公开(公告)号：US20060108522A1

公开(公告)日：2006-05-25

申请号：US11324231

申请日：2006-01-04

申请人： Hisashi Nagano ,  Izumi Waki ,  Yasuaki Takada

发明人： Hisashi Nagano ,  Izumi Waki ,  Yasuaki Takada

IPC分类号： H01J49/00

CPC分类号： H01J49/0027 ,  H01J49/0077 ,  Y10T436/24

摘要： An apparatus for detecting chemical substances which is high in sensitivity and selectivity is provided. An organic acid or an organic acid salt is used to generate an organic acid gas from an organic acid gas generator 3 to be mixed with a sample gas for introduction into an ion source 4 for ionization, thereby obtaining a mass spectrum by a mass analysis region 5. A data processor 6 determines the detection or non-detection of a specific m/z of an organic acid adduct ion obtained by adding a molecule generated from the organic acid to a molecule with specific m/z generated from a target chemical substance to be detected based on the obtained mass spectrum. When there is an ion peak with the m/z of the organic acid adduct ion, the presence of the target chemical substance to be detected is determined, and an alarm is sounded. False detection can be prevented.

摘要翻译： 提供一种用于检测灵敏度和选择性高的化学物质的装置。 使用有机酸或有机酸盐从有机酸气体发生器3产生有机酸性气体，与用于引入离子源4的样品气体混合，从而通过质量分析区域获得质谱 5。 数据处理器6确定通过将由有机酸产生的分子加入到由待检测的目标化学物质产生的具有特定m / z的分子而获得的有机酸加合物的特定m / z的检测或非检测 基于获得的质谱。 当存在有机酸加合离子的m / z的离子峰时，确定要检测的目标化学物质的存在，并发出报警。 可以防止误检。

公开(公告)号：US06943343B2

公开(公告)日：2005-09-13

申请号：US10628139

申请日：2003-07-29

申请人： Shigeru Honjo ,  Yasuaki Takada ,  Hisashi Nagano ,  Masumi Fukano ,  Yasuo Seto ,  Teruo Itoi ,  Kazumitsu Iura ,  Mieko Kataoka ,  Kouichiro Tsuge

发明人： Shigeru Honjo ,  Yasuaki Takada ,  Hisashi Nagano ,  Masumi Fukano ,  Yasuo Seto ,  Teruo Itoi ,  Kazumitsu Iura ,  Mieko Kataoka ,  Kouichiro Tsuge

IPC分类号： G01N27/62 ,  G01N27/64 ,  G01N27/68 ,  H01J49/04 ,  H01J49/10 ,  H01J49/42 ,  B01D59/44

CPC分类号： G01N27/622

摘要： An apparatus for detecting a chemical agent, capable of increasing a detection speed of a chemical agent, decreasing a false alarm rate, pinning down the kind of a chemical agent, and meeting specifications for unattended continuous monitoring equipment suitable for detecting sarin or soman. This detection apparatus comprises a sample introduction unit for introducing a sample, an ionizing unit for positively ionizing the sample from the sample introduction unit, a mass spectrometer unit for analyzing ions of the sample, and a computer for analyzing data, and is best suited for identifying a dangerous substance by detecting signals peculiar to chemical agents, such as sarin or soman.

摘要翻译： 用于检测化学试剂的装置，能够提高化学试剂的检测速度，降低误报率，固定化学试剂的种类，并满足适合于检测沙林或索曼的无人值守连续监测设备的规格。 该检测装置包括用于引入样品的样品引入单元，用于从样品引入单元正电离样品的离子化单元，用于分析样品的离子的质谱仪单元和用于分析数据的计算机，并且最适合于 通过检测诸如沙林或索曼等化学剂特有的信号来识别危险物质。

公开(公告)号：US20050092915A1

公开(公告)日：2005-05-05

申请号：US10644806

申请日：2003-08-21

申请人： Masumi Fukano ,  Shigeru Honjo ,  Hisashi Nagano ,  Yasuaki Takada ,  Yasuo Seto ,  Teruo Itoi ,  Kazumitsu Iura

发明人： Masumi Fukano ,  Shigeru Honjo ,  Hisashi Nagano ,  Yasuaki Takada ,  Yasuo Seto ,  Teruo Itoi ,  Kazumitsu Iura

IPC分类号： G01N27/62 ,  G01N27/68 ,  G01N33/00 ,  H01J49/04 ,  H01J49/00 ,  B01D59/44

CPC分类号： G01N33/0044 ,  G01N27/68 ,  H01J49/04

摘要： An object of the present invention is to obtain an apparatus and a method for the detection of chemical agents which are suitable for detecting sulfur mustard and lewisite 1 and are satisfactory from the viewpoint of the speed of detection of chemical agents, the reduction of the rate of wrong information, the specification of the kinds of the chemical agents, and an unmanned continuous-monitoring apparatus. In the present invention, the detecting apparatus comprises a sample introduction section 1 into which a sample is introduced to be heated, an ionization section 2 in which the sample from the sample introduction section is ionized, a mass spectrometry section 3, and a computer 6 for data analysis. When predetermined signals characteristic of sulfur mustard or lewisite 1 are observed, it becomes possible to specify the sample.

摘要翻译： 本发明的目的是获得一种适用于检测硫芥和虱子1的化学试剂的检测装置和方法，从化学试剂的检测速度，速率的降低的观点来看是令人满意的 错误信息，化学剂种类的规格，以及无人值守的连续监测装置。 在本发明中，检测装置包括：试样导入部1，其中导入待加热的试样，将来自试样导入部的试样离子化的电离部2，质谱分析部3和计算机6 用于数据分析。 当观察到硫芥子或虱子1的特征的预定信号时，可以指定样品。

公开(公告)号：US06844546B2

公开(公告)日：2005-01-18

申请号：US10229057

申请日：2002-08-28

申请人： Hisashi Nagano ,  Yasuaki Takada ,  Izumi Waki ,  Koushou Aikawa ,  Masayuki Takizawa ,  Shigenori Morishima

发明人： Hisashi Nagano ,  Yasuaki Takada ,  Izumi Waki ,  Koushou Aikawa ,  Masayuki Takizawa ,  Shigenori Morishima

IPC分类号： G01N27/62 ,  G01N1/22 ,  H01J49/00 ,  H01J49/04

CPC分类号： H01J49/0031

摘要： An explosive detection system including a sample injection region, an ion source region for generating ions of a sample injected by the ion injection region, a mass analysis region for analyzing mass of the ions, a heater for heating the sample injection region and the ion source region, a plurality of pumps for exhausting a chamber in which the mass analysis region is disposed, and a controller for controlling the regions and the plurality of pumps. The controller conducts control so as to heat the sample injection region and the ion source region with the heaters, then reduce heating electric power supplied to the heaters in order to prevent a predetermined electric power value from being exceeded, and drive the plurality of pumps successively to exhaust the chamber.

摘要翻译： 一种爆炸检测系统，包括样品注入区域，用于产生由离子注入区域注入的样品的离子的离子源区域，用于分析离子质量的质量分析区域，用于加热样品注入区域的加热器和离子源 区域，用于排出其中设置质量分析区域的室的多个泵，以及用于控制区域和多个泵的控制器。 控制器进行控制，以便利用加热器加热样品注入区域和离子源区域，然后减少供给到加热器的加热电力，以防止超过预定的电功率值，并且依次驱动多个泵 排气室。

公开(公告)号：US06677582B2

公开(公告)日：2004-01-13

申请号：US09941547

申请日：2001-08-30

申请人： Masuyoshi Yamada ,  Yasuaki Takada ,  Masao Suga

发明人： Masuyoshi Yamada ,  Yasuaki Takada ,  Masao Suga

IPC分类号： H01J4910

CPC分类号： H01J49/168

摘要： An apparatus for detecting the minor constituents of a sample with high efficiency in positive and negative ion monitoring modes. The directions in which the sample gas is forced to flow in the ionized region within the ion source are properly switched in the positive and negative ion monitoring modes, respectively, thereby enabling both positive ions and negative ions to be detected with high sensitivity.

摘要翻译： 一种用于在正离子和负离子监测模式下以高效率检测样品的次要成分的装置。 样品气体被迫在离子源内的离子化区域中流动的方向分别适当地在正离子和负离子监测模式中切换，从而能够以高灵敏度检测正离子和负离子。

公开(公告)号：US08586916B2

公开(公告)日：2013-11-19

申请号：US13189812

申请日：2011-07-25

申请人： Hideo Kashima ,  Yasuaki Takada ,  Izumi Waki

发明人： Hideo Kashima ,  Yasuaki Takada ,  Izumi Waki

IPC分类号： H01J49/26

CPC分类号： G01N1/2205 ,  G01N1/4022 ,  G01N2001/028 ,  G01N2001/4027

摘要： A technology for collecting a granular substance adhering to a baggage with high rate without touching the substance and inspecting whether a dangerous or specific sample material is adhered to the baggage. A method for simplifying or automating such an inspection is also provided. An adhering matter inspection equipment (1) is characterized in that the equipment comprises a collecting section (5) for collecting a sample material peeled off from an inspection object (25) whereupon the sample material is adhered by blowing compression gas through a capturing filter (52), and an inspecting section (2) for analyzing the sample material captured by the capturing filter (52), and further characterized in that the inspection equipment comprises a section (3) for delivering a baggage to the inspecting section (2), and a carrying section (4) for carrying the capturing filter (52) from the capturing section (5) to the inspecting section (2).

摘要翻译： 一种用于以高速率收集附着在行李上的颗粒物质而不接触物质并检查是否将危险的或具体的样品材料粘附在行李上的技术。 还提供了一种用于简化或自动化这种检查的方法。 附着物检查设备（1）的特征在于，该设备包括：收集部分（5），用于收集从检查对象（25）剥离的样品材料，然后通过吹扫压缩气体通过捕获过滤器（ 52）和用于分析由捕获过滤器（52）捕获的样品材料的检查部（2），其特征还在于，所述检查设备包括用于将行李传送到检查部（2）的部分（3） 以及用于将捕获过滤器（52）从捕获部分（5）运送到检查部分（2）的运送部分（4）。

公开(公告)号：US08044349B2

公开(公告)日：2011-10-25

申请号：US12173328

申请日：2008-07-15

申请人： Hiroyuki Satake ,  Yuichiro Hashimoto ,  Yasuaki Takada

发明人： Hiroyuki Satake ,  Yuichiro Hashimoto ,  Yasuaki Takada

IPC分类号： H01J49/00

CPC分类号： H01J49/004 ,  H01J49/422 ,  H01J49/4255 ,  H01J49/427

摘要： A mass spectrometer includes a linear multipole electrode, an auxiliary electrode that applies a DC potential on the center axis of the linear multipole electrode, and a DC power supply that supplies a DC power to the auxiliary electrode. The DC potential slope formed on the center axis of the multipole electrode is changed according to the measuring condition. The ejection time of ions can be adjusted optimally by adjusting the potential slope so as to satisfy the measuring condition. If the ejection time of ions is shortened, confusion of different ion information items that might otherwise occur on a spectrum can be avoided. If the ejection time of ions is lengthened, detection limit exceeding can be avoided and ions can be measured efficiently, thereby highly efficient ion measurements are always assured.

摘要翻译： 质谱仪包括线性多极电极，在线性多极电极的中心轴上施加直流电位的辅助电极和向辅助电极提供直流电力的直流电源。 根据测量条件改变在多极电极的中心轴上形成的直流电位斜率。 通过调整电位斜率以满足测量条件，可以最佳地调节离子的喷射时间。 如果离子的喷射时间缩短，则可以避免在光谱上可能发生的不同离子信息项的混淆。 如果离子的喷射时间延长，则可以避免超过检测极限，有效测量离子，从而确保高效的离子测量。

公开(公告)号：US07956322B2

公开(公告)日：2011-06-07

申请号：US12354245

申请日：2009-01-15

申请人： Masuyuki Sugiyama ,  Yuichiro Hashimoto ,  Hideki Hasegawa ,  Yasuaki Takada

发明人： Masuyuki Sugiyama ,  Yuichiro Hashimoto ,  Hideki Hasegawa ,  Yasuaki Takada

IPC分类号： B01D59/44 ,  H01J49/00

CPC分类号： H01J49/0045

摘要： An MS/MS spectrometric analysis method obtains throughput and mass resolving power of precursor ions. In a mass spectrometer, ions, which are introduced and accumulated in an ion trap unit, are resonance-extracted mass-selectively. A profile of precursor ions at the m/z axis of the ion trap and a profile at the mass analyzer portion, which performs mass analysis of the ions extracted from a collision induced dissociation portion, is obtained by performing a measurement when the injection energy to the collision induced dissociation portion is low, and when the injection energy to the collision induced dissociation portion is high. The profile at the m/z axis of the ion trap of the obtained two-dimensional spectrum is substituted with the profile at the m/z axis of the mass analyzer portion. In this way, the m/z of both the precursor ions and the fragment ions can be determined with high mass resolving power.

摘要翻译： MS / MS光谱分析方法获得前体离子的通量和质量分辨能力。 在质谱仪中，离子阱单元中引入和积聚的离子是质量选择性共振提取的。 在离子阱的m / z轴处的前体离子的轮廓和质量分析器部分的轮廓，其进行从碰撞诱导的解离部分提取的离子的质量分析，通过在将注入能量 碰撞诱导的解离部分低，并且当碰撞诱导解离部分的注入能量高时。 所获得的二维光谱的离子阱的m / z轴的轮廓被质量分析器部的m / z轴的轮廓所取代。 以这种方式，可以以高质量分辨能力确定前体离子和碎片离子两者的m / z。

公开(公告)号：US07829846B2

公开(公告)日：2010-11-09

申请号：US12037148

申请日：2008-02-26

申请人： Yuichiro Hashimoto ,  Hideki Hasegawa ,  Masuyuki Sugiyama ,  Yasuaki Takada

发明人： Yuichiro Hashimoto ,  Hideki Hasegawa ,  Masuyuki Sugiyama ,  Yasuaki Takada

IPC分类号： H01J49/40 ,  G06F19/00 ,  G01N31/00

CPC分类号： H01J49/0036

摘要： The present invention achieves accurate quantitative determination without reducing measurement throughput and also without having to add a multi-component reference standard. An analytical instrument of the present invention for determining the concentration of a target compound contained in a target sample includes: a means for ionizing a mixture having a specific compound added to the target sample; a means for performing mass analysis on resulting ions; and a database that stores dependence of signal intensity on the concentration of a specific matrix component for each of the target compound and the addition compound, wherein the database is used to calibrate the concentration of the target compound from a signal derived from the target compound and a signal derived from the addition compound, each signal obtained by the mass analysis means. The present invention achieves a multi-component analyzer using low-cost, high-throughput mass analysis, as compared to conventional technique.

摘要翻译： 本发明可以在不降低测量吞吐量的情况下实现准确的定量测定，而且不必添加多组分参考标准。 本发明的用于测定目标样品中包含的目标化合物的浓度的分析仪包括：将具有特定化合物的混合物电离于目标样品的装置; 对所得离子进行质量分析的手段; 以及数据库，其存储信号强度对于每种目标化合物和加成化合物的特定基质成分的浓度的依赖性，其中所述数据库用于从源自目标化合物的信号校准目标化合物的浓度，以及 来自加成化合物的信号，通过质量分析装置得到的各信号。 与现有技术相比，本发明实现了使用低成本，高吞吐量质量分析的多分量分析仪。

公开(公告)号：US07820965B2

公开(公告)日：2010-10-26

申请号：US12216993

申请日：2008-07-14

申请人： Hisashi Nagano ,  Izumi Waki ,  Yasuaki Takada

发明人： Hisashi Nagano ,  Izumi Waki ,  Yasuaki Takada

IPC分类号： H01J49/00 ,  B01D59/44

CPC分类号： H01J49/0027 ,  H01J49/0077 ,  Y10T436/24

摘要： An apparatus for detecting chemical substances which is high in sensitivity and selectivity is provided.An organic acid or an organic acid salt is used to generate an organic acid gas from an organic acid gas generator 3 to be mixed with a sample gas for introduction into an ion source 4 for ionization, thereby obtaining a mass spectrum by a mass analysis region 5. A data processor 6 determines the detection or non-detection of a specific m/z of an organic acid adduct ion obtained by adding a molecule generated from the organic acid to a molecule with specific m/z generated from a target chemical substance to be detected based on the obtained mass spectrum. When there is an ion peak with the m/z of the organic acid adduct ion, the presence of the target chemical substance to be detected is determined, and an alarm is sounded.False detection can be prevented.

摘要翻译： 提供一种用于检测灵敏度和选择性高的化学物质的装置。 使用有机酸或有机酸盐从有机酸气体发生器3产生有机酸性气体，与用于引入离子源4的样品气体混合，从而通过质量分析区域获得质谱 数据处理器6确定通过将由有机酸产生的分子加入到由目标化学物质产生的特定m / z的分子而获得的有机酸加合物的特定m / z的检测或非检测， 基于获得的质谱检测。 当存在有机酸加合离子的m / z的离子峰时，确定要检测的目标化学物质的存在，并发出报警。 可以防止误检。