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    Polypeptides for treating and/or limiting influenza infection
    86.
    发明授权
    Polypeptides for treating and/or limiting influenza infection 有权
    用于治疗和/或限制流感感染的多肽

    公开(公告)号：US09388217B2

    公开(公告)日：2016-07-12

    申请号：US14384901

    申请日：2013-03-12

    Applicant: University of Washington through its Center for Commercialization

    Inventor： David Baker ,  Timothy A. Whitehead ,  Sarel Fleishman

    IPC: A61K38/00 ,  A61K38/16 ,  A61K38/10 ,  C07K14/00 ,  C07K7/08 ,  G01N33/53 ,  G01N33/569

    CPC classification number: C07K14/00 ,  A61K38/00 ,  C07K7/08 ,  G01N33/56983 ,  G01N2333/11

    Abstract: Polypeptides that recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection are disclosed. Isolated nucleic acids encoding the polypeptides of the invention, recombinant expression vectors comprising the nucleic acids encoding the polypeptides of the invention operatively linked to a suitable control sequence, and recombinant host cells comprising the recombinant expression vectors of the invention are disclosed. Antibodies that selectively bind to the polypeptides of the invention, and pharmaceutical compositions comprising one or more polypeptides according to the invention and a pharmaceutically acceptable carrier are disclosed. Additionally, methods for treating and/or limiting an influenza infection, methods for diagnosing an influenza infection, or monitoring progression of an influenza infection, methods for identifying candidate influenza vaccines, and methods for identifying candidate compounds for treating, limiting, and/or diagnosing influenza infection are disclosed.

    Abstract translation: 公开了识别并且是甲型流感血凝素的强粘合剂并且可用于例如治疗和/或限制流感感染发展的多肽。 公开了编码本发明多肽的分离的核酸，包含编码可操作地连接到合适的对照序列的本发明的多肽的核酸的重组表达载体和包含本发明的重组表达载体的重组宿主细胞。 公开了选择性结合本发明的多肽的抗体以及包含一种或多种本发明的多肽和药学上可接受的载体的药物组合物。 另外，用于治疗和/或限制流感感染的方法，用于诊断流感感染的方法或监测流感感染的进展，用于鉴定候选流感疫苗的方法以及用于鉴定用于治疗，限制和/或诊断的候选化合物的方法 流行性感冒被披露。

    CONTROLLED CORONAL STIFFNESS PROSTHETIC ANKLE
    88.
    发明申请
    CONTROLLED CORONAL STIFFNESS PROSTHETIC ANKLE 审中-公开
    受控的冠状动脉僵硬前臂

    公开(公告)号：US20160151175A1

    公开(公告)日：2016-06-02

    申请号：US14905482

    申请日：2014-08-21

    Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

    Inventor： Glenn KLUTE ,  Jeffrey GORGES

    IPC: A61F2/66 ,  A61F2/70

    CPC classification number: A61F2/6607 ,  A61F2/70 ,  A61F2002/503 ,  A61F2002/5067 ,  A61F2002/5079 ,  A61F2002/701 ,  A61F2002/704 ,  A61F2002/7625 ,  A61F2002/764 ,  A61F2002/7645

    Abstract: A prosthetic ankle device and methods are provided herein to adjust stiffness of the prosthetic ankle. The prosthetic ankle including a base, and a vertical support having a first end pivotally coupled to the base. The prosthetic ankle may also include a first cantilever beam spring having a fixed end coupled to the base such that a length of the first cantilever beam spring in an unloaded position is substantially parallel to a longitudinal axis of the vertical support when (he vertical support is in a neutral position. The prosthetic ankle may also include a stiffness regulator movably coupled to the vertical support. The stiffness regulator may include a platform that defines a first contact surface adjacent the first cantilever beam spring. In addition, the stiffness regulator may pivot with the vertical support relative to the base.

    Abstract translation: 本文提供了一种假体脚踝装置和方法来调节假体踝的刚度。 包括基部的假体脚踝和具有枢转地联接到基部的第一端的垂直支撑件。 假肢脚踝还可以包括第一悬臂梁弹簧，其具有联接到基座的固定端，使得当处于垂直支撑的垂直支撑件（垂直支撑件）是垂直支撑件时，第一悬臂梁弹簧处于未加载位置的长度基本上平行于垂直支撑件的纵向轴线 假体脚踝还可以包括可移动地联接到垂直支撑件的刚度调节器，刚度调节器可以包括限定与第一悬臂梁弹簧相邻的第一接触表面的平台，另外，刚度调节器可以与 相对于底座的垂直支撑。

    METHODS FOR MATURING CARDIOMYOCYTES AND USES THEREOF
    89.
    发明申请
    METHODS FOR MATURING CARDIOMYOCYTES AND USES THEREOF 有权
    用于制备心脏纤维蛋白的方法及其用途

    公开(公告)号：US20160130555A1

    公开(公告)日：2016-05-12

    申请号：US14897403

    申请日：2014-06-12

    Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

    Inventor： Hannele RUOHOLA-BAKER ,  Kavitha KUPPUSAMY ,  Henrik SPERBER

    IPC: C12N5/077 ,  A61K35/34 ,  C12N15/113

    CPC classification number: C12N5/0657 ,  A61K35/34 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/30

    Abstract: Described herein are methods and compositions useful for inducing maturation of a cardiomyocyte to a mature (e.g., adult) phenotype, such that the function and morphology of the mature cardiomyocyte matches or more closely mimics that of the adult heart. The methods and compositions use Let-7 miRNAs and modified forms thereof. Such methods and compositions permit the study and treatment of adult-onset cardiac diseases, disorders or injuries with mature cardiomyocytes that mimic the heart function of an adult. Methods of using cardiomyocytes matured in this manner for drug identification and drug cardiotoxicity testing are also provided.

    Abstract translation: 本文描述的是用于诱导成熟（例如成人）表型的心肌细胞成熟的方法和组合物，使得成熟心肌细胞的功能和形态与成人心脏的功能和形态相匹配或更接近。 方法和组合物使用Let-7 miRNA及其修饰形式。 这些方法和组合物允许研究和治疗成人心脏病，成熟心肌细胞的障碍或损伤，其模拟成人的心脏功能。 还提供了以这种方式成熟的心肌细胞用于药物鉴定和药物心脏毒性测试的方法。

    STIMULI-RESPONSIVE MAGNETIC NANOPARTICLES
    90.
    发明申请
    STIMULI-RESPONSIVE MAGNETIC NANOPARTICLES 审中-公开
    刺激性磁性纳米粒子

    公开(公告)号：US20160116464A1

    公开(公告)日：2016-04-28

    申请号：US14893926

    申请日：2014-05-29

    Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION ,  NEXGENIA, INC.

    Inventor： Patrick S. Stayton ,  Jriuan Lai ,  Dagmara Monfort ,  Barrett James Nehilla

    IPC: G01N33/543

    CPC classification number: G01N33/54333 ,  A61K49/1839 ,  G01N2446/20 ,  G01N2446/84

    Abstract: The present disclosure provides stimuli-responsive magnetic nanoparticles, methods of making the magnetic nano-particles, and methods of using the magnetic nanoparticles. The magnetic nanoparticles include a metal oxide core; and a shell that includes a stimuli-responsive polymer having a terminal group that directly coordinates to the metal oxide core. The stimuli-responsive polymer does not include a micelle-forming group, at least at a proximal terminus of the polymer, with respect to the metal oxide core.

    Abstract translation: 本公开提供了刺激响应磁性纳米颗粒，制备磁性纳米颗粒的方法以及使用磁性纳米颗粒的方法。 磁性纳米颗粒包括金属氧化物核; 以及包含具有直接与金属氧化物核心配位的末端基团的刺激响应型聚合物的壳。 相对于金属氧化物核，刺激响应性聚合物至少在聚合物的近端处不包括胶束形成基团。

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