公开(公告)号：US06734967B1

公开(公告)日：2004-05-11

申请号：US09248876

申请日：1999-02-11

Applicant: Timothy R. Piwonka-Corle ,  Karen F. Scoffone ,  Xing Chen ,  Lloyd J. Lacomb, Jr. ,  Jean-Louis Stehle ,  Dorian Zahorski ,  John-Pierre Rey

Inventor： Timothy R. Piwonka-Corle ,  Karen F. Scoffone ,  Xing Chen ,  Lloyd J. Lacomb, Jr. ,  Jean-Louis Stehle ,  Dorian Zahorski ,  John-Pierre Rey

IPC: G01N2121

CPC classification number: G01N21/211

Abstract: A method and system for spectroscopic ellipsometry employing reflective optics to measure a small region of a sample by reflecting radiation (preferably broadband UV, visible, and near infrared radiation) from the region. The system preferably has an autofocus assembly and a processor programmed to determine from the measurements the thickness and/or complex refractive index of a thin film on the sample. Preferably, only reflective optics are employed along the optical path between the polarizer and analyzer, a sample beam reflects with low incidence angle from each component of the reflective optics, the beam is reflectively focused to a small, compact spot on the sample at a range of high incidence angles, and an incidence angle selection element is provided for selecting for measurement only radiation reflected from the sample at a single, selected angle (or narrow range of angles). The focusing mirror preferably has an elliptical shape to reduce off-axis aberrations in the focused beam. Some embodiments include both a spectrophotometer and an ellipsometer integrated together as a single instrument. In such instrument, the spectrophotometer and ellipsometer share a radiation source, and radiation from the source can be focused by either the spectrophotometer or the ellipsometer to the same focal point on a sample. Preferred embodiments of the ellipsometer employ a rotating, minimal-length Rochon prism as a polarizer, and include a spectrometer with an intensified photodiode array to measure reflected radiation from the sample, and a reference channel (in addition to a sample channel which detects radiation reflected from the sample).

Abstract translation: 使用反射光学器件的光谱椭偏仪的方法和系统通过从该区域反射辐射（优选宽带UV，可见光和近红外辐射）来测量样品的小区域。 该系统优选地具有自动对焦组件和被编程用于根据测量结果确定样品上薄膜的厚度和/或复合折射率的处理器。 优选地，沿着偏振器和分析器之间的光路仅采用反射光学元件，样品光束以反射光学器件的每个分量以低入射角反射，光束被反射聚焦到样品上的小的紧密斑点 并且提供入射角选择元件用于仅选择仅以单个选定角度（或窄范围的角度）从样品反射的辐射。 聚焦镜优选具有椭圆形以减少聚焦光束中的离轴像差。 一些实施例包括作为单个仪器集成在一起的分光光度计和椭偏仪。 在这种仪器中，分光光度计和椭偏仪共享一个辐射源，来自源的辐射可以通过分光光度计或椭偏仪聚焦到样品上的同一焦点。 椭偏仪的优选实施例采用旋转的，最小长度的Rochon棱镜作为偏振器，并且包括具有增强的光电二极管阵列的光谱仪，以测量来自样品的反射辐射，以及参考通道（除了检测辐射的样品通道 从样品）。

公开(公告)号：US06593137B1

公开(公告)日：2003-07-15

申请号：US09386658

申请日：1999-08-31

Applicant: Bernard F. Erlanger ,  Bi-Xing Chen

Inventor： Bernard F. Erlanger ,  Bi-Xing Chen

IPC: C12N520

CPC classification number: B82Y30/00 ,  B82Y5/00 ,  C07K16/44 ,  G01N33/5308 ,  G01N2430/00 ,  Y10S530/807

Abstract: This invention provides a hybridoma produced by the fusion of a mouse antibody-producing cell and a mouse myeloma which is designated 1-10F-8A and deposited with the ATCC under Accession Number PTA-279, said hybridoma producing a monoclonal antibody which binds to fullerene C60. This invention provides a mouse monoclonal antibody specific for a fullerene-C60 and produced by the mouse monoclonal antibody-producing hybridoma designated 1-10F-8A. The invention provides the amino acid and encoding nucleic acid sequences of the heavy and light chains of the 1-10F-8A monoclonal antibody. This invention also provides methods of determining a serum concentration of a fullerene in a subject and of purifying a fullerene from a sample.

Abstract translation: 本发明提供了通过将小鼠抗体产生细胞与小鼠骨髓瘤融合而产生的杂交瘤，其被命名为1-10F-8A，并以保藏号PTA-279保藏在ATCC中，所述杂交瘤产生结合富勒烯的单克隆抗体 C60。 本发明提供了对富勒烯-C60特异性并由指定为1-10F-8A的产生小鼠单克隆抗体的杂交瘤产生的小鼠单克隆抗体。 本发明提供1-10F-8A单克隆抗体的重链和轻链的氨基酸和编码核酸序列。 本发明还提供了确定受试者中富勒烯的血清浓度并从样品中纯化富勒烯的方法。

公开(公告)号：US06559408B2

公开(公告)日：2003-05-06

申请号：US10143061

申请日：2002-05-10

Applicant: Donald K. Smith ,  Xing Chen ,  William M. Holber ,  Eric Georgelis

Inventor： Donald K. Smith ,  Xing Chen ,  William M. Holber ,  Eric Georgelis

IPC: B23K1000

CPC classification number: H01J37/32009 ,  H01J27/16 ,  H01J37/321 ,  H01J37/32357 ,  H01J37/32862

Abstract: An apparatus for dissociating gases includes a plasma chamber that may be formed from a metallic material and a transformer having a magnetic core surrounding a portion of the plasma chamber and having a primary winding. The apparatus also includes one or more switching semiconductor devices that are directly coupled to a voltage supply and that have an output coupled to the primary winding of the transformer. The one or more switching semiconductor devices drive current in the primary winding that induces a potential inside the chamber that forms a plasma which completes a secondary circuit of the transformer.

公开(公告)号：US06470170B1

公开(公告)日：2002-10-22

申请号：US09858620

申请日：2001-05-16

Applicant: Hai Xing Chen ,  Qiang Li

Inventor： Hai Xing Chen ,  Qiang Li

IPC: G09B300

CPC classification number: G09B5/14 ,  G09B7/04

Abstract: A system for learning and examination training is disclosed. A student can log on the system through a website to review training history, to access a menu of levels of practice examinations of interest to him, and to select training exams on the website. During the examination, the student is able to indicate whether or not help is required at any given point or question. Without regard to whether or not the student believes help is required, all students are subject to a dynamic/interactive evaluation of responses in which a teacher who is on-line with the same website at the time of the student is able to intervene during an examination to invoke help options for the student. In the first instance, the teacher can intervene to change the exam level to either a lower or to a higher one. Among the help options available to a student during an examination within a given level are “auto coach” in which the student is provided with hints and examples; an adaptive question selection in which variations of the same questions are drawn from a database; real time talk support in which the on-line teacher can communicate with the student at the time that this option is invoked; and a multi-solution select option in which a database presents multiple means of problem to accommodate or discover the learning style of the student. The student can be scored, timed and graded in a variety of modes both during and after the examination.

Abstract translation: 披露了一个学习和考试培训系统。 学生可以通过网站登录系统，查看培训历史，访问他感兴趣的练习水平菜单，并在网站上选择培训考试。 在考试期间，学生能够表明在任何一点或问题上是否需要帮助。 不考虑学生是否需要帮助，所有学生都需要进行动态/互动的评估，在学生的同一网站在线同一网站的老师可以在 考试为学生提供帮助选择。 首先，老师可以进行干预，将考试级别更改为较低或更高级别。 在给定级别的考试期间，学生可以使用的帮助选项是“汽车教练”，其中提供了学生的提示和示例; 一种自适应问题选择，其中从数据库中提取相同问题的变体; 实时谈话支持，在线教师可以在调用此选项时与学生交流; 以及多解决方案选择选项，其中数据库提供多种问题的方式来适应或发现学生的学习风格。 在考试期间和考试之后，学生可以以各种模式得分，时间和等级。

公开(公告)号：US06452488B1

公开(公告)日：2002-09-17

申请号：US09770264

申请日：2001-01-26

Applicant: Yuan Jing He ,  Bi-Xing Chen

Inventor： Yuan Jing He ,  Bi-Xing Chen

IPC: B60Q126

CPC classification number: B60R25/104 ,  B60Q1/2611 ,  B60R25/1003

Abstract: A vehicle theft indicating device for alerting the police and others that the vehicle is stolen. The vehicle theft indicating device includes a light-emitting support member being adapted to be securely attached to a top of a roof of a vehicle; and also includes a light-emitting assembly including a light socket member being securely attached to the light-emitting support member and being adapted to be connected to a power supply, and also including a light-emitting member being disposed in the light socket member, and further including a transmitter for activating the light-emitting member; and further includes a transparent cover being removably disposed over the light-emitting member and being securely attached to the light-emitting support member with fasteners.

Abstract translation: 一种车辆盗窃指示装置，用于警告警察和其他人车辆被盗。 车辆盗窃指示装置包括适于牢固地附接到车辆顶部的发光支撑构件; 并且还包括发光组件，其包括牢固地附接到发光支撑构件并且适于连接到电源的灯座构件，并且还包括布置在灯座构件中的发光构件， 并且还包括用于激活所述发光构件的发射器; 并且还包括可移除地设置在所述发光构件上方并且用紧固件牢固地附接到所述发光支撑构件的透明盖。

公开(公告)号：US06388226B1

公开(公告)日：2002-05-14

申请号：US09502087

申请日：2000-02-10

Applicant: Donald K. Smith ,  Xing Chen ,  William M. Holber ,  Eric Georgelis

Inventor： Donald K. Smith ,  Xing Chen ,  William M. Holber ,  Eric Georgelis

IPC: B23K1000

CPC classification number: H01J37/32009 ,  H01J27/16 ,  H01J37/321 ,  H01J37/32357 ,  H01J37/32862

Abstract: An improved toroidal low-field plasma source allows plasma ignition within a wider range of gas conditions than permitted by prior art plasma sources. Power efficiency of the plasma source is improved by automatically adjusting the power delivered to the plasma based on the load to the power supply. The plasma source can be operated over a wider pressure range than allowed by prior art plasma sources. The plasma source can be operated so as to increase the output of atomic species from the source. The plasma source can be operated to increase the etch rate of organic materials. The plasma source can efficiently remove hazardous gas compounds from effluent gas streams by converting them into scrubbable products.

Abstract translation: 改进的环形低场等离子体源允许在比现有技术的等离子体源允许的更宽的气体条件范围内等离子体点火。 通过根据对电源的负载自动调节输送到等离子体的功率来提高等离子体源的功率效率。 等离子体源可以在比现有技术的等离子体源允许的更宽的压力范围内操作。 可以操作等离子体源，以便增加来自源的原子物质的输出。 可以操作等离子体源以增加有机材料的蚀刻速率。 通过将等离子体源转换成可擦洗的产品，等离子体源可以有效地从废气流中去除有害气体化合物。

公开(公告)号：US5604092A

公开(公告)日：1997-02-18

申请号：US390133

申请日：1995-02-17

Applicant: Bernard F. Erlanger ,  Bi-Xing Chen

Inventor： Bernard F. Erlanger ,  Bi-Xing Chen

IPC: A61K38/00 ,  A61K47/48 ,  C07K7/64 ,  C07K16/10 ,  C07K16/14 ,  C07K16/42 ,  C07K16/44 ,  C12P21/08 ,  G01N33/68 ,  G01N33/96 ,  C12Q1/70 ,  C07K16/00 ,  G01N33/53

CPC classification number: A61K47/48284 ,  C07K16/1054 ,  C07K16/14 ,  C07K16/4208 ,  C07K16/44 ,  C07K7/645 ,  G01N33/68 ,  G01N33/96 ,  A61K38/00 ,  G01N2410/08

Abstract: Monoclonal antibodies to cyclosporine A (CsA), a potent immunosuppressant, were generated in Balb/c mice using a novel antigen prepared by linking CsA to a protein carrier via a photoactive cross-linking reagent, 4-benzoylbenzoic acid (BBa). Twenty-two monoclonal anti-CsA antibodies were generated, using CsA-BBa-bovine serum albumin (CsA-BBa-BSA) as the immunogen. Epitope mapping studies were performed using a series of singly substituted CsA derivatives and an antibody was identified that recognizes N-methyl leucine residues 9 and 10 of CsA. This antibody also cross-reacts with the HIV-1 Gag protein. A method for the detection of HIV-1 in patient samples employing this monoclonal antibody is disclosed.

Abstract translation: 使用通过光活化交联剂4-苯甲酰基苯甲酸（BBa）将CsA与蛋白质载体连接而制备的新型抗原，在Balb / c小鼠中产生环孢菌素A（CsA）的单克隆抗体，其是有效的免疫抑制剂。 使用CsA-BBa-牛血清白蛋白（CsA-BBa-BSA）作为免疫原，产生二十二种单克隆抗CsA抗体。 使用一系列单取代的CsA衍生物进行表位作图研究，并鉴定出识别CsA的N-甲基亮氨酸残基9和10的抗体。 该抗体也与HIV-1Gag蛋白交叉反应。 公开了使用该单克隆抗体检测患者样品中HIV-1的方法。

公开(公告)号：US5332811A

公开(公告)日：1994-07-26

申请号：US693300

申请日：1991-05-01

Applicant: Kuo-Hsiung Lee ,  Xiao-Ming Zhou ,  Zhe-Qing Wang ,  Jang-Yang Chang ,  Hong-Xing Chen ,  Yung-Chi Cheng ,  Ya-Ching Shen ,  Fu-Shen Han ,  Hong Hu ,  Yi-Lin Zhang

Inventor： Kuo-Hsiung Lee ,  Xiao-Ming Zhou ,  Zhe-Qing Wang ,  Jang-Yang Chang ,  Hong-Xing Chen ,  Yung-Chi Cheng ,  Ya-Ching Shen ,  Fu-Shen Han ,  Hong Hu ,  Yi-Lin Zhang

IPC: C07D493/04 ,  C07D413/02 ,  C07D307/77

CPC classification number: C07D493/04

Abstract: Compounds which are analogs of etoposide and which exhibit anti-tumor activity are disclosed. These compounds having the following structure: ##STR1## wherein R is selected from ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are each independently selected from H, CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.7, i--C.sub.3 H.sub.7, C.sub.4 H.sub.9, CF.sub.3, OCH.sub.3, OC.sub.2 H.sub.5 , OC.sub.3 H.sub.7, OC.sub.4 H.sub.9, O--i--C.sub.3 H.sub.7, O--i--C.sub.4 H.sub.9, --OCH.sub.2 O--, --OCH.sub.2 CH.sub.2 O--, CH.sub.2 OH, C.sub.2 H.sub.4 OH, CH.sub.2 Cl C.sub.2 H.sub.4 Cl, CH.sub.2 F, C.sub.2 H.sub.4 F, CH.sub.2 OCH.sub.3, COCH.sub.3, COC.sub.2 H.sub.5, CO.sub.2 CH.sub.3, CO.sub.2 C.sub.2 H.sub.5, NO.sub.2, NH.sub.2, NH.sub.2.HCl, NH.sub.2.HAc, NH.sub.2.1/2H.sub.2 SO.sub.4 , NH.sub.2.1/3H.sub.3 PO.sub.4, N(CH.sub.3).sub.2, N(C.sub.2 H.sub.5).sub.2, OH, CN, N.sub.3, SO.sub.2 H, SO.sub.2 NH.sub.2 , SO.sub.2 Cl, phenyl, substituted phenyl, phenoxy, substituted phenoxy, anilinyl, substituted anilinyl, cyclohexyl, piperidine, ##STR3## wherein R.sub.6 is selected from hydrogen, methyl, ethyl, n-propyl, i-propyl, butyl and bridged methylene;wherein R.sub.7 is selected from ##STR4##

Abstract translation: 公开了依托泊苷的类似物并表现出抗肿瘤活性的化合物。 这些具有以下结构的化合物：其中R选自和，其中R1，R2，R3，R4和R5各自独立地选自H，CH3，C2H5，C3H7，i-C3H7，C4H9 ，CF3，OCH3，OC2H5，OC3H7，OC4H9，Oi-C3H7，O_4H9，-OCH2O-，-OCH2CH2O-，CH2OH，C2H4OH，CH2Cl C2H4Cl，CH2F，C2H4F，CH2OCH3，COCH3，COC2H5，CO2CH3，CO2C2H5， ，NH2，NH2HCl，NH2HAc，NH2 / 2H2SO4，NH2 / 3H3PO4，N（CH3）2，N（C2H5）2，OH，CN，N3，SO2H，SO2NH2，SO2Cl， 苯基，苯氧基，取代的苯氧基，苯乙烯基，取代的苯乙烯基，环己基，哌啶，其中R 6选自氢，甲基，乙基，正丙基，异丙基，丁基和桥连亚甲基; 其中R7选自

公开(公告)号：US11344008B1

公开(公告)日：2022-05-31

申请号：US16295155

申请日：2019-03-07

Applicant: Hai Xing Chen ,  Hong Yang Wang ,  Zhongtian Qi

Inventor： Hai Xing Chen ,  Hong Yang Wang ,  Zhongtian Qi

IPC: A01K67/027 ,  C12N9/22 ,  C12N15/85

Abstract: A method of producing a non-erythroid protein in erythrocytes of a transgenic animal using an erythroid-specific promoter includes synthesizing an erythroid-specific globin gene promoter and globin gene locus control region and cloning the promoter and the globin gene locus control region and a gene encoding a non-erythroid protein into a vector to obtain a transgene; introducing the transgene in pronuclear embryos collected from a mammalian animal in vitro; transplanting the pronuclear embryos containing the transgene into oviduct of a female recipient of the mammalian animal to obtain a transgenic animal which then expresses the non-erythroid protein in progenitor cells of erythrocytes; and collecting blood from the transgenic animal and isolating the non-erythroid protein from the erythrocytes. Further disclosed are a transgenic animal expressing a non-erythroid protein in progenitor cells of erythrocytes and an isolated erythrocyte of a non-human transgenic animal containing a human non-erythroid protein encoded by a transgene.

公开(公告)号：US10364511B1

公开(公告)日：2019-07-30

申请号：US15279867

申请日：2016-09-29

Applicant: Xing Chen ,  Ziyao Zhou

Inventor： Xing Chen ,  Ziyao Zhou

IPC: D01D5/00 ,  B33Y10/00 ,  B33Y30/00

Abstract: A system for incorporating ferromagnetic materials into several microwave application is described. The system employs a multi-layer substrate. A substrate for receiving microwave signals uses a base layer which has tunable elements and a nanofiber layer which uses magnetic nanotubes. The nanofibers have a high aspect ratio and the nanofiber layer is embedded in the base layer.