摘要:
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要:
There is provided a method of modifying a first clock to generate a second clock with reduced electromagnetic interference (EMI). The method comprises receiving the first clock, generating an upslew modulation form during an upslew frequency transition, generating a downslew modulation form during a downslew frequency transition, modulating a frequency of the first clock over a period of time using the upslew modulation form and the downslew modulation form to generate the second clock, and wherein the upslew modulation form and the downslew modulation form are different. The upslew modulation form and the downslew modulation form are defined by upslew modulation values and downslew modulation values, respectively, and the method further comprises receiving the upslew modulation values and the downslew modulation values, and generating fractional upslew modulation values and fractional downslew modulation, respectively, for modulating the frequency of the first clock.
摘要:
Processes for enhancing blown film processability and the blown films formed thereby are described herein. One embodiment of the processes generally includes providing a first propylene based heterophasic copolymer having a first melt flow rate, modifying the first propylene based heterophasic copolymer to form a second heterophasic polymer having a second melt flow rate, wherein the second melt flow rate is greater than the first melt flow rate, contacting the first heterophasic polymer, the second heterophasic copolymer or a combination thereof with a plurality of additives, wherein the plurality of additives include a nucleator, polyethylene and mineral oil to form a modified heterophasic copolymer and blowing the modified heterophasic polymer into a film.
摘要:
Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要:
A modular building comprises a sled comprising a rectangular box frame. A shed comprising a steel framework of spaced apart columns that are linked to one another by overhead ceiling beams to provide a rigid structural frame. A sliding expansion modules is attached to the shed.
摘要:
A voice amplifier for attachment to a mask has a sound reflector that faces outwardly of the mask when the voice amplifier is attached to the mask. A speaker faces inwards towards the sound reflector. Sound waves emanate from the speaker inward towards the sound reflector, reflect off the sound reflector and exit the voice amplifier through an outer peripheral gap and travel outwardly from the mask. The voice amplifier has an on/off switch mounted on the front of the voice amplifier. The voice amplifier cover has a front wall with a front surface facing away from the mask. The narrow end of the speaker is located closer to the front wall of the cover than the wide end. The cover front wall follows the profile of the speaker in a direction from the narrow end to the wide end of the speaker.