-
公开(公告)号：US20240329033A1
公开(公告)日：2024-10-03
申请号：US18515636
申请日：2023-11-21
发明人： Jay Rappaport , Sarah Vakili
IPC分类号： G01N33/50 , C07K14/705 , C07K14/73 , C07K14/735 , C12N5/0786
CPC分类号： G01N33/5047 , C07K14/70514 , C07K14/70535 , C07K14/70596 , C12N5/0645 , C12N2501/052 , C12N2501/22 , C12N2501/24 , C12N2501/25 , C12N2501/30 , C12N2501/39 , C12N2501/999
摘要： The invention provides monocytes expressing CD16 and CD163 and experimental system for drug screening or evaluating drug candidates where the modulation of CD16 and CD163 is desired.
-
公开(公告)号：US20240261436A1
公开(公告)日：2024-08-08
申请号：US18566468
申请日：2022-06-02
发明人： Kamel KHALILI , Rafal KAMINSKI
IPC分类号： A61K48/00 , A61K31/4985 , A61K31/505 , A61K31/52 , A61K31/7068 , A61P31/18 , C12N9/22 , C12N15/113
CPC分类号： A61K48/005 , A61K31/4985 , A61K31/505 , A61K31/52 , A61K31/7068 , A61P31/18 , C12N9/22 , C12N15/1132 , C12N15/1138 , C12N2310/20
摘要： Compositions for specifically cleaving target sequences in retroviruses include nucleic acids encoding a Clustered Regularly Interspace Short Palindromic Repeat (CRISPR) associated endonuclease and a guide RNA sequence complementary to a target sequence in a retrovirus and a receptor used by a retrovirus for infecting a cell. The CRISPR construct edits, for example, proviral HIV DNA, thereby eliminating the provirus from an infected cell and simultaneously edits a viral receptor, e.g. CCR5 preventing infection and reinfection of the host.
-
公开(公告)号：US20240245607A1
公开(公告)日：2024-07-25
申请号：US18426838
申请日：2024-01-30
发明人： Gregory S. Smutzer , Kevin Lee , Dhruti Patel
IPC分类号： A61K9/16 , A61K9/00 , A61K31/01 , A61K31/015 , A61K31/047 , A61K31/12 , A61K31/165 , A61K31/192 , A61K31/353 , A61K31/355 , A61K31/366 , A61K31/704 , A61K36/185 , A61K47/10 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/46
CPC分类号： A61K9/1617 , A61K9/0056 , A61K9/1623 , A61K9/1682 , A61K31/01 , A61K31/015 , A61K31/047 , A61K31/12 , A61K31/165 , A61K31/192 , A61K31/353 , A61K31/355 , A61K31/366 , A61K31/704 , A61K36/185 , A61K47/10 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/46
摘要： The present invention relates to compositions and methods for masking the taste of an agent. In certain aspects, the invention comprises a microsphere and at least one sweetener therein. In another aspect, the invention comprises an edible material comprising at least one microsphere comprising an agent and at least one microsphere comprising a sweetener.
-
公开(公告)号：US20240238346A1
公开(公告)日：2024-07-18
申请号：US18577300
申请日：2022-07-08
发明人： Sadia MOHSIN , Steven HOUSER , Hajime KUBO
CPC分类号： A61K35/28 , A61K38/1754 , A61K38/1793 , A61P9/00
摘要： Cell therapies and cell secretome compositions are utilized in the methods of treatment of cardiac injury. The compositions mediate myocardial homeostasis and cardiac wound healing process post-MI via the direct modulation of regulatory T cell (Treg) population dynamics and function.
-
公开(公告)号：US20240139294A1
公开(公告)日：2024-05-02
申请号：US18298913
申请日：2023-04-11
发明人： Kamel KHALILI , Wenhui Hu
CPC分类号： A61K38/465 , A61K9/0034 , A61K35/12 , A61K45/06 , A61K48/00 , A61K48/005 , C12N7/00 , C12N9/22 , C12N15/111 , C12N2310/20 , C12N2320/30 , C12N2740/16063 , C12Y301/21
摘要： A method of preventing transmission of a retrovirus from a mother to her offspring, by administering to the mother a therapeutically effective amount of a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and the two or more different multiplex gRNAs, wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of proviral DNA of the virus that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire HIV-1 proviral genome, eradicating the HIV-1 proviral DNA from the host cell, and preventing transmission of the proviral DNA to the offspring.
-
公开(公告)号：US11963938B2
公开(公告)日：2024-04-23
申请号：US17379305
申请日：2021-07-19
发明人： Mark A. Feitelson
IPC分类号： A61K31/19 , A61K9/00 , A61K35/744 , A61K35/747 , A61P35/00
CPC分类号： A61K31/19 , A61K9/0053 , A61K35/744 , A61K35/747 , A61P35/00
摘要： The invention relates to compositions for preventing or delaying the onset of hepatocellular cancer. The compositions of the invention may comprise short chain fatty acids. The compositions of the invention may also comprise probiotic bacteria. The compositions of the invention include compositions for preventing or delaying the onset of hepatocellular cancer by treating or preventing liver inflammation, liver disease, and precancerous lesions.
-
公开(公告)号：US20240058283A1
公开(公告)日：2024-02-22
申请号：US18336712
申请日：2023-06-16
申请人： West Virginia University Board of Governors on Behalf of West Virginia University , Temple University-Of the Commonwealth System of Higher Education , University of Pittsburgh-Of the Commonwealth System of Higher Education , The United States Government as represented by the Department of Veterans Affairs
IPC分类号： A61K31/167
CPC分类号： A61K31/167
摘要： A method of restoring the balance of osteoclast to osteoblast activity in a patient having rheumatoid arthritis comprising administering to a patient a therapeutically effective amount of the compound N-(3,4-dichlorophenyl)-N-methylpropanamide is provided. A method for treating arthritis-induced bone erosion in a patient comprising administering to a patient a therapeutically effective amount of the compound N-(3,4-dichlorophenyl)-N-methylpropanamide is provided. The compound N-(3,4-dichlorophenyl)-N-methylpropanamide is administered in a pharmaceutically acceptable composition to said patient. A mode of action of N-(3,4-dichlorophenyl)-N-methyl propanamide comprising targeting transient receptor potential channels is provided.
-
公开(公告)号：US11897870B2
公开(公告)日：2024-02-13
申请号：US16861075
申请日：2020-04-28
IPC分类号： C07D405/12 , C07D405/06 , C07D307/94 , C07D307/33
CPC分类号： C07D405/12 , C07D307/33 , C07D307/94 , C07D405/06
摘要： Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.
-
公开(公告)号：US11846629B2
公开(公告)日：2023-12-19
申请号：US16334808
申请日：2017-09-20
发明人： Jay Rappaport , Sarah Vakili
IPC分类号： C07K14/705 , C07K14/73 , C07K14/735 , C12N5/0786 , G01N33/50
CPC分类号： G01N33/5047 , C07K14/70514 , C07K14/70535 , C07K14/70596 , C12N5/0645 , C12N2501/052 , C12N2501/22 , C12N2501/24 , C12N2501/25 , C12N2501/30 , C12N2501/39 , C12N2501/999
摘要： The invention provides monocytes expressing CD16 and CD163 and experimental system for drug screening or evaluating drug candidates where the modulation of CD16 and CD163 is desired.
-
公开(公告)号：US11820774B2
公开(公告)日：2023-11-21
申请号：US17154761
申请日：2021-01-21
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma-2 receptor activity.
-
-
-
-
-
-
-
-
-
搜索结果
399 条记录 (耗时 0.04 秒)
