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公开(公告)号：US20120269727A1
公开(公告)日：2012-10-25
申请号：US13530498
申请日：2012-06-22
Applicant: ALAN CUTHBERTSON , MAGNE SOLBAKKEN
Inventor： ALAN CUTHBERTSON , MAGNE SOLBAKKEN
IPC: A61K51/04 , C07C311/29
CPC classification number: A61K49/0004 , A61K49/0002 , A61K49/0013 , A61K49/0438 , A61K51/0497 , C07C317/32
Abstract: The invention relates to compounds suitable for use in an imaging agent said imaging agent showing an improved pharmacokinetic profile.
Abstract translation: 本发明涉及适用于成像剂的化合物，所述显像剂显示出改善的药代动力学特征。
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公开(公告)号：US08236283B2
公开(公告)日：2012-08-07
申请号：US11813445
申请日：2006-01-06
Applicant: Alan Cuthbertson , Maria E. Verdugo-Gazdik
Inventor： Alan Cuthbertson , Maria E. Verdugo-Gazdik
IPC: A61K49/00
CPC classification number: A61K49/0056 , A61K47/60 , A61K49/0032 , A61K49/0043
Abstract: This invention relates to a method for imaging of wet age-related macular degeneration (AMD) using a contrast agent comprising a vector attached to an optical imaging reporter, wherein the vector has affinity for receptors associated with angiogenesis. The invention further provides such methods for monitoring the effect of treatment of AMD.
Abstract translation: 本发明涉及一种使用包含连接到光学成像报告物的载体的造影剂对湿性年龄相关性黄斑变性（AMD）进行成像的方法，其中所述载体对与血管发生相关的受体具有亲和力。 本发明还提供了用于监测AMD治疗效果的方法。
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公开(公告)号：US08231858B2
公开(公告)日：2012-07-31
申请号：US10544945
申请日：2004-02-10
Applicant: Anthony Storey , Julie Davis , Sally-Ann Ricketts , Marivi Mendizabal , Alan Cuthbertson , Joseph Arukwe , Kirsty Heywood , Ian Wilson , Duncan Wynn , Michael Schafers , Bodo Levkau , Stefan Wagner , Hans-Jörg Breyholz , Klaus Kopka
Inventor： Anthony Storey , Julie Davis , Sally-Ann Ricketts , Marivi Mendizabal , Alan Cuthbertson , Joseph Arukwe , Kirsty Heywood , Ian Wilson , Duncan Wynn , Michael Schafers , Bodo Levkau , Stefan Wagner , Hans-Jörg Breyholz , Klaus Kopka
CPC classification number: A61K51/0497
Abstract: The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.
Abstract translation: 本发明涉及诊断成像领域。 具体地，本发明涉及已知涉及特定基质金属蛋白酶的疾病的诊断成像。 本发明的一个实施方案是具有适用于诊断成像的基质金属蛋白酶抑制活性的化合物。 本发明还公开了一种药物组合物，其包含适合哺乳动物给药形式的本发明的诊断显像剂。 本发明还公开了合成本发明的诊断显像剂的中间体和用于制备本发明的药物组合物的试剂盒。 本发明的药物组合物可用于诊断已知涉及特定基质金属蛋白酶的疾病。
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公开(公告)号：US20120020882A1
公开(公告)日：2012-01-26
申请号：US13204935
申请日：2011-08-08
Applicant: Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin Mill Archer , Harry John Wadsworth
Inventor： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin Mill Archer , Harry John Wadsworth
CPC classification number: C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425 , A61K49/0002 , A61K51/082 , A61K51/088 , C07K14/745
Abstract: The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
Abstract translation: 本发明涉及用作诊断显像剂或作为治疗剂的新的基于肽的化合物，其中所述试剂包含与整联蛋白受体结合的靶向载体。
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公开(公告)号：US08022548B2
公开(公告)日：2011-09-20
申请号：US12569750
申请日：2009-09-29
Applicant: Isaiah O. Oladeji , Alan Cuthbertson
Inventor： Isaiah O. Oladeji , Alan Cuthbertson
IPC: H01L21/00
CPC classification number: H01L27/0805 , H01L21/76838 , H01L28/75
Abstract: A method of forming one or more capacitors on or in a substrate and a capacitor structure resulting therefrom is disclosed. The method includes forming a trench in the substrate, lining the trench with a first copper-barrier layer, and substantially filling the trench with a first copper layer. The first copper layer is substantially chemically isolated from the substrate by the first copper-barrier layer. A second copper-barrier layer is formed over the first copper layer and a first dielectric layer is formed over the second copper-barrier layer. The dielectric layer is substantially chemically isolated from the first copper layer by the second copper-barrier layer. A third copper-barrier layer is formed over the dielectric layer and a second copper layer is formed over the third copper-barrier layer. The second copper layer is formed in a non-damascene process.
Abstract translation: 公开了一种在衬底上或衬底中形成一个或多个电容器的方法以及由此产生的电容器结构。 该方法包括在衬底中形成沟槽，用第一铜阻挡层衬套沟槽，并用第一铜层基本上填充沟槽。 第一铜层通过第一铜阻挡层与衬底基本上化学隔离。 在第一铜层上形成第二铜阻挡层，在第二铜阻挡层上形成第一电介质层。 电介质层通过第二铜阻挡层与第一铜层基本上化学隔离。 在电介质层上形成第三铜阻挡层，在第三铜阻挡层上形成第二铜层。 第二铜层以非镶嵌工艺形成。
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Patent Agency Ranking
公开(公告)号：US07811551B2
公开(公告)日：2010-10-12
申请号：US12141123
申请日：2008-06-18
Applicant: Alan Cuthbertson , Magne Solbakken
Inventor： Alan Cuthbertson , Magne Solbakken
CPC classification number: C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425
Abstract: The invention relates to compounds of formula (I): and their use as targeting vectors that bind to receptors associated with angiogenesis. Such compounds may thus be used for diagnosis or therapy of, for example, malignant diseases, heart diseases, endometriosis, inflammation-related diseases, rheumatoid arthritis and Kaposi's sarcoma.
Abstract translation: 本发明涉及式（I）化合物及其作为靶向载体的用途，所述靶向载体与血管发生相关的受体结合。 因此，这样的化合物可用于诊断或治疗例如恶性疾病，心脏病，子宫内膜异位，炎症相关疾病，类风湿性关节炎和卡波西肉瘤。
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公开(公告)号：US20100111865A1
公开(公告)日：2010-05-06
申请号：US12519183
申请日：2007-12-19
Applicant: Helge Tolleshaug , Alan Cuthbertson , Hege Karlsen
Inventor： Helge Tolleshaug , Alan Cuthbertson , Hege Karlsen
CPC classification number: A61K49/0054 , A61K49/0032 , A61K49/0056
Abstract: The present invention provides novel compounds and pharmaceutical compositions containing such compounds, wherein the compounds have affinity for proteoglycans. The compounds comprise an amino acid based core unit linked to positively charged moieties. The compounds further comprise at least one imaging moiety detectable in in vivo imaging making the compounds useful as diagnostic contrast agents for imaging of proteoglycans, such as heparan sulphate proteoglycans.
Abstract translation: 本发明提供含有这些化合物的新化合物和药物组合物，其中化合物对蛋白聚糖具有亲和力。 所述化合物包含与带正电荷部分连接的基于氨基酸的核心单元。 所述化合物还包含在体内成像中可检测的至少一个成像部分，使得该化合物可用作蛋白聚糖成像的诊断造影剂，例如硫酸乙酰肝素蛋白聚糖。
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公开(公告)号：US20090232741A1
公开(公告)日：2009-09-17
申请号：US11813445
申请日：2006-01-06
Applicant: Alan Cuthbertson , Maria E. Verdugo-Gazdik
Inventor： Alan Cuthbertson , Maria E. Verdugo-Gazdik
IPC: A61K49/00
CPC classification number: A61K49/0056 , A61K47/60 , A61K49/0032 , A61K49/0043
Abstract: This invention relates to a method for imaging of wet age-related macular degeneration (AMD) using a contrast agent comprising a vector attached to an optical imaging reporter, wherein the vector has affinity for receptors associated with angiogenesis. The invention further provides such methods for monitoring the effect of treatment of AMD.
Abstract translation: 本发明涉及一种使用包含连接到光学成像报告物的载体的造影剂对湿性年龄相关性黄斑变性（AMD）进行成像的方法，其中所述载体对与血管发生相关的受体具有亲和力。 本发明还提供了用于监测AMD治疗效果的方法。
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公开(公告)号：US20080279769A1
公开(公告)日：2008-11-13
申请号：US11575977
申请日：2005-09-23
Applicant: Magne Solbakken , Alan Cuthbertson , Anthony Eamon Storey , Alexander Jackson , Sally-Ann Ricketts , Peter Brian Iveson
Inventor： Magne Solbakken , Alan Cuthbertson , Anthony Eamon Storey , Alexander Jackson , Sally-Ann Ricketts , Peter Brian Iveson
IPC: A61K51/04 , C07C233/47 , C07D209/20 , A61K31/404 , A61K31/16
CPC classification number: A61K49/10 , A61K49/085 , A61K51/0497
Abstract: The present invention discloses that imaging agents which comprise a specific type of matrix metalloproteinase inhibitors (MMPi's) of the hydroxamate class labelled with an imaging moiety, are useful diagnostic imaging agents for in vivo imaging and diagnosis of the mammalian body.
Abstract translation: 本发明公开了包含用成像部分标记的异羟肟酸酯类型的特定类型的基质金属蛋白酶抑制剂（MMPi）的成像剂是用于哺乳动物身体的体内成像和诊断的有用的诊断显像剂。
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公开(公告)号：US20080267881A1
公开(公告)日：2008-10-30
申请号：US12141123
申请日：2008-06-18
Applicant: Alan Cuthbertson , Magne Solbakken
Inventor： Alan Cuthbertson , Magne Solbakken
IPC: A61K49/04
CPC classification number: C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425
Abstract: The invention relates to compounds of formula (I): and their use as targeting vectors that bind to receptors associated with angiogenesis. Such compounds may thus be used for diagnosis or therapy of, for example, malignant diseases, heart diseases, endometriosis, inflammation-related diseases, rheumatoid arthritis and Kaposi's sarcoma.
Abstract translation: 本发明涉及式（I）化合物及其作为靶向载体的用途，所述靶向载体与血管发生相关的受体结合。 因此，这样的化合物可用于诊断或治疗例如恶性疾病，心脏病，子宫内膜异位，炎症相关疾病，类风湿性关节炎和卡波西肉瘤。
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