摘要:
A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein.
摘要:
Monoclonal antibodies that are specific for vascular endothelial growth factor receptor 1 (VEGFR-I). This invention also provides nucleotide sequences encoding and amino acid sequences comprising variable heavy and light chain immunoglobulin molecules, including sequences corresponding to the complementarity determining regions of CDR1, CDR2, and CDR3. The invention also provides methods for generation and expression of anti -VEGFR-I antibodies and methods of treating angiogenic-related disorders and reducing tumor growth by administering anti-VEGFR-I antibodies.
摘要:
A PMR writer in a read/write head is disclosed wherein an upper shield covering the coil layer is comprised of a magnetic layer optimized for magnetic performance and a second layer used for tuning mechanical protrusion. The composite layer simultaneously provides high saturation magnetization and high permeability from the magnetic layer and low CTE from the second layer which tunes the relative spacing between the writer, reader, and the rest of the slider. In one embodiment, first and second write shields are formed on a write gap layer and have front portions at the ABS and back portions in a back gap region. The upper write shield connects on one side with the second write shield at the ABS and on a second side with the back gap region. This design can yield better reader and writer spacing for the same physical clearance which enables products with higher recording density.
摘要:
The present invention provides a position mechanism including a locating body. The locating body defines a locating cavity and a receiving chamber communicating with the locating cavity. A locating stopper is received in the receiving chamber of the locating body with an end thereof toward the locating cavity, and an elastic component is received in the receiving chamber of the locating body and resiliently biases the locating stopper into the locating cavity.
摘要:
An optical refractometer is provided for measuring the refractive index of a liquid. Such a refractometer includes a first optical block having a transparent material whereto is secured a light source, a second optical block having a transparent material whereto is secured a position sensor. The optical blocks are arranged on either side of a conduit wherein the liquid flows.
摘要:
The invention provides various antibodies that bind to insulin-like growth factor-I receptor (IGF-1R), methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, cancer or aging. The antibodies include murine, chimeric, and humanized antibodies.
摘要:
A mold insert positioning mechanism of an injection mold includes a top clamping plate, a cavity insert, a restricting bar, multiple screws and a cavity plate fastened on the top clamping plate. The mold cavity is arranged in an approximate central position of the cavity plate so as to form a locating surface, a second back side and a third wall. The accepting space is arranged on the edge of the cavity plate and communicates with the mold cavity so as to form a first front side, a first connecting side, a second front and a connecting side. The second back side urges the cavity insert to move in on the locating surface so as to position the cavity insert once the cavity insert moves in the mold cavity. Multiple screws lock the restricting bar and the cavity plate as an integral so that the cavity insert is positioned in the mold cavity completely.
摘要:
The invention provides anti-Robo4 antibodies, and compositions comprising the antibodies and methods of using these antibodies, including diagnostic and therapeutic methods.