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5433 条记录 (耗时 0.043 秒)

    PROCESS FOR THE PREPARATION OF EXO-TERT-BUTYL N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)CARBAMATE
    81.
    发明申请
    PROCESS FOR THE PREPARATION OF EXO-TERT-BUTYL N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)CARBAMATE 有权

    公开(公告)号：US20220073469A1

    公开(公告)日：2022-03-10

    申请号：US17418480

    申请日：2019-12-24

    申请人： Hoffmann-La Roche Inc.

    发明人： Weichun CHEN ,  Guocai ZHANG

    IPC分类号： C07D221/22

    摘要： The present invention relates to a process for the preparation of a compound (I) or pharmaceutically acceptable salt thereof, which is useful as the key intermediate for the synthesis of compounds for prophylaxis and treatment of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

    Method for producing monomeric and multimeric molecules and uses thereof
    84.
    发明授权
    Method for producing monomeric and multimeric molecules and uses thereof 有权

    公开(公告)号：US11254728B2

    公开(公告)日：2022-02-22

    申请号：US16777138

    申请日：2020-01-30

    申请人： Hoffmann-La Roche Inc.

    发明人： Johannes Auer ,  Martin Bader ,  Stefan Dengl ,  Stefan Lorenz ,  Stefan Seeber

    IPC分类号： C07K14/525 ,  C07K14/715 ,  C07K16/00 ,  C07K16/32 ,  A61K49/00 ,  C07K14/52 ,  C07K14/54

    摘要： Herein is reported a method for the production of a polypeptide that is biologically active as n-mer comprising a nucleic acid encoding a fusion polypeptide according to the following formula (Bn-CSo-Is-CSp-FC-CSq-It-CSr-Bm)u, wherein B denotes a polypeptide that is biologically active as n-mer and forms non-defined aggregates/multimers upon expression in the absence of a fused Fc-region, FC denotes a heavy chain Fc-region polypeptide, CS denotes a cleavage site, and I denotes an intervening amino acid sequence, wherein FC does not substantially bind to an Fc-receptor, recovering the fusion polypeptide from the cell or the cultivation medium, optionally cleaving the fusion polypeptide with a protease, and thereby producing a polypeptide that is biologically active as n-mer and forms non-defined aggregates/multimers upon expression in the absence of a fused Fc-region.

    Combination stirrer
    85.
    发明授权
    Combination stirrer 有权

    公开(公告)号：US11253826B2

    公开(公告)日：2022-02-22

    申请号：US16103341

    申请日：2018-08-14

    申请人： HOFFMANN-LA ROCHE INC.

    发明人： Marco Jenzsch ,  Max Lechner ,  Michael Pohlscheidt ,  Christoph Reese ,  Alexander Scholz ,  Hermann Tebbe

    IPC分类号： B01F7/00 ,  C12M1/06

    摘要： The present patent application describes a stirrer comprising a combination of at least one axially-conveying element and at least one radially-conveying element relative to the rotary shaft of the stirrer wherein the largest diameter of the at least one axially-conveying element is equal to or less than the inner diameter di of the radially-conveying element. In one embodiment the stirrer according to the invention is a combination of one anchor stirrer with at least one inclined-blade stirrer. Furthermore the use of the stirrer according to the invention for the culture of cells in a dialysis method is described.

    MANUFACTURING A FLEXIBLE CONTAINER
    88.
    发明申请
    MANUFACTURING A FLEXIBLE CONTAINER 有权

    公开(公告)号：US20220024616A1

    公开(公告)日：2022-01-27

    申请号：US17296770

    申请日：2019-11-25

    申请人： HOFFMANN-LA ROCHE INC.

    发明人： Carmen LEMA MARTINEZ ,  Joerg LUEMKEMANN ,  Tobias WERK ,  Thomas ZUMSTEIN ,  Daniel KULLMANN

    IPC分类号： B65B3/00 ,  B29D22/00 ,  B65B5/04 ,  B65B3/02 ,  A61J1/10 ,  A61J1/14 ,  A61J1/20

    摘要： A method of manufacturing a flexible container (1) housing a drug substance, comprises: forming a first compartment (11) of the container (1) out of a flexible sheet-like material, filling a liquid (2) into the first compartment (11) of the container (1), sealing the first compartment (11), forming a second compartment (12) of the container (1) out of the flexible sheet-like material, filling a dry drug formulation (3) into the second compartment (12), and sealing the second compartment (12). The method further involves lyophilizing the drug formulation inside a tubular cartridge such that the dry drug formulation (3) is generated and held in the tubular cartridge, wherein filling the dry drug formulation (3) into the second compartment (12) comprises: introducing the tubular cartridge holding the dry drug formulation (3) through an opening of the second compartment (12) of the container (1) such that an open end of the tubular cartridge is positioned distant from the opening of the second compartment (12), providing the dry drug formulation (3) out of the open end of the tubular cartridge into the second compartment (12), and withdrawing the tubular cartridge out of the opening of the second compartment (12) of the container (1). The first compartment (11) is separated from the second compartment (12) by a frangible seal (14) which opens when the first compartment (11) is compressed.