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公开(公告)号：US20090269844A1
公开(公告)日：2009-10-29
申请号：US10458573
申请日：2003-06-10
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
CPC分类号： C07K14/54 , A61K38/00 , C07K14/7155 , C07K2319/30 , C12N2510/00 , G01N33/6869 , G01N2500/04 , G01N2800/24
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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公开(公告)号：US07585953B2
公开(公告)日：2009-09-08
申请号：US11226554
申请日：2005-09-13
申请人： Ruihuan Chen , Heidi S. Phillips , P. Mickey Williams , Thomas Wu , Zemin Zhang
发明人： Ruihuan Chen , Heidi S. Phillips , P. Mickey Williams , Thomas Wu , Zemin Zhang
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , C12P21/04 , C07H21/04
CPC分类号： C07K16/18 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K16/30 , C07K16/3023 , C07K16/40 , C07K2317/73 , G01N33/57407
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。
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83.发明申请公开(公告)号：US20090162350A1
公开(公告)日：2009-06-25
申请号：US11573629
申请日：2005-07-29
IPC分类号： A61K39/395 , C07K14/47 , G01N33/566 , C12Q1/68 , C12Q1/02 , C07K16/18 , A61K38/17
摘要： The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related disease.
摘要翻译： 本发明涉及含有新蛋白质的组合物和使用这些组合物来诊断和治疗免疫相关疾病的方法。
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公开(公告)号：US07070955B2
公开(公告)日：2006-07-04
申请号：US09989733
申请日：2001-11-20
申请人： Avi J. Ashkenazi , Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Ivar J. Kljavin , Mary A. Napier , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Zemin Zhang
发明人： Avi J. Ashkenazi , Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Ivar J. Kljavin , Mary A. Napier , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Zemin Zhang
CPC分类号： C07K14/4747 , C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US06927024B2
公开(公告)日：2005-08-09
申请号：US09449204
申请日：1999-11-24
申请人： Anthony H. Dodge , Yu-Ju G. Meng , Paul W. Sims , Dominick V. Sinicropi , P. Mickey Williams , Wai Lee Wong
发明人： Anthony H. Dodge , Yu-Ju G. Meng , Paul W. Sims , Dominick V. Sinicropi , P. Mickey Williams , Wai Lee Wong
CPC分类号： C12Q1/6804 , C40B40/00 , C12Q2563/179 , C12Q2545/114
摘要： An oligonucleotide assay is useful for the detection of target compounds in samples which may contain the target compound.
摘要翻译： 寡核苷酸测定可用于检测可能含有目标化合物的样品中的目标化合物。
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公开(公告)号：US06348351B1
公开(公告)日：2002-02-19
申请号：US09202089
申请日：1998-12-08
申请人： Sherman Fong , Napoleone Ferrara , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth Hillan , P. Mickey Williams
发明人： Sherman Fong , Napoleone Ferrara , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth Hillan , P. Mickey Williams
IPC分类号： C07K14475
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligand homologues NL2, NL3 and NL6 (FLS139), the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
摘要翻译： 本发明涉及编码新型TIE配体同源物NL2，NL3和NL6（FLS139）的分离的核酸分子，由这种核酸分子编码的蛋白质，以及用于制备和使用该核酸和蛋白质分子的方法和手段。
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公开(公告)号：US6074873A
公开(公告)日：2000-06-13
申请号：US143068
申请日：1998-08-28
申请人： Sherman Fong , Napoleone Ferrara , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth Hillan , P. Mickey Williams
发明人： Sherman Fong , Napoleone Ferrara , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth Hillan , P. Mickey Williams
IPC分类号： G01N33/53 , A61K38/00 , A61K38/22 , A61K39/395 , A61K49/00 , A61P9/00 , A61P9/10 , A61P17/02 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/475 , C07K16/18 , C07K16/22 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12N15/11
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligand homologues NL2, NL3 andNL6 (FLS139), the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
摘要翻译： 本发明涉及编码新型TIE配体同源物NL2，NL3和N6（FLS139）的分离的核酸分子，由这种核酸分子编码的蛋白质以及用于制备和使用该核酸和蛋白质分子的方法和手段。
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公开(公告)号：US20090318340A1
公开(公告)日：2009-12-24
申请号：US11976812
申请日：2007-10-29
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC分类号： A61K38/17 , C07K14/435 , C07K16/00
CPC分类号： C07K14/705 , A61K38/00 , C07K14/54 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N2500/04
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20090136491A1
公开(公告)日：2009-05-28
申请号：US11907315
申请日：2007-10-11
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC分类号： A61K39/395 , C07K16/24 , A61P19/00
CPC分类号： A61K38/20 , C07K14/54 , C07K14/7155 , C07K2319/30 , C12N15/1136 , C12N2310/11 , C12N2310/12 , C12N2310/15
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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公开(公告)号：US20090117114A1
公开(公告)日：2009-05-07
申请号：US11907316
申请日：2007-10-11
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC分类号： A61K39/395 , C07K16/00 , A61P37/00
CPC分类号： A61K38/20 , C07K14/54 , C07K14/7155 , C07K2319/30 , C12N15/1136 , C12N2310/11 , C12N2310/12 , C12N2310/15
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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