公开(公告)号：US07022519B2

公开(公告)日：2006-04-04

申请号：US10251157

申请日：2002-09-20

Applicant: Guangping Gao ,  James M Wilson

Inventor： Guangping Gao ,  James M Wilson

IPC: C12N5/10 ,  C12N15/63

CPC classification number: G01R31/275 ,  C12N15/86 ,  C12N2710/10344 ,  C12N2750/14143 ,  C12N2750/14151 ,  C12N2840/20 ,  G01R31/013 ,  G01R31/316

Abstract: A method for producing recombinant adeno-associated virus in the absence of contaminating helper virus or wild-type virus involves culturing a mammalian host cell containing an rAd/AAV hybrid virus, an AAV rep sequence and an AAV cap sequence under the control of regulatory sequences directing expression thereof. The rAd/AAV hybrid virus contains a rAAV construct to be packaged into an AAV virion in an backbone containing the adenoviral sequences necessary to express E1a and E1b gene products and to permit replication of the hybrid virus. The method of the invention permits replication of the hybrid virus and production of rAAV virion in this host cell in the absence of a helper virus and obviates a subsequent purification step to purify rAAV from contaminating virus.

公开(公告)号：US07021176B2

公开(公告)日：2006-04-04

申请号：US10818149

申请日：2004-04-05

Applicant: Toshifumi Sato ,  Toru Okabe

Inventor： Toshifumi Sato ,  Toru Okabe

IPC: B21L9/04 ,  B27B13/00

CPC classification number: B21L9/065 ,  B21L9/04 ,  F16G13/04

Abstract: In the manufacture of a link plate for a silent chain, a band of sheet steel is intermittently forwarded to string of punching dies and shaving dies. The band tends to follow a slightly curved path, which causes alignment errors in a conventional punching and shaving operation. However, in this case, each shaving die and its corresponding punching die are disposed in symmetrical relationship with respect to an intermediate position along the path of movement of the band, and the intermediate position coincides with the location at which the deviation of the band. As a result, the shaving dies are more accurately aligned with the punched surfaces produced by the corresponding punching dies.

Abstract translation: 在无声链的连接板的制造中，将钢带带间歇地送往冲压模具和剃须刀片组。 乐队倾向于遵循稍微弯曲的路径，这在常规的冲压和剃刮操作中导致对准错误。 然而，在这种情况下，每个剃须刀片及其对应的冲压模具相对于沿着带的移动路径的中间位置对称地设置，并且中间位置与带的偏离位置重合。 结果，剃削模具更精确地与由相应的冲压模具产生的冲压表面对准。

公开(公告)号：US07008622B2

公开(公告)日：2006-03-07

申请号：US10086208

申请日：2002-02-28

Applicant: Gideon Goldstein

Inventor： Gideon Goldstein

IPC: A61K39/42

CPC classification number: C07K14/005 ,  A61K38/10 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/6037 ,  C07K16/1072 ,  C07K2317/34 ,  C07K2319/60 ,  C12N2740/15022 ,  C12N2740/16322 ,  C12N2740/16334

Abstract: A composition which elicits antibodies to greater than 95%, and even greater than 99%, of the known variants of HIV-1 Tat protein contains at least one peptide or polypeptide of the formula of Epitope I (based on amino acids 2-10 of HIV-1 Tat consensus sequence) and optionally one or more of a peptide or polypeptide of Epitope II (based on amino acids 41 to 51 of that sequence), of Epitope III (based on amino acids 52-62 of that sequence), or of Epitope IV (based on amino acids 62 through 72 of that sequence with a C-terminal Pro). Vaccinal and pharmaceutical compositions can contain the antibodies induced by the peptide compositions for use in passive therapy. Diagnostic compositions and uses are described for assessing the immune status of vaccinated patients.

公开(公告)号：US07008609B2

公开(公告)日：2006-03-07

申请号：US10658106

申请日：2003-09-09

Applicant: Masao Watanabe ,  Yoko Watanabe

Inventor： Masao Watanabe ,  Yoko Watanabe

IPC: C01B3/08 ,  C01F7/42

CPC classification number: B01J7/02 ,  B01J19/18 ,  B01J2219/182 ,  C01B3/08 ,  Y02E60/36

Abstract: There is provided a method of producing hydrogen gas serving as fuel for a portable fuel cell, whereby hydrogen gas can be provided easily, safely, and at a low cost. To that end, the method of producing hydrogen gas comprises the steps of causing friction and mechanical fracture accompanying the friction to occur to a metallic material under water and increasing thereby chemical reactivity of atoms of the metallic material, in close proximity of the surface thereof; wherein water molecules are decomposed by accelerating corrosion reaction of water with the metallic material. Further, for the metallic material, an aluminum or aluminum alloy material is used as industrial waste including refuse and cutting chips (curls) of an industrial aluminum material. Meanwhile, pure water not substantially containing ionic impurities and organic molecules is used for the water.

Abstract translation: 提供了一种生产用作便携式燃料电池的燃料的氢气的方法，由此可以容易地，安全地和低成本地提供氢气。 为此，制造氢气的方法包括以下步骤：伴随摩擦的摩擦和机械断裂发生在水下的金属材料上，从而增加金属材料的原子在其表面附近的化学反应性; 其中水分子通过加速水与金属材料的腐蚀反应而分解。 此外，对于金属材料，使用铝或铝合金材料作为工业废物，包括工业铝材料的垃圾和切割屑（卷曲）。 同时，水中不含有离子杂质和有机分子的纯水。

公开(公告)号：US06982261B2

公开(公告)日：2006-01-03

申请号：US10342719

申请日：2003-01-15

Applicant: Mark A. Collins ,  Valerie A. Mackner ,  Jay E. Wrobel ,  Lin Zhi ,  Todd K. Jones ,  James P. Edwards ,  Christopher M. Tegley

Inventor： Mark A. Collins ,  Valerie A. Mackner ,  Jay E. Wrobel ,  Lin Zhi ,  Todd K. Jones ,  James P. Edwards ,  Christopher M. Tegley

IPC: A61K31/54 ,  A01K31/535 ,  C07D279/16 ,  C07D498/00

CPC classification number: C07D403/04 ,  A61K31/405 ,  A61K31/5415 ,  C07D413/04

Abstract: This invention provides a progesterone receptor antagonist of formula 1 having the structure wherein T is O, S, or absent; R1, and R2 are each, independently, hydrogen, alkyl, substituted alkyl; or R1 and R2 are taken together form a ring and together contain —CH2(CH2)nCH2—, —CH2CH2CMe2CH2CH2—, —O(CH2)pCH2—, —O(CH2)qO—, —CH2CH2OCH2CH2—, or —CH2CH2NR7CH2CH2—; n=1–5; p=1–4; q=1–4; R3 is hydrogen, OH, NH2, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or CORA; RA is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R4 is hydrogen, halogen, CN, NH2, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R5 is hydrogen, alkyl, or substituted alkyl; R6 is hydrogen, alkyl, substituted alkyl, or CORB; RB is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R7 is hydrogen or alkyl, or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明提供具有其中T为O，S或不存在的结构的式1的孕酮受体拮抗剂; R 1，R 2和R 2各自独立地为氢，烷基，取代的烷基; 或R 1和R 2一起形成环，并且一起含有-CH 2（CH 2）2 CH 2 CH 2 - ， - CH 2 CH 2 CH 2 CH 2 N 2 CH 2 2 CH 2 - ， - O（CH 2）2 CH 2 - ， - （CH 2 CH 2） O（CH 2 CH 2）q O - ， - CH 2 CH 2 OCH 2 - / SUB CH 2，或CH 2 CH 2，NR 7，CH 2，CH 2， CH 2 - ; n = 1-5; p = 1-4; q = 1-4; R 3是氢，OH，NH 2，烷基，取代的烷基，烯基，取代的烯基，炔基，取代的炔基或COR A。 R A是氢，烷基，取代的烷基，烷氧基，取代的烷氧基，氨基烷基或取代的氨基烷基; R 4是氢，卤素，CN，NH 2，烷基，取代的烷基，烷氧基，取代的烷氧基，氨基烷基或取代的氨基烷基; R 5是氢，烷基或取代的烷基; R 6是氢，烷基，取代的烷基或COR B; R B是氢，烷基，取代的烷基，烷氧基，取代的烷氧基，氨基烷基或取代的氨基烷基; R 7是氢或烷基，或其药学上可接受的盐。

公开(公告)号：US06976567B2

公开(公告)日：2005-12-20

申请号：US10778004

申请日：2004-02-12

Applicant: Hisanao Kitabayashi

Inventor： Hisanao Kitabayashi

IPC: F16D65/853 ,  F16D25/0638 ,  F16D25/12 ,  F16D55/40 ,  F16D13/74

CPC classification number: F16D25/0638 ,  F16D25/123

Abstract: A wet-type friction engaging apparatus 10 comprises a friction disk 30 which is fitted by spline with a hub 20 and a mating plate 40 which is fitted by spline with a drum D. The friction disk 30 and the mating plate 40 are arranged alternately, and torque is transmitted when the friction disk 30 and the mating plate 40 are engaged with each other. The inner surface of the hub 20 is in a stepped taper shape in order to let lubricating oil B leak from an opening end 26 of the hub 20, and an oil bore 24 is provided in each step in a radial direction of the hub 20. A periphery of an inlet of each oil bore 24 is in a concave shape. During low-speed rotation when centrifugal force is relatively small, the lubricating oil B leaks from the opening end 26 of the hub 20 and drag torque is reduced, and during high-speed rotation when centrifugal force is relatively large, lubricating oil which splashes from a shaft is securely concentrated and then be drained through the oil bore 24.

Abstract translation: 湿式摩擦接合装置10包括通过花键与轮毂20配合的摩擦盘30和通过花键与滚筒D配合的配合板40.摩擦盘30和配合板40交替布置， 并且当摩擦盘30和配合板40彼此接合时传递扭矩。 轮毂20的内表面为阶梯状，以使润滑油B从轮毂20的开口端26泄漏，并且在轮毂20的径向方向上的每个台阶上设有油孔24。 每个油孔24的入口的周边呈凹形。 当离心力相对较小时，在低速旋转时，润滑油B从轮毂20的开口端26泄漏，并且减小扭矩，并且在离心力相对较大的高速旋转时，从 轴被牢固地集中，然后被排出通过油孔24。

公开(公告)号：US06966858B2

公开(公告)日：2005-11-22

申请号：US10621135

申请日：2003-07-16

Applicant: Osamu Yoshida ,  Hiroshi Hashimoto

Inventor： Osamu Yoshida ,  Hiroshi Hashimoto

IPC: F16H7/08

CPC classification number: F16H7/0848 ,  F16H2007/0806 ,  F16H2007/0812 ,  F16H2007/0853 ,  F16H2007/0859

Abstract: A chain tensioner comprising a housing, a plunger having racks formed on its opposite sides, a protrusion biasing spring, cams arranged in oblique guide grooves in the housing and engageable with the racks of the plunger, and a spacer supporting a cam biasing spring. The minimum backlash distance X is equal to h/tan θ, where h is the height of the rack teeth, and θ is the angle of the cam guide surfaces relative to the protruding direction of the plunger. The angle θ is between 15° and 70°. The tensioner prevents wobbling noises produced by a timing chain on starting an engine, prevents whistling sounds due to excess tensioning of the chain, and allows backlash to be readily set to accommodate the requirements of a wide variety of engines.

Abstract translation: 链条张紧器，其包括壳体，具有形成在其相对侧上的齿条的柱塞，突起偏置弹簧，布置在壳体中的倾斜导向槽中并可与柱塞的齿条接合的凸轮以及支撑凸轮偏置弹簧的间隔件。 最小间隙距离X等于h /tanθ，其中h是齿条齿的高度，θ是凸轮引导表面相对于柱塞突出方向的角度。 角度θ在15°和70°之间。 张紧器防止起动发动机时的正时链产生的摆动噪声，防止由于链条的过度张紧引起的呼啸声，并允许容易地设定间隙以适应各种发动机的要求。

公开(公告)号：US06963162B1

公开(公告)日：2005-11-08

申请号：US10459883

申请日：2003-06-12

Applicant: Dominick Centurioni

Inventor： Dominick Centurioni

IPC: H01J27/02 ,  H01J27/08 ,  H05H1/00

CPC classification number: H01J27/022 ,  H01J27/146

Abstract: A gas distributor for an ion source includes a plate having a recess and a series of apertures spaced radially outward from the recess. The apertures define paths for the flow of a gas through the plate, and the gas distributor further includes a sacrificial element that is separate from the plate and that is receivable and seats within the recess. The sacrificial element forms an area of the gas distributor that is subjected to erosive forces during normal operations of the ion source, and therefore, prevents erosion of the surface of the plate. The sacrificial element is removable from the plate and replaceable with another sacrificial element during a procedure which neither requires the plate to be removed from the ion source nor the ion source to be disassembled.

Abstract translation: 用于离子源的气体分配器包括具有凹部的板和从凹部径向向外间隔开的一系列孔。 所述孔限定了通过所述板的气体流动的路径，并且所述气体分配器还包括与所述板分离并且可接收并位于所述凹部内的牺牲元件。 牺牲元件形成在离子源的正常操作期间经受侵蚀力的气体分配器的区域，因此防止了板的表面的侵蚀。 牺牲元件可以从板移除并且在过程期间可以替换为另外的牺牲元件，这既不需要将板从离子源移除，也不需要拆卸离子源。

公开(公告)号：US06960391B2

公开(公告)日：2005-11-01

申请号：US10432517

申请日：2002-08-08

Applicant: Takashi Natsume ,  Fumiaki Akase

Inventor： Takashi Natsume ,  Fumiaki Akase

IPC: H05K1/09 ,  B32B15/08 ,  H05K1/16 ,  H05K3/00 ,  H05K3/02 ,  H05K3/46 ,  B32B15/04

CPC classification number: H05K3/4626 ,  H05K1/16 ,  H05K1/162 ,  H05K1/167 ,  H05K3/025 ,  H05K2201/0209 ,  H05K2201/0355 ,  H05K2201/0358 ,  H05K2203/0152 ,  Y10T428/12438 ,  Y10T428/12569 ,  Y10T428/24777 ,  Y10T428/24802 ,  Y10T428/31529 ,  Y10T428/31678

Abstract: The present invention relates to a carrier-added copper foil and a print substrate using such copper foil characterized in comprising a resin layer and a functional material layer at least on a part of the copper foil. A carrier-added copper foil and a print substrate using such copper foil are obtained by forming an insulating layer and functional material layer having an area smaller than the area of the copper foil on the surface of the carrier-added copper foil with the screen printing method, thereby improving the handling of such copper foil, preventing the adhesion of contaminants such as resin powder on the copper foil surface during the cutting procedure, preventing scratches and dimples caused by foreign matter, and effectively preventing the generation of scratches, wrinkles and creases during the cutting, packaging and transportation procedures.

Abstract translation: 本发明涉及使用这种铜箔的载体添加铜箔和印刷基板，其特征在于至少在铜箔的一部分上包括树脂层和功能材料层。 使用这种铜箔的载体添加铜箔和印刷基板通过在载体添加铜箔的表面上通过丝网印刷形成绝缘层和具有小于铜箔的面积的功能材料层而获得 方法，从而改善这种铜箔的处理，防止在切割过程中在铜箔表面上粘附诸如树脂粉末的污染物，防止由异物引起的划痕和凹痕，并且有效地防止产生划痕，褶皱和折痕 在切割，包装和运输过程中。

公开(公告)号：US06953406B2

公开(公告)日：2005-10-11

申请号：US10610179

申请日：2003-06-30

Applicant: Yoshio Kurokawa ,  Toyonaga Saitoh

Inventor： Yoshio Kurokawa ,  Toyonaga Saitoh

IPC: F16H7/08

CPC classification number: F16H7/0848 ,  F16H2007/0806 ,  F16H2007/0812 ,  F16H2007/0853 ,  F16H2007/0878

Abstract: A plunger stop for temporarily holding the plunger of a ratchet type chain tensioner in place during installation of the tensioner, or during mounting or removal of the chain, comprises a bifurcated part inserted into a groove in which a pivoted ratchet pawl is situated. The bifurcated part is sandwiched between the pivoted ratchet pawl and a part of the tensioner housing, with the bifurcated part straddling a ratchet pawl-biasing spring in the groove. A grip, which is integral with the bifurcated part protrudes outside the tensioner housing so that it can be grasped manually for removal.

Abstract translation: 用于在安装张紧器期间或在安装或移除链条期间暂时将棘轮式链条张紧器的柱塞暂时保持在适当位置的柱塞挡块包括插入到其中枢转的棘爪的凹槽中的分叉部分。 分叉部分夹在枢转的棘爪和张紧器壳体的一部分之间，其中分叉部分跨越槽中的棘爪偏压弹簧。 与分叉部分成一体的把手突出在张紧器壳体的外部，从而可以手动抓取以便拆卸。