摘要:
A bowling lane maintenance machine utilizes flexible wick segments to transfer lane dressing to the applicator roll of the machine. The wick segments are caused to flex into and out of contacting engagement with a transfer roll associated with the applicator roll by rotatable cams that engage cam followers associated with the wick segments. The cams are all secured to a common cam shaft and are rotated in unison through successive short segments of rotational travel by an indexing motor that responds to a controller. Each wick segment has at least one spring that urges the segment into contacting engagement with the transfer roll, while the cam for that segment is disposed to engage the follower and flex the wick segment off the transfer roll against the action of the spring when the lobe of the cam is in contacting engagement with the follower.
摘要:
The present invention relates to novel compositions comprising polymeric moieties covalently attached to therapeutic agents, wherein the therapeutic agent is attached to the polymeric moiety through a tether. By selecting from a variety of tether groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein.
摘要:
A method is provided for making an integrated circuit dielectric. A structure-directing agent (SDA) is provided. Preferably this structure-directing agent is a salt of a polycyclic organic compound. By use of the structure-directing agent, a film of a zeolite having a framework density below 15 T atoms per 1000 cubic angstroms and comprising primarily silicon and/or germanium atoms in the T positions is provided on a semiconductor substrate. Preferably the zeolite has the LTA structure. The structure-directing agent is removed from the film. The removal may be effected, for example, by heating or by chemically and/or photochemically decomposing the structure-directing agent, preferably in a manner which allows it to be recovered. The film is then optionally modified to reduce its hydrophilicity.
摘要:
A bowling lane conditioning machine has dressing application mechanism that includes an elongated, non-rotating strip brush which transfers dressing from a dispensing means to another surface, such as a bristle-type, lane-engaging applicator roll, a metal transfer roll that in turn transfers the dressing to the applicator roll, or the lane surface itself. In a preferred embodiment, dressing is dispensed to an upper one of two strip brushes that extend along the length of an applicator roll and engage its bristles at circumferentially spaced locations around its periphery. Dressing dispensed to the upper strip brush migrates by gravity to the bristles of the applicator roll and becomes applied to the lane surface as the roll rotates down into engagement with the surface. No dressing is dispensed to the second strip brush, which feathers the dressing on the applicator roll and reduces splattering.
摘要:
The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要:
A rollable sports ballast base for supporting a sports apparatus support member comprising a base member having a top surface and a bottom surface. The bottom surface contacts a support surface such as a driveway or other playing surface. There is at least one wheel assembly, retractable from a lower position to a raised position. The wheel assembly includes a pivoting connector coupled to the base member and a wheel bracket coupled to the pivoting connector. The wheel bracket includes an axle, at least one wheel, and a handle extending outwardly from the wheel bracket. The handle is used to pivotally rotate the wheel assembly about a transverse axis. When the handle is rotated away from the base member, the wheel assembly is placed in a lowered position whereby the wheel contacts the support surface thus separating the bottom surface of the base member from the support surface.
摘要:
Supported phase catalysts in which the support phase is highly polar, most preferably ethylene glycol or glycerol, are disclosed. An organometallic compound, preferably a metal complex of chiral sulfonated 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP) is dissolved in the support phase. Such supported phase catalysts are useful for asymmetric synthesis of optically active compounds, including the asymmetric hydrogenation of prochiral unsaturated carbon-hetero atom bonds, such as ketones, imines and beta-keto esters. The phenyl groups of the BINAP ligand are at least meno-sulfonated and the ligand overall is terra- to hexa-sulfonated. Ruthemium is the perferred metal.
摘要:
Mesoporous, alumina compositions having an average pore diameter substantially ranging from about 15 .ANG. to about 40 .ANG. and an average surface area of no less than about 500 meter square/gram are disclosed. These materials can be formed by treating an aluminum source that is derived from an aluminum alkoxide in an organic-aqueous solution with an organic structured directing agent to form meso-sized micelles followed by calcination of the resulting composition. Appropriate organic structural directing agents are alkyl carboxylic acids.
摘要:
The present invention relates to water soluble chiral sulfonated 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl and its use as organometallic catalysts for asymmetric synthesis of optically active compounds. Asymmetric reactions of the present invention include those reactions in which organometallic catalysts are commonly used. Such reactions include, but are not limited to, reduction and isomerization reactions on unsaturated substrates and carbon--carbon bond forming reactions. Examples of such reactions include, but are not limited to, hydrogenation, hydroboration, hydrosilylation, hydride reduction, hydroformylation, alkylation, allylic alkylation, arylation, alkenylation, epoxidation, hydrocyanation, disilylation, cyclization and isomerization reactions. The catalysts of the present invention provide the advantage of functioning in the presence of water without loss in enantioselectivity relative to the nonsulfonated BINAP catalyst in an organic solvent. As a result, the catalysts of the present invention may be employed in water, water miscible solvents, in aqueous-organic two phase solvent systems and in supported aqueous phase catalysts in organic solvents without loss in enantioselectivity. Further, the catalysts of the present invention may also be effectively employed in highly polar solvents such as primary alcohols and ethylene glycol. The present invention also relates to a method for conducting asymmetric reactions on prochiral unsaturated bonds contained within a compound using the water soluble chiral sulfonated 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl organometallic catalysts of the present invention.