公开(公告)号：US11249059B2

公开(公告)日：2022-02-15

申请号：US16994118

申请日：2020-08-14

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Stefan Quint ,  Benjamin Tiemann ,  Florian Schweinberger ,  Martin Stingl

IPC: G01N30/72 ,  G01N30/86 ,  H01J49/00 ,  H01J49/16 ,  G01N35/10 ,  H01J49/04 ,  G01N30/62 ,  G01N15/12 ,  G01N30/04

Abstract: An automated method of monitoring a state of an analyzer is provided including a mass spectrometer (MS) with an electrospray ionization (ESI) source coupled to a liquid chromatography (LC) stream, including monitoring an electrospray ionization current of the ESI source and identifying a condition of multiple conditions of the analyzer based on the monitored ionization current of the ESI source, one of the conditions being a presence of a dead volume in a liquid chromatography stream of the analyzer downstream of an LC column of the LC stream.

公开(公告)号：US20220006746A1

公开(公告)日：2022-01-06

申请号：US17360539

申请日：2021-06-28

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Stephen Martin ,  Alexandra Paun ,  Jakub Winiarz

IPC: H04L12/851 ,  H04L12/26

Abstract: A computer implemented method and associated apparatus, networked system, computer readable medium, and computer program element are presented. The computer-implemented method generates a message filter configuration based on a message priority indication received from a first analyzer network. The first analyzer network comprises at least one analytical device configured to generate a message. The method comprises receiving, at a data processing agent, a message priority indication indicating a priority assigned to the message in the first analyzer network, providing, at the data processing agent, at least one message filter configuration based on the message priority indication of the message, and communicating the message filter configuration, or a portion thereof, to a second analyzer network comprising a second analytical device.

公开(公告)号：US20220003788A1

公开(公告)日：2022-01-06

申请号：US17304467

申请日：2021-06-22

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Jean-Pierre Bolliger ,  Rik Harbers ,  Rolf Knobel

IPC: G01N33/72 ,  G01N33/92 ,  G01N21/59 ,  G01N21/25 ,  G01N21/51

Abstract: A method of determining a level of interference with a photometric in-vitro diagnostic assay and an in-vitro diagnostic analyzer for carrying out the method are described. The method comprises treating an aliquot of a sample with at least one reagent to obtain a sample/reagent mixture and subjecting the sample/reagent mixture to a photometric measurement in order to obtain a result of the in-vitro diagnostic assay, and during the same photometric measurement determining a preliminary level of interference by semi-quantitatively determining one or more interfering substances in the same sample/reaction mixture. The method further comprises triggering a separate photometric measurement of another aliquot of the same sample either undiluted or diluted with a liquid other than a reagent in order to determine an effective level of interference by quantitatively determining the one or more interfering substances, only upon determining a preliminary level of interference above a predetermined threshold.

公开(公告)号：US20210402394A1

公开(公告)日：2021-12-30

申请号：US17304344

申请日：2021-06-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Adrian Sievers-Engler

IPC: B01L3/00 ,  G01N35/02

Abstract: A sample concentrating unit and a sample concentrating method are described, which enable fast, precise and reproducible analyte concentration in a sample by evaporation of sample solvent. A specifically directed gas stream in cooperation with a vacuum generated in the sample concentrating unit keeps the sample at boiling point during the entire evaporation procedure while reducing analyte loss and risk of cross-contamination. The fully automated sample concentrating unit is designed to be integrated into an in-vitro diagnostic analyzer.

公开(公告)号：US11204361B2

公开(公告)日：2021-12-21

申请号：US15875215

申请日：2018-01-19

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Armin Birrer ,  Andreas Drechsler ,  Rik Harbers

IPC: G01N35/10 ,  G01N21/51 ,  G06T7/60 ,  G01N35/04 ,  G06T7/00 ,  G01N35/00 ,  B65G54/02

Abstract: A laboratory automation system for processing sample containers containing laboratory samples and/or for processing the samples is presented. The laboratory automation system comprises a digital camera configured to take an image of the sample container together with a calibration element. The image comprises image data related to the sample container and image data related to the calibration element. The laboratory automation system also comprises an image processing device configured to determine geometrical properties of the sample container depending on the image data related to the sample container and the image data related to the calibration element.

公开(公告)号：US20210381987A1

公开(公告)日：2021-12-09

申请号：US17405742

申请日：2021-08-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Hans-Peter JOSEL ,  Herbert ANDRES ,  Michaela WINDFUHR ,  Oliver LARBOLETTE ,  Stefan QUINT

IPC: G01N21/76 ,  G01N33/543 ,  C07F15/00 ,  G01N21/66

Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electro-chemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.

公开(公告)号：US20210355472A1

公开(公告)日：2021-11-18

申请号：US17386106

申请日：2021-07-27

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Thomas Greiner-Stoeffele ,  Stefan Schoenert

IPC: C12N9/52 ,  C07K14/195 ,  C12N5/071

Abstract: The present disclosure provides the sequence of a Paenibacillus polymyxa preproenzyme which is the precursor of a neutral protease, expression thereof in a transformed host organism, and methods for production of the neutral protease, by recombinant means. Further, use of the recombinantly produced neutral protease is disclosed in the field of cell biology, particularly for the purpose of tissue dissociation. The disclosure also includes blends with other proteases. Further disclosed are nucleotide sequences encoding the neutral protease.

公开(公告)号：US20210333277A1

公开(公告)日：2021-10-28

申请号：US16856162

申请日：2020-04-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Alexander Riedel ,  Christian Scholz ,  Peter Muench ,  Juliane Benz ,  Markus Eckl ,  Frederik Baumkoetter

IPC: G01N33/569 ,  C12N7/00

Abstract: The present invention relates to a Corona antigen comprising a Corona nucleocapsid specific amino acid sequence, compositions, and reagent kits comprising the same and methods of producing it. Also encompassed are methods of detecting anti-Corona antibodies in samples using said Corona antigen, and methods of differential diagnosis of an immune response in a patient due to natural Corona infection or due to vaccination against Corona.

公开(公告)号：US20210304886A1

公开(公告)日：2021-09-30

申请号：US17207957

申请日：2021-03-22

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Urs Suter ,  Javier Jimenez Roda ,  Stefan Bucheli ,  Isabella Kanne Castejon ,  Dirk Abeln

IPC: G16H40/40 ,  G06K9/00 ,  H04L29/08 ,  G06T11/00 ,  G06F16/955 ,  G03H1/00

Abstract: A computer-implemented method for tracking laboratory resources is disclosed. The laboratory resource comprises an identification feature. The method comprises an identification step comprising detecting the laboratory resource in the laboratory with an imaging sensor of an augmented reality device and identifying the laboratory resource with an identification unit of the augmented reality device by receiving identification information from the identification feature, a data retrieving step comprising retrieving information about the identified laboratory resource from a data server via a communication interface of the augmented reality device, and a tracking step comprising generating and displaying augmented reality information on a display device of the augmented reality device. The augmented reality information comprises a hologram comprising the retrieved information about the identified laboratory resource and/an instruction depending on the retrieved information about the identified laboratory resource.

公开(公告)号：US20210302449A1

公开(公告)日：2021-09-30

申请号：US17211113

申请日：2021-03-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Goran Savatic

IPC: G01N35/00

Abstract: The present disclosure relates to a method to re-identify a carrier on a laboratory transport system after a system failure. The carrier is associated with an identity and is configured to move over a transport plane of the laboratory transport system. The laboratory transport system comprises a monitoring system configured to monitor motion positions of the carrier on the transport plane when the laboratory transport system is activated. After a system failure, the identity dissociates from the carrier and the carrier keeps moving on the transport plane. After reactivation of the laboratory transport system, a predicted position of the identity is compared to an actual position of the carrier by a control unit of the laboratory transport system. The control unit assigns the identity to the carrier if the predicted position of the identity matches with the actual position of the carrier.