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    Method of imaging using encapsulated magnetite particles
    82.
    发明授权
    Method of imaging using encapsulated magnetite particles 失效
    使用封装的磁铁矿颗粒成像的方法

    公开(公告)号：US5545395A

    公开(公告)日：1996-08-13

    申请号：US421330

    申请日：1995-04-13

    申请人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

    发明人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

    IPC分类号： A61K9/127 ,  A61B5/055 ,  A61K20060101 ,  A61K49/00 ,  A61K49/18

    CPC分类号： A61K49/1806 ,  A61K49/1839 ,  Y10S977/838 ,  Y10S977/904 ,  Y10S977/905 ,  Y10S977/927 ,  Y10S977/96 ,  Y10T428/2991 ,  Y10T428/2998 ,  Y10T436/24

    摘要： Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or glycerophospholipid/surfactant three dimensional shell surrounding the core. The core and the monoester or a micellar glycerophospholipid form an urchin-like structure which is further interlaced or intertwined with a non-ionic surfactant to produce a protective three dimensional shell which renders particles almost undetectable by the macrophages. Particles prepared according to the invention are kept in the blood circulation for long periods and represent excellent long lasting blood pool agents. Key components in the shell are (a) a polybasic mineral-organic species such as glycero phosphatidic acid in micellar form and (b) a block copolymer having successive hydrophilic and hydrophobic segments.

    摘要翻译： 适合于注射到患有肝脏和脾脏的RES的聚集和摄取的抗性的患者血液中的磁铁矿颗粒。 颗粒基本上由氧化铁芯和磷酸单烷基或链烯基酯或包含核心的甘油磷脂/表面活性剂三维壳组成。 核心和单酯或胶束甘油磷脂形成海胆样结构，其进一步与非离子表面活性剂交织或交织在一起，以产生保护性三维壳，其使颗粒几乎不被巨噬细胞检测到。 根据本发明制备的颗粒长时间保持在血液循环中并且代表优异的持久的血液池剂。 壳中的关键组分是（a）多元矿物有机物质，例如胶束形式的甘油磷脂酸，和（b）具有连续亲水和疏水链段的嵌段共聚物。

    QUANTIFICATION ANALYSIS OF IMMOBILIZED CONTRAST AGENT IN MEDICAL IMAGING APPLICATIONS
    84.
    发明申请
    QUANTIFICATION ANALYSIS OF IMMOBILIZED CONTRAST AGENT IN MEDICAL IMAGING APPLICATIONS 有权
    医疗成像应用中定量对比剂的定量分析

    公开(公告)号：US20110015522A1

    公开(公告)日：2011-01-20

    申请号：US12811089

    申请日：2008-12-23

    申请人： Marcel Arditi ,  Tristan Messager ,  Michel Schneider ,  Peter Frinking

    发明人： Marcel Arditi ,  Tristan Messager ,  Michel Schneider ,  Peter Frinking

    IPC分类号： A61B6/00 ,  G06G7/58 ,  G06G7/60

    CPC分类号： A61B8/481 ,  A61B8/14 ,  A61B8/5223 ,  G06F19/12

    摘要： An embodiment of a solution is proposed for analyzing a body part of a patient, which is perfused with a contrast agent capable of circulating within the patient and of being substantially immobilized on a biological target. An embodiment of a corresponding system includes means for providing an echo signal indicative of a response over time to an interrogation signal of the body part, means for associating the echo signal with a model function of time modeling an evolution over time of the contrast agent in the body part, the model function including a combination of a circulation function modeling the circulation of the contrast agent and a decay function modeling a decay of the echo signal from the immobilized contrast agent, and means for estimating at least one kinetics indicator of the contrast agent from the model function.

    摘要翻译： 提出了一种解决方案的实施例，用于分析患者的身体部位，其被灌注了能够在患者体内循环并且基本上固定在生物靶上的造影剂。 相应系统的实施例包括用于提供指示随着时间的响应的回声信号到身体部位的询问信号的装置，用于将回波信号与造影剂随时间推移的模型函数相关联的模块的装置 身体部分，模型功能包括建模造影剂的循环的循环功能和从固定的造影剂对回波信号衰减建模的衰减函数的组合，以及用于估计对比度的至少一个动力学指标的装置 代理从模型函数。

    Process of preparing particles for NMR imaging
    86.
    发明授权
    Process of preparing particles for NMR imaging 失效
    制备核磁共振成像颗粒的方法

    公开(公告)号：US5587199A

    公开(公告)日：1996-12-24

    申请号：US421329

    申请日：1995-04-13

    申请人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

    发明人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

    IPC分类号： A61K9/127 ,  A61B5/055 ,  A61K20060101 ,  A61K49/00 ,  A61K49/18 ,  B05D7/00 ,  B05D3/12 ,  B06B1/00 ,  B32B9/00

    CPC分类号： A61K49/1806 ,  A61K49/1839 ,  Y10S977/838 ,  Y10S977/904 ,  Y10S977/905 ,  Y10S977/927 ,  Y10S977/96 ,  Y10T428/2991 ,  Y10T428/2998 ,  Y10T436/24

    摘要： Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or glycerophospholipid/surfactant three dimensional shell surrounding the core. The core and the monoester or a micellar glycerophospholipid form an urchin-like structure which is further interlaced or intertwined with a non-ionic surfactant to produce a protective three dimensional shell which renders particles almost undetectable by the macrophages. Particles prepared according to the invention are kept in the blood circulation for long periods and represent excellent long lasting blood pool agents. Key components in the shell are (a) a polybasic mineral-organic species such as glycero phosphatidic acid in micellar form and (b) a block copolymer having successive hydrophilic and hydrophobic segments.

    摘要翻译： 适合于注射到患有肝脏和脾脏的RES的聚集和摄取的抗性的患者血液中的磁铁矿颗粒。 颗粒基本上由氧化铁芯和磷酸单烷基或链烯基酯或包含核心的甘油磷脂/表面活性剂三维壳组成。 核心和单酯或胶束甘油磷脂形成海胆样结构，其进一步与非离子表面活性剂交织或交织在一起，以产生保护性三维壳，其使颗粒几乎不被巨噬细胞检测到。 根据本发明制备的颗粒长时间保持在血液循环中并且代表优异的持久的血液池剂。 壳中的关键组分是（a）多元矿物有机物质，例如胶束形式的甘油磷脂酸，和（b）具有连续亲水和疏水链段的嵌段共聚物。

    Particles for NMR imaging
    87.
    发明授权
    Particles for NMR imaging 失效
    核磁共振成像用颗粒

    公开(公告)号：US5464696A

    公开(公告)日：1995-11-07

    申请号：US096414

    申请日：1993-07-26

    申请人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

    发明人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

    IPC分类号： A61K9/127 ,  A61B5/055 ,  A61K20060101 ,  A61K49/00 ,  A61K49/18 ,  B23B5/16

    CPC分类号： A61K49/1806 ,  A61K49/1839 ,  Y10S977/838 ,  Y10S977/904 ,  Y10S977/905 ,  Y10S977/927 ,  Y10S977/96 ,  Y10T428/2991 ,  Y10T428/2998 ,  Y10T436/24

    摘要： Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or glycerophospholipid/surfactant three dimensional shell surrounding the core. The core and the monoester or a micellar glycerophospholipid form an urchin-like structure which is further interlaced or intertwined with a non-ionic surfactant to produce a protective three dimensional shell which renders particles almost undetectable by the macrophages. Particles prepared according to the invention are kept in the blood circulation for long periods and represent excellent long lasting blood pool agents. Key components in the shell are (a) a polybasic mineral-organic species such as glycero phosphatidic acid in micellar form and (b) a block copolymer having successive hydrophilic and hydrophobic segments.

    摘要翻译： 适合于注射到患有肝脏和脾脏的RES的聚集和摄取的抗性的患者血液中的磁铁矿颗粒。 颗粒基本上由氧化铁芯和磷酸单烷基或链烯基酯或包含核心的甘油磷脂/表面活性剂三维壳组成。 核心和单酯或胶束甘油磷脂形成海胆样结构，其进一步与非离子表面活性剂交织或交织在一起，以产生保护性三维壳，其使颗粒几乎不被巨噬细胞检测到。 根据本发明制备的颗粒长时间保持在血液循环中并且代表优异的持久的血液池剂。 壳中的关键组分是（a）多元矿物有机物质，例如胶束形式的甘油磷脂酸，和（b）具有连续亲水和疏水链段的嵌段共聚物。

    Device for injecting divided solid materials in a smelting blast furnace
    89.
    发明授权
    Device for injecting divided solid materials in a smelting blast furnace 失效
    在冶炼高炉中注入分散固体材料的装置

    公开(公告)号：US4771993A

    公开(公告)日：1988-09-20

    申请号：US858927

    申请日：1986-05-02

    申请人： Hugues Zanetta ,  Yann de Lassat de Pressigny ,  Michel Schneider

    发明人： Hugues Zanetta ,  Yann de Lassat de Pressigny ,  Michel Schneider

    IPC分类号： C21B7/16 ,  C21B5/00

    CPC分类号： C21B5/002 ,  C21B5/003

    摘要： The tuyere comprises a substantially cylindrical or slightly convergent frusto-conical downstream part, and a divergent frusto-conical upstream part; the plasma torch is placed co-axially to the tuyere at the inlet to the upstream part thereof; the solid materials injection nozzle issues at an angle into the upstream part of the tuyere and the angle of taper of the upstream part of the tuyere substantially corresponds to the angle of natural expansion of the plasma jet, so that said materials are carried with the plasma jet and that part of them are provided onto the inner wall of the tuyere.

    摘要翻译： 风口包括大致圆柱形或略微收敛的截头圆锥形下游部分和发散的截头圆锥形上游部分; 等离子体焰炬与其上游部分的入口同时地放置在风口上; 固体材料注入喷嘴以一定角度向风口的上游部分出现，并且风口的上游部分的锥角基本对应于等离子体射流的自然膨胀角，使得所述材料与等离子体 并且其中的一部分被提供到风口的内壁上。

    Device for injecting pulverulent material, such as coal, in a blast furnace
    90.
    发明授权
    Device for injecting pulverulent material, such as coal, in a blast furnace 失效
    在高炉中注入煤等粉状物质的装置

    公开(公告)号：US4700930A

    公开(公告)日：1987-10-20

    申请号：US851204

    申请日：1986-04-14

    申请人： Yann de Lassat de Pressigny ,  Michel Schneider

    发明人： Yann de Lassat de Pressigny ,  Michel Schneider

    IPC分类号： C21B7/00 ,  C21B5/00 ,  F27B1/16 ,  C21B7/16

    CPC分类号： C21B5/003 ,  C21B5/002

    摘要： The invention relates to a device for injecting pulverulent material, such as coal, into a blast furnace. The device includes a hot blast tuyere issuing into the blast furnace, a nozzle fixed against said tuyere and co-axial thereto for bringing the hot blast, a branch connection produced obliquely on the nozzle and directed towards the tuyere, and an injection pipe traversing the branch connection to issue into the tuyere. According to the invention, the injection pipe is substantially an arc of circle, the convexity of which is directed towards the axis of the nozzle and of the tuyere. The radius of curvature is at least equal to one hundred times its inner diameter.

    摘要翻译： 本发明涉及一种将诸如煤等粉状材料注入高炉的装置。 该装置包括一个放入高炉中的热风风口，一个固定在所述风嘴上并与之同轴的喷嘴，用于引起热风，一个在喷嘴上倾斜产生并指向风口的分支连接， 分支连接发送到风口。 根据本发明，注射管基本上是圆弧，其凸出面朝向喷嘴和风口的轴线。 曲率半径至少等于其内径的一百倍。