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81.发明申请公开(公告)号：US20120196347A1
公开(公告)日：2012-08-02
申请号：US13449395
申请日：2012-04-18
Applicant: HOWARD GLENN DAMUDE , QUINN QUN ZHU
Inventor： HOWARD GLENN DAMUDE , QUINN QUN ZHU
IPC: C12N9/02
CPC classification number: C12P7/6427 , C12N9/0083 , C12N15/8247
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-8 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) and using these delta-8 desaturases in plants.
Abstract translation: 分离的核酸片段和包含编码δ-8去饱和酶的片段以及制备长链多不饱和脂肪酸（PUFA）的方法并在植物中使用这些δ-8去饱和酶的重组构建体。
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82.发明申请NOVEL DELTA-9 FATTY ACID ELONGASE GENES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS 有权新型DELTA-9脂肪酸快速基因及其在制备聚氨酯脂肪酸中的应用公开(公告)号：US20120177805A1
公开(公告)日：2012-07-12
申请号：US13428133
申请日：2012-03-23
Applicant: Brian MCGONIGLE , Anthony J. Kinney , Howard Glenn Damude
Inventor： Brian MCGONIGLE , Anthony J. Kinney , Howard Glenn Damude
CPC classification number: C12N15/8247 , A23D9/00 , C12N9/1029 , C12P7/6427
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding novel delta-9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-9 elongases in plants.
Abstract translation: 分离的核酸片段和包含编码新的Δ-9延伸酶的这种片段的重组构建物以及在植物中使用这些δ-9延长酶制备长链多不饱和脂肪酸（PUFA）的方法。
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83.发明授权Delta-9 fatty acid elongase genes and their use in making polyunsaturated fatty acids 有权Delta-9脂肪酸延伸酶基因及其在制备多不饱和脂肪酸中的应用公开(公告)号：US08168858B2
公开(公告)日：2012-05-01
申请号：US12487768
申请日：2009-06-19
Applicant: Brian McGonigle , Anthony J. Kinney , Howard Glenn Damude
Inventor： Brian McGonigle , Anthony J. Kinney , Howard Glenn Damude
CPC classification number: C12N15/8247 , A23D9/00 , C12N9/1029 , C12P7/6427
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding novel delta-9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-9 elongases in plants.
Abstract translation: 分离的核酸片段和包含编码新的Δ-9延伸酶的这种片段的重组构建物以及在植物中使用这些δ-9延长酶制备长链多不饱和脂肪酸（PUFA）的方法。
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84.发明申请DGAT GENES FROM YARROWIA LIPOLYTICA FOR INCREASED SEED STORAGE LIPID PRODUCTION AND ALTERED FATTY ACID PROFILES IN SOYBEAN 审中-公开来自YARROWIA LIPOLYTICA的DGAT基因用于增加种子脂肪生产和改变的大豆脂肪酸分布公开(公告)号：US20120058246A1
公开(公告)日：2012-03-08
申请号：US13295345
申请日：2011-11-14
Applicant: Knut Meyer , William D. Hitz , Narendra S. Yadav , Howard Glenn Damude
Inventor： Knut Meyer , William D. Hitz , Narendra S. Yadav , Howard Glenn Damude
CPC classification number: C12N15/8247 , C12N9/1029 , C12Y203/01158
Abstract: Transgenic soybean seed having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of non-transgenic, null segregant soybean seed are described. DGAT genes from Yarrowia Lipolytica are used to achieve the increase in seed storage lipids.
Abstract translation: 描述了与非转基因，无偏分离大豆种子的总脂肪酸含量相比，具有至少10％的总脂肪酸含量增加和改变的脂肪酸分布的转基因大豆种子。 来自解脂耶氏酵母的DGAT基因用于实现种子储存脂质的增加。
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85.发明授权公开(公告)号：US08058517B2
公开(公告)日：2011-11-15
申请号：US12298563
申请日：2007-04-26
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
CPC classification number: C12N15/8247 , C12N9/0083
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding a delta-8 desaturase along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using this delta-8 desaturase in plants and oleaginous yeast are disclosed.
Abstract translation: 公开了分离的核酸片段和重组构建体，其包含编码Δ-8去饱和酶的片段以及使用该植物中的δ-8去饱和酶和油性酵母制备长链多不饱和脂肪酸（PUFA）的方法。
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Patent Agency Ranking
86.发明申请Plant Membrane Bound O-Acyl Transferase (MBOAT) Family Protein Sequences And Their Uses For Altering Fatty Acid Compositions 失效植物膜结合的O-酰基转移酶（MBOAT）家族蛋白质序列及其用于改变脂肪酸组合物公开(公告)号：US20110162104A1
公开(公告)日：2011-06-30
申请号：US12969782
申请日：2010-12-16
Applicant: HOWARD GLENN DAMUDE , KNUT MEYER
Inventor： HOWARD GLENN DAMUDE , KNUT MEYER
IPC: C12N15/82 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/19 , C12N1/00 , A01H5/10 , A01H5/00 , C07C57/03 , A23D9/00
CPC classification number: C12N15/8247 , A23D9/00 , C12N9/1029
Abstract: This invention is in the field of biotechnology, in particular, this pertains to polynucleotide sequences encoding membrane bound O-acyltransferase genes and the use of these acyltransferases for altering fatty acid profiles in oilseed plants. Methods for increasing elongation and desaturation conversion efficiencies are also disclosed.
Abstract translation: 本发明涉及生物技术领域，特别涉及编码膜结合的O-酰基转移酶基因的多核苷酸序列以及这些酰基转移酶用于改变油菜植物脂肪酸分布的用途。 还公开了提高伸长率和去饱和转化效率的方法。
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公开(公告)号：US20110086919A1
公开(公告)日：2011-04-14
申请号：US12893469
申请日：2010-09-29
Applicant: Howard Glenn Damude , Peter John Gillies , Daniel Joseph Macool , Stephen K. Picataggio , Dana M. Walters Pollak , James John Ragghianti , Zhixiong Xue , Narendra S. Yadav , Hongxiang Zhang , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Peter John Gillies , Daniel Joseph Macool , Stephen K. Picataggio , Dana M. Walters Pollak , James John Ragghianti , Zhixiong Xue , Narendra S. Yadav , Hongxiang Zhang , Quinn Qun Zhu
IPC: A61K31/202 , C12N1/15 , C12P7/64 , C07C57/03 , A61P9/00 , A61P3/10 , A61P19/02 , A61P1/00 , A61P17/02 , A61P19/10
CPC classification number: C12P7/6427 , A23D9/00 , A23K20/158 , A23L33/12 , A23V2002/00 , C12N1/16 , C12N9/0083 , C12N9/1029 , C12N15/52 , C12N15/746 , C12N15/815 , C12P7/6472 , A23V2250/187 , A23V2200/30
Abstract: Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 25% eicosapentaenoic acid (EPA, an ω-3 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of EPA. Production host cells are claimed, as are methods for producing EPA within said host cells.
Abstract translation: 描述了能够在总油馏分中产生大于25％二十碳五烯酸（EPA，ω-3多不饱和脂肪酸）的含油酵母解脂耶氏酵母解脂耶氏酵母菌的工程菌株。 这些菌株包括表达异源去饱和酶，延伸酶和酰基转移酶的各种嵌合基因，并且任选地包含各种天然去饱和酶和酰基转移酶敲除，以使EPA能够合成和高度积累。 要求生产宿主细胞，以及在所述宿主细胞内生产EPA的方法。
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88.发明申请MUTANT DELTA-8 DESATURASE GENES ENGINEERED BY TARGETED MUTAGENESIS AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS 有权突变的DELTA-8去饱和基因通过靶向的诱变工程及其在制备多糖脂肪酸中的应用公开(公告)号：US20100297713A1
公开(公告)日：2010-11-25
申请号：US12726390
申请日：2010-03-18
Applicant: HOWARD GLENN DAMUDE , Hongxian He , Der-ing Liao , Quinn Qun Zhu
Inventor： HOWARD GLENN DAMUDE , Hongxian He , Der-ing Liao , Quinn Qun Zhu
CPC classification number: C12N9/0083
Abstract: The present invention relates to mutant Δ8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 ω-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic acid [20:3 ω-3, ETrA] to eicosatetraenoic acid [20:3 ω-3, ETA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ8 desaturase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these mutant Δ8 desaturases in plants and oleaginous yeast are disclosed.
Abstract translation: 本发明涉及具有将二十碳二烯酸[20:2ω-6，EDA]转化为二高-γ-亚麻酸[20:3，DGLA]和/或二十碳三烯酸[ 20：3ω-3，ETrA]至二十碳四烯酸[20：3ω-3，ETA]。 公开了分离的核酸片段和重组构建体，其包含编码“Dgr”8去饱和酶的片段以及使用这些突变体和Dgr。8去饱和酶在植物和油质酵母中制备长链多不饱和脂肪酸（PUFA）的方法。
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89.发明授权公开(公告)号：US07790156B2
公开(公告)日：2010-09-07
申请号：US12099811
申请日：2008-04-09
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
CPC classification number: C12P7/6427 , C12N9/0083 , C12N15/8247
Abstract: The present invention relates to Δ8 desaturase genes, which have the ability to convert eicosadienoic acid (EDA; 20:2 ω-6) to dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) and/or eicosatrienoic acid (ETrA; 20:3 ω-3) to eicosatetraenoic acid (ETA; (20:3 ω-3). Isolated nucleic acid fragments and recombinant DNA constructs comprising such fragments encoding Δ8 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ8 desaturases in oleaginous yeast are disclosed.
Abstract translation: 本发明涉及具有将二十碳二烯酸（EDA; 20：2ω-6）转化为二高-γ-亚麻酸（DGLA; 20：3ω-6）和/或二十碳三烯酸的能力的Dgr .8去饱和酶基因 分离的核酸片段和重组DNA构建体，其包含编码“Dgr。8”去饱和酶的片段，以及一种制备长链多糖的方法， 公开了在含油酵母中使用这些＆Dgr。8去饱和酶的链多不饱和脂肪酸（PUFA）。
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90.发明申请DELTA-5 DESATURASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS 审中-公开DELTA-5 DESATURASES及其在制备聚氨酯脂肪酸中的应用公开(公告)号：US20100189868A1
公开(公告)日：2010-07-29
申请号：US12594011
申请日：2008-05-01
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
IPC: A01H1/00 , C07H21/00 , C12N15/74 , C12N5/10 , A01H5/00 , C11B1/00 , C12P7/64 , A01H5/10 , A23D9/00 , A23K1/00
CPC classification number: C12N9/0071 , A23D9/00 , A23D9/02 , A23K20/158 , A23L33/115 , C12N9/0083 , C12N15/8247 , C12Y114/19
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-5 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-5 desaturases in plants are disclosed.
Abstract translation: 公开了分离的核酸片段和包含编码Δ-5去饱和酶的片段的重组构建物以及在植物中使用这些Δ-5去饱和酶制备长链多不饱和脂肪酸（PUFA）的方法。
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