公开(公告)号：US07189529B2

公开(公告)日：2007-03-13

申请号：US10013927

申请日：2001-10-25

申请人： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

发明人： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C12P21/06 ,  C12N1/12 ,  C12N15/00 ,  C07H21/04

CPC分类号： C07K14/47

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US06723535B2

公开(公告)日：2004-04-20

申请号：US09906700

申请日：2001-07-16

申请人： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Jennie P. Mather ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

发明人： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Jennie P. Mather ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C12N1512

CPC分类号： C07K16/18

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US06664376B2

公开(公告)日：2003-12-16

申请号：US09905125

申请日：2001-07-12

申请人： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Jennie P. Mather ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

发明人： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Jennie P. Mather ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C07K14435

CPC分类号： C07K14/47 ,  C07K14/705 ,  C07K2319/00

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20060074228A1

公开(公告)日：2006-04-06

申请号：US10243136

申请日：2002-09-12

申请人： Kevin Baker ,  Dan Eaton ,  Ellen Filvaroff ,  Audrey Goddard ,  J. Grimaldi ,  Austin Gurney ,  Victoria Smith ,  Jean Stephan ,  Colin Watanabe ,  William Wood ,  Zemin Zhang ,  Sheman Fong

发明人： Kevin Baker ,  Dan Eaton ,  Ellen Filvaroff ,  Audrey Goddard ,  J. Grimaldi ,  Austin Gurney ,  Victoria Smith ,  Jean Stephan ,  Colin Watanabe ,  William Wood ,  Zemin Zhang ,  Sheman Fong

IPC分类号： C07K16/18

CPC分类号： C07H21/04 ,  C07K14/435 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07217412B2

公开(公告)日：2007-05-15

申请号：US09854208

申请日：2001-05-10

申请人： Jian Chen ,  Ellen Filvaroff ,  Audrey Goddard ,  Austin Gurney ,  Hanzhong Li ,  William I. Wood

发明人： Jian Chen ,  Ellen Filvaroff ,  Audrey Goddard ,  Austin Gurney ,  Hanzhong Li ,  William I. Wood

IPC分类号： A61K45/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/52 ,  C07K14/54 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.

摘要翻译： 本发明涉及与IL-17具有序列同一性的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病的方法。

公开(公告)号：US20090022725A1

公开(公告)日：2009-01-22

申请号：US12188054

申请日：2008-08-07

申请人： Jian CHEN ,  Ellen Filvaroff ,  Audrey Goddard ,  Austin Gurney ,  Hanzhong Li ,  William I. Wood

发明人： Jian CHEN ,  Ellen Filvaroff ,  Audrey Goddard ,  Austin Gurney ,  Hanzhong Li ,  William I. Wood

IPC分类号： A61K39/395 ,  C07K16/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/52 ,  C07K14/54 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.

摘要翻译： 本发明涉及与IL-17具有序列同一性的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病的方法。

公开(公告)号：US08075888B2

公开(公告)日：2011-12-13

申请号：US12788129

申请日：2010-05-26

申请人： Jian Chen ,  Ellen Filvaroff ,  Audrey Goddard ,  Austin Gurney ,  Hanzhong Li ,  William I. Wood

发明人： Jian Chen ,  Ellen Filvaroff ,  Audrey Goddard ,  Austin Gurney ,  Hanzhong Li ,  William I. Wood

IPC分类号： A61K39/395

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/52 ,  C07K14/54 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.

摘要翻译： 本发明涉及与IL-17具有序列同一性的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病的方法。

公开(公告)号：US07115398B2

公开(公告)日：2006-10-03

申请号：US09854280

申请日：2001-05-10

申请人： Jian Chen ,  Ellen Filvaroff ,  Audrey Goddard ,  Austin Gurney ,  Hanzhong Li ,  William I. Wood

发明人： Jian Chen ,  Ellen Filvaroff ,  Audrey Goddard ,  Austin Gurney ,  Hanzhong Li ,  William I. Wood

IPC分类号： C12P21/04

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/52 ,  C07K14/54 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.

公开(公告)号：US20120128627A1

公开(公告)日：2012-05-24

申请号：US13315061

申请日：2011-12-08

申请人： Jian Chen ,  Ellen Filvaroff ,  Audrey Goddard ,  Austin Gurney ,  Hanzhong Li ,  William I. Wood

发明人： Jian Chen ,  Ellen Filvaroff ,  Audrey Goddard ,  Austin Gurney ,  Hanzhong Li ,  William I. Wood

IPC分类号： A61K38/20 ,  A61K39/395 ,  A61P19/02

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/52 ,  C07K14/54 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.

摘要翻译： 本发明涉及与IL-17具有序列同一性的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病的方法。

公开(公告)号：US20110038868A1

公开(公告)日：2011-02-17

申请号：US12788129

申请日：2010-05-26

申请人： Jian Chen ,  Ellen Filvaroff ,  Audrey Goddard ,  Austin Gurney ,  Hanzhong Li ,  William I. Wood

发明人： Jian Chen ,  Ellen Filvaroff ,  Audrey Goddard ,  Austin Gurney ,  Hanzhong Li ,  William I. Wood

IPC分类号： A61K39/395 ,  A61P19/02

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/52 ,  C07K14/54 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.

摘要翻译： 本发明涉及与IL-17具有序列同一性的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病的方法。