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公开(公告)号：US20050153335A1
公开(公告)日：2005-07-14
申请号：US11002756
申请日：2004-12-03
Applicant: David LaFleur , Steven Ruben , Craig Rosen , Paul Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
Inventor： David LaFleur , Steven Ruben , Craig Rosen , Paul Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
IPC: G01N33/50 , A61K31/711 , A61K38/00 , A61K48/00 , A61P7/02 , A61P9/00 , A61P9/10 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/15 , C07H21/04 , C12N9/00
CPC classification number: C12Q1/6883 , A61K35/13 , A61K38/00 , C07K14/47 , G01N33/6893 , Y02A50/465
Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
Abstract translation: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US20050095612A1
公开(公告)日：2005-05-05
申请号：US10866831
申请日：2004-06-15
Applicant: Steven Ruben , Paul Young , Laurie Brewer , Reinhard Ebner , Henrik Olsen , Kimberly Florence , Craig Rosen , Roxanne Duan , Paul Moore , Yanggu Shi , David LaFleur , Charles Florence , Daniel Soppet , Gregory Endress , Ping Feng , George Komatsoulis
Inventor： Steven Ruben , Paul Young , Laurie Brewer , Reinhard Ebner , Henrik Olsen , Kimberly Florence , Craig Rosen , Roxanne Duan , Paul Moore , Yanggu Shi , David LaFleur , Charles Florence , Daniel Soppet , Gregory Endress , Ping Feng , George Komatsoulis
IPC: G01N33/53 , A61K38/00 , A61P43/00 , C07K14/47 , C07K16/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/68 , C07H21/04 , C12N9/00
CPC classification number: C07K14/47 , A61K38/00 , G01N33/6893 , G01N2500/20
Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
Abstract translation: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US20050079537A1
公开(公告)日：2005-04-14
申请号：US11002755
申请日：2004-12-03
Applicant: David LaFleur , Steven Ruben , Craig Rosen , Paul Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
Inventor： David LaFleur , Steven Ruben , Craig Rosen , Paul Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
IPC: G01N33/50 , A61K31/711 , A61K38/00 , A61K48/00 , A61P7/02 , A61P9/00 , A61P9/10 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/15 , C07H21/04 , C12N9/00
CPC classification number: C12Q1/6883 , A61K35/13 , A61K38/00 , C07K14/47 , G01N33/6893 , Y02A50/465
Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：US20050037966A1
公开(公告)日：2005-02-17
申请号：US10901210
申请日：2004-07-29
Applicant: Steven Ruben , Pablo Jimenez , Roxanne Duan , Mark Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul Moore , Timothy Coleman , Joachim Gruber , Patrick Dillon , Reiner Gentz
Inventor： Steven Ruben , Pablo Jimenez , Roxanne Duan , Mark Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul Moore , Timothy Coleman , Joachim Gruber , Patrick Dillon , Reiner Gentz
CPC classification number: C07K14/50 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00
Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
Abstract translation: 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。 本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。 本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。
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公开(公告)号：US20050019866A1
公开(公告)日：2005-01-27
申请号：US10883936
申请日：2004-07-06
Applicant: Jian Ni , Kevin Baker , Charles Birse , Michele Fiscella , George Komatsoulis , Craig Rosen , Daniel Soppet , Paul Young , Reinhard Ebner , D. Duan , Henrik Olsen , David La Fleur , Paul Moore , Yanggu Shi , Ping Wei , Kimberly Florence
Inventor： Jian Ni , Kevin Baker , Charles Birse , Michele Fiscella , George Komatsoulis , Craig Rosen , Daniel Soppet , Paul Young , Reinhard Ebner , D. Duan , Henrik Olsen , David La Fleur , Paul Moore , Yanggu Shi , Ping Wei , Kimberly Florence
IPC: G01N33/50 , A61K38/00 , A61K48/00 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/04 , C12N9/42
CPC classification number: C07K14/70532 , A61K38/00 , C07K14/47
Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
Abstract translation: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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Patent Agency Ranking
公开(公告)号：US20050009085A1
公开(公告)日：2005-01-13
申请号：US10918446
申请日：2004-08-16
Applicant: David LaFleur , Steven Ruben , Craig Rosen , Paul Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
Inventor： David LaFleur , Steven Ruben , Craig Rosen , Paul Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
IPC: G01N33/50 , A61K31/711 , A61K38/00 , A61K48/00 , A61P7/02 , A61P9/00 , A61P9/10 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/15 , C07H21/04
CPC classification number: C12Q1/6883 , A61K35/13 , A61K38/00 , C07K14/47 , G01N33/6893 , Y02A50/465
Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
Abstract translation: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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87.发明授权公开(公告)号：US06635471B1
公开(公告)日：2003-10-21
申请号：US09700757
申请日：2000-11-20
Applicant: Martin A Lee , Dario L Leslie , Paul Moore
Inventor： Martin A Lee , Dario L Leslie , Paul Moore
IPC: C12M102
Abstract: The use of incubation means for the controlled heating of biological materials, said means comprising an electrically conducting polymer connectable to a power supply, said polymer being either contiguous or integral with an incubation vessel, or adapted to be in thermal contact with an incubation vessel. Incubation apparatus including such means and a method for culturing biological materials using them are also described and claimed.
Abstract translation: 使用用于受控加热生物材料的温育装置，所述装置包括可连接到电源的导电聚合物，所述聚合物与培养容器相邻或一体，或适于与培养容器热接触。 还描述并要求保护包括这些装置的培养装置和使用它们培养生物材料的方法。
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公开(公告)号：US06474687B2
公开(公告)日：2002-11-05
申请号：US09292202
申请日：1999-04-15
Applicant: Douglas Michael Cappabianca , Dale Paul Moore , Joseph A. Bollo , Kumar Balakrishna Kulkarni , Ravi Thyagarajan , Venkat Reddy
Inventor： Douglas Michael Cappabianca , Dale Paul Moore , Joseph A. Bollo , Kumar Balakrishna Kulkarni , Ravi Thyagarajan , Venkat Reddy
IPC: B60R21045
CPC classification number: B60R21/04 , B60R21/045 , B60R2021/0414
Abstract: A one-piece knee bolster for a motor vehicle includes a knee bolster cover adapted to mount to vehicle structure in an interior of a motor vehicle and at least one hollow reinforcing channel member extending along the knee bolster cover to reinforce the knee bolster cover.
Abstract translation: 用于机动车辆的单件膝垫包括适于安装到机动车辆内部的车辆结构的膝盖盖以及沿着膝盖盖延伸的至少一个中空加强通道构件，以加强膝盖盖。
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89.发明授权Eyeglass lens with multiple optical zones having varying optical properties for enhanced visualization of different scenes in outdoor recreational activities 有权具有多个光学区域的眼镜镜片具有不同的光学特性，用于增强户外娱乐活动中不同场景的可视化公开(公告)号：US06250759B1
公开(公告)日：2001-06-26
申请号：US09469916
申请日：1999-12-22
Applicant: David V. Kerns, Jr. , J. Paul Moore
Inventor： David V. Kerns, Jr. , J. Paul Moore
IPC: G02C710
Abstract: A lens for eyeglasses is provided with two or more optical zones on the lens body having different optical properties that enhance visualization of different scenes, including target objects within the scenes, that are associated with a specific recreational activity such as golf, hunting, or fishing. A first optical zone in an upper portion of the lens can be provided with pre-defined focus distance, transmission percentage, and/or transmission spectrum parameters for enhanced visualization of distant scenes associated with the specific recreational activity. A second optical zone in a lower portion of the lens can be provided with different pre-defined focus distance, transmission percentage, and/or transmission spectrum parameters for enhanced visualization of close-in scenes associated with the specific recreational activity.
Abstract translation: 用于眼镜的镜片在透镜主体上设置有两个或更多个光学区域，该光学区域具有不同的光学特性，其增强了与诸如高尔夫，狩猎或钓鱼之类的特定娱乐活动相关联的不同场景（包括场景内的目标物体）的可视化 。 透镜上部的第一光学区域可以设置有预定义的焦距，传输百分比和/或透射光谱参数，用于增强与特定娱乐活动相关联的遥远场景的可视化。 透镜下部的第二光学区域可以具有不同的预定焦距，传输百分比和/或透射光谱参数，用于增强与特定娱乐活动相关联的近景场景的可视化。
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公开(公告)号：US2172314A
公开(公告)日：1939-09-05
申请号：US4720235
申请日：1935-10-28
Applicant: WALTER C O KANE , PAUL MOORE
Inventor： ADAMS JAMES F , NIKITIN ALEXANDER A
IPC: A01N59/20
CPC classification number: A01N59/20
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