公开(公告)号：USD1062035S1

公开(公告)日：2025-02-11

申请号：US29784886

申请日：2021-05-21

Applicant: STAMFORD DEVICES LIMITED

Designer： Colm Carmody ,  Micheal Casey ,  John Merrigan

公开(公告)号：US20240207881A1

公开(公告)日：2024-06-27

申请号：US18551731

申请日：2022-03-16

Applicant: STAMFORD DEVICES LIMITED

Inventor： Michael TIMOTHY

IPC: B05B17/06 ,  A61M11/00 ,  B06B1/06

CPC classification number: B05B17/0607 ,  B06B1/0688 ,  A61M11/005 ,  B06B2201/77

Abstract: An acrosol generator core (1) has an integral body (2) and membrane (4), and a vibratory drive connected to an electrical voltage supply. In some examples the body provides the vibration drive and comprises a piezoelectric polymer (2) of P(VDF-TrFE) material. In this manner a single manufacturing operation can provide the membrane. the support. and the vibration drive. and operations such as attaching a membrane to an annular support are avoided.

公开(公告)号：US11998678B2

公开(公告)日：2024-06-04

申请号：US17194369

申请日：2021-03-08

Applicant: Stamford Devices Limited

Inventor： Joseph Grehan ,  Michael Casey ,  Shaun Porter ,  Niall Smith

IPC: A61M11/00 ,  B05B12/08 ,  B05B15/14 ,  B05B17/00 ,  B05B17/06 ,  B06B1/02

CPC classification number: A61M11/00 ,  A61M11/005 ,  B05B15/14 ,  B05B17/0646 ,  B05B17/0669 ,  B06B1/0253 ,  A61M2205/3317 ,  A61M2205/3386 ,  A61M2205/50 ,  A61M2205/583 ,  B05B12/081 ,  B06B2201/77

Abstract: A digital processor of a nebulizer controller controls and monitors drive current (I) applied to an aperture plate. The drive current is detected as a series of discrete values at each of multiple measuring points, each having a particular drive frequency The processor in real time calculates a slope or rate of change of drive current with frequency and additionally determines a minimum value for drive current leading up to the peak value. The processor uses both the value of the minimum drive current during the scan and also the maximum slope value to achieve reliable prediction of end of dose, when the aperture plate becomes dry.

公开(公告)号：US11872573B2

公开(公告)日：2024-01-16

申请号：US17818484

申请日：2022-08-09

Applicant: Stamford Devices Limited

Inventor： Brendan Hogan ,  Hong Xu

IPC: B05B1/02 ,  B05B17/00 ,  B05B1/06 ,  C25D7/04 ,  C25D1/08 ,  B05B17/06 ,  A61M11/00 ,  A61M15/00

CPC classification number: B05B1/02 ,  B05B17/0638 ,  B05B17/0653 ,  C25D1/08 ,  C25D7/04 ,  A61M11/005 ,  A61M15/0085 ,  A61M2207/00

Abstract: An aperture plate is manufactured by plating metal around a mask of resist columns having a desired size, pitch, and profile, which yields a wafer about 60 μm thickness. This is approximately the full desired target aperture plate thickness. The plating is continued so that the metal overlies the top surfaces of the columns until the desired apertures are achieved. This needs only one masking/plating cycle to achieve the desired plate thickness. Also, the plate has passageways formed beneath the apertures, formed as an integral part of the method, by mask material removal. These are suitable for entrainment of aerosolized droplets exiting the apertures.

公开(公告)号：US11839891B2

公开(公告)日：2023-12-12

申请号：US16621604

申请日：2018-08-23

Applicant: STAMFORD DEVICES LIMITED

Inventor： Joseph Grehan ,  Noel Coyle ,  Russell Greaney ,  Stephen Thornton

IPC: B05B12/08 ,  A61M11/00 ,  B05B17/00 ,  B05B17/06 ,  A61M15/00

CPC classification number: B05B12/081 ,  A61M11/005 ,  A61M15/0085 ,  B05B17/0646 ,  B05B17/0669 ,  A61M2205/3317 ,  A61M2205/50

Abstract: An aerosol delivery system has an aerosol generator with a vibrating aperture plate (10) and an actuator (11, 16, 17, 19), a controller (18, 19). The controller in real time monitors (201) the aerosol generator as it is driven for vibration of the aperture plate, and detects (202) a change in an electrical characteristic in response to a transition from a wet state to a dry state of the aperture plate. It automatically modifies (203, 205, 206), during the transition, operation of the aerosol generator in response to the detected change. The modification includes reducing applied power (203). The controller continues (204) to monitor during the transition, including monitoring the aperture plate for presence of residual liquid on the aperture plate first surface. The controller monitors at a number of drive frequencies and maintains data representing trends in a combination of the electrical characteristic signals at the different frequencies, and identifies a start of a transition if a calculated value rises above a threshold. There is one threshold for triggering a check scan for residual volume and a higher threshold to trigger an immediate shut down.

公开(公告)号：US20230381429A1

公开(公告)日：2023-11-30

申请号：US18446553

申请日：2023-08-09

Applicant: Stamford Devices Limited

Inventor： Patrick Joseph POWER ,  Jimmy EATON-EVANS

IPC: A61M11/02 ,  A61M15/00 ,  A61M16/06 ,  A61M16/20

CPC classification number: A61M11/02 ,  A61M15/0021 ,  A61M16/06 ,  A61M15/0085 ,  A61M16/208 ,  A61M11/003

Abstract: A system for delivery of aerosol therapy to spontaneously breathing patients comprises a housing which defines a chamber. The housing has a base, a top and a main body extending between the base and the top. An ambient air inlet is located adjacent to the base and is normally closed by an inlet valve. The housing also has a patient port for receiving a mouthpiece or a face mask. The mouthpiece has an exhaust outlet closed by an exhaust valve. Similarly, the face mask has an exhaust outlet closed by an exhaust valve. Exhaled air is exhausted through the valves and to prevent recirculation through the chamber which would adversely affect dose efficiencies. The housing also has an aerosol port for receiving a vibrating mesh aerosol generating device. The aerosol port is located in a side of the main body of the housing for delivery of aerosol into the chamber between the inlet valve and the patient port. A boss extends upwardly from the base and is spaced-apart inwardly of the main body of the housing to define a reception space or well.

公开(公告)号：US20230182162A1

公开(公告)日：2023-06-15

申请号：US18045543

申请日：2022-10-11

Applicant: Stamford Devices Limited

Inventor： Ronan MACLOUGHLIN ,  Conor Paul DUFFY ,  Brendan HOGAN ,  Patrick Martin KELLY

IPC: B05B17/00 ,  A61M11/00

CPC classification number: B05B17/0646 ,  A61M11/003 ,  A61M11/005

Abstract: A method for aerosolising a liquid comprises the steps of: —providing an aperture plate having at least 100 outlet holes per mm; delivering liquid to the aperture plate; and vibrating the aperture plate to produce an aerosol. The viscosity of the liquid is in the range of from 1 to 15 cP and the surface tension of the liquid is in the range of from 72 to 0.5 mN/m. The output rate of the generated aerosol is greater than 0.01 mL/min.

公开(公告)号：US20220265940A1

公开(公告)日：2022-08-25

申请号：US17632145

申请日：2020-07-23

Applicant: STAMFORD DEVICES LIMITED

Inventor： Colin TELFER ,  Patrick Power

IPC: A61M15/00

Abstract: A nebulizer device has an aerosol generator mounted in a housing, and a mouthpiece. The device is adapted for delivery of an active agent in an aerosol into the buccal cavity, with droplet size greater than 10 μm. Aerosolization is started at or after the end of breath inhalation and is stopped at or before the start of breath inhalation. The flow is via mouthpiece with internal ridges which periodically narrow the flow path volume to so that droplets coalesce in the flow path before the mesh.

公开(公告)号：US20220016360A1

公开(公告)日：2022-01-20

申请号：US17371460

申请日：2021-07-09

Applicant: Stamford Devices Limited

Inventor： John POWER ,  Ronan MacLOUGHLIN ,  Michael CASEY ,  Conor DUFFY ,  Aidan DUFFY

IPC: A61M11/04 ,  A61M11/00

Abstract: A single dose aerosol chamber is used with a dispensing apparatus by users to take a chamber, fill the chamber with an aerosolized vaccine, and dispose of used chambers. A display provides instructions to encourage prompt inhalation by the user from a dispensed and filled chamber. The station allows very fast administration of vaccines to large numbers of people. The aerosol dispenser apparatus detects the chamber is in correct position and delivers a pre-determined dose of aerosol. The chamber has a nebulizer delivery port optimized for delivery of aerosol into the chamber container and to act as a vent during inhalation via the inhalation port.

公开(公告)号：US11065399B2

公开(公告)日：2021-07-20

申请号：US16572298

申请日：2019-09-16

Applicant: Stamford Devices Limited

Inventor： Joseph Grehan ,  Niall Smith

IPC: A61M11/00 ,  B05B17/06 ,  G01N29/22 ,  G01N29/42 ,  B05B17/00 ,  B06B1/02 ,  B05B15/14 ,  G16H20/10 ,  G16H20/13 ,  B05B12/00 ,  B05B12/08

Abstract: A nebulizer has an aperture plate, a mounting, an actuator, and an aperture plate drive circuit (2-4). A controller measures an electrical drive parameter at each of a plurality of measuring points, each measuring point having a drive frequency; and based on the values of the parameter at the measuring points makes a determination of optimum drive frequency and also an end-of-dose prediction. The controller performs a short scan at regular sub-second intervals at which drive current is measured at two measuring points with different drive frequencies. According to drive parameter measurements at these points the controller determines if a full scan sweeping across a larger number of measuring points should be performed. The full scan provides the optimum drive frequency for the device and also an end of dose indication.