A method of packaging and displaying an email, comprising the steps of creating an email having at least a first independent digital object and a corresponding first tag, and at least a first dependent digital object associated with the first independent digital object through said first tag; processing the email for extraction of said first dependent digital object for matching with the associated first independent digital object, thereby forming a first processed content; and displaying the email such that the first independent digital object and the first dependent digital object of the first processed content are presented simultaneously. According to the present invention both the sender composing the message, having at least an independent digital object and at least an associated dependent object, and the recipient to whom the message is presented, are faced with a user-friendly interface.

    Lactam-bridged melanocortin receptor-specific peptides
    80.
    发明授权
    Lactam-bridged melanocortin receptor-specific peptides 有权
    内酰胺桥接的黑皮质素受体特异性肽

    公开(公告)号：US09273098B2

    公开(公告)日：2016-03-01

    申请号：US13311817

    申请日：2011-12-06

    Applicant: Xin Chen ,  Wei Yang

    Inventor： Xin Chen ,  Wei Yang

    IPC: C07K7/50 ,  C07K7/56 ,  C07K5/117 ,  C07K14/685 ,  A61K38/00

    CPC classification number: C07K7/56 ,  A61K38/00 ,  C07K5/1024 ,  C07K14/685

    Abstract: Lactam-bridged melanocortin receptor-specific cyclic peptides of the formula where R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification, compositions and formulations including the peptides of the foregoing formula, and methods of preventing, ameliorating or treating melanocortin receptor-mediated diseases, indications, conditions and syndromes, including obesity, modulation of feeding behavior, related metabolic syndrome, sexual dysfunction, male erectile dysfunction and female sexual dysfunction.

    Abstract translation: R1，R2，R3，R4，R5，R6，R7，R8和R9如说明书中所定义的内酰胺交联的黑皮质素受体特异性环肽，包括上述式的肽的组合物和制剂以及方法 预防，改善或治疗黑皮质素受体介导的疾病，适应症，病症和综合征，包括肥胖症，调节进食行为，相关代谢综合征，性功能障碍，男性勃起功能障碍和女性性功能障碍。

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