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188 条记录 (耗时 0.046 秒)

    Antibodies against vascular endothelial growth factor receptor-1
    1.
    发明授权
    Antibodies against vascular endothelial growth factor receptor-1 有权
    抗血管内皮生长因子受体-1的抗体

    公开(公告)号：US08143025B2

    公开(公告)日：2012-03-27

    申请号：US13112152

    申请日：2011-05-20

    申请人： Yan Wu ,  Peter Bohlen ,  Daniel J. Hicklin

    发明人： Yan Wu ,  Peter Bohlen ,  Daniel J. Hicklin

    IPC分类号： C12P21/06 ,  C12P19/30 ,  C07H21/04

    CPC分类号： C07K16/2863 ,  A61K39/39541 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

    摘要： Monoclonal antibodies that are specific for vascular endothelial growth factor receptor 1 (VEGFR-I). This invention also provides nucleotide sequences encoding and amino acid sequences comprising variable heavy and light chain immunoglobulin molecules, including sequences corresponding to the complementarity determining regions of CDR1, CDR2, and CDR3. The invention also provides methods for generation and expression of anti-VEGFR-I antibodies and methods of treating angiogenic-related disorders and reducing tumor growth by administering anti-VEGFR-I antibodies.

    摘要翻译： 对血管内皮生长因子受体1（VEGFR-1）特异的单克隆抗体。 本发明还提供编码核苷酸序列和包含可变重链和轻链免疫球蛋白分子的氨基酸序列，其包括对应于CDR1，CDR2和CDR3的互补决定区的序列。 本发明还提供了用于产生和表达抗VEGFR-1抗体的方法以及通过施用抗VEGFR-1抗体治疗血管生成相关病症并降低肿瘤生长的方法。

    Antibodies against vascular endothelial growth factor receptor-1
    3.
    发明授权
    Antibodies against vascular endothelial growth factor receptor-1 有权
    抗血管内皮生长因子受体-1的抗体

    公开(公告)号：US07972596B2

    公开(公告)日：2011-07-05

    申请号：US11719677

    申请日：2005-11-18

    申请人： Yan Wu ,  Danny J. Hicklin ,  Peter Bohlen

    发明人： Yan Wu ,  Danny J. Hicklin ,  Peter Bohlen

    IPC分类号： A61K39/395 ,  C12P21/08 ,  C07K16/18 ,  C07K16/28

    CPC分类号： C07K16/2863 ,  A61K39/39541 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

    摘要： Monoclonal antibodies that are specific for vascular endothelial growth factor receptor 1 (VEGFR-I). This invention also provides nucleotide sequences encoding and amino acid sequences comprising variable heavy and light chain immunoglobulin molecules, including sequences corresponding to the complementarity determining regions of CDR1, CDR2, and CDR3. The invention also provides methods for generation and expression of anti -VEGFR-I antibodies and methods of treating angiogenic-related disorders and reducing tumor growth by administering anti-VEGFR-I antibodies.

    摘要翻译： 对血管内皮生长因子受体1（VEGFR-1）特异的单克隆抗体。 本发明还提供编码核苷酸序列和包含可变重链和轻链免疫球蛋白分子的氨基酸序列，其包括对应于CDR1，CDR2和CDR3的互补决定区的序列。 本发明还提供了产生和表达抗-VEGFR-1抗体的方法以及通过施用抗VEGFR-1抗体治疗血管生成相关病症并降低肿瘤生长的方法。

    Writer shields with modified shapes for reduced flux shunting
    9.
    发明授权
    Writer shields with modified shapes for reduced flux shunting 有权
    作者盾牌具有改进的形状，用于减少通量分流

    公开(公告)号：US08542461B2

    公开(公告)日：2013-09-24

    申请号：US12806803

    申请日：2010-08-20

    申请人： Zhigang Bai ,  Moris Dovek ,  Yan Wu

    发明人： Zhigang Bai ,  Moris Dovek ,  Yan Wu

    IPC分类号： G11B5/147 ,  G11B5/187

    CPC分类号： G11B5/3163 ,  G11B5/1278 ,  G11B5/3116 ,  G11B5/312 ,  G11B5/3146

    摘要： A perpendicular magnetic recording (PMR) head is fabricated with a configuration of leading edge shields and trailing edge shields that reduce the leakage of flux between the main pole and the shields. The reduction of leakage is achieved by eliminating the sharp 90° corner between the backside surfaces of the shields and the surfaces adjacent to the main pole. In one embodiment the corner is replaced by two successive acute angles, in another embodiment it is replaced by a rounded surface. In a final embodiment, leakage between the pole and trailing edge shield is achieved by shortening the length of the write gap by forming the shield with a double taper.

    摘要翻译： 垂直磁记录（PMR）头被制造成具有前缘屏蔽和后缘屏蔽的结构，其减小主极和屏蔽之间的通量泄漏。 通过消除屏蔽的背面和与主极相邻的表面之间的尖锐的90°角来实现泄漏的减少。 在一个实施例中，角部被两个连续的锐角取代，在另一个实施例中，它被圆形表面所代替。 在最终实施例中，通过用双锥形形成屏蔽来缩短写入间隙的长度来实现极和后缘屏蔽之间的泄漏。