公开(公告)号：US20090050374A1

公开(公告)日：2009-02-26

申请号：US12160999

申请日：2007-02-13

Applicant: Paul Matthew Spiecker ,  Pavlin B. Entchev ,  Ramesh Gupta ,  Richard Polizzotti ,  Barbara Carstensen ,  Dennis G. Peiffer ,  Norman Pokutylowicz

Inventor： Paul Matthew Spiecker ,  Pavlin B. Entchev ,  Ramesh Gupta ,  Richard Polizzotti ,  Barbara Carstensen ,  Dennis G. Peiffer ,  Norman Pokutylowicz

IPC: E21B21/06

CPC classification number: E21B21/002 ,  E21B21/00 ,  E21B21/062 ,  E21B21/066 ,  Y10S507/906

Abstract: A method and system for drilling a wellbore is described. The system includes a wellbore with a variable density drilling mud, drilling pipe, a bottom hole assembly disposed in the wellbore and a drilling mud processing unit in fluid communication with the wellbore. The variable density drilling mud has compressible particles and drilling fluid. The bottom hole assembly is coupled to the drilling pipe while the drilling mud processing unit is configured to separate the compressible particles from the variable density drilling mud. The compressible particles in this embodiment may include compressible hollow objects filled with pressurized gas an configured to maintain the mud weight between the fracture pressure gradient and the pore pressure gradient. In addition, the system and method may also manage the use of compressible particles having different characteristics, such as size, during the drilling operations.

Abstract translation: 描述了钻井井的方法和系统。 该系统包括具有可变密度钻井泥浆，钻井管，设置在井筒中的井底组件和与井筒流体连通的钻井泥浆处理单元的井筒。 可变密度钻井泥浆具有可压缩颗粒和钻井液。 井底组件联接到钻井管道，而钻井泥浆处理单元构造成将可压缩颗粒与可变密度钻井泥浆分离。 该实施例中的可压缩颗粒可以包括填充有加压气体的可压缩中空物体，其构造成在破裂压力梯度和孔隙压力梯度之间保持泥浆重量。 此外，该系统和方法还可以在钻井操作期间管理具有不同特征的尺寸的可压缩颗粒的使用。

公开(公告)号：US20080207608A1

公开(公告)日：2008-08-28

申请号：US11578354

申请日：2005-04-11

Applicant: Prabhat Kumar ,  Uttam Mane ,  Ramesh Gupta ,  Sunil Nadkarni ,  Anookh Mohanan ,  Ruchi Tandon ,  Siralee Munshi

Inventor： Prabhat Kumar ,  Uttam Mane ,  Ramesh Gupta ,  Sunil Nadkarni ,  Anookh Mohanan ,  Ruchi Tandon ,  Siralee Munshi

IPC: A61K31/5377 ,  A61K31/44 ,  A61K31/445 ,  A61K31/47 ,  A61P29/00 ,  A61P9/00 ,  C07D215/00 ,  C07D239/72 ,  C07D241/36 ,  C07D295/00 ,  C07D241/00 ,  C07D239/02 ,  C07D213/00 ,  A61P43/00 ,  A61P25/00 ,  A61K31/495 ,  A61K31/517

CPC classification number: C07D215/42 ,  C07D213/72 ,  C07D215/14 ,  C07D241/12 ,  C07D241/18 ,  C07D241/44 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention relates to novel compounds of 2-propene-1-one series, of general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, wherein R5, R6, Q and Y are as defined in the specification. The present invention also relates to a process for preparing such compounds, compositions containing such compounds, and use of such compound and composition in medicine. The compounds of the general formula (I) induce HSP-70 and are useful for the treatment of diseases accompanying pathological stress in a living mammalian organism, including a human being, such as stroke, myocardial infarction, inflammatory disorder, hepatotoxicity, sepsis, diseases of viral origin, allograft rejection, tumourous diseases, gastric mucosal damage, brain haemorrhage, endothelial dysfunctions, diabetic complications, neuro-degenerative diseases, post-traumatic neuronal damage, acute renal failure, glaucoma and aging related skin degeneration.

Abstract translation: 本发明涉及通式（I）的2-丙烯-1-酮系列的新化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，药学上可接受的盐，药学上可接受的溶剂合物和含有它们的药学上可接受的组合物， 其中R 5，R 6，Q和Y如说明书中所定义。 本发明还涉及制备这种化合物的方法，含有这些化合物的组合物，以及这些化合物和组合物在医药中的用途。 通式（I）的化合物诱导HSP-70，并且可用于治疗活的哺乳动物生物体中伴随病理应激的疾病，包括人类，如中风，心肌梗死，炎性疾病，肝毒性，败血症，疾病 病毒来源，同种异体移植排斥，肿瘤性疾病，胃粘膜损伤，脑出血，内皮功能障碍，糖尿病并发症，神经退行性疾病，创伤后神经元损伤，急性肾功能衰竭，青光眼和衰老相关的皮肤退化。

公开(公告)号：US20080060073A1

公开(公告)日：2008-03-06

申请号：US11852932

申请日：2007-09-10

Applicant: Steven Haeffele ,  Ramesh Gupta ,  Ananth Raman ,  Srikant Vissamsetti

Inventor： Steven Haeffele ,  Ramesh Gupta ,  Ananth Raman ,  Srikant Vissamsetti

IPC: G06F12/14

CPC classification number: H04L63/0218 ,  H04L63/0227 ,  H04L63/1408 ,  H04L63/1441 ,  H04L63/20

Abstract: A system, method and computer program product are provided including a router and a security sub-system coupled to the router. Such security sub-system includes a plurality of virtual firewalls, a plurality of virtual intrusion prevention systems (IPSs), and a plurality of virtual virus scanners. Further, each of the virtual firewalls, IPSs, and virus scanners is assigned to at least one of a plurality of user and is configured in a user-specific

Abstract translation: 提供了一种系统，方法和计算机程序产品，其包括路由器和耦合到路由器的安全子系统。 这种安全子系统包括多个虚拟防火墙，多个虚拟入侵防御系统（IPS）以及多个虚拟病毒扫描器。 此外，每个虚拟防火墙，IPS和病毒扫描器被分配给多个用户中的至少一个，并且被配置为用户特定的

公开(公告)号：US20080006394A1

公开(公告)日：2008-01-10

申请号：US11482720

申请日：2006-07-10

Applicant: Ramesh Gupta ,  Yoshihiro Iwashita

Inventor： Ramesh Gupta ,  Yoshihiro Iwashita

IPC: F28D15/00

CPC classification number: F28D15/02 ,  B60H1/00 ,  F01N5/02 ,  F01N2240/02 ,  F28D21/0003 ,  F28F2225/04 ,  F28F2270/00 ,  Y02T10/16

Abstract: An exhaust path 3 and a heated portion 5 such as an air duct of an internal combustion engine are connected to each other by a heat pipe 1. A heat pipe working fluid (water) vaporized by the heat of the exhaust gas in a heat receiving portion 1c of the heat pipe 1 is condensed in a heat discharging portion 1d of the heat pipe 1 and heated in the heated portion by the heat of the exhaust gas. An outer cylinder 10 is formed around the casing la of the heat pipe 1, and the exhaust path 3 and the heated portion 5 are connected to each other through heat insulating members 13, 15, while at the same time supporting the heat pipe body through heat insulating members 11. By doing so, the structural strength can be maintained by the outer cylinder and no load is imposed on the heat pipe, so that the thickness of the casing can be reduced. Also, since the heat conduction from the heating portion to the heated portion through the outer cylinder is suppressed by the heat insulating members, the overheating of the heated portion at high temperatures is suppressed.

Abstract translation: 排气路径3和内燃机的风道等的加热部5通过热管1相互连接。热管工作流体（水）通过排气的热量在受热中被蒸发 热管1的部分1c在热管1的放热部分1d中被冷凝，并通过排气的热量在加热部分中加热。 外筒10形成在热管1的壳体1a的周围，排气路3和加热部5通过绝热构件13,15连接，同时支撑热管体通过 隔热构件11.通过这样做，可以通过外筒保持结构强度，并且不会对热管施加负荷，从而可以减小外壳的厚度。 此外，由于通过绝热构件抑制从加热部到通过外筒的加热部的热传导，所以抑制了加热部在高温下的过热。

公开(公告)号：US20060037589A1

公开(公告)日：2006-02-23

申请号：US11187672

申请日：2005-07-22

Applicant: Ramesh Gupta ,  Sanjay Bhatia ,  George Walchuk ,  Randall Partridge ,  Walter Weissman

Inventor： Ramesh Gupta ,  Sanjay Bhatia ,  George Walchuk ,  Randall Partridge ,  Walter Weissman

IPC: F02G5/00 ,  F02B13/00

CPC classification number: F02M37/0064 ,  C10G31/11 ,  F02D19/0649 ,  F02D19/0671 ,  F02G5/02 ,  F02M1/165 ,  Y02T10/166 ,  Y02T10/36

Abstract: In an internal combustion engine fuel system having a membrane separator for separating a primary fuel into a high octane fuel and a low octane fuel, and wherein the primary fuel is heated for separation in the membrane separator, the improvement comprising a heat pipe having an evaporator section positioned to be in the heat exchange relationship with exhaust gas from the internal combustion engine under conditions of use; and a heat output area in heat exchange relationship with a primary fuel as it is fed into the separator whereby the primary fuel is heated. In one embodiment the heat pipe is a variable conductance heat pipe having a top operating temperature not greater than about 160° C.

Abstract translation: 在具有用于将初级燃料分离为高辛烷值燃料和低辛烷值燃料的膜分离器的内燃机燃料系统中，在膜分离器中加热主要燃料进行分离，其改进包括具有蒸发器的热管 在使用条件下被定位成与来自内燃机的废气的热交换关系; 以及当其被馈送到隔板中时与主要燃料的热交换关系的热输出区域，由此主要燃料被加热。 在一个实施例中，热管是可变电导热管，其顶部操作温度不大于约160℃

公开(公告)号：US20050204629A1

公开(公告)日：2005-09-22

申请号：US10753024

申请日：2004-01-07

Applicant: Craig Gittleman ,  Ramesh Gupta

Inventor： Craig Gittleman ,  Ramesh Gupta

IPC: B01D53/04 ,  B01D53/047 ,  B01D53/06 ,  B01D53/86 ,  C01B3/16 ,  C01B3/32 ,  C01B3/38 ,  C01B3/48 ,  C01B3/56 ,  H01M8/00 ,  H01M8/04 ,  H01M8/06 ,  H01M8/10 ,  B01D53/62 ,  C01B3/24

CPC classification number: B01D53/06 ,  B01D53/047 ,  B01D53/864 ,  B01D2253/102 ,  B01D2253/104 ,  B01D2253/108 ,  B01D2253/112 ,  B01D2256/16 ,  B01D2257/502 ,  B01D2257/504 ,  B01D2259/40052 ,  B01D2259/40062 ,  B01D2259/41 ,  C01B3/16 ,  C01B3/48 ,  C01B3/56 ,  C01B2203/0205 ,  C01B2203/0283 ,  C01B2203/0425 ,  C01B2203/047 ,  C01B2203/0475 ,  C01B2203/0495 ,  C01B2203/066 ,  C01B2203/0811 ,  C01B2203/0822 ,  C01B2203/0827 ,  C01B2203/0883 ,  C01B2203/1005 ,  C01B2203/1047 ,  C01B2203/1082 ,  C01B2203/1223 ,  C01B2203/1229 ,  C01B2203/1241 ,  C01B2203/1247 ,  C01B2203/146 ,  C01B2203/1604 ,  C01B2203/1652 ,  C01B2203/82 ,  H01M8/0612 ,  H01M8/0668 ,  Y02C10/08 ,  Y02P20/128 ,  Y02P20/129 ,  Y02P20/152

Abstract: An apparatus removes CO from a hydrogen-rich gas stream in a hydrogen fuel cell system. CO fouls costly catalytic particles in the membrane electrode assemblies. Both a catalyst adapted to perform a water gas shift reaction, and a carbon dioxide adsorbent are disposed in a rotating pressure swing adsorber housing. The adsorption of carbon dioxide shifts equilibrium toward carbon monoxide consumption. A second adsorbent may be disposed in the housing for adsorbing carbon monoxide at low temperatures, and is adapted to desorb carbon monoxide at high temperatures. The present invention advantageously eliminates a unit operation from a space-constrained fuel cell vehicle by combining the WGS catalyst and a CO2 adsorbent in a single reactor/housing. The apparatus further eliminates the use of a PROX reactor, by providing an apparatus which incorporates CO2 adsorption and consequent carbon monoxide consumption in the place of the PROX reactor.

Abstract translation: 一种装置从氢燃料电池系统中的富氢气流中除去CO。 CO会损坏膜电极组件中昂贵的催化颗粒。 适用于执行水煤气变换反应的催化剂和二氧化碳吸附剂均设置在旋转变压吸附器壳体中。 二氧化碳的吸附将平衡转移到一氧化碳消耗。 第二吸附剂可以设置在壳体中用于在低温下吸附一氧化碳，并且适于在高温下解吸一氧化碳。 本发明通过在单个反应器/壳体中组合WGS催化剂和CO 2 H 2吸附剂有利地消除了来自空间受限的燃料电池车辆的单元操作。 该设备进一步消除了PROX反应器的使用，通过提供一种包含CO 2吸附和随后的一氧化碳消耗代替PROX反应器的装置。

公开(公告)号：US5989411A

公开(公告)日：1999-11-23

申请号：US177735

申请日：1998-10-23

Applicant: Ramesh Gupta

Inventor： Ramesh Gupta

IPC: C10G65/02 ,  C10G25/00 ,  C10G45/00 ,  C10G45/02 ,  C10G45/32 ,  C10G45/44 ,  C10G45/58 ,  C10G47/00 ,  C10G49/00 ,  C10G65/04 ,  C10G67/02 ,  C10G67/04 ,  C10G73/02 ,  C10G17/00

CPC classification number: C10G49/002 ,  C10G67/04 ,  Y10S203/06

Abstract: A hydroprocessing process for removing impurities from a feed comprising a hydrocarbonaceous liquid comprises at least two cocurrent, upflow hydroprocessing reaction stages and a non-catalytic, vapor-liquid contacting stage. The reaction and contacting stages may all be in the same reactor vessel. The feed and a hydrogen treat gas are passed up into a catalyst bed which comprises the first reaction stage, which produces a partially hydroprocessed liquid and vapor effluent. This first stage vapor is passed up into the contacting stage in which it contacts a hydrocarbonaceous liquid which reduces the vapor impurity content. The impurity-enriched contacting liquid passes down and mixes with the first stage liquid effluent. The combined effluents and hydrogen are passed up into the second reaction stage to form a processed product liquid and hydrogen-containing vapor effluent. This second reaction stage vapor effluent is passed up into the first stage to provide at least a portion of the hydrogen for the first stage reaction. Additional product liquid may be recovered by cooling the contacting and condensing the purified contacting stage vapor effluent.

Abstract translation: 用于从包含烃液体的进料中除去杂质的加氢处理方法包括至少两个并流，向上加氢处理反应阶段和非催化气液接触阶段。 反应和接触阶段都可以在同一反应容器中。 进料和氢气处理气体被送入催化剂床，催化剂床包括第一反应段，其产生部分加氢处理的液体和蒸气流出物。 该第一级蒸气通入其接触阶段，在该阶段中，其接触含烃液体，这降低了蒸气杂质含量。 杂质富集的接触液体向下流动并与第一级液体流出物混合。 将合并的废水和氢气输送到第二反应阶段以形成加工产物液体和含氢蒸汽流出物。 将该第二反应段蒸气流出物向上流入第一阶段以提供用于第一阶段反应的氢的至少一部分。 可以通过冷却接触并冷凝纯化的接触级蒸气流出物来回收附加的产物液体。

公开(公告)号：US4526757A

公开(公告)日：1985-07-02

申请号：US437905

申请日：1982-11-01

Applicant: Ramesh Gupta

Inventor： Ramesh Gupta

IPC: B01J8/04 ,  G05D9/00 ,  B01J8/02

CPC classification number: B01J8/0492 ,  Y10S423/09 ,  Y10T137/2774 ,  Y10T137/2802

Abstract: A process for automatically providing for periodic surge flow or liquid slugs in the catalyst bed to insure that the catalyst is periodically fully wetted. Therefore, before dry spots develop in the bed and some catalyst particles are deprived of the liquid reactants, the aforesaid liquid pulse or slug will rewet the catalyst. This desired periodic introduction of a liquid slug through a catalyst bed is accomplished by the provision of a plurality of automatically actuating and operating siphon means disposed and distributed across the area of the distributor tray means within the reactor.

Abstract translation: 一种用于在催化剂床中自动提供周期性浪涌流动或液体段的过程，以确保催化剂周期性地完全润湿。 因此，在床上发生干斑之前，一些催化剂颗粒被剥夺了液体反应物，所以前述的液体脉冲或细粒将再润湿催化剂。 通过设置多个自动致动和操作的虹吸装置来实现液体塞通过催化剂床的周期性引入，该多个自动启动和操作的虹吸装置设置并分布在反应器内的分配器托盘装置的区域上。

公开(公告)号：US4385033A

公开(公告)日：1983-05-24

申请号：US336420

申请日：1981-12-31

Applicant: Ramesh Gupta

Inventor： Ramesh Gupta

IPC: B01J8/02 ,  B01J8/04 ,  C10G49/00

CPC classification number: B01J8/0492 ,  B01J8/0278 ,  B01J8/0453 ,  C10G49/002

Abstract: The invention is for a fixed bed reactor with two phase gas and liquid flow. The reactor has at least one auxiliary bed of solid particles disposed above the main bed of solid particles. The auxiliary bed has a liquid bypass comprised of hollow tubing extending through the auxiliary bed. Liquid receptacles provide a liquid seal above the liquid bypasses, thereby preventing gas from bypassing along with the liquid. The liquid spilled from the flow receptacles seeks its lowest level and flows through the auxiliary bed. The tubing provides a bypass first for the liquid and later for both the liquid and gas when the auxiliary bed becomes fouled and the liquid seal is thereby broken. This feed arrangement allows for a low pressure drop bypassing of the auxiliary bed, when the auxiliary bed becomes fouled and clogged. The invention is also applicable to other apparatuses which use a flow arrangement similar to fixed bed reactors, but which do not necessarily utilize a chemical reaction. One example of such apparatus is a packed absorption tower having co-current downflow of gas and liquid.

Abstract translation: 本发明是用于具有两相气体和液体流的固定床反应器。 反应器具有至少一个固体颗粒辅助床，其设置在固体颗粒主床上方。 辅助床具有包括延伸​​穿过辅助床的中空管的液体旁路。 液体容器在液体旁路之上提供液体密封，从而防止气体与液体一起旁路。 从流动容器溢出的液体寻求其最低水平并流过辅助床。 当辅助床被污染并且液体密封件被破坏时，管道首先为液体提供旁路并且随后用于液体和气体。 当辅助床被弄脏并堵塞时，该馈送装置允许辅助床的低压降旁路。 本发明也适用于使用类似于固定床反应器但不一定利用化学反应的流动布置的其它装置。 这种装置的一个实例是具有气流和液体的并流下流的填充吸收塔。

公开(公告)号：US4380529A

公开(公告)日：1983-04-19

申请号：US261985

申请日：1981-05-08

Applicant: Ramesh Gupta

Inventor： Ramesh Gupta

IPC: B01J8/02 ,  B01J8/04 ,  C10G49/00 ,  C10G23/02

CPC classification number: C10G49/002 ,  B01J8/0278 ,  B01J8/0453 ,  B01J8/0492

Abstract: The invention is for a fixed bed reactor with two phase gas and liquid flow. The reactor has at least one auxiliary bed of solid particles disposed above the main bed of solid particles. The auxiliary bed has separate liquid and gas bypasses comprised of hollow tubing extending through the auxiliary bed to a distributor tray. A liquid layer on the tray provides a liquid seal above the liquid bypasses, thereby preventing gas from bypassing along with the liquid. This feed arrangement allows for a low pressure drop bypassing of the auxiliary bed, when the auxiliary bed becomes fouled and clogged. The invention is also applicable to other apparatuses which use a flow arrangement similar to fixed bed reactors, but which do not necessarily utilize a chemical reaction. One example of such apparatus is a packed absorption tower having co-current downflow of gas and liquid.

Abstract translation: 本发明是用于具有两相气体和液体流的固定床反应器。 反应器具有至少一个固体颗粒辅助床，其设置在固体颗粒主床上方。 辅助床具有分离的液体和气体旁路，其包括通过辅助床延伸到分配器托盘的中空管。 托盘上的液体层在液体旁路上提供液体密封，从而防止气体与液体一起旁路。 当辅助床被弄脏并堵塞时，该馈送装置允许辅助床的低压降旁路。 本发明也适用于使用类似于固定床反应器但不一定利用化学反应的流动布置的其它装置。 这种装置的一个实例是具有气流和液体的并流下流的填充吸收塔。