公开(公告)号：US20210069511A1

公开(公告)日：2021-03-11

申请号：US16771435

申请日：2018-12-11

Applicant: Galvani Bioelectronics Limited

Inventor： Gerald Edwin HUNSBERGER ,  Arun SRIDHAR

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/20

Abstract: Modulation of neural activity of a cardiac-related nerve at an interganglionic nerve branch in the sympathetic chain results in preferential reduction of sympathetic signals to the heart, thereby providing ways of treating and preventing cardiac dysfunction such as arrhythmias.

公开(公告)号：US10441787B2

公开(公告)日：2019-10-15

申请号：US15552475

申请日：2016-02-24

Applicant: GALVANI BIOELECTRONICS LIMITED ,  THE JOHNS HOPKINS UNIVERSITY

Inventor： Brendan J. Canning ,  Michael John Carr ,  Marian Kollarik

IPC: A61N1/36 ,  A61N1/05 ,  A61F7/00 ,  A61N1/20 ,  A61N5/06 ,  A61N7/00 ,  A61N5/067

Abstract: The invention provides devices and methods that can prevent or ameliorate bronchoconstriction. In particular, the invention provides devices and methods in which a signal is delivered to the vagus nerve or the pulmonary branches of the vagus nerves. The signal is able to treat bronchoconstriction and prevent and/or ameliorate bronchoconstriction.

公开(公告)号：US12161869B2

公开(公告)日：2024-12-10

申请号：US18140387

申请日：2023-04-27

Applicant: Galvani Bioelectronics Limited

Inventor： Margarita J. Vervoordeldonk ,  Eric Irwin ,  Daniel John Chew ,  Matteo Donega ,  Cindy Cleypool ,  Isha Gupta

IPC: A61N1/00 ,  A61N1/05 ,  A61N1/36 ,  A61N1/08

Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.

公开(公告)号：US12157007B2

公开(公告)日：2024-12-03

申请号：US17893924

申请日：2022-08-23

Applicant: Galvani Bioelectronics Limited

Inventor： Gerald Edwin Hunsberger ,  Arun Sridhar

IPC: A61N1/05 ,  A61N1/36

Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.

公开(公告)号：US12121718B2

公开(公告)日：2024-10-22

申请号：US18213964

申请日：2023-06-26

Applicant: Galvani Bioelectronics Limited

Inventor： Matteo Donega ,  Daniel John Chew ,  Margarita J. Vervoordeldonk ,  Isha Gupta

IPC: A61N1/00 ,  A61N1/05 ,  A61N1/36 ,  A61N1/378

CPC classification number: A61N1/0556 ,  A61N1/0553 ,  A61N1/36053 ,  A61N1/36057 ,  A61N1/36071 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/36171 ,  A61N1/3787

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.

公开(公告)号：US12036413B2

公开(公告)日：2024-07-16

申请号：US17415599

申请日：2019-12-13

Applicant: Galvani Bioelectronics Limited

Inventor： David Karl Lee Peterson ,  Daniel John Chew ,  Matteo Donega ,  Xu Meng

IPC: A61N1/00 ,  A61N1/05 ,  A61N1/36

CPC classification number: A61N1/36167 ,  A61N1/0551

Abstract: A system (1) for electrically stimulating a nerve (3), the system comprising: a first stimulator (5) and a second stimulator (7) for electrically stimulating the nerve, the first stimulator and the second stimulator spaced apart from one another by a first distance; and a controller (9) arranged to: a) set a time interval as a function of the first distance and the speed of propagation of an action potential in the nerve; b) activate the first stimulator for a first stimulation period, thus inducing electrical activity in the nerve; and c) activate the second stimulator for a second stimulation period after the time interval has elapsed after the end of the first time period. Preferably, the time interval is a sum of the first time period and a buffer time period for allowing the nerve to recover from stimulation.

公开(公告)号：US20240131327A1

公开(公告)日：2024-04-25

申请号：US18537151

申请日：2023-12-12

Applicant: Galvani Bioelectronics Limited

Inventor： Michael John Carr ,  Kevin K. Kwong ,  Gerald E. Hunsberger

IPC: A61N1/20 ,  A61B5/00 ,  A61B5/08 ,  A61B5/087 ,  A61B5/091 ,  A61B5/145 ,  A61B5/388 ,  A61N1/36

CPC classification number: A61N1/205 ,  A61B5/0816 ,  A61B5/087 ,  A61B5/091 ,  A61B5/14542 ,  A61B5/388 ,  A61B5/4035 ,  A61B5/4836 ,  A61N1/36053 ,  A61N1/36057 ,  A61N1/3611 ,  A61N1/36171 ,  A61B5/08

Abstract: The present invention provides devices and methods that can prevent or ameliorate bronchoconstriction by stimulating neural activity, in contrast to those techniques based on denervation, ablation or blocking of neural activity. Methods and devices according to the invention may act responsively or on demand, can preserve neuronal structure and function and will be associated with minimal collateral side-effects. In particular, the invention provides devices and methods in which signals are delivered to the vagus nerve in order to stimulate neural activity in the vagal nerve.

公开(公告)号：US20240100345A1

公开(公告)日：2024-03-28

申请号：US18267686

申请日：2021-12-15

Applicant: Galvani Bioelectronics Limited

Inventor： Eric Irwin

IPC: A61N1/375 ,  A61B17/04 ,  A61B17/10 ,  A61B17/34 ,  A61N1/05

CPC classification number: A61N1/37518 ,  A61B17/0469 ,  A61B17/10 ,  A61B17/3468 ,  A61N1/0507 ,  A61B2017/320044

Abstract: A method of inserting and affixing an implant by making an incision in an abdominal wall is disclosed. A subcutaneous pocket is formed between a first layer of the abdominal wall and a second layer of the abdominal wall, such that the pocket is at least 2 centimeters from the costal margin. An implant is placed into the subcutaneous pocked and affixed within the subcutaneous pocket in the abdominal wall.

公开(公告)号：USD994595S1

公开(公告)日：2023-08-08

申请号：US29826935

申请日：2022-02-16

Applicant: Galvani Bioelectronics Limited

Designer： Jay Canham ,  David Lari ,  Cindy Au ,  Melissa Lara ,  Daniel Nobre ,  Ryan Jongwoo Choi

Abstract: FIG. 1 is a top perspective view of a charger;
FIG. 2 is a bottom perspective view thereof;
FIG. 3 is top plan view thereof;
FIG. 4 is a bottom plan view thereof;
FIG. 5 is a front elevation view thereof;
FIG. 6 is a right side elevation view thereof;
FIG. 7 is a left side elevation view thereof; and,
FIG. 8 is a rear elevation view thereof.
The broken lines in the drawings are for the purpose of illustrating portions of the charger that form no part of the claimed design.

公开(公告)号：US11633601B2

公开(公告)日：2023-04-25

申请号：US16955282

申请日：2018-12-20

Applicant: Galvani Bioelectronics Limited

Inventor： Margarita J. Vervoordeldonk ,  Robert Coatney ,  Cindy Cleypool

IPC: A61N1/05 ,  A61N1/36

Abstract: Modulation of the neural activity of a nerve adjacent to the left gastro epiploic artery (LGEA) and/or a nerve adjacent to a short gastric artery (SGA) can modulate the neural activity of the sympathetic nerves that impact splenic function. This is useful for reducing inflammation and providing ways of treating inflammatory disorders.