公开(公告)号：US07732218B2

公开(公告)日：2010-06-08

申请号：US11905605

申请日：2007-10-02

申请人： Shino Takeda ,  Masae Yukawa ,  Yoshikazu Nishimura

发明人： Shino Takeda ,  Masae Yukawa ,  Yoshikazu Nishimura

IPC分类号： G01N1/00 ,  G01N1/28

CPC分类号： G01N23/2202 ,  G01N1/286 ,  Y10T436/10 ,  Y10T436/25 ,  Y10T436/25875

摘要： There is provided a method for preparing an analytical standard used for microbeam X-ray fluorescence analysis which includes: a mixing step in which an element is added to a base material, and the base material and the element are mixed by stirring to obtain a mixed solution; a deaeration step in which the mixed solution is deaerated; a freeze step in which the mixed solution is slowly frozen; and a cutting step in which a thin section is cut out from the frozen mixed solution. In order to surely remove bubbles from the mixed solution, the deaeration step may contain a stationary step in which the mixed solution is allowed to stand still at room temperature; or the stationary step includes a removal step in which gas contained in the mixed solution which is allowed to stand still is removed with a suction apparatus.

摘要翻译： 提供了一种用于制备用于微束X射线荧光分析的分析标准的方法，其包括：混合步骤，其中将元素添加到基材中，并且通过搅拌将基材和元素混合以获得混合 解; 脱气步骤，其中混合溶液脱气; 冷冻步骤，其中混合溶液缓慢冷冻; 以及切割步骤，其中从冷冻混合溶液中切出薄片。 为了确保从混合溶液中除去气泡，脱气步骤可以包含固定步骤，其中使混合溶液在室温下静置; 或者固定步骤包括除去步骤，其中使用抽吸装置除去容纳在静止的混合溶液中的气体。

公开(公告)号：US07711080B2

公开(公告)日：2010-05-04

申请号：US11918521

申请日：2005-10-19

申请人： Shinichirou Mori ,  Masahiro Endo

发明人： Shinichirou Mori ,  Masahiro Endo

IPC分类号： G01N23/083 ,  H05G1/62

CPC分类号： A61B6/032 ,  A61B6/027 ,  A61B6/481 ,  A61B6/503 ,  A61B6/504 ,  A61B6/541

摘要： When a repeatedly periodically moving site of a to-be-examined subject in a gantry is subjected to computed tomography and is reconstructed, the gantry is rotated in synchronization with the movement of the periodically moving site, and a dynamic image showing a transient phenomenon is obtained in which the periodic movement of the moving site has been stopped. As a result, the flow of a contrast agent or the like can be observed in a state of stopping the movement of an internal organ that moves repeatedly periodically.

摘要翻译： 当台架中待检查对象的重复周期性移动位置进行计算机断层摄影并重建时，台架与周期性移动位置的运动同步旋转，并且显示瞬时现象的动态图像为 获得的移动站点的周期性移动已经停止。 结果，可以在停止周期性地重复移动的内脏的运动的状态下观察造影剂等的流动。

公开(公告)号：US20100032574A1

公开(公告)日：2010-02-11

申请号：US12450529

申请日：2007-08-30

申请人： Eiji Yoshida ,  Kengo Shibuya ,  Taiga Yamaya ,  Hideo Murayama ,  Keishi Kitamura

发明人： Eiji Yoshida ,  Kengo Shibuya ,  Taiga Yamaya ,  Hideo Murayama ,  Keishi Kitamura

IPC分类号： G01T1/20 ,  G01T1/164

CPC分类号： G01T1/2985 ,  A61B6/037 ,  G01T1/1647

摘要： Upon detection of radiation by using a (three-dimensional) detector capable of distinguishing a detection position in a depth direction and energy, an energy window for distinguishing between a signal and noise is changed depending on the detection position in the depth direction, thus making it possible to obtain scattering components inside the detector. Alternatively, a weight is given to a detection event depending on the detection position in the depth direction and energy information to obtain scattering components inside the detector. Thereby, scattering components inside the detector can be obtained to increase the sensitivity of the detector. In this case, different detecting elements can be used depending on the detection position in the depth direction.

摘要翻译： 通过使用能够区分深度方向的检测位置和能量的（三维）检测器来检测辐射，根据深度方向上的检测位置来改变用于区分信号和噪声的能量窗口，从而使 可能在检测器内部获得散射成分。 或者，根据深度方向上的检测位置和能量信息给予检测事件的权重，以获得检测器内部的散射成分。 因此，可以获得检测器内部的散射分量，以提高检测器的灵敏度。 在这种情况下，根据深度方向的检测位置，可以使用不同的检测元件。

公开(公告)号：US20090069592A1

公开(公告)日：2009-03-12

申请号：US12161974

申请日：2006-11-29

申请人： Kazutoshi Suzuki ,  Ming-Rong Zhang ,  Katsushi Kumata

发明人： Kazutoshi Suzuki ,  Ming-Rong Zhang ,  Katsushi Kumata

IPC分类号： C07C309/29 ,  C07C233/65

CPC分类号： C07B59/001 ,  C07B2200/05 ,  C07C233/88 ,  C07C309/00 ,  Y10T436/196666

摘要： A phenyl tin compound is synthesized by using a derivative having various functional groups and a bromo- or iodo-benzene ring as a labeling material of a radioactive ligand. On the other hand, a novel hydroxytosyl iodobenzene compound having an electron-donating group is obtained by oxidizing iodobenzene having one or more electron-donating groups and reacting it with tosylic acid. Then, a diphenyliodonium salt which is a labeling precursor is synthesized by reacting the resulting compound with various phenyl tin compounds. Finally, a 18F-labeled ligand having various functional groups and a [18F] fluorobenzene ring is synthesized by reacting the resulting diphenyliodonium salt with [18F]F−.

摘要翻译： 通过使用具有各种官能团的衍生物和溴或碘 - 苯环作为放射性配体的标记材料来合成苯基锡化合物。 另一方面，通过氧化具有一个或多个给电子基团的碘苯并将其与甲苯磺酸反应得到具有给电子基团的新的羟基苯基碘苯化合物。 然后，通过使所得化合物与各种苯基锡化合物反应来合成作为标记前体的二苯基碘鎓盐。 最后，通过使得到的二苯基碘鎓盐与[18 F] F- - 反应合成具有各种官能团和[18 F]氟苯环的18 F标记的配体。

公开(公告)号：US07500785B2

公开(公告)日：2009-03-10

申请号：US11889516

申请日：2007-08-14

申请人： Takashi Moritake ,  Hiroto Koizumi ,  Hironobu Ono

发明人： Takashi Moritake ,  Hiroto Koizumi ,  Hironobu Ono

IPC分类号： H01J35/16 ,  A61B6/02 ,  G21K5/10

CPC分类号： A61B6/06 ,  A61B6/107 ,  G21K1/04

摘要： An X-ray shield device according to one embodiment of the present invention comprises an X-ray shielding plate positioned between an X-ray source and a support member for a subject; a shielding plate driving mechanism including a supporting portion for supporting the X-ray shielding plate, the shielding plate driving mechanism being operable to move the shield plate supported by the supporting portion in a movement plane of the shielding plate perpendicular to a path of X-ray irradiation; and an X-ray shielding plate exchanging means for exchanging the X-ray shielding plate supported by the supporting portion for another X-ray shielding plate of different size.

摘要翻译： 根据本发明的一个实施例的X射线屏蔽装置包括位于X射线源和被摄体的支撑构件之间的X射线屏蔽板， 屏蔽板驱动机构，包括用于支撑所述X射线屏蔽板的支撑部分，所述屏蔽板驱动机构可操作以将所述屏蔽板支撑在所述屏蔽板的移动平面中，所述屏蔽板垂直于所述X线路径， 射线照射; 以及X射线屏蔽板交换装置，用于将由支撑部支撑的X射线屏蔽板交换为不同尺寸的另一X射线屏蔽板。

公开(公告)号：US07498135B2

公开(公告)日：2009-03-03

申请号：US11085681

申请日：2005-03-21

申请人： Masumi Abe

发明人： Masumi Abe

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6809 ,  C12Q1/6858 ,  C12Q2527/107 ,  C12Q2525/191 ,  C12Q2525/131 ,  C12Q2531/113 ,  C12Q2565/125

摘要： The present invention provides a method for preparing a gene expression profile with a high precision, by carrying out the annealing of primers to templates in the temperature range of TmMAX+6° C. to TmMAX+14° C. of the primer in a PCR step of a HiCEP method.

摘要翻译： 本发明提供了通过在引物的TmMAX + 6℃至TmMAX + 14℃的温度范围内对引物进行PCR的退火，从而提供了高精度制备基因表达谱的方法。 HiCEP方法的一步。

公开(公告)号：US20090052625A1

公开(公告)日：2009-02-26

申请号：US11913970

申请日：2006-05-11

申请人： Hiroyuki Nose ,  Daisuke Ishida ,  Namio Kaneko ,  Hisaharu Sakae ,  Mitsuru Uesaka ,  Atsushi Fukasawa ,  Katsuhiro Dobashi

发明人： Hiroyuki Nose ,  Daisuke Ishida ,  Namio Kaneko ,  Hisaharu Sakae ,  Mitsuru Uesaka ,  Atsushi Fukasawa ,  Katsuhiro Dobashi

IPC分类号： H01J35/10 ,  H01J35/08

CPC分类号： A61N5/10 ,  A61B6/00 ,  A61B6/4092 ,  H01J35/14 ,  H01J35/16 ,  H01J35/28 ,  H01J2235/08 ,  H01J2235/086 ,  H01J2235/10 ,  H01J2235/163 ,  H05G2/00 ,  H05H6/00

摘要： There is disclosed a device including: an electron beam generation device 10 which accelerates a pulse electron beam 1 to transmit the beam through a predetermined rectilinear orbit 2; a laser generation device 20 which generates a pulse laser light 3; a laser light introduction device 30 which introduces the pulse laser light 3 onto the rectilinear orbit 2 so as to collide with the pulse electron beam 1; a metal target 42 which generates a particular X-ray 5 by collision with the pulse electron beam 1: and a target moving device 40 capable of moving the metal target between a collision position 2a on the rectilinear orbit and a retreat position out of the orbit. A collision surface of the metal target 42 is positioned spatially at the same position as that of the collision point 2a. At the retreat position of the metal target, the pulse electron beam 1 collides with the pulse laser light 3 to generate a monochromatic hard X-ray 4. At the collision position of the metal target 42, the pulse electron beam 1 collides with the metal target 42 to generate the particular X-ray 5 from the same light source position 2a.

摘要翻译： 公开了一种装置，包括：电子束产生装置10，其加速脉冲电子束1以将光束穿过预定的直线轨道2; 产生脉冲激光3的激光产生装置20; 激光引入装置30，其将脉冲激光3引入到直线轨道2上以与脉冲电子束1碰撞; 通过与脉冲电子束1碰撞而产生特定X射线5的金属靶42和能够将金属靶移动到直线轨道上的碰撞位置2a和轨道之间的退避位置的目标移动装置40 。 金属靶42的碰撞面在空间上位于与碰撞点2a相同的位置。 在金属靶的退避位置，脉冲电子束1与脉冲激光3碰撞，生成单色硬X射线4.在金属靶42的碰撞位置，脉冲电子束1与金属 目标42从相同的光源位置2a产生特定的X射线5。

公开(公告)号：US20090051937A1

公开(公告)日：2009-02-26

申请号：US12162912

申请日：2007-03-07

申请人： Daisuke Ishida ,  Hiroyuki Nose ,  Namio Kaneko ,  Mitsuru Uesaka ,  Fumito Sakamoto ,  Katsuhiro Dobashi

发明人： Daisuke Ishida ,  Hiroyuki Nose ,  Namio Kaneko ,  Mitsuru Uesaka ,  Fumito Sakamoto ,  Katsuhiro Dobashi

IPC分类号： G01B11/14

CPC分类号： H05G2/00

摘要： A device for measuring profiles of an electron beam and a laser beam is provided with a profile measuring device 30 for measuring cross-section profiles of the beams in the vicinity of a collision position where an electron beam 1 and a laser beam 3 are brought into frontal collision, and a moving device 40 for continuously moving the profile measuring device in a predetermined direction which substantially coincides with the axial directions of the beams. Furthermore, based on the cross-section profiles measured by the profile measuring device, the position of the profile measuring device in the predetermined direction, and the oscillation timings of the beams, temporal changes in three-dimensional profiles of the electron beam and the laser beam are created by a profile creating device 50.

摘要翻译： 用于测量电子束和激光束的轮廓的装置设置有轮廓测量装置30，用于测量在电子束1和激光束3进入的碰撞位置附近的梁的横截面轮廓 正面碰撞，以及移动装置40，用于沿着与梁的轴向大致重合的预定方向连续移动轮廓测量装置。 此外，基于由型材测量装置测量的横截面轮廓，轮廓测量装置在预定方向上的位置和梁的振动定时，电子束和激光器的三维轮廓的时间变化 光束由简档创建设备50创建。

公开(公告)号：US07430282B2

公开(公告)日：2008-09-30

申请号：US10594513

申请日：2005-03-29

申请人： Shinichirou Mori ,  Masahiro Endo

发明人： Shinichirou Mori ,  Masahiro Endo

IPC分类号： G21K3/00

CPC分类号： G21K1/10 ,  A61B6/032 ,  A61B6/4042 ,  A61B6/583

摘要： A heel effect compensation filter is configured to have a thickness distribution that uniforms an X-ray intensity angular distribution that is nonuniform in the body axis direction of a subject in an X-ray flux irradiated space. The space is formed by an X-ray flux diverging from an anode in a body width direction of the subject and diverging in a shape of an approximate sector in the body axis direction due to the heel effect, when the X-ray flux generated on the anode by irradiating a thermoelectron beam flux from a cathode to the anode is irradiated on the subject. The thickness distribution can be obtained using a predetermined formula.

摘要翻译： 脚跟效应补偿滤波器被配置为具有使X射线通量照射空间中的被检体的体轴方向不均匀的X射线强度分布均匀的厚度分布。 该空间由在被检体的体宽方向上从阳极发散的X射线通量形成，并且由于脚跟效应而在体轴方向上以大致扇形的形状发散，当在其上产生的X射线通量 通过从阴极向阳极照射热电子束通量来照射阳极。 可以使用预定公式获得厚度分布。

公开(公告)号：US20080123816A1

公开(公告)日：2008-05-29

申请号：US10594513

申请日：2005-03-29

申请人： Shinichirou Mori ,  Masahiro Endo

发明人： Shinichirou Mori ,  Masahiro Endo

IPC分类号： G21K3/00

CPC分类号： G21K1/10 ,  A61B6/032 ,  A61B6/4042 ,  A61B6/583

摘要： An X-ray flux irradiation intensity distribution which is nonuniform due to a heel effect can be made uniform, and a subject can be prevented from being unnecessarily exposed. In addition, image quality of image data obtained with an X-ray CT scanner can be made uniform and improved in a body axis direction.A heel effect compensation filter is configured to have a thickness distribution that uniforms an X-ray intensity angular distribution that is nonuniform in the body axis direction of a subject in an X-ray flux irradiated space. The space is formed by an X-ray flux diverging from an anode in a body width direction of the subject and diverging in a shape of an approximate sector in the body axis direction due to the heel effect, when the X-ray flux generated on the anode by irradiating a thermoelectron beam flux from a cathode to the anode is irradiated on the subject. The thickness distribution can be obtained using a predetermined formula.

摘要翻译： 可以使由于脚跟效应而不均匀的X射线通量照射强度分布均匀，并且可以防止被摄体不必要地暴露。 此外，可以使用X射线CT扫描仪获得的图像数据的图像质量在体轴方向上均匀且改善。 脚跟效应补偿滤波器被配置为具有使X射线通量照射空间中的被检体的体轴方向不均匀的X射线强度分布均匀的厚度分布。 该空间由在被检体的体宽方向上从阳极发散的X射线通量形成，并且由于脚跟效应而在体轴方向上以大致扇形的形状发散，当在其上产生的X射线通量 通过从阴极向阳极照射热电子束通量来照射阳极。 可以使用预定公式获得厚度分布。