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公开(公告)号：US6094972A
公开(公告)日：2000-08-01
申请号：US123146
申请日：1998-07-27
CPC分类号： G01Q10/06 , B82Y35/00 , G01Q30/04 , G01Q60/32 , Y10S977/851
摘要： An xy scanning unit produces a scanning signal along an x-direction and a scanning signal along a y-direction, which are determined by a contour of a sample to be monitored, scanning time of the x-direction, and a pixel number of the x-direction, supplied from a CPU. Then, the xy scanning unit outputs these scanning signals along the x-direction and the y-direction to a piezoelectric scanning apparatus. On the other hand, a second oscillator outputs a sine wave signal having a frequency determined by the scanning time of the x-direction and the pixel number of the x-direction to a second piezoelectric plate. A sample/hold circuit holds observation data of a probe at such timing after preselected time has passed since the output of the second oscillator becomes maximum, and then outputs the held observation data to a differential amplifier and a P.I control system. An output signal Q of the P.I control system is applied to a z-fine-moving electrode of the piezoelectric scanning apparatus, and also is converted into a digital signal by an A/D converter. This digital signal is stored into a memory in a sampling manner.
摘要翻译： xy扫描单元产生沿着x方向的扫描信号和沿着y方向的扫描信号，其由待监视的样本的轮廓，x方向的扫描时间和x方向的像素数确定 x方向，由CPU提供。 然后，xy扫描单元将这些扫描信号沿x方向和y方向输出到压电扫描装置。 另一方面，第二振荡器输出具有由x方向的扫描时间和x方向的像素数确定的频率的正弦波信号到第二压电板。 采样/保持电路在从第二振荡器的输出变为最大之后经过预选时间之后的这样的定时保持探测器的观测数据，然后将保持的观测数据输出到差分放大器和P.I控制系统。 P.I控制系统的输出信号Q被施加到压电扫描装置的z-微细电极上，并且还通过A / D转换器转换成数字信号。 该数字信号以采样方式存储到存储器中。
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公开(公告)号：US5201824A
公开(公告)日：1993-04-13
申请号：US820451
申请日：1992-01-13
申请人： Takafumi Kato , Kazutoshi Watanabe
发明人： Takafumi Kato , Kazutoshi Watanabe
IPC分类号： H01H13/705
CPC分类号： H01H13/705 , H01H2215/006 , H01H2215/02 , H01H2217/01 , H01H2221/026 , H01H2227/036 , H01H2233/056 , H01H2237/004
摘要： A push button switch including a case, a key top fastened to the case, an elastic member disposed between the case and the key top and acting to upwards urge the key top and a contact portioned so as to confront a spring member fastened to an operation member of the key top so that the contact portion is pressed by the spring member when the key top is depressed, the push button switch comprising: a movable member disposed between the operation member of the key top and a projection wall of the case whereby the operation member and the movable member can be moved with respect to each other and the movable member and the projection wall can be moved with respect to each other.
摘要翻译： 一种按钮开关，包括壳体，紧固到壳体的键顶，弹性构件，其设置在壳体和键顶之间，并且用于向上推动键顶和接触部分，以抵抗固定到操作的弹簧构件 键顶部的构件，使得当键顶被按压时接触部分被弹簧构件按压，按钮开关包括：可移动构件，设置在键顶的操作构件和壳体的突出壁之间， 操作构件和可动构件可以相对于彼此移动，并且可移动构件和突出壁可以相对于彼此移动。
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公开(公告)号：US5120923A
公开(公告)日：1992-06-09
申请号：US584558
申请日：1990-09-18
申请人： Takafumi Kato , Kazutoshi Watanabe
发明人： Takafumi Kato , Kazutoshi Watanabe
IPC分类号： H01H13/20 , H01H13/705
CPC分类号： H01H13/705 , H01H13/20 , H01H2215/006 , H01H2215/02 , H01H2217/01 , H01H2221/026 , H01H2227/036 , H01H2233/056 , H01H2237/004
摘要： A push button switch including a case, a key top fastened to the case, an elastic member disposed between the case and the key top and acting to upwards urge the key top and a contact portioned so as to confront a spring member fastened to an operation member of the key top so that the contact portion is pressed by the spring member when the key top is depressed, the push button switch comprising: a movable member disposed between the operation member of the key top and a projection wall of the case whereby the operation member and the movable member can be moved with respect to each other and the movable member and the projection wall can be moved with respect to each other.
摘要翻译： 一种按钮开关，包括壳体，紧固到壳体的键顶，弹性构件，其设置在壳体和键顶之间，并且用于向上推动键顶和接触部分，以抵抗固定到操作的弹簧构件 键顶部的构件，使得当键顶被按压时接触部分被弹簧构件按压，按钮开关包括：可移动构件，设置在键顶的操作构件和壳体的突出壁之间， 操作构件和可动构件可以相对于彼此移动，并且可移动构件和突出壁可以相对于彼此移动。
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![3-[1,4]oxazepane-4-pyrimidone derivatives](/abs-image/US/2015/08/18/US09108957B2/abs.jpg.150x150.jpg)
公开(公告)号：US09108957B2
公开(公告)日：2015-08-18
申请号：US13262396
申请日：2010-04-01
申请人： Kazutoshi Watanabe , Kazuki Nakayama , Daiki Sakai
发明人： Kazutoshi Watanabe , Kazuki Nakayama , Daiki Sakai
IPC分类号： A61K31/553 , C07D401/14 , C07D403/14 , C07D413/14
CPC分类号： C07D413/14 , C07D401/14 , C07D403/14
摘要： A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein Z represents nitrogen atom, C—F or the like; R1 represents a C1-C3 alkyl group; Y represents oxygen atom or N—R7; R2, R3, R4, R5, R6 and R7 each independently represents hydrogen atom, a C1-C6 alkyl group, or a group represented by the formula (II): which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐：其中Z表示氮原子，C-F等; R1表示C1-C3烷基; Y表示氧原子或N-R7; R2，R3，R4，R5，R6和R7各自独立地表示氢原子，C1-C6烷基或由式（II）表示的基团：其用于预防和/或治疗由 tau蛋白激酶1多动症如神经变性疾病（如阿兹海默症）。
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公开(公告)号：US09006232B2
公开(公告)日：2015-04-14
申请号：US13389512
申请日：2010-08-11
IPC分类号： A61K31/5377 , A61K31/536 , A61K31/505 , A61K31/55 , C07D403/14 , C07D413/14 , C07D265/14 , C07D401/12 , C07D233/76 , C07D401/14 , C07D407/12 , C07D409/14
CPC分类号： C07D401/12 , C07D233/76 , C07D401/14 , C07D407/12 , C07D409/14 , C07D413/14
摘要： A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein Z represents nitrogen atom or C—X; X represents hydrogen atom or fluorine atom; R1 is hydrogen atom or a C1-C3 alkyl group; L represents single bond or a C1-C6 alkylene group which may be substituted; Y represents single bond, sulfur atom, oxygen atom, NH, or the like; R2 represents hydrogen atom or a cyclic group which may be substituted, which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of tau protein kinase 1 such as a neurodegenerative diseases (e.g. Alzheimer disease).
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐：其中Z表示氮原子或C-X; X表示氢原子或氟原子; R1是氢原子或C1-C3烷基; L表示单键或可以被取代的C1-C6亚烷基; Y表示单键，硫原子，氧原子，NH等; R2代表氢原子或可被取代的环状基团，其用于预防和/或治疗由tau蛋白激酶1的异常活性如神经变性疾病（例如阿尔茨海默病）引起的疾病。
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86.发明授权2-substituted-6-heterocyclic pyrimidone derivatives as tau protein kinase 1 inhibitors 失效作为tau蛋白激酶1抑制剂的2-取代-6-杂环嘧啶酮衍生物公开(公告)号：US08592417B2
公开(公告)日：2013-11-26
申请号：US12518997
申请日：2007-12-26
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D413/14
摘要： A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein each R1 represents hydrogen atom or the like; X represents oxygen atom or the like; A represents a C3-C7 cycloalkyl group, a C6-C10 aryl group or a heterocyclic group; R6 represents a halogen atom or the like; s represents 0 or an integer of 1 to 5; Q represents a pyridine ring which may be substituted or pyrimidine ring; and R2 represents hydrogen atom or the like, which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of tau protein kinase 1 such as a neurodegenerative diseases (e.g. Alzheimer disease).
摘要翻译： 由式（I）表示的化合物或其光学活性异构体或其药学上可接受的盐：其中每个R 1表示氢原子等; X表示氧原子等; A表示C 3 -C 7环烷基，C 6 -C 10芳基或杂环基; R6表示卤素原子等; s表示0或1〜5的整数， Q表示可以被取代或嘧啶环的吡啶环; R2代表氢原子等，其用于预防和/或治疗由tau蛋白激酶1的异常活性引起的疾病，例如神经变性疾病（例如阿尔茨海默病）。
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公开(公告)号：US08198437B2
公开(公告)日：2012-06-12
申请号：US12677213
申请日：2008-09-12
IPC分类号： C07D413/00
CPC分类号： C07D413/14
摘要： A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of tau protein kinase 1 such as a neurodegenerative diseases (e.g. Alzheimer disease).
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐：用于预防和/或治疗由tau蛋白激酶1的异常活性（例如神经变性疾病（例如阿尔茨海默病））引起的疾病。
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88.发明申请公开(公告)号：US20110038392A1
公开(公告)日：2011-02-17
申请号：US12806364
申请日：2010-08-11
摘要： In a local softening point measuring apparatus and thermal conductivity measuring apparatus using a probe microscope as a base, environment of the prob˜ and a sample surface is set to 1/100 atmospheric pressure (103 Pa) or lower. Otherwise, a side surface of the probe is coated with a thermal insulation material having a thickness that enables thermal dissipation to be reduced to 1/100 or lower, to thereby reduce the thermal dissipation from the side surface of the probe, and exchange heat substantially only at the contacting portion between the probe and the sample surface.
摘要翻译： 在使用探针显微镜作为基础的局部软化点测定装置和热导率测定装置中，将试样表面的环境设定为1/100大气压（103Pa）以下。 否则，探针的侧表面涂覆有能够使散热减小到1/100或更低的厚度的绝热材料，从而减少从探针侧表面的散热，并且基本上交换热量 仅在探针和样品表面之间的接触部分处。
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89.发明授权公开(公告)号：US07787133B2
公开(公告)日：2010-08-31
申请号：US11840549
申请日：2007-08-17
IPC分类号： G01B11/14
CPC分类号： G01Q20/02
摘要： The optical displacement-detecting mechanism has: a light source for irradiating a target for measurement with light; a light source-driving circuit for driving the light source; an optical detector made from a semiconductor for receiving light after the irradiation of the target for measurement by the light source and converting the light into an electric signal thereby to detect an intensity of light; and an amplifier including a current-voltage conversion circuit for performing current-to-voltage conversion on a detection signal of the optical detector with a predetermined amplification factor. In the optical displacement-detecting mechanism, a light source having a spectrum half width of 10 nm or larger is used, whereby the light source can be driven with an output power of 2 mW or larger without generating mode hop noise and optical feedback noise.
摘要翻译： 光学位移检测机构具有：用光照射被测物的光源; 用于驱动光源的光源驱动电路; 由半导体制成的光检测器，用于在由光源照射测量目标物之后接收光，并将光转换成电信号从而检测光的强度; 以及放大器，其包括用于以预定的放大系数对光学检测器的检测信号进行电流 - 电压转换的电流 - 电压转换电路。 在光学位移检测机构中，使用光谱半宽度为10nm以上的光源，由此可以以2mW以上的输出功率驱动光源，而不产生模式跳噪声和光反馈噪声。
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90.发明授权Method of correcting opaque defect of photomask using atomic force microscope fine processing device 有权使用原子力显微镜精细加工装置校正光掩模不透明缺陷的方法公开(公告)号：US07571639B2
公开(公告)日：2009-08-11
申请号：US11796996
申请日：2007-04-27
申请人： Toshio Doi , Kazutoshi Watanabe , Osamu Takaoka , Atsushi Uemoto
发明人： Toshio Doi , Kazutoshi Watanabe , Osamu Takaoka , Atsushi Uemoto
IPC分类号： H01J37/352
摘要： An opaque defect is processed by scanning with a high load or height fixed mode using a probe harder than a pattern material of a photomask at the time of going scanning, and is observed by scanning with a low load or intermittent contact mode at the time of returning scanning so as to detect an ending point of the opaque defect by the height information. When there is a portion reaching to a glass substrate as an ending point, this portion is not scanned by the high load or height fixed mode in the next processing, and only a portion not reaching to the ending point is scanned by the high load or height fixed mode.
摘要翻译： 通过使用在扫描时比光掩模的图案材料更硬的探针，以高负载或高度固定模式进行扫描来处理不透明缺陷，并且通过在低负载或间歇接触模式下扫描来观察不透明缺陷 返回扫描，以便通过高度信息检测不透明缺陷的终点。 当到达玻璃基板的部分为终点时，在下一个处理中该部分不被高负载或高度固定模式扫描，并且只有未到达终点的部分被高负载扫描 高度固定模式。
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