公开(公告)号：US20090258029A1

公开(公告)日：2009-10-15

申请号：US12489205

申请日：2009-06-22

Applicant: Syed Faiyaz Ahmed Hossainy ,  Ni Ding

Inventor： Syed Faiyaz Ahmed Hossainy ,  Ni Ding

IPC: A61K39/44 ,  C08B37/10 ,  C07K17/08 ,  C08L39/06 ,  A61P7/02

CPC classification number: A61K31/727 ,  A61K47/61 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/606 ,  A61L2300/80 ,  C08B37/0075 ,  C09D105/10

Abstract: A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

Abstract translation: 提供了包含肝素和药物的前药。 前药可用于在医疗装置上形成涂层。 前药还可以与聚合物材料一起使用以在医疗装置上形成涂层。 聚合物材料可以是疏水性聚合物，亲水性聚合物，非结垢聚合物，或其组合。 医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

公开(公告)号：US07560492B1

公开(公告)日：2009-07-14

申请号：US10723137

申请日：2003-11-25

Applicant: Charles D. Claude ,  Ni Ding ,  Yeung Siu Yu

Inventor： Charles D. Claude ,  Ni Ding ,  Yeung Siu Yu

IPC: A61K47/00

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/606 ,  C08L81/06

Abstract: A polymeric composition comprising a polysulfone polymer and an elastomeric polymer for use as a coating composition for coating an implantable device, such as a DES, and methods of making and using the implantable device are provided.

Abstract translation: 提供了一种聚合物组合物，其包含聚砜聚合物和用作涂覆可植入装置（例如DES）的涂料组合物的弹性体聚合物，以及制造和使用可植入装置的方法。

公开(公告)号：US20080262606A1

公开(公告)日：2008-10-23

申请号：US12135921

申请日：2008-06-09

Applicant: Ni Ding ,  Stephen D. Pacetti

Inventor： Ni Ding ,  Stephen D. Pacetti

IPC: A61F2/82 ,  C08G77/04 ,  A61F2/00

CPC classification number: C08G77/442 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L83/04

Abstract: A polymer of siloxanes as flexibility monomers and strength monomers is provided. It is also provided a polymer blend that contains a polymer formed of siloxane monomers and strength monomers and another biocompatible polymer. The biocompatible polymer or polymer blend described herein and optionally a bioactive agent can form a coating on an implantable device such as a drug-delivery stent. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

Abstract translation: 提供了作为柔性单体和强度单体的硅氧烷的聚合物。 还提供了一种聚合物共混物，其包含由硅氧烷单体和强度单体形成的聚合物和另一种生物相容性聚合物。 本文所述的生物相容性聚合物或聚合物共混物和任选的生物活性剂可以在可植入装置如药物递送支架上形成涂层。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管阻塞 ，输尿管阻塞，肿瘤阻塞或其组合。

公开(公告)号：US20080234810A1

公开(公告)日：2008-09-25

申请号：US11769581

申请日：2007-06-27

Applicant: James M. Carlson ,  Ni Ding

Inventor： James M. Carlson ,  Ni Ding

IPC: A61F2/82 ,  C23C16/453

CPC classification number: A61L31/022 ,  A61L31/082 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/608 ,  A61L2400/12 ,  A61L2420/08

Abstract: An implantable medical device that can include an amorphous glass primer layer, an amorphous glass drug-containing layer and a nanoporous amorphous glass top-coat layer is disclosed.

Abstract translation: 公开了可包括非晶玻璃底漆层，非晶玻璃药物含量层和纳米多孔无定形玻璃顶涂层的可植入医疗装置。

公开(公告)号：US20070198080A1

公开(公告)日：2007-08-23

申请号：US11528891

申请日：2006-09-27

Applicant: Ni Ding ,  Leslie Coleman

Inventor： Ni Ding ,  Leslie Coleman

IPC: A61L33/00 ,  B05D3/00 ,  A61F2/06 ,  A61F2/02 ,  A61F2/82

CPC classification number: A61L31/10 ,  Y10T428/1307

Abstract: A coating including an antioxidant or a combination of antioxidant and another bioactive agent on a medical device is described.

Abstract translation: 描述了包括抗氧化剂或抗氧化剂和另一种生物活性剂在医疗装置上的组合的涂层。

公开(公告)号：US07247313B2

公开(公告)日：2007-07-24

申请号：US10176504

申请日：2002-06-21

Applicant: Wouter E. Roorda ,  Ni Ding ,  Stephen D. Pacetti ,  Eugene T. Michal ,  Ashok A. Shah ,  Syed F. A. Hossainy

Inventor： Wouter E. Roorda ,  Ni Ding ,  Stephen D. Pacetti ,  Eugene T. Michal ,  Ashok A. Shah ,  Syed F. A. Hossainy

IPC: A61F2/02 ,  A61K9/00

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  C08L33/10 ,  C08L33/06

Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polyacrylate, a blend of polyacrylates, or a blend of the polyacrylate with other polymers, for example, poly(ethylene-co-vinyl alcohol).

Abstract translation: 描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。 涂层可以包括聚丙烯酸酯，聚丙烯酸酯的共混物或聚丙烯酸酯与其它聚合物的共混物，例如聚（乙烯 - 共 - 乙烯醇）。

公开(公告)号：US20060177482A1

公开(公告)日：2006-08-10

申请号：US11400433

申请日：2006-04-06

Applicant: Ni Ding

Inventor： Ni Ding

IPC: A61K31/4745 ,  A61F2/00

CPC classification number: A61K31/4745 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  B82Y30/00 ,  B82Y40/00 ,  Y10T428/24

Abstract: A medical device with a coating, particularly a drug eluting stent, is described. The coating includes a self-assembled monolayer.

Abstract translation: 描述了具有涂层的医疗装置，特别是药物洗脱支架。 涂层包括自组装单层。

公开(公告)号：US07033602B1

公开(公告)日：2006-04-25

申请号：US10177116

申请日：2002-06-21

Applicant: Stephen D. Pacetti ,  Eugene T Michal ,  Syed F A Hossainy ,  Ni Ding ,  Wouter E Roorda

Inventor： Stephen D. Pacetti ,  Eugene T Michal ,  Syed F A Hossainy ,  Ni Ding ,  Wouter E Roorda

IPC: A61F2/02

CPC classification number: A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61L31/10 ,  C08L89/00

Abstract: Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.

Abstract translation: 公开了包括聚阳离子肽如L-精氨酸的医疗器械用涂层和制造涂层的方法。

公开(公告)号：US20060062821A1

公开(公告)日：2006-03-23

申请号：US11218654

申请日：2005-09-02

Applicant: Murthy Simhambhatla ,  Ni Ding ,  Stephen Pacetti

Inventor： Murthy Simhambhatla ,  Ni Ding ,  Stephen Pacetti

IPC: A61F13/00

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/606 ,  A61L2300/622 ,  A61L2300/626 ,  C08L77/04

Abstract: Polycationic peptide coatings for implantable medical devices and methods of making the same are described. The methods include applying an emulsion on the device, the emulsion including a polymer and a polycationic peptide. Other methods include incorporation of the polycationic peptide in microspheres and liposomes.

公开(公告)号：US20050175666A1

公开(公告)日：2005-08-11

申请号：US11027822

申请日：2004-12-29

Applicant: Ni Ding

Inventor： Ni Ding

IPC: A61K38/17 ,  A61K48/00 ,  A61L31/10 ,  A61L31/16 ,  A61F2/00

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61K38/1709 ,  A61L31/10 ,  A61L2300/252 ,  A61L2300/416

Abstract: An implantable medical device is disclosed comprising a high-density lipoprotein (HDL), recombinant HDL, high-density lipoprotein mimics (HDLm), or a combination thereof. Method are also disclosed for local and systemic administration HDL, recombinant HDL or HDLm for the prevention, treatment, or amelioration of a vascular disorder, disease or occlusion such as restenosis or vulnerable plaque.

Abstract translation: 公开了一种植入式医疗装置，其包括高密度脂蛋白（HDL），重组HDL，高密度脂蛋白模拟物（HDLm）或其组合。 还公开了局部和全身给药HDL，重组HDL或HDLm用于预防，治疗或改善血管疾病，疾病或闭塞如再狭窄或易损斑块的方法。