公开(公告)号：US20100184772A1

公开(公告)日：2010-07-22

申请号：US12445260

申请日：2007-10-10

Applicant: Helmut H. Buschmann ,  Antonio Torrens-Jover ,  Josef Mas-Prio ,  Susana Yenes-Minguez

Inventor： Helmut H. Buschmann ,  Antonio Torrens-Jover ,  Josef Mas-Prio ,  Susana Yenes-Minguez

IPC: C07D231/06 ,  A61K31/415 ,  A61K31/4178 ,  C07D403/12 ,  C07D409/12 ,  A61K31/4155 ,  A61K31/428 ,  C07D417/12 ,  C07D405/12 ,  C07D413/12 ,  A61K31/422 ,  A61K31/513 ,  C07D401/12 ,  A61K31/4709 ,  A61K31/4439 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/427 ,  A61K31/4725 ,  A61K31/498 ,  C07D513/04 ,  A61K31/429 ,  A61P5/00 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P37/00 ,  A61P15/00 ,  A61P1/00 ,  A61P35/00 ,  A61P19/00 ,  A61P3/00

CPC classification number: C07D231/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D513/04

Abstract: The present invention relates to substituted pyrazoline compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

Abstract translation: 本发明涉及通式（I）的取代吡唑啉化合物，其制备方法，包含这些化合物的药物及其制备用于治疗人和动物的药物的用途。

公开(公告)号：US20100105684A1

公开(公告)日：2010-04-29

申请号：US12593464

申请日：2008-03-28

Applicant: Monica Garcia-Lopez ,  Antonio Torrens-Jover ,  Helmut Buschmann

Inventor： Monica Garcia-Lopez ,  Antonio Torrens-Jover ,  Helmut Buschmann

IPC: A61K31/5377 ,  C07D231/12 ,  A61K31/415 ,  C07D403/02 ,  A61K31/4155 ,  A61K31/497 ,  C07D401/02 ,  A61K31/445 ,  C07D413/02

CPC classification number: C07D231/12 ,  C07D213/38 ,  C07D261/08 ,  C07D307/52 ,  C07D333/20

Abstract: The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen-amine compounds of general formula (I) and compositions thereof, methods for their preparation, and the use of said compounds for the treatment or prophylaxis of various disorders of humans or animals.

Abstract translation: 本发明涉及通式（I）的杂环基 - 取代 - 四氢 - 萘胺化合物及其组合物，其制备方法以及所述化合物用于治疗或预防人或动物各种疾病的用途。

公开(公告)号：US20100075992A1

公开(公告)日：2010-03-25

申请号：US11663358

申请日：2005-09-20

Applicant: Helmut Buschmann ,  Frank Hay Kong Shum ,  Kim Noel Fisher ,  Anh Ho Ngoc ,  Michel Hamon

Inventor： Helmut Buschmann ,  Frank Hay Kong Shum ,  Kim Noel Fisher ,  Anh Ho Ngoc ,  Michel Hamon

IPC: A61K31/519 ,  A61P25/00

CPC classification number: A61K31/519

Abstract: The present invention refers to the use of a sodium channel blocker such as tetrodotoxin or saxitoxin, their analogues and derivatives as well as their physiologically acceptable salts, in medicinal products for human therapeutics for the treatment of peripheral-nervously derived neuropathic pain.

Abstract translation: 本发明涉及用于治疗周围神经性神经性疼痛的人类治疗剂的药物中使用钠通道阻断剂如河豚毒素或类似物和衍生物及其生理学上可接受的盐。

公开(公告)号：US20100035936A1

公开(公告)日：2010-02-11

申请号：US12525461

申请日：2008-02-06

Applicant: Monica Garcia-Lopez ,  Antonio Torrens-Jover ,  Helmut Buschmann

Inventor： Monica Garcia-Lopez ,  Antonio Torrens-Jover ,  Helmut Buschmann

IPC: A61K31/44 ,  C07D231/12 ,  A61K31/415 ,  C07D261/06 ,  A61K31/42 ,  C07C211/33 ,  A61K31/135 ,  C07D213/63 ,  A61P29/00 ,  A61P25/00 ,  A61P9/00 ,  A61P13/00 ,  A61P1/00

CPC classification number: C07D231/12 ,  C07D213/64 ,  C07D261/08

Abstract: The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen compounds of general formula (I), methods for their preparation, and compositions comprising these compounds as well as their use for the treatment or prophylaxis of various disorders in humans or animals.

Abstract translation: 本发明涉及通式（I）的杂环基 - 取代 - 四氢 - 萘化合物，其制备方法和包含这些化合物的组合物及其用于治疗或预防人或动物各种疾病的用途。

公开(公告)号：US20090221572A1

公开(公告)日：2009-09-03

申请号：US12281317

申请日：2007-03-02

Applicant: Jordi Corbera-Arjona ,  Daniel Martinez-Olmo ,  David Vano-Domenech

Inventor： Jordi Corbera-Arjona ,  Daniel Martinez-Olmo ,  David Vano-Domenech

IPC: A61K31/5377 ,  C07D409/06 ,  A61K31/4535 ,  A61K31/381 ,  C07D333/58 ,  C07D413/08 ,  A61P37/06

CPC classification number: C07D471/10 ,  C07D333/54 ,  C07D409/06 ,  C07D409/14 ,  C07D491/10

Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (σ) receptor, and more particularly to some 4, 5, 6, 7 tetrahydrobenzo[b]thiophene derivatives, wherein n is selected from 0, 1, 2, 3 or 4; m is selected from 0, 1 or 2; the dotted line represents either a single or a double bond; to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and prophylaxis, in particular for the treatment of psychosis.

Abstract translation: 本发明涉及对σ（sigma）受体具有药理活性的化合物，更具体地说涉及约4,5,6,7,7,8-四氢苯并[b]噻吩衍生物，其中n选自0,1,2,3或4 ; m选自0,1或2; 虚线表示单键或双键; 涉及制备这些化合物的方法，包括它们的药物组合物，以及它们在治疗和预防中的用途，特别是用于治疗精神病。

公开(公告)号：US20090197915A1

公开(公告)日：2009-08-06

申请号：US12281300

申请日：2007-03-02

Applicant: Jordi Corbera-Arjona ,  David Vano-Domenech ,  Joerg Holenz

Inventor： Jordi Corbera-Arjona ,  David Vano-Domenech ,  Joerg Holenz

IPC: A61K31/454 ,  A61K31/403 ,  C07D209/02 ,  C07D401/08 ,  A61P25/00

CPC classification number: C07D209/08 ,  C07D401/06

Abstract: The present invention relates to compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.

Abstract translation: 本发明涉及式（I）化合物，其制备方法，包含这些化合物的药物及其在制备用于治疗人和动物的药物中的用途。

公开(公告)号：US20090042898A1

公开(公告)日：2009-02-12

申请号：US11658153

申请日：2005-07-25

Applicant: Jose Manuel Baeyens Cabrera

Inventor： Jose Manuel Baeyens Cabrera

IPC: A61K31/495 ,  A61K31/135

CPC classification number: A61K31/519

Abstract: The present invention refert to the use of compounds active on the sigma receptor for the treatment of mechanical allodynia.

Abstract translation: 本发明涉及在σ受体上活性的化合物用于治疗机械异常性疼痛的用途。

公开(公告)号：US20080281094A1

公开(公告)日：2008-11-13

申请号：US11568902

申请日：2005-05-10

Applicant: Pedro Noheda Marin ,  Manuel Bernabe Pajares ,  Sergio Maroto Quintana ,  Nuria Tabares Cantero ,  Raul Benito Arenas

Inventor： Pedro Noheda Marin ,  Manuel Bernabe Pajares ,  Sergio Maroto Quintana ,  Nuria Tabares Cantero ,  Raul Benito Arenas

IPC: C07D205/04

CPC classification number: C07D205/12 ,  C07C271/16 ,  C07D491/048 ,  C07D491/056 ,  C07D491/107

Abstract: The invention provides highly functionalised spiro-fused lactams of en formula (I) having a cyclohexane moiety with the desired number of protected or un-protected functional groups or carbonated structures, which are introduced with high stereo and regioselectivity, as well as processes for their obtention. These compounds are useful for the synthesis of abroad range of bioactive molecules, such as condoritols and aminoinositols and their analogues.

Abstract translation: 本发明提供具有式（I）的具有所需数目的保护或未保护的官能团或碳酸化结构的环己烷部分的具有高立体和区域选择性的高官能度的螺 - 稠合的内酰胺，以及它们的方法 获得 这些化合物可用于合成国外范围的生物活性分子，如冷冻立方醇和氨基肌醇及其类似物。

公开(公告)号：US20070203121A1

公开(公告)日：2007-08-30

申请号：US11673328

申请日：2007-02-09

Applicant: Ramon Merce Vidal ,  Alberto Dordal Zueras ,  Xavier Codony Soler

Inventor： Ramon Merce Vidal ,  Alberto Dordal Zueras ,  Xavier Codony Soler

IPC: A61K31/55 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  A61K31/405 ,  C07D417/02 ,  C07D413/02 ,  C07D403/02

CPC classification number: C07D209/18 ,  C07D209/42 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D513/04

Abstract: The present invention relates to substituted indole compounds of general formula (I), a process for their preparation, medicaments comprising substituted indole compounds as well as the use of substituted indole compounds for the preparation medicaments, which are suitable e.g., for the prophylaxis and/or treatment of disorders or diseases that are at least partially mediated via 5-HT6 receptors.

Abstract translation: 本发明涉及通式（I）的取代的吲哚化合物，其制备方法，包含取代的吲哚化合物的药物以及用于制备药物的取代的吲哚化合物的用途，其适用于预防和/ 或治疗至少部分通过5-HT 6受体介导的病症或疾病。

公开(公告)号：US20070185207A1

公开(公告)日：2007-08-09

申请号：US10566403

申请日：2004-07-29

Applicant: Ramon Merce Vidal ,  Xavier Codony Sler ,  Alberto Dordal Zueras

Inventor： Ramon Merce Vidal ,  Xavier Codony Sler ,  Alberto Dordal Zueras

IPC: A61K31/18

CPC classification number: C07D409/12 ,  C07D209/08 ,  C07D513/04

Abstract: The present invention refers to new sulfonamide derivatives, of general formula (1a, 1b, ic), optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate, or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or their salts, preferably the corresponding, physiologically acceptable salts, or corresponding solvates; to the processes for their preparation, to their application as medicaments in human and/or veterinary therapeutics, and to the pharmaceutical compositions containing them.

Abstract translation: 本发明涉及通式（1a，1b，ic）的新的磺酰胺衍生物，任选地以其立体异构体之一的形式，优选对映异构体或非对映异构体，其外消旋体或其至少两种立体异构体的混合物的形式 ，优选对映异构体或非对映体，以任何混合比例，或其盐，优选相应的生理学上可接受的盐或相应的溶剂合物; 其制备方法，作为人和/或兽医治疗剂中的药物的应用，以及含有它们的药物组合物。