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169 条记录 (耗时 0.043 秒)

    Click chemistry surface functionalization for resonant micro-cavity sensors
    81.
    发明授权
    Click chemistry surface functionalization for resonant micro-cavity sensors 有权
    点击谐振微腔传感器的化学表面官能化

    公开(公告)号：US08092855B2

    公开(公告)日：2012-01-10

    申请号：US12324605

    申请日：2008-11-26

    申请人： Andrea M. Armani ,  Akinleye C. Alabi ,  Mark E. Davis ,  Richard C. Flagan ,  Scott E. Fraser

    发明人： Andrea M. Armani ,  Akinleye C. Alabi ,  Mark E. Davis ,  Richard C. Flagan ,  Scott E. Fraser

    IPC分类号： G01N1/28

    CPC分类号： G01N21/7746 ,  G01N33/54353 ,  G01N2021/7789

    摘要： Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.

    摘要翻译： 微腔谐振传感器具有使用点击化学功能化的外表面，例如涉及炔官能团和叠氮官能团的环加成反应。 第一聚合物连接元件与微腔的外表面结合并具有叠氮化物官能团，其结合环加成反应的结果与第二聚合物连接元素的炔官能团结合。 用于感测靶分子的功能化元件如抗体，抗原或蛋白质被结合到第二连接元件。

    Method of maintaining a bowling lane
    82.
    发明授权
    Method of maintaining a bowling lane 有权
    保龄球道的方法

    公开(公告)号：US08051528B2

    公开(公告)日：2011-11-08

    申请号：US11424027

    申请日：2006-06-14

    申请人： Mark E. Davis ,  John M. Davis

    发明人： Mark E. Davis ,  John M. Davis

    IPC分类号： A47L11/10

    CPC分类号： A63D5/10

    摘要： A bowling lane maintenance machine has its operating functions designed and controlled in such a manner that the machine may be battery-operated without loss of performance. Included in the operation are special movements of the machine at the pin deck to flick moisture off blades of the squeegee assembly and limited activation of the vacuum motor to reduce battery drain.

    摘要翻译： 保龄球道维护机具有设计和控制的操作功能，使得机器可以在不损失性能的情况下进行电池供电。 操作中包括机器在销甲板处的特殊运动，以从刮板组件的叶片上抽出湿气，并限制真空电机的启动以减少电池消耗。

    Inhibitor Nucleic Acids
    83.
    发明申请
    Inhibitor Nucleic Acids 审中-公开
    抑制剂核酸

    公开(公告)号：US20100093987A1

    公开(公告)日：2010-04-15

    申请号：US12576146

    申请日：2009-10-08

    申请人： Mark E. Davis

    发明人： Mark E. Davis

    IPC分类号： C07H21/02

    CPC分类号： A61K31/7125 ,  A61K31/713 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2310/315 ,  C12N2310/322 ,  C12N2310/3519 ,  C12N2310/53 ,  C12N2320/32 ,  C12N2320/50

    摘要： The present invention provides methods and compositions for attenuating expression of a target gene in vivo. In general, the method includes administering RNAi constructs (such as small-interfering RNAs (i.e., siRNAs) that are targeted to particular mRNA sequences, or nucleic acid material that can produce siRNAs in a cell), in an amount sufficient to attenuate expression of a target gene by an RNA interference mechanism. In particular, the RNAi constructs may include one or more modifications to improve serum stability, cellular uptake and/or to avoid non-specific effect. In certain embodiments, the RNAi constructs contain an aptamer portion. The aptamer may bind to human serum albumin to improve serum half life. The aptamer may also bind to a cell surface protein that improves uptake of the construct.

    摘要翻译： 本发明提供用于在体内减弱靶基因表达的方法和组合物。 一般来说，该方法包括以足以减弱表达的表达的量施用RNAi构建体（例如靶向特定mRNA序列的小干扰RNA（即siRNA）或可在细胞中产生siRNA的核酸材料） 一种RNA干扰机制的靶基因。 特别地，RNAi构建体可以包括一种或多种修饰以改善血清稳定性，细胞摄取和/或避免非特异性效应。 在某些实施方案中，RNAi构建体含有适体部分。 适体可以结合人血清白蛋白以改善血清半衰期。 适体也可以结合细胞表面蛋白，改善构建体的摄取。

    Bowling lane conditioning machine having cam-actuated wick segments
    84.
    发明授权
    Bowling lane conditioning machine having cam-actuated wick segments 有权
    保龄球道调节机具有凸轮驱动的油绳段

    公开(公告)号：US07531041B2

    公开(公告)日：2009-05-12

    申请号：US11181277

    申请日：2005-07-14

    申请人： Mark E. Davis

    发明人： Mark E. Davis

    IPC分类号： B05C11/00

    CPC分类号： A63D5/10

    摘要： A bowling lane maintenance machine utilizes flexible wick segments to transfer lane dressing to the applicator roll of the machine. The wick segments are caused to flex into and out of contacting engagement with a transfer roll associated with the applicator roll by rotatable cams that engage cam followers associated with the wick segments. The cams are all secured to a common cam shaft and are rotated in unison through successive short segments of rotational travel by an indexing motor that responds to a controller. Each wick segment has at least one spring that urges the segment into contacting engagement with the transfer roll, while the cam for that segment is disposed to engage the follower and flex the wick segment off the transfer roll against the action of the spring when the lobe of the cam is in contacting engagement with the follower.

    摘要翻译： 保龄球道维护机器利用柔性油绳段将车道修整传送到机器的涂抹辊。 通过与与灯芯段相关联的凸轮从动件的可旋转凸轮使油缸部分弯曲进入和脱离与与涂布辊相关联的传送辊的接触接合。 凸轮都固定到共同的凸轮轴上，并且通过响应于控制器的分度马达通过连续的旋转行程的短段旋转。 每个油绳段具有至少一个弹簧，该弹簧促使该段与转移辊接触接合，同时该段的凸轮设置成与从动件相接合，并且当油嘴凸起时抵抗弹簧的作用使油绳段离开转移辊 凸轮正在与跟随者接触。

    Zeolite films for low k applications
    86.
    发明授权
    Zeolite films for low k applications 有权
    沸石薄膜用于低k应用

    公开(公告)号：US07109130B2

    公开(公告)日：2006-09-19

    申请号：US11123504

    申请日：2005-05-04

    申请人： Mark E. Davis

    发明人： Mark E. Davis

    IPC分类号： H01L21/26 ,  H01L21/42 ,  H01L21/324 ,  H01L21/477

    CPC分类号： C01B39/04 ,  H01L21/02126 ,  H01L21/02145 ,  H01L21/02203 ,  H01L21/02282 ,  H01L21/02337 ,  H01L21/02359 ,  H01L21/31695 ,  Y10S438/967

    摘要： A method is provided for making an integrated circuit dielectric. A structure-directing agent (SDA) is provided. Preferably this structure-directing agent is a salt of a polycyclic organic compound. By use of the structure-directing agent, a film of a zeolite having a framework density below 15 T atoms per 1000 cubic angstroms and comprising primarily silicon and/or germanium atoms in the T positions is provided on a semiconductor substrate. Preferably the zeolite has the LTA structure. The structure-directing agent is removed from the film. The removal may be effected, for example, by heating or by chemically and/or photochemically decomposing the structure-directing agent, preferably in a manner which allows it to be recovered. The film is then optionally modified to reduce its hydrophilicity.

    摘要翻译： 提供了一种制造集成电路电介质的方法。 提供结构导向剂（SDA）。 优选地，该结构导向剂是多环有机化合物的盐。 通过使用结构导向剂，在半导体衬底上提供了具有低于15T原子/ 1000立方埃并且主要由T位置的硅和/或锗原子构成的沸石薄膜。 优选地，沸石具有LTA结构。 从薄膜中除去结构导向剂。 除去可以例如通过加热或通过化学和/或光化学分解结构导向剂来进行，优选以允许其回收的方式进行。 然后任选地修饰膜以降低其亲水性。

    Strip brush bowling lane dressing application mechanism
    87.
    发明授权
    Strip brush bowling lane dressing application mechanism 有权
    剥线保龄球道敷料应用机制

    公开(公告)号：US07056384B2

    公开(公告)日：2006-06-06

    申请号：US10791413

    申请日：2004-03-02

    申请人： Mark E. Davis ,  Anthony Crews

    发明人： Mark E. Davis ,  Anthony Crews

    IPC分类号： B05C1/06

    CPC分类号： A63D5/10

    摘要： A bowling lane conditioning machine has dressing application mechanism that includes an elongated, non-rotating strip brush which transfers dressing from a dispensing means to another surface, such as a bristle-type, lane-engaging applicator roll, a metal transfer roll that in turn transfers the dressing to the applicator roll, or the lane surface itself. In a preferred embodiment, dressing is dispensed to an upper one of two strip brushes that extend along the length of an applicator roll and engage its bristles at circumferentially spaced locations around its periphery. Dressing dispensed to the upper strip brush migrates by gravity to the bristles of the applicator roll and becomes applied to the lane surface as the roll rotates down into engagement with the surface. No dressing is dispensed to the second strip brush, which feathers the dressing on the applicator roll and reduces splattering.

    摘要翻译： 保龄球道调理机具有敷料施用机构，其包括细长的不旋转的带状刷，其将敷料从分配装置转移到另一表面，例如刷毛型，车道接合的涂抹辊，依次转动的金属转移辊 将敷料转移到涂布辊或车道表面本身。 在优选实施例中，敷料被分配到两个带状刷的上部，其沿着涂布辊的长度延伸并且在其周边周围间隔开的位置处接合其刷毛。 分配到上条带上的敷料通过重力移动到施加辊的刷毛上，并随着辊沿着与表面接合而施加到车道表面。 没有将敷料分配到第二条带刷上，这使得涂抹辊上的敷料发生羽毛并且减少飞溅。

    Rollable sports base
    89.
    发明授权
    Rollable sports base 有权

    公开(公告)号：US06412746B1

    公开(公告)日：2002-07-02

    申请号：US09813881

    申请日：2001-03-22

    申请人： Mark E. Davis ,  Ronald A. White ,  Craig Saunders ,  Rene Polin ,  Keith Kristiansen ,  Michael Ballone ,  Gary Grossman

    发明人： Mark E. Davis ,  Ronald A. White ,  Craig Saunders ,  Rene Polin ,  Keith Kristiansen ,  Michael Ballone ,  Gary Grossman

    IPC分类号： F16M1300

    摘要： A rollable sports ballast base for supporting a sports apparatus support member comprising a base member having a top surface and a bottom surface. The bottom surface contacts a support surface such as a driveway or other playing surface. There is at least one wheel assembly, retractable from a lower position to a raised position. The wheel assembly includes a pivoting connector coupled to the base member and a wheel bracket coupled to the pivoting connector. The wheel bracket includes an axle, at least one wheel, and a handle extending outwardly from the wheel bracket. The handle is used to pivotally rotate the wheel assembly about a transverse axis. When the handle is rotated away from the base member, the wheel assembly is placed in a lowered position whereby the wheel contacts the support surface thus separating the bottom surface of the base member from the support surface.