-
公开(公告)号：US5407948A
公开(公告)日：1995-04-18
申请号：US239197
申请日：1994-05-06
申请人： Peter Fey , Walter Hubsch , Jurgen Dressel , Rudolf Hanko , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
发明人： Peter Fey , Walter Hubsch , Jurgen Dressel , Rudolf Hanko , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4427 , A61K31/50 , A61K31/53 , A61P9/10 , A61P9/12 , A61P43/00 , C07D213/60 , C07D213/64 , C07D213/71 , C07D213/76 , C07D213/78 , C07D213/79 , C07D401/10 , C07D401/14
CPC分类号： C07D401/14
摘要： Substituted mono- and bipyridylmethylpyridones are prepared either by reaction of pyridones with mono- or bipyridylmethylhalogen compounds or by reaction of pyridone-substituted halogenopyridines with tetrazolylphenylboronic acids. The substituted mono- and bipyridylmethylpyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
摘要翻译： 取代的单 - 和二吡啶基甲基吡啶酮通过吡啶酮与单吡啶基或联吡啶甲基卤化合物的反应或通过吡啶酮取代的卤代吡啶与四唑基苯基硼酸的反应来制备。 取代的单吡啶基和联吡啶基甲基吡啶酮可用作药物中的活性化合物，特别是用于治疗动脉高血压和动脉粥样硬化。
-
公开(公告)号：US5318980A
公开(公告)日：1994-06-07
申请号：US18961
申请日：1993-02-18
申请人： Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
发明人： Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
IPC分类号： A61K31/415 , A61K31/40 , A61K31/4427 , A61K31/445 , A61P9/10 , A61P9/12 , A61P43/00 , C07D233/64 , C07D233/68 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , A61K31/535 , A61K31/495
CPC分类号： C07D401/12 , C07D233/68 , C07D403/12
摘要： Sulphonylbenzyl-substituted imidazoles can be prepared by first reacting imidazolylaldehydes with sulphonylbenzyl compounds and then oxidising or reducing the aldehyde function in the customary manner.The sulphonylbenzyl-substituted imidazoles can be used as active compounds in medicaments.
摘要翻译： 磺酰基苄基取代的咪唑可以通过首先使咪唑基醛与磺酰基苄基化合物反应，然后以常规方式氧化或还原醛官能团来制备。 磺酰苄基取代的咪唑可用作药物中的活性化合物。
-
公开(公告)号：US5095006A
公开(公告)日：1992-03-10
申请号：US553493
申请日：1990-07-13
IPC分类号： A61K31/19 , A61K31/215 , A61K38/00 , A61K38/55 , A61P9/12 , A61P43/00 , C07C229/22 , C07C229/34 , C07C237/22 , C07C271/22 , C07C311/19 , C07D207/08 , C07D209/48 , C07D233/54 , C07D233/64 , C07D263/22 , C07D263/26 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/078 , C07K5/08 , C07K14/81
CPC分类号： C07D209/48 , C07C229/34 , C07C271/22 , C07C311/19 , C07D207/08 , C07D233/64 , C07D263/26 , C07K5/0205 , C07K5/06147 , A61K38/00 , C07C2101/14
摘要： Renin-inhibiting peptides of the formula ##STR1## in which X represents a group of the formula ##STR2## represents hydroxyl, alkoxy having up to 8 carbon atoms, benzyloxy or a group of the formula --NR.sup.4 R.sup.5,A, B, D and E are identical or different and in each caserepresent a direct bond,represent a radical of the formula ##STR3## in which Q1 denotes oxygen, sulphur or the methylene grouprepresent a grouping of the formula ##STR4## m represents a number 0, 1 or 2, and L represents a group of the formula --CH.sub.2 NR.sup.2 R.sup.3and physiologically acceptable salts thereof.
摘要翻译： 式（I）的肾素抑制肽，其中X表示下式的基团：表示羟基，具有至多8个碳原子的烷氧基，苄氧基或式-NR4R5基团，A ，B，D和E相同或不同，并且在每种情况下代表直接键，表示式为“IMAGE”的基团，其中Q1表示氧，硫或亚甲基表示下式的基团：m表示 数字0,1或2，L表示式-CH2NR2R3的基团及其生理上可接受的盐。
-
公开(公告)号：US5010057A
公开(公告)日：1991-04-23
申请号：US395392
申请日：1989-08-17
IPC分类号： A61K38/55 , A61P5/38 , A61P9/00 , A61P9/12 , C07C323/65 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/08 , C07K5/10 , C07K7/02 , C07K14/81
CPC分类号： C07K5/0227 , C07K5/0205 , C07K7/02 , Y02P20/55
摘要： Renin-inhibiting aminomethyl peptides of the formula ##STR1## in which A is H, an alkyl radical, a sulphonyl radical or an amino-protecting group,B, D, E and F each independently is a direct bond or an amino-organo-carbonyl group,R.sup.1 is an optionally substituted alkyl or aryl radical,R.sup.2 is H, alkyl or acyl,R.sup.3 is H, alkyl, aryl or acyl, andR.sup.4 is alkyl, alkoxy, aryl or amino,and physiologically acceptable salts thereof.
摘要翻译： 其中A为H，烷基，磺酰基或氨基保护基的式（I）所示的抑制N-羟基抑制性氨基甲基肽，B，D，E和F各自独立地为直接键或氨基 - 有机 - 羰基，R 1是任选取代的烷基或芳基，R 2是H，烷基或酰基，R 3是H，烷基，芳基或酰基，R 4是烷基，烷氧基，芳基或氨基，和其生理上可接受的盐 。
-
公开(公告)号：US09150580B2
公开(公告)日：2015-10-06
申请号：US14115871
申请日：2012-05-02
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Alexander Straub , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Alexander Straub , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li
IPC分类号： C07D487/04 , A61K31/5025 , A61K31/53 , A61K45/06
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/53 , A61K45/06
摘要： The present application relates to novel substituted imidazopyridazines having the following formula (I): to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及具有下式（I）的新型取代的咪唑并哒嗪：其制备方法，其单独使用或组合用于治疗和/或预防疾病及其用于生产药物的用途 治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
-
公开(公告)号：US09018258B2
公开(公告)日：2015-04-28
申请号：US13312320
申请日：2011-12-06
申请人： Thomas Lampe , Michael G. Hahn , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Sherif El Sheikh , Volkhart Min-Jian Li , Eva-Maria Becker , Friederike Stoll , Andŕeas Knorr , Peter Kolkhof , Elisabeth Woltering
发明人： Thomas Lampe , Michael G. Hahn , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Sherif El Sheikh , Volkhart Min-Jian Li , Eva-Maria Becker , Friederike Stoll , Andŕeas Knorr , Peter Kolkhof , Elisabeth Woltering
IPC分类号： A61K31/196 , C07C233/55 , C07C231/02 , C07C233/24
CPC分类号： C07C231/02 , A61K31/196 , C07C233/24 , C07C233/55
摘要： The present application relates to novel substituted 1-benzylcycloalkylcarboxylic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的1-苄基环烷基羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，特别是 用于治疗和/或预防心血管疾病。
-
公开(公告)号：US08796335B2
公开(公告)日：2014-08-05
申请号：US13431934
申请日：2012-03-27
申请人： Michael Hahn , Thomas Lampe , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Volkhart Min-Jian Li , Eva-Maria Becker , Friederike Stoll , Andreas Knorr , Elisabeth Woltering
发明人： Michael Hahn , Thomas Lampe , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Volkhart Min-Jian Li , Eva-Maria Becker , Friederike Stoll , Andreas Knorr , Elisabeth Woltering
IPC分类号： A01N37/12 , A01N37/44 , A61K31/195 , C07C45/00
CPC分类号： C07C231/14 , A61K9/0053 , A61K31/196 , A61K45/06 , C07C233/55 , C07C235/38 , C07C2601/02 , C07C2601/04 , C07C2601/08
摘要： The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
-
88.发明申请Substituted 2, 6-Diamino-3, 5-Dicyano-4-Aryl-Pyridines And Their Use As Adenosine-Receptor-Selective Ligands 审中-公开取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶及其作为腺苷受体选择性配体公开(公告)号：US20130040992A1
公开(公告)日：2013-02-14
申请号：US13584722
申请日：2012-08-13
申请人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： A61K31/444 , A61K31/4418 , C07D401/12 , A61K31/4439 , C07D409/12 , A61K31/4436 , A61K31/443 , C07D405/14 , C07D417/14 , A61P9/00 , A61P9/12 , A61P9/06 , A61P9/10 , A61P25/00 , C07D213/85
CPC分类号： C07D401/12 , C07D213/85 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/14
摘要： The present invention relates to substituted 2,6-diamino-3,5-dicyano-4-arylpyridines of the formula (I) wherein the definitions of substituent groups R1-R7 are as provided in the specification and claims, to a pharmaceutical composition containing such a compound, to a process for preparation of such materials, and to their use as medicaments for the treatment of cardiovascular disorders and diabetes.
摘要翻译： 本发明涉及式（I）的取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶，其中取代基R1-R7的定义如说明书和权利要求中所述，含有 这样的化合物，制备这种材料的方法，以及它们作为用于治疗心血管疾病和糖尿病的药物的用途。
-
89.发明授权Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands 失效取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶及其作为腺苷受体选择配体的用途公开(公告)号：US08242281B2
公开(公告)日：2012-08-14
申请号：US11607262
申请日：2006-12-01
申请人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： C07D213/72 , C07D213/00 , A01N43/40
CPC分类号： C07D401/12 , C07D213/85 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/14
摘要： The present invention relates to substituted 2,6-diamino-3,5-dicyano-4-arylpyridines of the formula (I) wherein the definitions of substituent groups R1-R7 are as provided in the specification and claims, to a pharmaceutical composition containing such a compound, to a process for preparation of such materials, and to their use as medicaments for the treatment of cardiovascular disorders and diabetes.
摘要翻译： 本发明涉及式（I）的取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶，其中取代基R1-R7的定义如说明书和权利要求中所述，含有 这样的化合物，制备这种材料的方法，以及它们作为用于治疗心血管疾病和糖尿病的药物的用途。
-
公开(公告)号：US20120034629A1
公开(公告)日：2012-02-09
申请号：US12673780
申请日：2007-08-17
IPC分类号： G01N33/566 , C12M1/34
CPC分类号： G01N33/6893 , G01N2333/70575 , G01N2800/323 , G01N2800/324 , G01N2800/347
摘要： The present invention relates to methods and systems for the prediction of atherothrombotic events in human subjects. Preferably the human subjects are afflicted with a cardiovascular disease, such as end-stage renal disease. Methods and systems of the invention are particularly suited to predict atherothrombotic events in patients on hemodialysis.
摘要翻译： 本发明涉及用于预测人类受试者中动脉粥样硬化血栓形成事件的方法和系统。 优选地，人类受试者患有心血管疾病，例如终末期肾病。 本发明的方法和系统特别适用于预测血液透析患者的动脉粥样硬化血栓形成事件。
-
-
-
-
-
-
-
-
-
搜索结果
182 条记录 (耗时 0.059 秒)
