公开(公告)号：US07070822B1

公开(公告)日：2006-07-04

申请号：US10327023

申请日：2002-12-20

申请人： Yong-Cheng Shi ,  Yayun Liu ,  Robert L. Billmers ,  Russell Stoop ,  David Huang

发明人： Yong-Cheng Shi ,  Yayun Liu ,  Robert L. Billmers ,  Russell Stoop ,  David Huang

IPC分类号： A23L1/09

CPC分类号： A23L29/35 ,  A23L29/219

摘要： The present invention is directed toward a free flowing powdered blend of a polysaccharide and a crystalline polyol for use as an edible adhesive for particulate materials such as seasonings and flavorings. The powdered adhesive blend can easily be mixed with seasonings or flavorings and will melt during a heating process to a sticky viscose liquid capable of adhering seasoning particles to the food substrate. The blends of the present invention have the benefits of being easy to prepare, use and store as they will stay a free flowing powder under most ambient conditions.

摘要翻译： 本发明涉及多糖和结晶多元醇的自由流动的粉末状共混物，用作颗粒材料如调味料和调味剂的食用粘合剂。 粉状粘合剂混合物可以容易地与调味料或调味剂混合，并且将在加热过程中熔化成能够将调味颗粒粘附到食品基材上的粘性粘胶液体。 本发明的共混物具有易于制备，使用和储存的优点，因为它们将在大多数环境条件下保持自由流动的粉末。

公开(公告)号：US20050113741A1

公开(公告)日：2005-05-26

申请号：US10965314

申请日：2004-10-14

申请人： David Huang ,  John Hall ,  Mark Goodin ,  David Thompson

发明人： David Huang ,  John Hall ,  Mark Goodin ,  David Thompson

IPC分类号： A61F9/007 ,  A61M1/00

CPC分类号： A61M1/0031 ,  A61F9/00736 ,  A61M1/0064

摘要： A device for, when connected to a vacuum system, conducting aspiration fluid away from a surgical site includes a conduit having a portion adapted for insertion into the surgical site. The device also includes a flow limiter interposed between the vacuum system and the conduit and in fluid communication with the conduit. The flow limiter has at least two orifices arranged in series and a flow path interconnecting the at least two orifices. The flow path has a flow area that is greater than a flow area of each one of the at least two orifices. Aspiration fluid flows through the conduit and the flow limiter in response to a pressure drop between the surgical site and the vacuum system. The flow limiter produces a non-linear relationship between a rate of aspiration fluid flow and the pressure drop.

摘要翻译： 用于当连接到真空系统时将远离外科手术部位的吸引流体连接的装置包括具有适于插入外科手术部位的部分的导管。 该装置还包括插入在真空系统和导管之间并与导管流体连通的限流器。 流量限制器具有串联布置的至少两个孔和将至少两个孔相互连接的流路。 流动路径具有大于至少两个孔中的每一个的流动面积的流动面积。 吸入流体响应于手术部位和真空系统之间的压降而流过导管和流量限制器。 流量限制器在抽吸流体流量和压降之间产生非线性关系。

公开(公告)号：US20050064593A1

公开(公告)日：2005-03-24

申请号：US10479307

申请日：2002-05-30

申请人： Andreas Strasser ,  Hamsa Puthalakath ,  Andreas Villunger ,  Leigh Coultas ,  Jennifer Beaumont ,  Lorraine O'reilly ,  David Huang

发明人： Andreas Strasser ,  Hamsa Puthalakath ,  Andreas Villunger ,  Leigh Coultas ,  Jennifer Beaumont ,  Lorraine O'reilly ,  David Huang

IPC分类号： A01K67/027 ,  A61K38/00 ,  A61K45/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07K14/47 ,  C07K16/18 ,  C12N5/10 ,  C12N15/09 ,  C12N15/11 ,  C12N15/12 ,  C12P21/08 ,  G01N33/53 ,  A61K48/00 ,  C07H21/04

CPC分类号： C07K14/4747 ,  A01K2217/05 ,  A61K38/00

摘要： The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bmf”, and to genetic sequences encoding same and to regulatory sequences such as a promoter sequence directing expression of Bmf. Bmf comprises a BH3 domain which facilitates interaction to pro-survival Bcl-2 family members thereby triggering apoptosis. Bmf is regarded, therefore, as a BH3-only molecule. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry. The present invention further contemplates genetically modified animals in which one or both alleles of Bmf are mutated or partially or wholly deleted alone or in combination with a mutation in one or both alleles of another Bcl-2-type molecule such as but not limited to Bim. The genetically modified animals are useful inter alia in screening for agents which ameliorate the symptoms of diseases caused by defects in apoptosis or which specifically promote apoptosis of target cells.

摘要翻译： 本发明一般涉及能够特别调节哺乳动物细胞凋亡和编码其的遗传序列的新型分子。 更具体地，本发明涉及Bcl-2家族蛋白质的新成员，本文称为“Bmf”，以及编码它们的遗传序列以及调节序列，例如引导Bmf表达的启动子序列。 Bmf包含BH3结构域，其促进与生存Bcl-2家族成员的相互作用，从而引发细胞凋亡。 因此，Bmf被认为是仅BH3分子。 本发明的分子可用于例如治疗，诊断，抗体产生以及作为能够调节生理细胞死亡或生存和/或调节细胞周期进入的治疗剂的筛选工具。 本发明进一步考虑了遗传修饰的动物，其中Bmf的一个或两个等位基因单独突变或部分或全部缺失，或与另一个Bcl-2型分子的一个或两个等位基因中的突变组合，例如但不限于Bim 。 遗传修饰的动物尤其可用于筛选改善由凋亡缺陷引起的疾病症状或特异性促进靶细胞凋亡的药剂。

公开(公告)号：US06520956B1

公开(公告)日：2003-02-18

申请号：US09410022

申请日：1999-10-01

申请人： David Huang

发明人： David Huang

IPC分类号： A61F9007

CPC分类号： A61F9/008 ,  A61F2009/00844 ,  A61F2009/00853 ,  A61F2009/00872

摘要： Apparatus and method for preforming laser thermal keratoplasty capable of treating treatment areas with shapes that reduce regression. Both contact and non-contact apparatuses and methods are provided. The apparatus includes laser sources, a projection optical system, observation system, and control system. In some embodiments, the projection system uses two steering mirrors or a mask to control laser beam position on the cornea. This projection system enables precise control of the area of corneal heat shrinkage using relatively low-powered lasers, such as diode lasers. Desired changes in corneal refractive power are produced by selected patterns of photothermal shrinkage of corneal collagen tissue. The selected patterns are arrangements of oblong shapes that are preferably tapered at the ends of the long axis. The oblong shape and tapering distribute tension in the cornea over a wider area of collagen shrinkage and improve the stability of refractive correction. The long axes of the oblong treatment areas are preferably oriented radially for hyperopia correction and circumferentially for astigmatism correction.

摘要翻译： 用于预处理激光热角膜移植术的装置和方法，其能够处理具有减少回归的形状的治疗区域。 提供接触和非接触式设备和方法。 该装置包括激光源，投影光学系统，观察系统和控制系统。 在一些实施例中，投影系统使用两个转向镜或掩模来控制角膜上的激光束位置。 该投影系统能够使用诸如二极管激光器的相对低功率的激光器来精确地控制角膜热收缩的面积。 角膜屈光力的期望变化由角膜胶原组织的光热收缩的选择图案产生。 所选择的图案是长轴形状的布置，其优选在长轴的端部处是锥形的。 椭圆形和锥形分布在角膜的更大面积的胶原收缩中分布张力，并提高屈光矫正的稳定性。 长圆形处理区域的长轴优选径向地进行远视校正，并且周向地用于散光校正。

公开(公告)号：US06494573B1

公开(公告)日：2002-12-17

申请号：US09952176

申请日：2001-09-13

申请人： David Huang

发明人： David Huang

IPC分类号： G02C508

CPC分类号： G02C5/2263 ,  G02C5/006

摘要： A foldable spectacle frame having two lens frames forming a plane, two temples which are foldable to a thin form in substantially the same plane as the lens frames without lapping over the lens frames. Each of the temples comprises an auxiliary temple member supported by a pivot provided at an outer portion of the lens frames and being movable about the pivot in an auxiliary plane of pivotal movement substantially orthogonal to the plane of the lens frames, and a main temple member pivoted to the auxiliary temple rotatably in a main plane of pivotal movement orthogonal to the auxiliary plane of pivotal movement of the auxiliary temple member. The spectacle frame further comprises a slide member slidably provided within the auxiliary temple and having a length permitting a base end thereof to project from the auxiliary temple member, and biasing means for biasing the slide member away from the pivot when folding the spectacle frame. The pivot includes engaging means for engaging the slide member with the pivot of the lens frames by cooperation of the slide member, the pivot, and the main temple member. The slide member will engage with the pivot when the main temple member is brought into an unfolded state, and will disengage from the pivot when the main temple member or the auxiliary temple member is folded.

摘要翻译： 一种具有形成平面的两个透镜框架的可折叠眼镜框架，两个镜腿可折叠成与镜片框架基本相同的平面中的薄形而不在镜片框架上研磨。 每个镜腿包括辅助镜腿元件，该辅助镜腿元件由设置在透镜框架的外部的枢轴支撑，并且能够在与透镜框架的平面基本正交的枢转运动的辅助平面中围绕枢轴运动，并且主镜腿元件 在辅助镜腿构件的枢转运动的辅助平面正交的枢轴运动的主平面中可旋转地枢转到辅助镜腿。 眼镜架还包括可滑动地设置在辅助镜腿内并且具有允许其基端从辅助镜腿构件突出的长度的滑动构件，以及当折叠眼镜框时偏置滑动构件远离枢轴的偏压装置。 所述枢轴包括用于通过所述滑动构件，所述枢轴和所述主镜腿构件的配合将所述滑动构件与所述透镜框的枢轴接合的接合装置。 当主镜腿构件处于展开状态时，滑动构件将与枢轴接合，并且当主镜腿构件或辅助镜腿构件折叠时，滑动构件将与枢轴脱离。

公开(公告)号：US6033396A

公开(公告)日：2000-03-07

申请号：US744936

申请日：1996-11-06

申请人： David Huang ,  Peter J. McDonnell

发明人： David Huang ,  Peter J. McDonnell

IPC分类号： A61F9/007 ,  A61F9/01 ,  A61N5/02

CPC分类号： A61F9/008 ,  A61F2009/00853 ,  A61F2009/00872

摘要： Noncontact apparatus and method for preforming laser thermal keratoplasty capable of scanning of treatment areas with shapes that reduce regression. The apparatus includes laser sources, a projection optical system, observation system, and control system The projection system uses two steering mirrors to control laser beam position on the cornea. This projection system enables precise control of the area of corneal heat shrinkage using relatively low-powered lasers, such as diode lasers. Desired changes in corneal refractive power are produced by selected patterns of photothermal shrinkage of corneal collagen tissue. The selected patterns are arrangements of oblong shapes that are preferably tapered at the ends of the long axis. The oblong shape and tapering distribute tension in the cornea over a wider area of collagen shrinkage and improve the stability of refractive correction. The long axes of the oblong treatment areas are preferably oriented radially for hyperopia correction and circumferentially for astigmatism correction.

摘要翻译： 用于预激光热角膜移植术的非接触式装置和方法，其能够扫描具有减少回归的形状的治疗区域。 该装置包括激光源，投影光学系统，观察系统和控制系统。投影系统使用两个转向镜来控制角膜上的激光束位置。 该投影系统能够使用诸如二极管激光器的相对低功率的激光器来精确地控制角膜热收缩的面积。 角膜屈光力的期望变化由角膜胶原组织的光热收缩的选择图案产生。 所选择的图案是长轴形状的布置，其优选在长轴的端部处是锥形的。 椭圆形和锥形分布在角膜的更大面积的胶原收缩中分布张力，并提高屈光矫正的稳定性。 长圆形处理区域的长轴优选径向地进行远视校正，并且周向地用于散光校正。

公开(公告)号：US5896185A

公开(公告)日：1999-04-20

申请号：US880267

申请日：1997-06-23

申请人： David Huang

发明人： David Huang

IPC分类号： G02C5/00 ,  G02C5/08 ,  G02C5/20 ,  G02C11/18

CPC分类号： G02C5/143 ,  G02C5/006 ,  G02C5/08 ,  G02C5/20 ,  G02C2200/12

摘要： A pair of foldable compact glasses comprises two frames for retraining two lenses therein and each provided with a hinge device at the outer sides thereof, two temples respectively pivoting to the hinge devices, and a bridge device connecting the two frames. The bridge device can be folded about the normal axes of the frames such that the glasses can be subsequently received within a rigid container after folding.

摘要翻译： 一对可折叠紧凑型眼镜包括两个框架，用于在其中再培训两个透镜，并且每个在其外侧设置有铰链装置，分别枢转到铰链装置的两个镜腿和连接两个框架的桥接装置。 桥梁装置可以围绕框架的法线折叠，使得眼镜可以在折叠之后随后被容纳在刚性容器内。

公开(公告)号：US5756350A

公开(公告)日：1998-05-26

申请号：US477993

申请日：1995-06-07

申请人： Raphael C. Lee ,  David Huang

发明人： Raphael C. Lee ,  David Huang

IPC分类号： A61F2/08 ,  A61L27/38 ,  C12M3/00 ,  C12N5/077 ,  C12N5/00

CPC分类号： A61L27/3804 ,  A61L27/386 ,  C12M21/08 ,  C12M35/04 ,  C12N5/066 ,  A61F2/08 ,  C12N2501/15 ,  C12N2533/54

摘要： The present invention pertains to an oriented tissue-equivalent formed by contracting a collagen solution with connective tissue cells. In the method of the present invention, the contraction of collagen fibrils by the connective tissue cells is restrained along an axis of cell alignment defined by at least two structural members within the gel, whereby the connective tissue cells align along the axis thereby producing an oriented tissue-equivalent.

摘要翻译： 本发明涉及通过用结缔组织细胞收缩胶原溶液形成的定向组织当量。 在本发明的方法中，通过结缔组织细胞的胶原原纤维的收缩沿着由凝胶内的至少两个结构构件限定的细胞对准轴限制，由此结缔组织细胞沿着轴对准，从而产生定向 组织等价物

公开(公告)号：US5165060A

公开(公告)日：1992-11-17

申请号：US771607

申请日：1991-10-04

申请人： David Huang

发明人： David Huang

IPC分类号： G02C5/20 ,  G02C5/22

CPC分类号： G02C5/146 ,  G02C5/20 ,  G02C5/2236 ,  G02C2200/30

摘要： An adjustable eyeglass bow includes an elongated metal bow and a molded plastic connector seat having a rear end provided with a socket to securely receive one end of the elongated metal bow and a front end provided with a longitudinal blind bore. A washer divides the blind bore into an outer receiving chamber and an inner receiving chamber. A bolt piece is disposed in the blind bore and has a head portion extending into the inner receiving chamber and a threaded end portion passing through the washer and into the outer receiving chamber. A hinge piece includes a shaft portion slidably extending into the outer receiving chamber and having a rear end provided with an axial screw socket to engage the threaded end portion of the bolt piece. The hinge piece further includes a rounded pivot projection formed on a front end of the shaft portion and extending out of the outer receiving chamber to permit the mounting of the adjustable eyeglass bow onto a lens frame. A compression spring is disposed inside the inner receiving space and biases the bolt piece in order to pull the hinge piece inwardly into the outer receiving chamber. No welding operation is employed to assemble the adjustable eyeglass bow, thereby obviating the presence of scars.

摘要翻译： 可调节的眼镜弓包括细长的金属弓和模制的塑料连接器座，其具有设置有插座的后端，以牢固地容纳细长金属弓的一端和设置有纵向盲孔的前端。 垫圈将盲孔分为外接收室和内接收室。 螺栓件设置在盲孔中并且具有延伸到内部容纳室中的头部部分和穿过垫圈并进入外部容纳室的螺纹端部。 铰链件包括可滑动地延伸到外部容纳室中的轴部分，并且具有后端，该后端设置有用于接合螺栓件的螺纹端部的轴向螺钉插座。 铰链片还包括形成在轴部的前端上并从外部容纳室延伸的圆形枢轴突起，以允许将可调节的眼镜弓安装到透镜框上。 压缩弹簧设置在内部容纳空间的内部并且偏压螺栓件，以将铰链片向内拉入外部容纳室。 不用焊接操作来组装可调节的眼镜弓，从而避免存在疤痕。

公开(公告)号：US10070784B2

公开(公告)日：2018-09-11

申请号：US14890035

申请日：2014-05-12

申请人： Oregon Health & Science University ,  James Fujimoto ,  Chen Lu ,  David Huang ,  Yimin Wang ,  David Wilson ,  J. Timothy Stout

发明人： David Huang ,  Yimin Wang ,  David Wilson ,  J. Timothy Stout ,  James Fujimoto ,  Chen Lu

IPC分类号： A61B3/12 ,  A61B3/10 ,  G02B3/00 ,  G01B9/02 ,  A61B5/00 ,  A61F9/007 ,  A61B5/026 ,  G02B26/00 ,  G02B26/08 ,  G02B27/14 ,  G02B27/30

CPC分类号： A61B3/12 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/0261 ,  A61F9/00736 ,  G01B9/02004 ,  G01B9/02063 ,  G01B9/02091 ,  G01B2290/65 ,  G02B3/0087 ,  G02B26/005 ,  G02B26/0833 ,  G02B27/141 ,  G02B27/30

摘要： Disclosed herein are vitrectomy probes configured for use with optical coherence tomography.