公开(公告)号：US08679331B2

公开(公告)日：2014-03-25

申请号：US12006815

申请日：2008-01-03

申请人： Jeffrey A. Bowers ,  Kenneth G. Caldeira ,  Alistair K. Chan ,  William H. Gates, III ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  John Latham ,  Nathan P. Myhrvold ,  Stephen H. Salter ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr.

发明人： Jeffrey A. Bowers ,  Kenneth G. Caldeira ,  Alistair K. Chan ,  William H. Gates, III ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  John Latham ,  Nathan P. Myhrvold ,  Stephen H. Salter ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr.

IPC分类号： C02F1/00 ,  E02B9/08 ,  F03B13/14 ,  A01G15/00

CPC分类号： E02B1/003 ,  Y02E10/38

摘要： A structure described generally for altering one or more properties within a body of water includes a vessel configured to hold water. The vessel may have at least one wall. The at least one wall extends at least above a mean surface water level. At least one conduit extends downward from the holding vessel. The at least one conduit has a length that extends below the surface of the water. A propulsion system may be coupled to at least one of the vessel or the conduit and may be configured to provide forces to the vessel.

摘要翻译： 通常用于改变水体内的一个或多个性质的结构包括构造成保持水的容器。 船只至少有一个墙壁。 至少一个壁至少延伸至平均地表水位以上。 至少一个导管从保持容器向下延伸。 所述至少一个导管具有在水表面下方延伸的长度。 推进系统可以联接到容器或管道中的至少一个，并且可以被配置为向容器提供力。

公开(公告)号：US20130257144A1

公开(公告)日：2013-10-03

申请号：US13436290

申请日：2012-03-30

申请人： Kenneth G. Caldeira ,  Alistair K. Chan ,  Daniel B. Cook ,  William David Duncan ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  John Latham ,  Stephen H. Salter ,  Clarence T. Tegreene ,  David B. Tuckerman ,  Thomas A. Weaver ,  Charles Whitmer ,  Victoria Y.H. Wood ,  Lowell L. Wood, JR.

发明人： Kenneth G. Caldeira ,  Alistair K. Chan ,  Daniel B. Cook ,  William David Duncan ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  John Latham ,  Stephen H. Salter ,  Clarence T. Tegreene ,  David B. Tuckerman ,  Thomas A. Weaver ,  Charles Whitmer ,  Victoria Y.H. Wood ,  Lowell L. Wood, JR.

IPC分类号： B60L1/00

CPC分类号： B60L11/1801 ,  B60L11/18 ,  B60L11/1868 ,  B60L2200/12 ,  B60L2200/26 ,  B60L2200/28 ,  B60L2200/40 ,  H02J7/0054 ,  Y02P90/60 ,  Y02T10/7005 ,  Y02T10/7066

摘要： The present invention may include a towable trailer being mechanically couplable to a vehicle, the towable trailer including an auxiliary battery housing unit, a wheel being rotatably connected to the towable trailer, an auxiliary battery disposed within the auxiliary battery housing unit of the towable trailer, the vehicle including a storage battery, the auxiliary battery of the towable trailer being electrically couplable with the storage battery of the vehicle via a bidirectional pathway, and a control system configured to control a transfer of electrical energy between the auxiliary battery of the towable trailer and the storage battery of the vehicle along the bidirectional pathway.

摘要翻译： 本发明可以包括可车辆连接的拖车拖车，该牵引拖车包括一个辅助蓄电池壳体单元，一个可转动地连接到该拖车上的轮子，一个设置在该拖车拖车的辅助蓄电池容纳单元内的辅助蓄电池， 所述车辆包括蓄电池，所述拖曳拖车的辅助电池经由双向路径与所述车辆的蓄电池电耦合;以及控制系统，被配置为控制所述可拖曳拖车的辅助电池和 车辆的蓄电池沿着双向路径。

公开(公告)号：US08348550B2

公开(公告)日：2013-01-08

申请号：US12455311

申请日：2009-05-29

申请人： Jeffrey A. Bowers ,  Kenneth G. Caldeira ,  Alistair K. Chan ,  William Gates ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  John Latham ,  Nathan P. Myhrvold ,  Stephen H. Salter ,  Clarence T. Tegreene ,  Willard H. Wattenburg ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

发明人： Jeffrey A. Bowers ,  Kenneth G. Caldeira ,  Alistair K. Chan ,  William Gates ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  John Latham ,  Nathan P. Myhrvold ,  Stephen H. Salter ,  Clarence T. Tegreene ,  Willard H. Wattenburg ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

IPC分类号： A01G15/00 ,  E02B9/00

CPC分类号： F03G7/04 ,  A01G15/00 ,  Y10T137/8593

摘要： A system is described generally for a water capture structure that is configured to capture wave water lapping over at least one wall of the water capture structure. The at least one wall extends at least above a nominal surface water level and at least one conduit extends downward from the water capture structure. The at least one conduit has a length extending to a depth at which at least one property of water at the depth differs substantially from that of water at the surface. The at least one conduit is configured to provide thermal energy to water outside of the at least one conduit. The at least one conduit has at least one conduit wall.

摘要翻译： 通常描述一种用于捕获水结构的系统，其被配置成捕获在水捕获结构的至少一个壁上的波浪水。 所述至少一个壁至少在标称表面水位上方延伸，并且至少一个管道从捕水结构向下延伸。 所述至少一个管道具有延伸到所述深度处的水的至少一个特性与所述表面处的水的至少一个特性的深度的长度。 所述至少一个管道构造成向所述至少一个管道外部的水提供热能。 至少一个导管具有至少一个导管壁。

公开(公告)号：US20120321636A1

公开(公告)日：2012-12-20

申请号：US13592116

申请日：2012-08-22

申请人： David G. Winkler ,  Jiye Shi ,  John Latham

发明人： David G. Winkler ,  Jiye Shi ,  John Latham

IPC分类号： A61K39/395 ,  C12N5/12 ,  C07K16/46 ,  G01N33/53 ,  G01N33/577 ,  C07K14/435 ,  A61P19/10 ,  C12N5/10 ,  C12N1/19 ,  C12N1/15 ,  C07K7/06 ,  C07K7/08 ,  C07K16/18 ,  A61P19/08

CPC分类号： C07K16/22 ,  A61K47/643 ,  A61K47/646 ,  C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  C07K2317/76 ,  G01N33/6854 ,  G01N2333/4704

摘要： Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

摘要翻译： 提供了与特异性结合TGF-β结合蛋白的抗体相关的组合物和方法。 这些方法和组合物涉及通过干扰TGF-β结合蛋白质硬化蛋白和TGF-β超家族成员，特别是骨形态发生蛋白之间的相互作用来改变骨矿物质密度。 增加骨矿物质密度在低骨矿物质密度代表骨质减少症，骨质疏松症和骨折等疾病和病症中具有应用价值。

公开(公告)号：US20120141982A1

公开(公告)日：2012-06-07

申请号：US13204915

申请日：2011-08-08

申请人： Anne Elisabeth Carvalho Jensen ,  Leon Garcia ,  Ethan Ojala ,  John Latham

发明人： Anne Elisabeth Carvalho Jensen ,  Leon Garcia ,  Ethan Ojala ,  John Latham

IPC分类号： G01N33/53 ,  C12Q1/68

CPC分类号： C12Q1/6881 ,  C07K16/00 ,  C07K16/241 ,  C07K16/248 ,  C12N5/0635 ,  C12N2502/11

摘要： The present invention relates to methods of isolating antigen-specific cells and producing antibodies therefrom.

摘要翻译： 本发明涉及分离抗原特异性细胞并由其产生抗体的方法。

公开(公告)号：US08178101B2

公开(公告)日：2012-05-15

申请号：US12391717

申请日：2009-02-24

申请人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

发明人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

IPC分类号： A61K39/395 ,  C12P21/08 ,  C07K16/24

CPC分类号： C07K16/248 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76

摘要： The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.

摘要翻译： 本发明涉及对IL-6具有结合特异性的抗体及其片段和人源化形式。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还涉及抗IL-6抗体及其与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗IL-6抗体及其结合片段的方法。 本发明的实施方案还涉及抗IL-6抗体及其结合片段用于诊断，评估和治疗与IL-6相关的疾病和病症的用途。 这些抗体可以结合可溶性IL-6，细胞表面表达的IL-6，IL-6 / IL-6R中的至少一种和/或阻止IL-6和IL-6R的结合，IL-6 / IL -6R和gp130，或者形成IL-6 / IL-6R / gp130多聚体，从而抑制与前述任何相关的生物学作用。

公开(公告)号：US08003108B2

公开(公告)日：2011-08-23

申请号：US11410540

申请日：2006-04-25

申请人： Hsieng Sen Lu ,  Christpher Paszty ,  Martyn Kim Robinson ,  Alistair James Henry ,  Kelly Sue Warmington ,  John Latham ,  Alastair Lawson ,  David Winkler ,  Aaron George Winters

发明人： Hsieng Sen Lu ,  Christpher Paszty ,  Martyn Kim Robinson ,  Alistair James Henry ,  Kelly Sue Warmington ,  John Latham ,  Alastair Lawson ,  David Winkler ,  Aaron George Winters

IPC分类号： A61K39/00 ,  A61K38/00 ,  A61K38/10 ,  A61K38/16 ,  C07K5/00

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K14/51 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/63

摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.

摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。

公开(公告)号：US20110195453A1

公开(公告)日：2011-08-11

申请号：US12958195

申请日：2010-12-01

申请人： David G. Winkler ,  Jiye Shi ,  John Latham

发明人： David G. Winkler ,  Jiye Shi ,  John Latham

IPC分类号： C12P21/04 ,  C07H21/00 ,  C12N15/63 ,  C12N1/00 ,  C12N5/10

CPC分类号： C07K16/22 ,  A61K47/643 ,  A61K47/646 ,  C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  C07K2317/76 ,  G01N33/6854 ,  G01N2333/4704

摘要： Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

公开(公告)号：US07985834B2

公开(公告)日：2011-07-26

申请号：US12504296

申请日：2009-07-16

申请人： David G. Winkler ,  John Latham ,  Jiye Shi

发明人： David G. Winkler ,  John Latham ,  Jiye Shi

IPC分类号： C07K11/00 ,  C07K14/00 ,  A61K38/04

CPC分类号： C07K16/22 ,  A01K2217/05 ,  A01K2217/075 ,  A61K48/00 ,  C07K14/51 ,  C07K16/18 ,  C07K2317/11 ,  C07K2317/23 ,  C07K2319/00 ,  C12N2799/021 ,  G01N33/6872 ,  G01N2333/495 ,  G01N2500/04 ,  G01N2800/108

摘要： A novel class or family of TGF-β binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

摘要翻译： 一种新型的TGF- 公开了结合蛋白。 还公开了用于选择用于增加骨矿化的分子的测定法和利用这种分子的方法。 特别地，提供了与特异性结合TGF-β结合蛋白的抗体相关的组合物和方法。 这些方法和组合物涉及通过干扰TGF-β结合蛋白质硬化蛋白和TGF-β超家族成员，特别是骨形态发生蛋白之间的相互作用来改变骨矿物质密度。 增加骨矿物质密度在低骨矿物质密度代表骨质减少症，骨质疏松症和骨折等疾病和病症中具有应用价值。

公开(公告)号：US20100290993A1

公开(公告)日：2010-11-18

申请号：US12601295

申请日：2008-05-21

申请人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  John Latham ,  Brian Kovacevich ,  Jeffrey T.L. Smith

发明人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  John Latham ,  Brian Kovacevich ,  Jeffrey T.L. Smith

IPC分类号： A61K49/00 ,  A61K39/395 ,  G01N33/53 ,  C12N5/10 ,  C12N1/19 ,  C12N15/63 ,  G01N33/566 ,  C07K16/24 ,  C07H21/04 ,  A61P19/02 ,  A61P17/06 ,  A61P37/06 ,  A61P19/10 ,  A61P35/00 ,  A61P35/04 ,  A61P3/10 ,  A61P3/04 ,  A61P11/06 ,  A61P25/28 ,  A61P7/06 ,  A61P25/24 ,  A61P7/02 ,  A61P29/00

摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.

摘要翻译： 本发明涉及对IL-6具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还涉及抗IL-6抗体及其与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗IL-6抗体及其结合片段的方法。 本发明的实施方案还涉及抗IL-6抗体及其结合片段用于诊断，评估和治疗与IL-6相关的疾病和病症的用途。 这些抗体可以结合可溶性IL-6，细胞表面表达的IL-6，IL-6 / IL-6R中的至少一种和/或阻止IL-6和IL-6R的结合，IL-6 / IL -6R和gp130，或者形成IL-6 / IL-6R / gp130多聚体，从而抑制与前述任何相关的生物学作用。