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1.发明申请公开(公告)号：US20100075387A1
公开(公告)日：2010-03-25
申请号：US12619706
申请日：2009-11-17
Applicant: HOWARD GLENN DAMUDE , BRIAN MCGONIGLE , ZHIXIONG XUE , QUINN QUN ZHU
Inventor： HOWARD GLENN DAMUDE , BRIAN MCGONIGLE , ZHIXIONG XUE , QUINN QUN ZHU
CPC classification number: C12N15/8247 , C11B1/025 , C12N9/1029 , C12P7/6427 , C12P7/6463 , C12P7/6472
Abstract: The present invention relates to Δ9 elongases, which have the ability to convert linoleic acid [18:2, LA] to eicosadienoic acid [20:2, EDA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ9 elongase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ9 elongases in plants and oleaginous yeast are disclosed.
Abstract translation: 本发明涉及具有将亚油酸[18：2，LA]转化成二十碳烯酸[20：2，EDA]的能力的“Dgr”9延伸酶。 公开了分离的核酸片段和重组构建体，其包含编码'Dgr 9延长酶的这种片段以及使用这些植物和油性酵母中的这些Dgr 9延伸酶制备长链多不饱和脂肪酸（PUFA）的方法。
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2.发明申请Mutant Delta-8 Desaturase Genes Engineered By Targeted Mutagensis and Their Use In Making Polyunsaturated Fatty Acids 审中-公开突变型Delta-8去饱和酶基因由目标突变体及其用于制备多不饱和脂肪酸公开(公告)号：US20110268864A1
公开(公告)日：2011-11-03
申请号：US13178292
申请日：2011-07-07
Applicant: HOWARD GLENN DAMUDE , HONGXIAN HE , DER-ING LIAO , QUINN QUN ZHU
Inventor： HOWARD GLENN DAMUDE , HONGXIAN HE , DER-ING LIAO , QUINN QUN ZHU
CPC classification number: C12N15/8247 , C12N9/0083
Abstract: The present invention relates to mutant delta-8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 omega-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic acid [20:3 omega-3, ETrA] to eicosatetraenoic acid [20:3 omega-3, ETA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-8 desaturase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these mutant delta-8 desaturases in plants and oleaginous yeast are disclosed.
Abstract translation: 本发明涉及具有将二十碳二烯酸[20：2ω-6，EDA]转化为二高-γ-亚麻酸[20:3，DGLA]和/或二十碳三烯酸[...]的能力的突变体δ-8去饱和酶基因[ 20：3ω-3，ETrA]至二十碳四烯酸[20：3ω-3，ETA]。 公开了分离的核酸片段和重组构建体，其包含编码δ-8去饱和酶的片段以及使用植物中的这些突变型δ-8去饱和酶和油性酵母制备长链多不饱和脂肪酸（PUFA）的方法。
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3.发明申请公开(公告)号：US20120196347A1
公开(公告)日：2012-08-02
申请号：US13449395
申请日：2012-04-18
Applicant: HOWARD GLENN DAMUDE , QUINN QUN ZHU
Inventor： HOWARD GLENN DAMUDE , QUINN QUN ZHU
IPC: C12N9/02
CPC classification number: C12P7/6427 , C12N9/0083 , C12N15/8247
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-8 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) and using these delta-8 desaturases in plants.
Abstract translation: 分离的核酸片段和包含编码δ-8去饱和酶的片段以及制备长链多不饱和脂肪酸（PUFA）的方法并在植物中使用这些δ-8去饱和酶的重组构建体。
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4.发明申请MUTANT DELTA-8 DESATURASE GENES ENGINEERED BY TARGETED MUTAGENESIS AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS 有权突变的DELTA-8去饱和基因通过靶向的诱变工程及其在制备多糖脂肪酸中的应用公开(公告)号：US20100297713A1
公开(公告)日：2010-11-25
申请号：US12726390
申请日：2010-03-18
Applicant: HOWARD GLENN DAMUDE , Hongxian He , Der-ing Liao , Quinn Qun Zhu
Inventor： HOWARD GLENN DAMUDE , Hongxian He , Der-ing Liao , Quinn Qun Zhu
CPC classification number: C12N9/0083
Abstract: The present invention relates to mutant Δ8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 ω-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic acid [20:3 ω-3, ETrA] to eicosatetraenoic acid [20:3 ω-3, ETA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ8 desaturase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these mutant Δ8 desaturases in plants and oleaginous yeast are disclosed.
Abstract translation: 本发明涉及具有将二十碳二烯酸[20:2ω-6，EDA]转化为二高-γ-亚麻酸[20:3，DGLA]和/或二十碳三烯酸[ 20：3ω-3，ETrA]至二十碳四烯酸[20：3ω-3，ETA]。 公开了分离的核酸片段和重组构建体，其包含编码“Dgr”8去饱和酶的片段以及使用这些突变体和Dgr。8去饱和酶在植物和油质酵母中制备长链多不饱和脂肪酸（PUFA）的方法。
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5.发明申请NOVEL DGAT GENES FOR INCREASED SEED STORAGE LIPID PRODUCTION AND ALTERED FATTY ACID PROFILES IN OILSEED PLANTS 有权新鲜DGAT基因在油菜植物中增加种子储存脂肪生产和改变的脂肪酸分布公开(公告)号：US20090293152A1
公开(公告)日：2009-11-26
申请号：US12470569
申请日：2009-05-22
Applicant: KEITH ROESLER , HOWARD GLENN DAMUDE , CHANGJIANG LI , KNUT MEYER , BO SHEN , ERICKA BERMUDEZ , MITCHELL C. TARCZYNSKI
Inventor： KEITH ROESLER , HOWARD GLENN DAMUDE , CHANGJIANG LI , KNUT MEYER , BO SHEN , ERICKA BERMUDEZ , MITCHELL C. TARCZYNSKI
CPC classification number: C12N15/8247 , A23K10/30 , A23L11/00 , A23V2002/00 , C12N9/1029 , C12Y203/0102
Abstract: Transgenic oilseeds having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of null segregant oilseeds are described. Novel DGAT genes are used to achieve the increase in seed storage lipids.
Abstract translation: 描述了与无分离油籽油的总脂肪酸含量相比，具有总脂肪酸含量增加至少10％和改变的脂肪酸分布的转基因油籽。 新型DGAT基因用于实现种子储存脂质的增加。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20110269983A1
公开(公告)日：2011-11-03
申请号：US13044984
申请日：2011-03-10
Applicant: ANTHONY J. KINNEY , EDGAR BENJAMIN CAHOON , HOWARD GLENN DAMUDE , ZHAN-BIN LIU
Inventor： ANTHONY J. KINNEY , EDGAR BENJAMIN CAHOON , HOWARD GLENN DAMUDE , ZHAN-BIN LIU
CPC classification number: C12N9/0083 , A21D2/165 , A23D9/00 , A23K20/158 , A23K50/40 , A23K50/80 , A23L11/01 , A23L11/03 , A23L11/05 , A23L11/07 , A23L33/12 , A23V2002/00 , A23V2300/21 , C12N9/1029 , C12N15/8247 , Y02A40/818 , A23V2250/1876 , A23V2250/1882
Abstract: Oilseed plants which have been transformed to produce very long chain polyunsaturated fatty acids, recombinant constructs used in such transformations, methods for producing such fatty acids in a plant are described and uses of oils and seeds obtained from such transformed plants in a variety of food and feed applications are described.
Abstract translation: 已经转化以产生非常长链多不饱和脂肪酸的油籽植物，用于这种转化的重组构建体，在植物中生产这种脂肪酸的方法，以及从这些转化植物获得的油和种子在多种食物中的应用，以及 描述饲料应用。
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7.发明申请NOVEL DGAT GENES FOR INCREASED SEED STORAGE LIPID PRODUCTION AND ALTERED FATTY ACID PROFILES IN OILSEED PLANTS 有权新鲜DGAT基因在油菜植物中增加种子储存脂肪生产和改变的脂肪酸分布公开(公告)号：US20120156360A1
公开(公告)日：2012-06-21
申请号：US13329939
申请日：2011-12-19
Applicant: KEITH ROESLER , HOWARD GLENN DAMUDE , CHANGJIANG LI , KNUT MEYER , BO SHEN , ERICKA BERMUDEZ , MITCHELL C. TARCZYNSKI
Inventor： KEITH ROESLER , HOWARD GLENN DAMUDE , CHANGJIANG LI , KNUT MEYER , BO SHEN , ERICKA BERMUDEZ , MITCHELL C. TARCZYNSKI
CPC classification number: C12N15/8247 , A23K10/30 , A23L11/00 , A23V2002/00 , C12N9/1029 , C12Y203/0102
Abstract: Transgenic oilseeds having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of null segregant oilseeds are described. Novel DGAT genes are used to achieve the increase in seed storage lipids.
Abstract translation: 描述了与无分离油籽油的总脂肪酸含量相比，具有总脂肪酸含量增加至少10％和改变的脂肪酸分布的转基因油籽。 新型DGAT基因用于实现种子储存脂质的增加。
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8.发明申请DGAT GENES FROM OLEAGINOUS ORGANISMS FOR INCREASED SEED STORAGE LIPID PRODUCTION AND ALTERED FATTY ACID PROFILES IN OILSEED PLANTS 有权来自有机体的DGAT基因，用于增加种子储存脂肪生产和改变油脂植物中的脂肪酸分布公开(公告)号：US20090293151A1
公开(公告)日：2009-11-26
申请号：US12470517
申请日：2009-05-22
Applicant: KNUT MEYER , HOWARD GLENN DAMUDE , KEVIN G. RIPP , KEVIN L. STECCA
Inventor： KNUT MEYER , HOWARD GLENN DAMUDE , KEVIN G. RIPP , KEVIN L. STECCA
CPC classification number: C12N15/8247 , C12N9/1029 , C12Y203/0102
Abstract: Transgenic soybean seed having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of non-transgenic, null segregant soybean seed are described. DGAT genes from oleaginous organisms are used to achieve the increase in seed storage lipids.
Abstract translation: 描述了与非转基因，无偏分离大豆种子的总脂肪酸含量相比，具有至少10％的总脂肪酸含量增加和改变的脂肪酸分布的转基因大豆种子。 来自含油生物的DGAT基因用于实现种子储存脂质的增加。
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9.发明申请DELTA-15 DESATURASES SUITABLE FOR ALTERING LEVELS OF POLYUNSATURATED FATTY ACIDS IN OILSEED PLANTS AND OLEAGINOUS YEAST 审中-公开DELTA-15适用于改变油性植物和油脂酵母中多糖脂肪酸含量的食物公开(公告)号：US20140050838A1
公开(公告)日：2014-02-20
申请号：US13897556
申请日：2013-05-20
Applicant: HOWARD GLENN DAMUDE , NARENDRA S. YADAV
Inventor： HOWARD GLENN DAMUDE , NARENDRA S. YADAV
CPC classification number: C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472
Abstract: The present invention relates to fungal Δ-15 fatty acid desaturases that are able to catalyze the conversion of linoleic acid (18:2, LA) to alpha-linolenic acid (18:3, ALA). Nucleic acid sequences encoding the desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising the desaturase genes, and recombinant host plants and microorganisms expressing increased levels of the desaturases are described. Methods of increasing production of specific omega-3 and omega-6 fatty acids by over-expression of the Δ-15 fatty acid desaturases are also described herein.
Abstract translation: 本发明涉及能够催化亚油酸（18:2，LA）转化为α-亚麻酸（18:3，ALA）的真菌Δ-15脂肪酸去饱和酶。 描述了编码去饱和酶的核酸序列，与其杂交的核酸序列，包含去饱和酶基因的DNA构建体和表达增加的去饱和酶水平的重组宿主植物和微生物。 本文还描述了通过过表达Δ-15脂肪酸去饱和酶增加特定ω-3和ω-6脂肪酸的产生的方法。
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10.发明申请Plant Membrane Bound O-Acyl Transferase (MBOAT) Family Protein Sequences And Their Uses For Altering Fatty Acid Compositions 失效植物膜结合的O-酰基转移酶（MBOAT）家族蛋白质序列及其用于改变脂肪酸组合物公开(公告)号：US20110162104A1
公开(公告)日：2011-06-30
申请号：US12969782
申请日：2010-12-16
Applicant: HOWARD GLENN DAMUDE , KNUT MEYER
Inventor： HOWARD GLENN DAMUDE , KNUT MEYER
IPC: C12N15/82 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/19 , C12N1/00 , A01H5/10 , A01H5/00 , C07C57/03 , A23D9/00
CPC classification number: C12N15/8247 , A23D9/00 , C12N9/1029
Abstract: This invention is in the field of biotechnology, in particular, this pertains to polynucleotide sequences encoding membrane bound O-acyltransferase genes and the use of these acyltransferases for altering fatty acid profiles in oilseed plants. Methods for increasing elongation and desaturation conversion efficiencies are also disclosed.
Abstract translation: 本发明涉及生物技术领域，特别涉及编码膜结合的O-酰基转移酶基因的多核苷酸序列以及这些酰基转移酶用于改变油菜植物脂肪酸分布的用途。 还公开了提高伸长率和去饱和转化效率的方法。
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