公开(公告)号：US09835506B2

公开(公告)日：2017-12-05

申请号：US14366888

申请日：2012-12-20

Applicant: Institut de Radioprotection et de Sûreté Nucléaire ,  Universite D'Aix-Marseille

Inventor： Serge Pons ,  Mickaël Coutin ,  Sébastien Luciani ,  Christophe Le Niliot ,  Fabrice Rigollet

IPC: G01K19/00 ,  G01K17/00 ,  G01N25/18

CPC classification number: G01K17/00 ,  G01K19/00 ,  G01N25/18

Abstract: The present invention relates to a method for estimating the thermophysical properties of a material (Ω) that incorporates at least one temperature sensor (1, 2, 3) and one point heat source (4), the distance between the at least one temperature sensor (1, 2, 3) and the point heat source (4) being known. The method includes the steps of: expression of the theoretical temperature as a function of time at the at least one temperature sensor (1, 2, 3) when the point heat source (4) is activated, said expression depending on the thermophysical parameters of the material (Ω); acquisition of a plurality of temperature measurements by the at least one temperature sensor (1, 2, 3) over a time period during which the point heat source (4) is activated; and determining of the values of the thermophysical parameters of the material (Ω), such that the difference between the theoretical temperatures obtained via said expression and the temperatures that are actually measured is minimal. The present invention also relates to a method for measuring a heat flow (φ(t)) across a surface (Γ) of a material (Ω) and a flow meter (10) designed for this purpose.

公开(公告)号：US20170315140A1

公开(公告)日：2017-11-02

申请号：US15528889

申请日：2015-11-26

Applicant: UNIVERSITE D'AIX MARSEILLE ,  ASSISTANCE PUBLIQUE-HOPITAUX DE MARSEILLE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Inventor： Jean Ruf ,  Régis Guieu ,  Franck Paganelli ,  Laurent Bonello ,  Giovanna Mottola ,  Nathalie Kipson

IPC: G01N33/74 ,  C07K16/28

CPC classification number: G01N33/74 ,  C07K16/286 ,  C07K16/2869 ,  C07K2317/75 ,  G01N33/6893 ,  G01N2333/726 ,  G01N2800/324 ,  G01N2800/52

Abstract: The invention relates to a method of diagnosis or prognosis of an obliterative arteriopathy in a subject, comprising determining the expression level of adenosine A2A receptors expressed at the cell surface of peripheral blood mononuclear cells obtained from said subject. The invention also relates to an agonist-like monoclonal antibody directed to the human adenosine A2A receptor, useful for carrying out this method.

公开(公告)号：US20170292199A1

公开(公告)日：2017-10-12

申请号：US15512666

申请日：2015-09-25

Applicant: Centre National de la Recherche Scientifique ,  Universite d'Aix Marseille ,  Ecole Centrale de Marseille

Inventor： Younes Achaoui ,  Serge Mensah ,  Zoubida Hammadi ,  Roger Claude Marcel Morin ,  Eric Debieu ,  Cédric Alain François Marie Payan

IPC: C25B15/02 ,  B06B1/02 ,  C25B1/04

CPC classification number: C25B15/02 ,  B01J19/0006 ,  B01J19/087 ,  B01J19/10 ,  B01J2219/0826 ,  B01J2219/0877 ,  B06B1/0215 ,  C25B1/04 ,  Y02E60/366

Abstract: The invention concerns a method for controlling at least one gas bubble produced in a localised manner in a medium (3′) allowing the movement of said at least one gas bubble, characterised in that it comprises a step consisting of generating at least one ultrasound burst towards said at least one gas bubble, said at least one burst being emitted for a burst duration at least partially covering a duration during which said gas is effectively being produced.

公开(公告)号：US20170275313A1

公开(公告)日：2017-09-28

申请号：US15503827

申请日：2015-08-13

Applicant: THE MEDICAL COLLEGE OF WISCONSIN, INC. ,  UNIVERSITE D'AIX-MARSEILLE 1

Inventor： Balaraman Kalyanaramn ,  Micael J. Hardy ,  Marcos Lopez ,  Olivier Ouari ,  Jacek Michal Zielonka

IPC: C07F9/54 ,  C07D213/20

CPC classification number: C07F9/5456 ,  A61K31/155 ,  A61K31/4425 ,  A61K31/662 ,  C07D213/20 ,  C07F9/5442

Abstract: The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer.

公开(公告)号：US20170249933A1

公开(公告)日：2017-08-31

申请号：US15324286

申请日：2015-07-09

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'AIX-MARSEILLE ,  ECOLE CENTRALE DE MARSEILLE

Inventor： Sergio BELLIZZI ,  Bruno COCHELIN ,  Renaud COTE ,  Philippe Martin HERZOG ,  Pierre-Olivier MATTEI ,  Marc PACHEBAT ,  Cedric PINHEDE

IPC: G10K11/178 ,  G10K11/00

Abstract: An attenuation device for attenuating sound waves, and a corresponding system and method, generated by a source emitting sound waves having frequencies between f1 and f2 and wherein the pressure levels are between n1 and n2. The attenuation device comprising at least one acoustic absorber comprising at least one non-linear membrane; the attenuation device being configured in such a way that the first face of the absorber is in acoustic communication with the source. The attenuation device also comprises at least one coupling element for coupling the second face with the source, the coupling element being configured to transmit to the second face sound waves according to the sound waves emitted by the source, and of which the phase and/or the amplitude leads to a pressure differential of the sound waves arriving respectively on the first and second face at the same time.

公开(公告)号：US20170233478A1

公开(公告)日：2017-08-17

申请号：US15492520

申请日：2017-04-20

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  INSTITUT JEAN PAOLI & IRENE CALMETTES ,  UNIVERSITE D'AIX-MARSEILLE ,  Universite Claude Bernard - Lyon 1 ,  Centre Leon Berard

Inventor： Julien Faget ,  Christophe Caux ,  Christine Menetrier-Caux ,  Jacques Nunes ,  Daniel Olive

IPC: C07K16/28

CPC classification number: C07K16/2818 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56972 ,  G01N33/57415

Abstract: The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNγ production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.

公开(公告)号：US20170191084A1

公开(公告)日：2017-07-06

申请号：US15304926

申请日：2015-04-20

Applicant: FONDATION MEDITERRANEE INFECTION ,  UNIVERSITE D'AIX MARSEILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

Inventor： Didier RAOULT ,  Saber KHELAIFIA ,  Michel DRANCOURT

IPC: C12P5/02 ,  C12P39/00

CPC classification number: C12P5/023 ,  C12N1/20 ,  C12N1/38 ,  C12P39/00 ,  Y02E50/343

Abstract: The present invention relates to the biological production of methane (Biogas) by co-culture in an aerobic atmosphere of a methanogenic bacterium and of an anaerobic bacterium capable of producing hydrogen, in a culture medium comprising or being supplemented with carbohydrate compound(s), notably starch and/or sugars, and supplemented with antioxidant compound(s).

公开(公告)号：US09637546B2

公开(公告)日：2017-05-02

申请号：US14282319

申请日：2014-05-20

Applicant: Universite d'Aix Marseille ,  INSERM (Institut National de la Sante et de la Recherche Medicale) ,  Institut Paoli Calmettes

Inventor： Daniel Olive ,  Nacer-Eddine Serriari ,  Jacques Nunes ,  Marguerite Ghiotto

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2896 ,  A61K2039/505 ,  C07K16/2827 ,  C07K2317/55 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

Abstract: The invention relates to PD-1 antibodies and PD-L1 antibodies and uses thereof.

公开(公告)号：US09605257B2

公开(公告)日：2017-03-28

申请号：US14403228

申请日：2013-05-24

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE D'AIX MARSEILLE ,  INSTITUT JEAN PAOLI & IRENE CALMETTES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Inventor： Daniel Baty ,  Patrick Chames

IPC: C40B30/04 ,  C12N15/10

CPC classification number: C12N15/1037 ,  C40B30/04

Abstract: The present invention relates to methods for selecting binders by phage display and masked selection. More particularly, the present invention relates to a method for selecting a plurality of binders specific for at least one relevant target comprising screening a phage binder library of binders against the relevant target in presence of a plurality of binders obtained from a library of binders directed against at least one irrelevant target and positively selecting the binders that are specific for the at least one relevant target.

公开(公告)号：US20170074876A1

公开(公告)日：2017-03-16

申请号：US15125409

申请日：2015-03-12

Applicant: INSERM (Institut National de la Sante et da la Recherche Medicale) ,  Universite d'Aix Marseille ,  GFRS (Groupe Francophone de Recherche sur la Sclerodermie Systemique)

Inventor： Nathalie Lambert ,  Fanny Arnoux ,  Doua Azzouz

IPC: G01N33/564

CPC classification number: G01N33/564 ,  G01N2800/104

Abstract: The present invention relates to an in vitro method for diagnosing lupus in a subject, said method comprising the step of detecting in a biological sample obtained from the subject the autoantibody recognizing the protein biomarker THEX1. More, the invention relates to kits and array useful for carrying out diagnosis methods according to the present invention.

Abstract translation: 本发明涉及一种用于诊断受试者的狼疮的体外方法，所述方法包括在从受试者获得的生物样品中检测识别蛋白质生物标志物THEX1的自身抗体的步骤。 更进一步地，本发明涉及可用于执行根据本发明的诊断方法的试剂盒和阵列。